MPPB_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MPPB_HUMAN
• UniProt AC: O75439
• Protein Name: Mitochondrial-processing peptidase subunit beta
• Gene Name: PMPCB
• Organism: Homo sapiens (Human).
• Sequence Length: 489
• Subcellular Localization: Mitochondrion matrix.
• Protein Description: Cleaves presequences (transit peptides) from mitochondrial protein precursors..
• Protein Sequence: MAAAAARVVLSSAARRRLWGFSESLLIRGAAGRSLYFGENRLRSTQAATQVVLNVPETRVTCLESGLRVASEDSGLSTCTVGLWIDAGSRYENEKNNGTAHFLEHMAFKGTKKRSQLDLELEIENMGAHLNAYTSREQTVYYAKAFSKDLPRAVEILADIIQNSTLGEAEIERERGVILREMQEVETNLQEVVFDYLHATAYQNTALGRTILGPTENIKSISRKDLVDYITTHYKGPRIVLAAAGGVSHDELLDLAKFHFGDSLCTHKGEIPALPPCKFTGSEIRVRDDKMPLAHLAIAVEAVGWAHPDTICLMVANTLIGNWDRSFGGGMNLSSKLAQLTCHGNLCHSFQSFNTSYTDTGLWGLYMVCESSTVADMLHVVQKEWMRLCTSVTESEVARARNLLKTNMLLQLDGSTPICEDIGRQMLCYNRRIPIPELEARIDAVNAETIREVCTKYIYNRSPAIAAVGPIKQLPDFKQIRSNMCWLRD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11	Phosphorylation	AAARVVLSSAARRRL HHHHHHHCHHHHHHH	13.30	-
12	Phosphorylation	AARVVLSSAARRRLW HHHHHHCHHHHHHHH	23.06	-
44	Phosphorylation	FGENRLRSTQAATQV CCCCHHHHCCCEEEE	29.48	30266825
45	Phosphorylation	GENRLRSTQAATQVV CCCHHHHCCCEEEEE	18.78	30266825
49	Phosphorylation	LRSTQAATQVVLNVP HHHCCCEEEEECCCC	25.55	30266825
58	Phosphorylation	VVLNVPETRVTCLES EECCCCCCCEEHHHH	25.11	27362937
95	Ubiquitination	GSRYENEKNNGTAHF CCCCCCCCCCCHHHH	68.26	21890473
111	O-linked_Glycosylation	EHMAFKGTKKRSQLD HHHHCCCCCCHHHHH	33.70	30379171
133	Phosphorylation	MGAHLNAYTSREQTV CHHHHHCCCCHHHHH	12.27	-
139	Phosphorylation	AYTSREQTVYYAKAF CCCCHHHHHHHHHHH	13.01	22210691
141	Phosphorylation	TSREQTVYYAKAFSK CCHHHHHHHHHHHCC	10.90	22817900
142	Phosphorylation	SREQTVYYAKAFSKD CHHHHHHHHHHHCCC	9.40	22817900
144	Ubiquitination	EQTVYYAKAFSKDLP HHHHHHHHHHCCCHH	33.57	-
148	Ubiquitination	YYAKAFSKDLPRAVE HHHHHHCCCHHHHHH	57.75	-
148	Malonylation	YYAKAFSKDLPRAVE HHHHHHCCCHHHHHH	57.75	26320211
205	Phosphorylation	HATAYQNTALGRTIL HHHHHCCCCCCCCCC	14.03	-
219	2-Hydroxyisobutyrylation	LGPTENIKSISRKDL CCCCCCHHHCCHHHH	54.01	-
219	Acetylation	LGPTENIKSISRKDL CCCCCCHHHCCHHHH	54.01	25953088
219	Malonylation	LGPTENIKSISRKDL CCCCCCHHHCCHHHH	54.01	26320211
219	Ubiquitination	LGPTENIKSISRKDL CCCCCCHHHCCHHHH	54.01	21906983
224	Malonylation	NIKSISRKDLVDYIT CHHHCCHHHHHHHHH	48.93	26320211
224	Ubiquitination	NIKSISRKDLVDYIT CHHHCCHHHHHHHHH	48.93	21890473
229	Phosphorylation	SRKDLVDYITTHYKG CHHHHHHHHHHHCCC	7.84	-
235	Acetylation	DYITTHYKGPRIVLA HHHHHHCCCCEEEEE	55.63	25953088
235	Ubiquitination	DYITTHYKGPRIVLA HHHHHHCCCCEEEEE	55.63	21890473
278	Acetylation	IPALPPCKFTGSEIR CCCCCCCCCCCCEEE	52.30	26822725
331	Sulfoxidation	DRSFGGGMNLSSKLA CHHCCCCCCHHHHHH	5.29	21406390
419	Glutathionylation	LDGSTPICEDIGRQM CCCCCCCCHHHHHHH	3.96	22555962
456	Ubiquitination	TIREVCTKYIYNRSP HHHHHHHHHHHHCCC	25.23	-
456	Acetylation	TIREVCTKYIYNRSP HHHHHHHHHHHHCCC	25.23	25953088
462	Phosphorylation	TKYIYNRSPAIAAVG HHHHHHCCCCCEECC	18.29	28674419
472	Ubiquitination	IAAVGPIKQLPDFKQ CEECCCHHHCCCHHH	49.25	21890473
472	Acetylation	IAAVGPIKQLPDFKQ CEECCCHHHCCCHHH	49.25	25953088
472	Succinylation	IAAVGPIKQLPDFKQ CEECCCHHHCCCHHH	49.25	27452117
478	Ubiquitination	IKQLPDFKQIRSNMC HHHCCCHHHHHHHCC	52.80	-
478	Acetylation	IKQLPDFKQIRSNMC HHHCCCHHHHHHHCC	52.80	25953088
478	Succinylation	IKQLPDFKQIRSNMC HHHCCCHHHHHHHCC	52.80	23954790

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MPPB_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MPPB_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MPPB_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
FRDA_HUMAN	FXN	physical	9700204
RFA2_HUMAN	RPA2	physical	22939629
P4R3A_HUMAN	SMEK1	physical	26186194
P4R3B_HUMAN	SMEK2	physical	26186194
PP4R1_HUMAN	PPP4R1	physical	26186194
PNPT1_HUMAN	PNPT1	physical	26344197
PRDX5_HUMAN	PRDX5	physical	26344197
PP4R1_HUMAN	PPP4R1	physical	28514442
P4R3A_HUMAN	SMEK1	physical	28514442
P4R3B_HUMAN	SMEK2	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.