NDUB4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NDUB4_HUMAN
• UniProt AC: O95168
• Protein Name: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4
• Gene Name: NDUFB4
• Organism: Homo sapiens (Human).
• Sequence Length: 129
• Subcellular Localization: Mitochondrion inner membrane ; Single-pass membrane protein ; Matrix side .
• Protein Description: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone..
• Protein Sequence: MSFPKYKPSSLRTLPETLDPAEYNISPETRRAQAERLAIRAQLKREYLLQYNDPNRRGLIENPALLRWAYARTINVYPNFRPTPKNSLMGALCGFGPLIFIYYIIKTERDRKEKLIQEGKLDRTFHLSY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSFPKYKPS ------CCCCCCCCH	50.70	22814378
5	Ubiquitination	---MSFPKYKPSSLR ---CCCCCCCCHHHC	64.99	21890473
6	Phosphorylation	--MSFPKYKPSSLRT --CCCCCCCCHHHCC	28.50	24719451
7	Ubiquitination	-MSFPKYKPSSLRTL -CCCCCCCCHHHCCC	44.54	21890473
7	Ubiquitination	-MSFPKYKPSSLRTL -CCCCCCCCHHHCCC	44.54	21890473
7	Ubiquitination	-MSFPKYKPSSLRTL -CCCCCCCCHHHCCC	44.54	21890473
9	Phosphorylation	SFPKYKPSSLRTLPE CCCCCCCHHHCCCCC	37.54	24719451
17	Phosphorylation	SLRTLPETLDPAEYN HHCCCCCCCCHHHHC	34.22	23186163
23	Phosphorylation	ETLDPAEYNISPETR CCCCHHHHCCCHHHH	21.65	30108239
26	Phosphorylation	DPAEYNISPETRRAQ CHHHHCCCHHHHHHH	17.04	21815630
29	Phosphorylation	EYNISPETRRAQAER HHCCCHHHHHHHHHH	28.92	30108239
47	Phosphorylation	RAQLKREYLLQYNDP HHHHHHHHHHHCCCC	19.42	29496907
51	Phosphorylation	KREYLLQYNDPNRRG HHHHHHHCCCCCCCC	22.85	28152594
77	Phosphorylation	YARTINVYPNFRPTP HHHHEECCCCCCCCC	6.48	26657352
83	Phosphorylation	VYPNFRPTPKNSLMG CCCCCCCCCCCHHHH	42.51	22210691
102	Phosphorylation	FGPLIFIYYIIKTER CHHHHHHEEHHHCCH	4.28	22210691
103	Phosphorylation	GPLIFIYYIIKTERD HHHHHHEEHHHCCHH	7.43	22210691
112	Ubiquitination	IKTERDRKEKLIQEG HHCCHHHHHHHHHCC	64.59	24816145
120	Ubiquitination	EKLIQEGKLDRTFHL HHHHHCCCCCCEEEC	46.60	27667366
123	Methylation	IQEGKLDRTFHLSY- HHCCCCCCEEECCC-	50.13	115484725

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NDUB4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NDUB4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NDUB4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NDUV2_HUMAN	NDUFV2	physical	22939629
NDUS6_HUMAN	NDUFS6	physical	22939629
TOM20_HUMAN	TOMM20	physical	22939629
PHB_HUMAN	PHB	physical	26344197
UCRI_HUMAN	UQCRFS1	physical	26344197
VDAC1_HUMAN	VDAC1	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.