NDUS6_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NDUS6_HUMAN
• UniProt AC: O75380
• Protein Name: NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial
• Gene Name: NDUFS6
• Organism: Homo sapiens (Human).
• Sequence Length: 124
• Subcellular Localization: Mitochondrion inner membrane ; Peripheral membrane protein ; Matrix side .
• Protein Description: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone..
• Protein Sequence: MAAAMTFCRLLNRCGEAARSLPLGARCFGVRVSPTGEKVTHTGQVYDDKDYRRIRFVGRQKEVNENFAIDLIAEQPVSEVETRVIACDGGGGALGHPKVYINLDKETKTGTCGYCGLQFRQHHH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
27	S-nitrosylation	SLPLGARCFGVRVSP HCCCCCEEEEEEECC	3.27	24105792
38	Ubiquitination	RVSPTGEKVTHTGQV EECCCCCEEEECCEE	54.50	-
46	Phosphorylation	VTHTGQVYDDKDYRR EEECCEEECCCCCEE	15.55	27642862
49	Ubiquitination	TGQVYDDKDYRRIRF CCEEECCCCCEEEEE	54.48	-
49	2-Hydroxyisobutyrylation	TGQVYDDKDYRRIRF CCEEECCCCCEEEEE	54.48	-
51	Phosphorylation	QVYDDKDYRRIRFVG EEECCCCCEEEEEEC	13.92	20393185
78	Phosphorylation	LIAEQPVSEVETRVI EEECCCCCCCEEEEE	42.48	-
82	Phosphorylation	QPVSEVETRVIACDG CCCCCCEEEEEEECC	35.10	-
98	Acetylation	GGALGHPKVYINLDK CCCCCCCEEEEECCC	41.83	25825284
100	Phosphorylation	ALGHPKVYINLDKET CCCCCEEEEECCCCC	7.10	27642862
105	Ubiquitination	KVYINLDKETKTGTC EEEEECCCCCCCCCC	71.14	-
105	2-Hydroxyisobutyrylation	KVYINLDKETKTGTC EEEEECCCCCCCCCC	71.14	-
105	Acetylation	KVYINLDKETKTGTC EEEEECCCCCCCCCC	71.14	26051181
108	Acetylation	INLDKETKTGTCGYC EECCCCCCCCCCCCC	46.15	25038526
114	Phosphorylation	TKTGTCGYCGLQFRQ CCCCCCCCCCCCCCC	5.86	28152594

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NDUS6_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NDUS6_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NDUS6_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NDUS7_HUMAN	NDUFS7	physical	22939629
NDUS8_HUMAN	NDUFS8	physical	22939629
OR4S2_HUMAN	OR4S2	physical	22939629
ZO1_HUMAN	TJP1	physical	22939629
NEDD8_HUMAN	NEDD8	physical	22939629
NNTM_HUMAN	NNT	physical	22939629
TMM65_HUMAN	TMEM65	physical	22939629
SEP11_HUMAN	SEPT11	physical	22939629
RS12_HUMAN	RPS12	physical	22939629
RALA_HUMAN	RALA	physical	22939629
NDUV3_HUMAN	NDUFV3	physical	24344204
NDUS1_HUMAN	NDUFS1	physical	24344204
NDUV2_HUMAN	NDUFV2	physical	24344204
NDUA9_HUMAN	NDUFA9	physical	24344204
NDUS2_HUMAN	NDUFS2	physical	24344204
NDUA7_HUMAN	NDUFA7	physical	24344204
NDUS3_HUMAN	NDUFS3	physical	24344204
NDUV1_HUMAN	NDUFV1	physical	24344204
NDUS8_HUMAN	NDUFS8	physical	24344204
NU4M_HUMAN	ND4	physical	24344204
NDUV3_HUMAN	NDUFV3	physical	28514442
NDUB7_HUMAN	NDUFB7	physical	28514442
NDUA7_HUMAN	NDUFA7	physical	28514442
NDUAC_HUMAN	NDUFA12	physical	28514442
NU5M_HUMAN	ND5	physical	28514442
NDUB6_HUMAN	NDUFB6	physical	28514442
NDUC2_HUMAN	NDUFC2	physical	28514442
NDUS4_HUMAN	NDUFS4	physical	28514442
NDUV2_HUMAN	NDUFV2	physical	28514442
NDUB8_HUMAN	NDUFB8	physical	28514442
NU4M_HUMAN	ND4	physical	28514442
NDUB3_HUMAN	NDUFB3	physical	28514442
NDUB1_HUMAN	NDUFB1	physical	28514442
NDUB5_HUMAN	NDUFB5	physical	28514442
NDUB9_HUMAN	NDUFB9	physical	28514442
NDUA8_HUMAN	NDUFA8	physical	28514442
NU1M_HUMAN	ND1	physical	28514442
NDUV1_HUMAN	NDUFV1	physical	28514442
FAHD1_HUMAN	FAHD1	physical	28514442
NU2M_HUMAN	ND2	physical	28514442
BCAT2_HUMAN	BCAT2	physical	28514442
DJC30_HUMAN	DNAJC30	physical	28514442
NDUA9_HUMAN	NDUFA9	physical	28514442
HEM1_HUMAN	ALAS1	physical	28514442
RMD5A_HUMAN	RMND5A	physical	28514442
NDUB4_HUMAN	NDUFB4	physical	28514442
ARMC8_HUMAN	ARMC8	physical	28514442
GID4_HUMAN	GID4	physical	28514442
NDUS5_HUMAN	NDUFS5	physical	28514442
NDUA6_HUMAN	NDUFA6	physical	28514442
GID8_HUMAN	GID8	physical	28514442
NDUA2_HUMAN	NDUFA2	physical	28514442
NDUS1_HUMAN	NDUFS1	physical	28514442
NDUA1_HUMAN	NDUFA1	physical	28514442
ZMY19_HUMAN	ZMYND19	physical	28514442
NDUA3_HUMAN	NDUFA3	physical	28514442
NDUBA_HUMAN	NDUFB10	physical	28514442
NDUS8_HUMAN	NDUFS8	physical	28514442
ACPM_HUMAN	NDUFAB1	physical	28514442
NDUS2_HUMAN	NDUFS2	physical	28514442
PCKGM_HUMAN	PCK2	physical	28514442
RBP10_HUMAN	RANBP10	physical	28514442
ILKAP_HUMAN	ILKAP	physical	28514442

Drug and Disease Associations

• Kegg Disease
• H00473: Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.