NDUS2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NDUS2_HUMAN
• UniProt AC: O75306
• Protein Name: NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial
• Gene Name: NDUFS2
• Organism: Homo sapiens (Human).
• Sequence Length: 463
• Subcellular Localization: Mitochondrion inner membrane ; Peripheral membrane protein ; Matrix side .
• Protein Description: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. [PubMed: 12611891]
• Protein Sequence: MAALRALCGFRGVAAQVLRPGAGVRLPIQPSRGVRQWQPDVEWAQQFGGAVMYPSKETAHWKPPPWNDVDPPKDTIVKNITLNFGPQHPAAHGVLRLVMELSGEMVRKCDPHIGLLHRGTEKLIEYKTYLQALPYFDRLDYVSMMCNEQAYSLAVEKLLNIRPPPRAQWIRVLFGEITRLLNHIMAVTTHALDLGAMTPFFWLFEEREKMFEFYERVSGARMHAAYIRPGGVHQDLPLGLMDDIYQFSKNFSLRLDELEELLTNNRIWRNRTIDIGVVTAEEALNYGFSGVMLRGSGIQWDLRKTQPYDVYDQVEFDVPVGSRGDCYDRYLCRVEEMRQSLRIIAQCLNKMPPGEIKVDDAKVSPPKRAEMKTSMESLIHHFKLYTEGYQVPPGATYTAIEAPKGEFGVYLVSDGSSRPYRCKIKAPGFAHLAGLDKMSKGHMLADVVAIIGTQDIVFGEVDR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
62	Acetylation	SKETAHWKPPPWNDV CCCCCCCCCCCCCCC	37.47	-
62	Ubiquitination	SKETAHWKPPPWNDV CCCCCCCCCCCCCCC	37.47	-
73	Ubiquitination	WNDVDPPKDTIVKNI CCCCCCCCCCEEEEE	73.26	-
118	Dimethylation	PHIGLLHRGTEKLIE CCCEECCCCHHHHHH	54.41	-
118	Methylation	PHIGLLHRGTEKLIE CCCEECCCCHHHHHH	54.41	24838397
122	Methylation	LLHRGTEKLIEYKTY ECCCCHHHHHHHHHH	55.38	115367561
122	Ubiquitination	LLHRGTEKLIEYKTY ECCCCHHHHHHHHHH	55.38	-
127	Ubiquitination	TEKLIEYKTYLQALP HHHHHHHHHHHHHCC	20.22	-
141	Phosphorylation	PYFDRLDYVSMMCNE CCCCCCHHHHHHCCH	10.06	22817900
143	Phosphorylation	FDRLDYVSMMCNEQA CCCCHHHHHHCCHHH	8.45	27461979
151	Phosphorylation	MMCNEQAYSLAVEKL HHCCHHHHHHHHHHH	12.15	27461979
152	Phosphorylation	MCNEQAYSLAVEKLL HCCHHHHHHHHHHHH	16.93	27461979
266	Methylation	EELLTNNRIWRNRTI HHHHHCCCCCCCCCE	31.73	115484743
272	Phosphorylation	NRIWRNRTIDIGVVT CCCCCCCCEEEEEEE	26.93	22210691
279	Phosphorylation	TIDIGVVTAEEALNY CEEEEEEEHHHHHHC	26.41	22210691
286	Phosphorylation	TAEEALNYGFSGVML EHHHHHHCCCCCEEE	22.01	28450419
289	Phosphorylation	EALNYGFSGVMLRGS HHHHCCCCCEEEECC	26.56	28450419
304	Ubiquitination	GIQWDLRKTQPYDVY CCCCCCCCCCCCCEE	59.83	21906983
323	Methylation	FDVPVGSRGDCYDRY EEECCCCCCCCHHHH	38.75	4204239
350	Acetylation	IIAQCLNKMPPGEIK HHHHHHCCCCCCCCE	39.57	26051181
357	Acetylation	KMPPGEIKVDDAKVS CCCCCCCEECCCCCC	35.00	26051181
364	Phosphorylation	KVDDAKVSPPKRAEM EECCCCCCCCCHHHH	34.48	-
425	Acetylation	RPYRCKIKAPGFAHL CCEECEEECCCCHHH	33.74	26051181
425	Ubiquitination	RPYRCKIKAPGFAHL CCEECEEECCCCHHH	33.74	-
437	Ubiquitination	AHLAGLDKMSKGHML HHHCCCCCCCCCCCH	50.55	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
364	S	Phosphorylation	Kinase	CDK1	P06493	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
118	R	Methylation	Dimethylation at Arg-118 by NDUFAF7 takes place after NDUFS2 assembles into the complex I, leading to stabilize the early intermediate complex.	24089531

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NDUS2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
NDUV2_HUMAN	NDUFV2	physical	22939629
NDUS3_HUMAN	NDUFS3	physical	22939629
NDUS8_HUMAN	NDUFS8	physical	22939629
NDUS7_HUMAN	NDUFS7	physical	22939629
NDUV1_HUMAN	NDUFV1	physical	22939629
NDUS6_HUMAN	NDUFS6	physical	22939629
RT21_HUMAN	MRPS21	physical	22939629
DLDH_HUMAN	DLD	physical	26344197
LMAN2_HUMAN	LMAN2	physical	26344197
NDUS1_HUMAN	NDUFS1	physical	26344197
NDUS3_HUMAN	NDUFS3	physical	26344197
NDUV1_HUMAN	NDUFV1	physical	26344197
ODO1_HUMAN	OGDH	physical	26344197
C560_HUMAN	SDHC	physical	26344197
MKLN1_HUMAN	MKLN1	physical	27173435

Drug and Disease Associations

• Kegg Disease
• H00473: Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (
• OMIM Disease
• 252010: Mitochondrial complex I deficiency (MT-C1D)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB00997: Doxorubicin