NDUS1_HUMAN - dbPTM
NDUS1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID NDUS1_HUMAN
UniProt AC P28331
Protein Name NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
Gene Name NDUFS1
Organism Homo sapiens (Human).
Sequence Length 727
Subcellular Localization Mitochondrion inner membrane.
Protein Description Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). This is the largest subunit of complex I and it is a component of the iron-sulfur (IP) fragment of the enzyme. It may form part of the active site crevice where NADH is oxidized..
Protein Sequence MLRIPVRKALVGLSKSPKGCVRTTATAASNLIEVFVDGQSVMVEPGTTVLQACEKVGMQIPRFCYHERLSVAGNCRMCLVEIEKAPKVVAACAMPVMKGWNILTNSEKSKKAREGVMEFLLANHPLDCPICDQGGECDLQDQSMMFGNDRSRFLEGKRAVEDKNIGPLVKTIMTRCIQCTRCIRFASEIAGVDDLGTTGRGNDMQVGTYIEKMFMSELSGNIIDICPVGALTSKPYAFTARPWETRKTESIDVMDAVGSNIVVSTRTGEVMRILPRMHEDINEEWISDKTRFAYDGLKRQRLTEPMVRNEKGLLTYTSWEDALSRVAGMLQSFQGKDVAAIAGGLVDAEALVALKDLLNRVDSDTLCTEEVFPTAGAGTDLRSNYLLNTTIAGVEEADVVLLVGTNPRFEAPLFNARIRKSWLHNDLKVALIGSPVDLTYTYDHLGDSPKILQDIASGSHPFSQVLKEAKKPMVVLGSSALQRNDGAAILAAVSSIAQKIRMTSGVTGDWKVMNILHRIASQVAALDLGYKPGVEAIRKNPPKVLFLLGADGGCITRQDLPKDCFIIYQGHHGDVGAPIADVILPGAAYTEKSATYVNTEGRAQQTKVAVTPPGLAREDWKIIRALSEIAGMTLPYDTLDQVRNRLEEVSPNLVRYDDIEGANYFQQANELSKLVNQQLLADPLVPPQLTIKDFYMTDSISRASQTMAKCVKAVTEGAQAVEEPSIC
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
14PhosphorylationRKALVGLSKSPKGCV
HHHHHCCCCCCCCCH		25.76-
15UbiquitinationKALVGLSKSPKGCVR
HHHHCCCCCCCCCHH		75.67-
16PhosphorylationALVGLSKSPKGCVRT
HHHCCCCCCCCCHHH		28.59-
58SulfoxidationQACEKVGMQIPRFCY
HHHHHHCCCCCCCCC		3.5021406390
84AcetylationMCLVEIEKAPKVVAA
EEEEEHHHCCHHHHH		75.5426822725
98AcetylationACAMPVMKGWNILTN
HHHCCCCCCCHHCCC		62.0925038526
108UbiquitinationNILTNSEKSKKAREG
HHCCCCHHHHHHHHH		68.35-
143PhosphorylationECDLQDQSMMFGNDR
CCCCCCCHHHCCCCH		22.0928176443
157MethylationRSRFLEGKRAVEDKN
HHHHHCCCHHHHCCC		28.01115973823
163UbiquitinationGKRAVEDKNIGPLVK
CCHHHHCCCHHHHHH		36.64-
170AcetylationKNIGPLVKTIMTRCI
CCHHHHHHHHHHHHH		39.7625038526
177 (in isoform 2)Ubiquitination-3.21-
239PhosphorylationTSKPYAFTARPWETR
CCCCEEEECCCCCCC		17.3727251275
253PhosphorylationRKTESIDVMDAVGSN
CCCCCCEEEHHCCCC		3.4027251275
289AcetylationNEEWISDKTRFAYDG
CHHHHCCCHHHCCCC		34.5125825284
289UbiquitinationNEEWISDKTRFAYDG
CHHHHCCCHHHCCCC		34.51-
294PhosphorylationSDKTRFAYDGLKRQR
CCCHHHCCCCHHHCC		14.0829496907
298UbiquitinationRFAYDGLKRQRLTEP
HHCCCCHHHCCCCCC		52.6021906983
298MethylationRFAYDGLKRQRLTEP
HHCCCCHHHCCCCCC		52.602402125
303 (in isoform 2)Ubiquitination-39.99-
311UbiquitinationEPMVRNEKGLLTYTS
CCCCCCCCCCEEECC		59.4121906983
311AcetylationEPMVRNEKGLLTYTS
CCCCCCCCCCEEECC		59.4123954790
312UbiquitinationPMVRNEKGLLTYTSW
CCCCCCCCCEEECCH		21.5321906983
312 (in isoform 2)Ubiquitination-21.53-
316PhosphorylationNEKGLLTYTSWEDAL
CCCCCEEECCHHHHH		9.95-
317PhosphorylationEKGLLTYTSWEDALS
CCCCEEECCHHHHHH		23.33-
325UbiquitinationSWEDALSRVAGMLQS
CHHHHHHHHHHHHHH		24.1321906983
325 (in isoform 2)Ubiquitination-24.13-
329SulfoxidationALSRVAGMLQSFQGK
HHHHHHHHHHHHCCC		1.9121406390
356AcetylationEALVALKDLLNRVDS
HHHHHHHHHHHCCCC		58.1819608861
410AcetylationVGTNPRFEAPLFNAR
EECCCCCCCHHHCHH		51.1319608861
420UbiquitinationLFNARIRKSWLHNDL
HHCHHHHHHHHCCCC		43.54-
421PhosphorylationFNARIRKSWLHNDLK
HCHHHHHHHHCCCCE		25.6425404012
431AcetylationHNDLKVALIGSPVDL
CCCCEEEEECCCEEC		5.2219608861
434PhosphorylationLKVALIGSPVDLTYT
CEEEEECCCEECEEE		18.11-
434 (in isoform 2)Ubiquitination-18.11-
439PhosphorylationIGSPVDLTYTYDHLG
ECCCEECEEEECCCC		14.89-
440PhosphorylationGSPVDLTYTYDHLGD
CCCEECEEEECCCCC		15.5929496907
441PhosphorylationSPVDLTYTYDHLGDS
CCEECEEEECCCCCC		19.7629496907
448PhosphorylationTYDHLGDSPKILQDI
EECCCCCCHHHHHHH		26.71-
450UbiquitinationDHLGDSPKILQDIAS
CCCCCCHHHHHHHHC		61.06-
467UbiquitinationHPFSQVLKEAKKPMV
CCHHHHHHHCCCCEE		57.6919608861
467AcetylationHPFSQVLKEAKKPMV
CCHHHHHHHCCCCEE		57.6925825284
467SuccinylationHPFSQVLKEAKKPMV
CCHHHHHHHCCCCEE		57.6923954790
470MalonylationSQVLKEAKKPMVVLG
HHHHHHCCCCEEEEC		59.5126320211
470UbiquitinationSQVLKEAKKPMVVLG
HHHHHHCCCCEEEEC		59.51-
471UbiquitinationQVLKEAKKPMVVLGS
HHHHHCCCCEEEECC		45.45-
478PhosphorylationKPMVVLGSSALQRND
CCEEEECCHHHHCCC		14.3120068231
479PhosphorylationPMVVLGSSALQRNDG
CEEEECCHHHHCCCH		31.0620068231
481AcetylationVVLGSSALQRNDGAA
EEECCHHHHCCCHHH		5.4819608861
481 (in isoform 2)Ubiquitination-5.48-
494PhosphorylationAAILAAVSSIAQKIR
HHHHHHHHHHHHHHH		15.9922210691
495PhosphorylationAILAAVSSIAQKIRM
HHHHHHHHHHHHHHH		18.4922210691
499UbiquitinationAVSSIAQKIRMTSGV
HHHHHHHHHHHCCCC		24.21-
499MalonylationAVSSIAQKIRMTSGV
HHHHHHHHHHHCCCC		24.2126320211
499AcetylationAVSSIAQKIRMTSGV
HHHHHHHHHHHCCCC		24.21155457
503PhosphorylationIAQKIRMTSGVTGDW
HHHHHHHCCCCCCCH		16.69-
504PhosphorylationAQKIRMTSGVTGDWK
HHHHHHCCCCCCCHH		23.17-
507PhosphorylationIRMTSGVTGDWKVMN
HHHCCCCCCCHHHHH		32.71-
513 (in isoform 2)Ubiquitination-1.98-
531UbiquitinationAALDLGYKPGVEAIR
HHHHCCCCCCHHHHH		33.23-
539AcetylationPGVEAIRKNPPKVLF
CCHHHHHHCCCEEEE		68.6325038526
545 (in isoform 2)Ubiquitination-2.90-
554GlutathionylationLLGADGGCITRQDLP
EEECCCCEECCCCCC		3.3422555962
593PhosphorylationGAAYTEKSATYVNTE
CCCCCCCCEEEECCC		21.4420068231
595PhosphorylationAYTEKSATYVNTEGR
CCCCCCEEEECCCCC		34.7820068231
596PhosphorylationYTEKSATYVNTEGRA
CCCCCEEEECCCCCC		7.4528152594
599PhosphorylationKSATYVNTEGRAQQT
CCEEEECCCCCCEEE		29.7620068231
607UbiquitinationEGRAQQTKVAVTPPG
CCCCEEEEEEECCCC		24.692190698
610PhosphorylationAQQTKVAVTPPGLAR
CEEEEEEECCCCHHH		10.3927642862
611PhosphorylationQQTKVAVTPPGLARE
EEEEEEECCCCHHHH		17.6417137347
621UbiquitinationGLAREDWKIIRALSE
CHHHHHHHHHHHHHH		40.3521906983
621 (in isoform 2)Ubiquitination-40.35-
621AcetylationGLAREDWKIIRALSE
CHHHHHHHHHHHHHH		40.3525953088
624MethylationREDWKIIRALSEIAG
HHHHHHHHHHHHHHC		32.71115384981
635 (in isoform 2)Ubiquitination-18.78-
650PhosphorylationRNRLEEVSPNLVRYD
HHHHHHHCCCCCCHH		16.0225999147
697PhosphorylationTIKDFYMTDSISRAS
EEHHHEECHHHHHHH		18.40-
709UbiquitinationRASQTMAKCVKAVTE
HHHHHHHHHHHHHHH		28.83-
709AcetylationRASQTMAKCVKAVTE
HHHHHHHHHHHHHHH		28.83-
727GlutathionylationAVEEPSIC-------
HHCCCCCC-------		5.5322555962
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of NDUS1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of NDUS1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of NDUS1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
NDUS2_HUMANNDUFS2physical
22939629
NDUV2_HUMANNDUFV2physical
22939629
NDUS7_HUMANNDUFS7physical
22939629
NDUV1_HUMANNDUFV1physical
22939629
NDUS8_HUMANNDUFS8physical
22939629
NDUV3_HUMANNDUFV3physical
22939629
OPA1_HUMANOPA1physical
22939629
SC24C_HUMANSEC24Cphysical
22939629
RL27_HUMANRPL27physical
22939629
STX12_HUMANSTX12physical
22939629
RAB5B_HUMANRAB5Bphysical
22939629
T126B_HUMANTMEM126Bphysical
22939629
RM13_HUMANMRPL13physical
22939629
KDM1A_HUMANKDM1Aphysical
23455924
AFG32_HUMANAFG3L2physical
26344197
AT1A1_HUMANATP1A1physical
26344197
VA0D1_HUMANATP6V0D1physical
26344197
CLH1_HUMANCLTCphysical
26344197
GBB2_HUMANGNB2physical
26344197
COX2_HUMANCOX2physical
26344197
NU1M_HUMANND1physical
26344197
NDUA9_HUMANNDUFA9physical
26344197
NDUS4_HUMANNDUFS4physical
26344197
NDUV2_HUMANNDUFV2physical
26344197
RS15_HUMANRPS15physical
26344197
TECR_HUMANTECRphysical
26344197
QCR7_HUMANUQCRBphysical
26344197
VAPA_HUMANVAPAphysical
26344197
SOAT1_HUMANSOAT1physical
27173435
ACAP2_HUMANACAP2physical
27173435
MBOA7_HUMANMBOAT7physical
27173435
EHBP1_HUMANEHBP1physical
27173435
GDIA_HUMANGDI1physical
27173435
STOM_HUMANSTOMphysical
27173435
Drug and Disease Associations
Kegg Disease
H00473 Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (
OMIM Disease
252010Mitochondrial complex I deficiency (MT-C1D)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of NDUS1_HUMAN

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Related Literatures of Post-Translational Modification

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