PP4R1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PP4R1_HUMAN
• UniProt AC: Q8TF05
• Protein Name: Serine/threonine-protein phosphatase 4 regulatory subunit 1
• Gene Name: PPP4R1
• Organism: Homo sapiens (Human).
• Sequence Length: 950
• Protein Description: Regulatory subunit of serine/threonine-protein phosphatase 4. May play a role in regulation of cell division in renal glomeruli. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3..
• Protein Sequence: MADLSLLQEDLQEDADGFGVDDYSSESDVIIIPSALDFVSQDEMLTPLGRLDKYAASENIFNRQMVARSLLDTLREVCDDERDCIAVLERISRLADDSEPTVRAELMEQVPHIALFCQENRPSIPYAFSKFLLPIVVRYLADQNNQVRKTSQAALLALLEQELIERFDVETKVCPVLIELTAPDSNDDVKTEAVAIMCKMAPMVGKDITERLILPRFCEMCCDCRMFHVRKVCAANFGDICSVVGQQATEEMLLPRFFQLCSDNVWGVRKACAECFMAVSCATCQEIRRTKLSALFINLISDPSRWVRQAAFQSLGPFISTFANPSSSGQYFKEESKSSEEMSVENKNRTRDQEAPEDVQVRPEDTPSDLSVSNSSVILENTMEDHAAEASGKPLGEISVPLDSSLLCTLSSESHQEAASNENDKKPGNYKSMLRPEVGTTSQDSALLDQELYNSFHFWRTPLPEIDLDIELEQNSGGKPSPEGPEEESEGPVPSSPNITMATRKELEEMIENLEPHIDDPDVKAQVEVLSAALRASSLDAHEETISIEKRSDLQDELDINELPNCKINQEDSVPLISDAVENMDSTLHYIHSDSDLSNNSSFSPDEERRTKVQDVVPQALLDQYLSMTDPSRAQTVDTEIAKHCAYSLPGVALTLGRQNWHCLRETYETLASDMQWKVRRTLAFSIHELAVILGDQLTAADLVPIFNGFLKDLDEVRIGVLKHLHDFLKLLHIDKRREYLYQLQEFLVTDNSRNWRFRAELAEQLILLLELYSPRDVYDYLRPIALNLCADKVSSVRWISYKLVSEMVKKLHAATPPTFGVDLINELVENFGRCPKWSGRQAFVFVCQTVIEDDCLPMDQFAVHLMPHLLTLANDRVPNVRVLLAKTLRQTLLEKDYFLASASCHQEAVEQTIMALQMDRDSDVKYFASIHPASTKISEDAMSTASSTY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
53	Ubiquitination	TPLGRLDKYAASENI CCCHHHHHHHHHCCC	41.19	-
69	Phosphorylation	NRQMVARSLLDTLRE CHHHHHHHHHHHHHH	24.44	18767875
73	Phosphorylation	VARSLLDTLREVCDD HHHHHHHHHHHHCCC	27.90	18767875
139	Phosphorylation	LLPIVVRYLADQNNQ HHHHHHHHHHHCCCH	8.47	-
150	Phosphorylation	QNNQVRKTSQAALLA CCCHHHHHHHHHHHH	18.59	25693802
151	Phosphorylation	NNQVRKTSQAALLAL CCHHHHHHHHHHHHH	22.36	25693802
182	Ubiquitination	PVLIELTAPDSNDDV CEEEEEECCCCCCCC	20.66	29967540
199	Ubiquitination	EAVAIMCKMAPMVGK HHHHHHHHHHHHCCC	22.25	29967540
338	Phosphorylation	YFKEESKSSEEMSVE CCCCCCCCCCCCCCC	52.87	28985074
339	Phosphorylation	FKEESKSSEEMSVEN CCCCCCCCCCCCCCC	41.11	28102081
342	Sulfoxidation	ESKSSEEMSVENKNR CCCCCCCCCCCCCCC	4.83	30846556
343	Phosphorylation	SKSSEEMSVENKNRT CCCCCCCCCCCCCCC	29.56	28102081
405	Phosphorylation	ISVPLDSSLLCTLSS ECCCCCHHHHHHHCC	25.65	24275569
432	Phosphorylation	KKPGNYKSMLRPEVG CCCCCCHHHCCCCCC	16.82	24719451
440	Phosphorylation	MLRPEVGTTSQDSAL HCCCCCCCCCCCCHH	28.57	28348404
441	Phosphorylation	LRPEVGTTSQDSALL CCCCCCCCCCCCHHH	20.61	28348404
442	Phosphorylation	RPEVGTTSQDSALLD CCCCCCCCCCCHHHC	31.65	28348404
453	Phosphorylation	ALLDQELYNSFHFWR HHHCHHHHHHHCCCC	14.17	-
455	Phosphorylation	LDQELYNSFHFWRTP HCHHHHHHHCCCCCC	13.42	28348404
495	Phosphorylation	ESEGPVPSSPNITMA CCCCCCCCCCCCCHH	59.67	25850435
496	Phosphorylation	SEGPVPSSPNITMAT CCCCCCCCCCCCHHC	18.85	25850435
500	Phosphorylation	VPSSPNITMATRKEL CCCCCCCCHHCHHHH	13.85	25850435
503	Phosphorylation	SPNITMATRKELEEM CCCCCHHCHHHHHHH	31.30	24719451
510	Sulfoxidation	TRKELEEMIENLEPH CHHHHHHHHHHCCCC	3.21	30846556
533	Ubiquitination	QVEVLSAALRASSLD HHHHHHHHHHHHCCC	8.33	29967540
537	Phosphorylation	LSAALRASSLDAHEE HHHHHHHHCCCCCHH	25.62	26657352
538	Phosphorylation	SAALRASSLDAHEET HHHHHHHCCCCCHHH	29.32	28450419
545	Phosphorylation	SLDAHEETISIEKRS CCCCCHHHEEEHHHH	19.62	28555341
547	Phosphorylation	DAHEETISIEKRSDL CCCHHHEEEHHHHHC	31.92	23312004
550	Ubiquitination	EETISIEKRSDLQDE HHHEEEHHHHHCCCC	56.37	29967540
552	Phosphorylation	TISIEKRSDLQDELD HEEEHHHHHCCCCCC	54.46	25693802
554	Ubiquitination	SIEKRSDLQDELDIN EEHHHHHCCCCCCHH	7.93	21963094
573	Phosphorylation	CKINQEDSVPLISDA CCCCCHHCCCCCHHH	25.53	23898821
578	Phosphorylation	EDSVPLISDAVENMD HHCCCCCHHHHHCCC	27.48	23898821
584	Ubiquitination	ISDAVENMDSTLHYI CHHHHHCCCHHCCHH	2.45	21963094
586	Phosphorylation	DAVENMDSTLHYIHS HHHHCCCHHCCHHCC	23.31	23898821
587	Phosphorylation	AVENMDSTLHYIHSD HHHCCCHHCCHHCCC	17.19	23898821
590	Phosphorylation	NMDSTLHYIHSDSDL CCCHHCCHHCCCCCC	11.93	23898821
593	Phosphorylation	STLHYIHSDSDLSNN HHCCHHCCCCCCCCC	29.29	23898821
595	Phosphorylation	LHYIHSDSDLSNNSS CCHHCCCCCCCCCCC	43.39	23898821
595 (in isoform 2)	Ubiquitination	-	43.39	21890473
598	Phosphorylation	IHSDSDLSNNSSFSP HCCCCCCCCCCCCCC	38.67	23898821
601	Phosphorylation	DSDLSNNSSFSPDEE CCCCCCCCCCCCCHH	36.69	23898821
602	Phosphorylation	SDLSNNSSFSPDEER CCCCCCCCCCCCHHH	31.69	23898821
604	Phosphorylation	LSNNSSFSPDEERRT CCCCCCCCCCHHHHH	33.13	23898821
612	Ubiquitination	PDEERRTKVQDVVPQ CCHHHHHHHHHHHHH	35.77	21906983
612 (in isoform 1)	Ubiquitination	-	35.77	21890473
626	Ubiquitination	QALLDQYLSMTDPSR HHHHHHHHCCCCHHH	2.04	21963094
641	Ubiquitination	AQTVDTEIAKHCAYS CCCCCHHHHHHHHHC	7.22	21890473
642	Ubiquitination	QTVDTEIAKHCAYSL CCCCHHHHHHHHHCC	6.84	21963094
643	Ubiquitination	TVDTEIAKHCAYSLP CCCHHHHHHHHHCCC	44.90	21963094
647	Ubiquitination	EIAKHCAYSLPGVAL HHHHHHHHCCCCHHH	19.01	23000965
671	Ubiquitination	LRETYETLASDMQWK HHHHHHHHHHHHHHH	2.61	21890473
677	Ubiquitination	TLASDMQWKVRRTLA HHHHHHHHHHHHHHH	8.42	23000965
678	Ubiquitination	LASDMQWKVRRTLAF HHHHHHHHHHHHHHC	14.69	21963094
695	Ubiquitination	HELAVILGDQLTAAD HHHHHHHCCCCCHHH	14.97	21963094
713	Ubiquitination	IFNGFLKDLDEVRIG HHCCHHCCHHHHHHH	62.59	21890473
713 (in isoform 2)	Ubiquitination	-	62.59	21890473
714	Ubiquitination	FNGFLKDLDEVRIGV HCCHHCCHHHHHHHH	6.06	21890473
719	Ubiquitination	KDLDEVRIGVLKHLH CCHHHHHHHHHHHHH	5.59	23000965
729	Ubiquitination	LKHLHDFLKLLHIDK HHHHHHHHHHHCHHH	4.81	21890473
730	Ubiquitination	KHLHDFLKLLHIDKR HHHHHHHHHHCHHHH	49.34	23000965
730 (in isoform 1)	Ubiquitination	-	49.34	21890473
735	Ubiquitination	FLKLLHIDKRREYLY HHHHHCHHHHHHHHH	27.88	23000965
736	Ubiquitination	LKLLHIDKRREYLYQ HHHHCHHHHHHHHHH	53.40	23000965
744	Ubiquitination	RREYLYQLQEFLVTD HHHHHHHHHHHHHCC	3.13	21890473
764	Phosphorylation	RFRAELAEQLILLLE HHHHHHHHHHHHHHH	59.55	32142685
765	Ubiquitination	FRAELAEQLILLLEL HHHHHHHHHHHHHHH	28.35	21890473
771	Ubiquitination	EQLILLLELYSPRDV HHHHHHHHHCCCHHH	45.70	23000965
781	Phosphorylation	SPRDVYDYLRPIALN CCHHHHHHHHHHHHH	6.21	32142685
782	Ubiquitination	PRDVYDYLRPIALNL CHHHHHHHHHHHHHH	4.85	21890473
786	Ubiquitination	YDYLRPIALNLCADK HHHHHHHHHHHHCCC	7.96	21890473
786 (in isoform 2)	Ubiquitination	-	7.96	21890473
788	Ubiquitination	YLRPIALNLCADKVS HHHHHHHHHHCCCCH	24.85	23000965
798	Ubiquitination	ADKVSSVRWISYKLV CCCCHHHHHHHHHHH	27.27	22505724
801	Phosphorylation	VSSVRWISYKLVSEM CHHHHHHHHHHHHHH	14.84	30631047
802	Ubiquitination	SSVRWISYKLVSEMV HHHHHHHHHHHHHHH	10.14	21890473
803	Ubiquitination	SVRWISYKLVSEMVK HHHHHHHHHHHHHHH	35.30	21963094
803 (in isoform 1)	Ubiquitination	-	35.30	21890473
806	Phosphorylation	WISYKLVSEMVKKLH HHHHHHHHHHHHHHH	30.34	22673903
807	Ubiquitination	ISYKLVSEMVKKLHA HHHHHHHHHHHHHHH	40.28	22817900
816	Phosphorylation	VKKLHAATPPTFGVD HHHHHHCCCCCCCHH	30.50	25159151
828	Ubiquitination	GVDLINELVENFGRC CHHHHHHHHHHHCCC	5.18	22505724
837	Ubiquitination	ENFGRCPKWSGRQAF HHHCCCCCCCCCCEE	58.58	22817900
838	Ubiquitination	NFGRCPKWSGRQAFV HHCCCCCCCCCCEEE	7.37	21890473
850	Phosphorylation	AFVFVCQTVIEDDCL EEEEEEEEEECCCCC	20.51	24043423
855	Ubiquitination	CQTVIEDDCLPMDQF EEEEECCCCCCHHHH	24.06	21890473
870	Ubiquitination	AVHLMPHLLTLANDR HHHHHHHHHHHHCCC	3.01	22505724
872	Phosphorylation	HLMPHLLTLANDRVP HHHHHHHHHHCCCCC	30.13	24043423
879	Ubiquitination	TLANDRVPNVRVLLA HHHCCCCCCHHHHHH	34.20	22817900
886	Ubiquitination	PNVRVLLAKTLRQTL CCHHHHHHHHHHHHH	9.91	22505724
887	Ubiquitination	NVRVLLAKTLRQTLL CHHHHHHHHHHHHHH	48.32	22505724
892	Phosphorylation	LAKTLRQTLLEKDYF HHHHHHHHHHHCCCE	27.20	-
895	Ubiquitination	TLRQTLLEKDYFLAS HHHHHHHHCCCEECC	47.17	22817900
896	Ubiquitination	LRQTLLEKDYFLASA HHHHHHHCCCEECCC	58.67	22817900
909	Ubiquitination	SASCHQEAVEQTIMA CCCCHHHHHHHHHHH	11.99	29967540
920 (in isoform 2)	Ubiquitination	-	37.97	21890473
922	Ubiquitination	MALQMDRDSDVKYFA HHHHCCCCCCHHHEE	44.95	22505724
926	Ubiquitination	MDRDSDVKYFASIHP CCCCCCHHHEEECCC	39.37	29967540
927	Phosphorylation	DRDSDVKYFASIHPA CCCCCHHHEEECCCC	12.29	27642862
930	Phosphorylation	SDVKYFASIHPASTK CCHHHEEECCCCCCC	16.13	33259812
931	Ubiquitination	DVKYFASIHPASTKI CHHHEEECCCCCCCC	3.96	22817900
935	Phosphorylation	FASIHPASTKISEDA EEECCCCCCCCCHHH	34.38	28348404
936	Phosphorylation	ASIHPASTKISEDAM EECCCCCCCCCHHHH	34.21	25849741
937	Ubiquitination	SIHPASTKISEDAMS ECCCCCCCCCHHHHH	41.56	2190698
937 (in isoform 1)	Ubiquitination	-	41.56	21890473
939	Phosphorylation	HPASTKISEDAMSTA CCCCCCCCHHHHHHH	30.86	29514088
939	Ubiquitination	HPASTKISEDAMSTA CCCCCCCCHHHHHHH	30.86	22505724
944	Phosphorylation	KISEDAMSTASSTY- CCCHHHHHHHCCCC-	23.65	25159151
945	Phosphorylation	ISEDAMSTASSTY-- CCHHHHHHHCCCC--	19.92	25159151
947	Phosphorylation	EDAMSTASSTY---- HHHHHHHCCCC----	24.25	25159151
948	Phosphorylation	DAMSTASSTY----- HHHHHHCCCC-----	29.30	25159151
948	Ubiquitination	DAMSTASSTY----- HHHHHHCCCC-----	29.30	22817900
949	Phosphorylation	AMSTASSTY------ HHHHHCCCC------	30.65	23663014
950	Phosphorylation	MSTASSTY------- HHHHCCCC-------	20.64	20068231

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PP4R1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PP4R1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PP4R1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PP4C_HUMAN	PPP4C	physical	16085932
PP4C_MOUSE	Ppp4c	physical	10026142
MAP4_HUMAN	MAP4	physical	22863883
TRAF2_HUMAN	TRAF2	physical	25134449
CTND1_HUMAN	CTNND1	physical	26496610
LDHB_HUMAN	LDHB	physical	26496610
NDUB4_HUMAN	NDUFB4	physical	26496610
PP2AA_HUMAN	PPP2CA	physical	26496610
2AAA_HUMAN	PPP2R1A	physical	26496610
2AAB_HUMAN	PPP2R1B	physical	26496610
PP4C_HUMAN	PPP4C	physical	26496610
CCDC6_HUMAN	CCDC6	physical	26496610
MAP7_HUMAN	MAP7	physical	26496610
MED24_HUMAN	MED24	physical	26496610
S61A1_HUMAN	SEC61A1	physical	26496610
FAKD5_HUMAN	FASTKD5	physical	26496610

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.