dbPTM

DLDH_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	DLDH_HUMAN
UniProt AC	P09622
Protein Name	Dihydrolipoyl dehydrogenase, mitochondrial
Gene Name	DLD
Organism	Homo sapiens (Human).
Sequence Length	509
Subcellular Localization	Mitochondrion matrix . Nucleus . Cell projection, cilium, flagellum . Cytoplasmic vesicle, secretory vesicle, acrosome . Mainly localizes in the mitochondrion. A small fraction localizes to the nucleus, where the 2-oxoglutarate dehydrogenase complex
Protein Description	Lipoamide dehydrogenase is a component of the glycine cleavage system as well as an E3 component of three alpha-ketoacid dehydrogenase complexes (pyruvate-, alpha-ketoglutarate-, and branched-chain amino acid-dehydrogenase complex). [PubMed: 15712224]
Protein Sequence	MQSWSRVYCSLAKRGHFNRISHGLQGLSAVPLRTYADQPIDADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYHMAHGKDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGKNQVTATKADGGTQVIDTKNILIATGSEVTPFPGITIDEDTIVSSTGALSLKKVPEKMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKLNTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELDPRGRIPVNTRFQTKIPNIYAIGDVVAGPMLAHKAEDEGIICVEGMAGGAVHIDYNCVPSVIYTHPEVAWVGKSEEQLKEEGIEYKVGKFPFAANSRAKTNADTDGMVKILGQKSTDRVLGAHILGPGAGEMVNEAALALEYGASCEDIARVCHAHPTLSEAFREANLAASFGKSINF

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
23	Acetylation	HFNRISHGLQGLSAV CCCHHCCCCCCCCCC	16.95	-
28	Ubiquitination	SHGLQGLSAVPLRTY CCCCCCCCCCCCCCC	33.76	-
33	Ubiquitination	GLSAVPLRTYADQPI CCCCCCCCCCCCCCC	21.44	-
34	Phosphorylation	LSAVPLRTYADQPID CCCCCCCCCCCCCCC	30.64	21406692
35	Phosphorylation	SAVPLRTYADQPIDA CCCCCCCCCCCCCCC	11.18	21406692
44	Acetylation	DQPIDADVTVIGSGP CCCCCCCEEEECCCC	5.02	-
44	Ubiquitination	DQPIDADVTVIGSGP CCCCCCCEEEECCCC	5.02	-
44	Acetylation	DQPIDADVTVIGSGP CCCCCCCEEEECCCC	5.02	19608861
44	Ubiquitination	DQPIDADVTVIGSGP CCCCCCCEEEECCCC	5.02	19608861
45	Phosphorylation	QPIDADVTVIGSGPG CCCCCCEEEECCCCC	13.62	21406692
49	Phosphorylation	ADVTVIGSGPGGYVA CCEEEECCCCCHHHH	30.59	21406692
54	Phosphorylation	IGSGPGGYVAAIKAA ECCCCCHHHHHHHHH	7.88	21406692
59	Ubiquitination	GGYVAAIKAAQLGFK CHHHHHHHHHHCCCE	32.70	-
59	Ubiquitination	GGYVAAIKAAQLGFK CHHHHHHHHHHCCCE	32.70	-
60	Ubiquitination	GYVAAIKAAQLGFKT HHHHHHHHHHCCCEE	8.37	-
66	Acetylation	KAAQLGFKTVCIEKN HHHHCCCEEEEEECC	37.95	-
66	2-Hydroxyisobutyrylation	KAAQLGFKTVCIEKN HHHHCCCEEEEEECC	37.95	-
66	Acetylation	KAAQLGFKTVCIEKN HHHHCCCEEEEEECC	37.95	25825284
66	Malonylation	KAAQLGFKTVCIEKN HHHHCCCEEEEEECC	37.95	26320211
66	Methylation	KAAQLGFKTVCIEKN HHHHCCCEEEEEECC	37.95	-
66	Succinylation	KAAQLGFKTVCIEKN HHHHCCCEEEEEECC	37.95	-
66	Succinylation	KAAQLGFKTVCIEKN HHHHCCCEEEEEECC	37.95	27452117
67	Acetylation	AAQLGFKTVCIEKNE HHHCCCEEEEEECCC	20.53	-
67	Ubiquitination	AAQLGFKTVCIEKNE HHHCCCEEEEEECCC	20.53	-
67	Phosphorylation	AAQLGFKTVCIEKNE HHHCCCEEEEEECCC	20.53	30576142
72	Acetylation	FKTVCIEKNETLGGT CEEEEEECCCCCCCE	39.92	25953088
81	Ubiquitination	ETLGGTCLNVGCIPS CCCCCEEEECCEECC	6.13	21890473
88	Phosphorylation	LNVGCIPSKALLNNS EECCEECCHHHHCCC	15.62	24719451
104	Ubiquitination	YYHMAHGKDFASRGI CHHHHCCCCHHHCCC	39.54	21890473
104	Acetylation	YYHMAHGKDFASRGI CHHHHCCCCHHHCCC	39.54	-
104	Ubiquitination	YYHMAHGKDFASRGI CHHHHCCCCHHHCCC	39.54	21890473
104	2-Hydroxyisobutyrylation	YYHMAHGKDFASRGI CHHHHCCCCHHHCCC	39.54	-
104	Acetylation	YYHMAHGKDFASRGI CHHHHCCCCHHHCCC	39.54	23954790
104	Malonylation	YYHMAHGKDFASRGI CHHHHCCCCHHHCCC	39.54	26320211
104	Succinylation	YYHMAHGKDFASRGI CHHHHCCCCHHHCCC	39.54	-
104	Succinylation	YYHMAHGKDFASRGI CHHHHCCCCHHHCCC	39.54	-
104	Ubiquitination	YYHMAHGKDFASRGI CHHHHCCCCHHHCCC	39.54	21890473
109	Ubiquitination	HGKDFASRGIEMSEV CCCCHHHCCCCHHHH	46.83	21890473
109	Methylation	HGKDFASRGIEMSEV CCCCHHHCCCCHHHH	46.83	-
120	Ubiquitination	MSEVRLNLDKMMEQK HHHHHHCHHHHHHHH	8.73	21890473
122	2-Hydroxyisobutyrylation	EVRLNLDKMMEQKST HHHHCHHHHHHHHHH	43.23	-
122	Acetylation	EVRLNLDKMMEQKST HHHHCHHHHHHHHHH	43.23	23954790
122	Succinylation	EVRLNLDKMMEQKST HHHHCHHHHHHHHHH	43.23	-
122	Succinylation	EVRLNLDKMMEQKST HHHHCHHHHHHHHHH	43.23	27452117
127	2-Hydroxyisobutyrylation	LDKMMEQKSTAVKAL HHHHHHHHHHHHHHH	36.15	-
127	Acetylation	LDKMMEQKSTAVKAL HHHHHHHHHHHHHHH	36.15	26210075
127	Ubiquitination	LDKMMEQKSTAVKAL HHHHHHHHHHHHHHH	36.15	-
132	Ubiquitination	EQKSTAVKALTGGIA HHHHHHHHHHHHHHH	34.90	21890473
132	Ubiquitination	EQKSTAVKALTGGIA HHHHHHHHHHHHHHH	34.90	21890473
132	2-Hydroxyisobutyrylation	EQKSTAVKALTGGIA HHHHHHHHHHHHHHH	34.90	-
132	Acetylation	EQKSTAVKALTGGIA HHHHHHHHHHHHHHH	34.90	25038526
132	Succinylation	EQKSTAVKALTGGIA HHHHHHHHHHHHHHH	34.90	-
132	Succinylation	EQKSTAVKALTGGIA HHHHHHHHHHHHHHH	34.90	21890473
132	Ubiquitination	EQKSTAVKALTGGIA HHHHHHHHHHHHHHH	34.90	21890473
135	Phosphorylation	STAVKALTGGIAHLF HHHHHHHHHHHHHHH	37.92	-
143	Ubiquitination	GGIAHLFKQNKVVHV HHHHHHHHCCCEEEE	60.36	21890473
143	2-Hydroxyisobutyrylation	GGIAHLFKQNKVVHV HHHHHHHHCCCEEEE	60.36	-
143	Acetylation	GGIAHLFKQNKVVHV HHHHHHHHCCCEEEE	60.36	19608861
143	Malonylation	GGIAHLFKQNKVVHV HHHHHHHHCCCEEEE	60.36	26320211
143	Methylation	GGIAHLFKQNKVVHV HHHHHHHHCCCEEEE	60.36	19608861
143	Succinylation	GGIAHLFKQNKVVHV HHHHHHHHCCCEEEE	60.36	-
143	Succinylation	GGIAHLFKQNKVVHV HHHHHHHHCCCEEEE	60.36	-
143	Ubiquitination	GGIAHLFKQNKVVHV HHHHHHHHCCCEEEE	60.36	21890473
146	Acetylation	AHLFKQNKVVHVNGY HHHHHCCCEEEECCC	43.04	25038526
153	Phosphorylation	KVVHVNGYGKITGKN CEEEECCCCEECCCC	15.28	28152594
155	Acetylation	VHVNGYGKITGKNQV EEECCCCEECCCCCE	28.72	30582533
159	Acetylation	GYGKITGKNQVTATK CCCEECCCCCEEEEE	35.24	25953088
159	Succinylation	GYGKITGKNQVTATK CCCEECCCCCEEEEE	35.24	-
159	Succinylation	GYGKITGKNQVTATK CCCEECCCCCEEEEE	35.24	27452117
159	Ubiquitination	GYGKITGKNQVTATK CCCEECCCCCEEEEE	35.24	-
166	2-Hydroxyisobutyrylation	KNQVTATKADGGTQV CCCEEEEECCCCCEE	41.85	-
166	Acetylation	KNQVTATKADGGTQV CCCEEEEECCCCCEE	41.85	23236377
166	Malonylation	KNQVTATKADGGTQV CCCEEEEECCCCCEE	41.85	26320211
166	Succinylation	KNQVTATKADGGTQV CCCEEEEECCCCCEE	41.85	-
166	Succinylation	KNQVTATKADGGTQV CCCEEEEECCCCCEE	41.85	-
166	Ubiquitination	KNQVTATKADGGTQV CCCEEEEECCCCCEE	41.85	21906983
168	Acetylation	QVTATKADGGTQVID CEEEEECCCCCEEEE	58.57	-
168	Acetylation	QVTATKADGGTQVID CEEEEECCCCCEEEE	58.57	19608861
208	Phosphorylation	VSSTGALSLKKVPEK EECCCCCCCCCCCCC	37.29	24719451
219	Acetylation	VPEKMVVIGAGVIGV CCCCEEEEECCEEEE	1.81	19608861
221	Acetylation	EKMVVIGAGVIGVEL CCEEEEECCEEEEHH	9.65	-
221	Ubiquitination	EKMVVIGAGVIGVEL CCEEEEECCEEEEHH	9.65	-
221	Acetylation	EKMVVIGAGVIGVEL CCEEEEECCEEEEHH	9.65	19608861
221	Ubiquitination	EKMVVIGAGVIGVEL CCEEEEECCEEEEHH	9.65	19608861
230	Phosphorylation	VIGVELGSVWQRLGA EEEEHHHHHHHHHCC	32.57	-
247	Acetylation	TAVEFLGHVGGVGID EEEHHHCCCCCCCCC	19.73	-
247	Ubiquitination	TAVEFLGHVGGVGID EEEHHHCCCCCCCCC	19.73	-
267	2-Hydroxyisobutyrylation	NFQRILQKQGFKFKL HHHHHHHHCCCEEEE	49.28	-
267	Acetylation	NFQRILQKQGFKFKL HHHHHHHHCCCEEEE	49.28	23954790
267	Malonylation	NFQRILQKQGFKFKL HHHHHHHHCCCEEEE	49.28	26320211
267	Succinylation	NFQRILQKQGFKFKL HHHHHHHHCCCEEEE	49.28	27452117
267	Ubiquitination	NFQRILQKQGFKFKL HHHHHHHHCCCEEEE	49.28	19608861
271	Acetylation	ILQKQGFKFKLNTKV HHHHCCCEEEEECEE	48.70	25038526
272	Ubiquitination	LQKQGFKFKLNTKVT HHHCCCEEEEECEEE	11.54	21890473
272	Acetylation	LQKQGFKFKLNTKVT HHHCCCEEEEECEEE	11.54	19608861
272	Ubiquitination	LQKQGFKFKLNTKVT HHHCCCEEEEECEEE	11.54	19608861
273	Acetylation	QKQGFKFKLNTKVTG HHCCCEEEEECEEEC	41.22	2402229
273	Succinylation	QKQGFKFKLNTKVTG HHCCCEEEEECEEEC	41.22	-
273	Succinylation	QKQGFKFKLNTKVTG HHCCCEEEEECEEEC	41.22	-
276	Phosphorylation	GFKFKLNTKVTGATK CCEEEEECEEECCEE	37.01	20068231
277	2-Hydroxyisobutyrylation	FKFKLNTKVTGATKK CEEEEECEEECCEEC	36.40	-
277	Acetylation	FKFKLNTKVTGATKK CEEEEECEEECCEEC	36.40	25953088
277	Succinylation	FKFKLNTKVTGATKK CEEEEECEEECCEEC	36.40	-
277	Succinylation	FKFKLNTKVTGATKK CEEEEECEEECCEEC	36.40	27452117
277	Ubiquitination	FKFKLNTKVTGATKK CEEEEECEEECCEEC	36.40	-
279	Phosphorylation	FKLNTKVTGATKKSD EEEECEEECCEECCC	23.74	20068231
282	Phosphorylation	NTKVTGATKKSDGKI ECEEECCEECCCCCE	40.11	20068231
283	2-Hydroxyisobutyrylation	TKVTGATKKSDGKID CEEECCEECCCCCEE	50.15	-
285	Phosphorylation	VTGATKKSDGKIDVS EECCEECCCCCEEEE	53.83	-
292	Phosphorylation	SDGKIDVSIEAASGG CCCCEEEEEEECCCC	15.80	27251275
297	Ubiquitination	DVSIEAASGGKAEVI EEEEEECCCCCEEEE	55.94	21890473
297	Phosphorylation	DVSIEAASGGKAEVI EEEEEECCCCCEEEE	55.94	25159151
298	Ubiquitination	VSIEAASGGKAEVIT EEEEECCCCCEEEEE	36.57	21890473
311	Acetylation	ITCDVLLVCIGRRPF EEEEEEEEEECCCCC	1.63	-
311	Ubiquitination	ITCDVLLVCIGRRPF EEEEEEEEEECCCCC	1.63	-
311	Acetylation	ITCDVLLVCIGRRPF EEEEEEEEEECCCCC	1.63	19608861
311	Ubiquitination	ITCDVLLVCIGRRPF EEEEEEEEEECCCCC	1.63	19608861
318	Acetylation	VCIGRRPFTKNLGLE EEECCCCCCCCCCHH	16.81	-
318	Ubiquitination	VCIGRRPFTKNLGLE EEECCCCCCCCCCHH	16.81	-
318	Acetylation	VCIGRRPFTKNLGLE EEECCCCCCCCCCHH	16.81	19608861
320	Ubiquitination	IGRRPFTKNLGLEEL ECCCCCCCCCCHHHH	51.02	21890473
320	2-Hydroxyisobutyrylation	IGRRPFTKNLGLEEL ECCCCCCCCCCHHHH	51.02	-
320	Acetylation	IGRRPFTKNLGLEEL ECCCCCCCCCCHHHH	51.02	23954790
320	Ubiquitination	IGRRPFTKNLGLEEL ECCCCCCCCCCHHHH	51.02	21906983
321	Acetylation	GRRPFTKNLGLEELG CCCCCCCCCCHHHHC	35.96	-
321	Ubiquitination	GRRPFTKNLGLEELG CCCCCCCCCCHHHHC	35.96	-
321	Acetylation	GRRPFTKNLGLEELG CCCCCCCCCCHHHHC	35.96	19608861
323	Ubiquitination	RPFTKNLGLEELGIE CCCCCCCCHHHHCCE	40.20	21890473
331	Ubiquitination	LEELGIELDPRGRIP HHHHCCEECCCCCCC	11.82	-
341	Ubiquitination	RGRIPVNTRFQTKIP CCCCCCCCCCCCCCC	32.85	-
341	Phosphorylation	RGRIPVNTRFQTKIP CCCCCCCCCCCCCCC	32.85	20068231
346	Ubiquitination	VNTRFQTKIPNIYAI CCCCCCCCCCCEEEE	45.44	21890473
346	Ubiquitination	VNTRFQTKIPNIYAI CCCCCCCCCCCEEEE	45.44	-
346	Acetylation	VNTRFQTKIPNIYAI CCCCCCCCCCCEEEE	45.44	23236377
346	Succinylation	VNTRFQTKIPNIYAI CCCCCCCCCCCEEEE	45.44	23954790
346	Ubiquitination	VNTRFQTKIPNIYAI CCCCCCCCCCCEEEE	45.44	21890473
362	Acetylation	DVVAGPMLAHKAEDE CEECCCHHCCCCCCC	5.20	19608861
362	Ubiquitination	DVVAGPMLAHKAEDE CEECCCHHCCCCCCC	5.20	19608861
369	Acetylation	LAHKAEDEGIICVEG HCCCCCCCCEEEEEC	43.74	19608861
372	Acetylation	KAEDEGIICVEGMAG CCCCCCEEEEECCCC	2.94	19608861
392	Ubiquitination	DYNCVPSVIYTHPEV ECCCCCEEEECCCCE	2.95	21890473
406	Ubiquitination	VAWVGKSEEQLKEEG EEECCCCHHHHHHCC	53.93	-
410	Acetylation	GKSEEQLKEEGIEYK CCCHHHHHHCCCEEE	54.11	19608861
410	Malonylation	GKSEEQLKEEGIEYK CCCHHHHHHCCCEEE	54.11	26320211
410	Succinylation	GKSEEQLKEEGIEYK CCCHHHHHHCCCEEE	54.11	-
410	Succinylation	GKSEEQLKEEGIEYK CCCHHHHHHCCCEEE	54.11	-
410	Ubiquitination	GKSEEQLKEEGIEYK CCCHHHHHHCCCEEE	54.11	19608861
417	Ubiquitination	KEEGIEYKVGKFPFA HHCCCEEEECCCCCC	31.55	21890473
417	2-Hydroxyisobutyrylation	KEEGIEYKVGKFPFA HHCCCEEEECCCCCC	31.55	-
417	Acetylation	KEEGIEYKVGKFPFA HHCCCEEEECCCCCC	31.55	19608861
417	Ubiquitination	KEEGIEYKVGKFPFA HHCCCEEEECCCCCC	31.55	19608861
420	Acetylation	GIEYKVGKFPFAANS CCEEEECCCCCCCCC	53.50	23954790
420	Malonylation	GIEYKVGKFPFAANS CCEEEECCCCCCCCC	53.50	26320211
420	Ubiquitination	GIEYKVGKFPFAANS CCEEEECCCCCCCCC	53.50	19608861
430	Acetylation	FAANSRAKTNADTDG CCCCCCCCCCCCCCC	41.00	26210075
430	Succinylation	FAANSRAKTNADTDG CCCCCCCCCCCCCCC	41.00	-
430	Succinylation	FAANSRAKTNADTDG CCCCCCCCCCCCCCC	41.00	27452117
430	Ubiquitination	FAANSRAKTNADTDG CCCCCCCCCCCCCCC	41.00	-
435	Phosphorylation	RAKTNADTDGMVKIL CCCCCCCCCCCCHHC	31.85	-
440	Ubiquitination	ADTDGMVKILGQKST CCCCCCCHHCCCCCC	24.26	21890473
440	2-Hydroxyisobutyrylation	ADTDGMVKILGQKST CCCCCCCHHCCCCCC	24.26	-
440	Ubiquitination	ADTDGMVKILGQKST CCCCCCCHHCCCCCC	24.26	21890473
445	2-Hydroxyisobutyrylation	MVKILGQKSTDRVLG CCHHCCCCCCCCEEE	54.23	-
445	Acetylation	MVKILGQKSTDRVLG CCHHCCCCCCCCEEE	54.23	25953088
445	Ubiquitination	MVKILGQKSTDRVLG CCHHCCCCCCCCEEE	54.23	-
477	Glutathionylation	ALEYGASCEDIARVC HHHHCCCHHHHHHHH	5.59	22555962
484	Glutathionylation	CEDIARVCHAHPTLS HHHHHHHHHHCCCHH	1.63	22555962
502	Phosphorylation	REANLAASFGKSINF HHHHHHHHHCCCCCC	28.99	25159151
505	Acetylation	NLAASFGKSINF--- HHHHHHCCCCCC---	46.26	-
505	Methylation	NLAASFGKSINF--- HHHHHHCCCCCC---	46.26	-
505	Succinylation	NLAASFGKSINF--- HHHHHHCCCCCC---	46.26	-
505	Succinylation	NLAASFGKSINF--- HHHHHHCCCCCC---	46.26	-
505	Ubiquitination	NLAASFGKSINF--- HHHHHHCCCCCC---	46.26	-
506	Phosphorylation	LAASFGKSINF---- HHHHHCCCCCC----	24.12	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
135	T	Phosphorylation	Kinase	RIPK3	Q9Y572	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of DLDH_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of DLDH_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ODB2_HUMAN	DBT	physical	22939629
ODP2_HUMAN	DLAT	physical	22939629
NDUB5_HUMAN	NDUFB5	physical	22939629
NDUA9_HUMAN	NDUFA9	physical	22939629
QCR2_HUMAN	UQCRC2	physical	22939629
UBAP2_HUMAN	UBAP2	physical	22939629
RM13_HUMAN	MRPL13	physical	22939629
RM11_HUMAN	MRPL11	physical	22939629
ETFB_HUMAN	ETFB	physical	22939629
RM23_HUMAN	MRPL23	physical	22939629
RM37_HUMAN	MRPL37	physical	22939629
KAD2_HUMAN	AK2	physical	22939629
QCR1_HUMAN	UQCRC1	physical	22939629
NONO_HUMAN	NONO	physical	22939629
RM42_HUMAN	MRPL42	physical	22939629
GGH_HUMAN	GGH	physical	22939629
KCRB_HUMAN	CKB	physical	22863883
LDHA_HUMAN	LDHA	physical	22863883
RL23_HUMAN	RPL23	physical	22863883
ODO2_HUMAN	DLST	physical	26186194
OGDHL_HUMAN	OGDHL	physical	26186194
ODO1_HUMAN	OGDH	physical	26186194
HLTF_HUMAN	HLTF	physical	26186194
PDK3_HUMAN	PDK3	physical	26186194
ODP2_HUMAN	DLAT	physical	26186194
SORL_HUMAN	SORL1	physical	26186194
SYPM_HUMAN	PARS2	physical	26186194
ODPA_HUMAN	PDHA1	physical	26186194
NFS1_HUMAN	NFS1	physical	26186194
FBX21_HUMAN	FBXO21	physical	26186194
FBW1A_HUMAN	BTRC	physical	26186194
FBW1B_HUMAN	FBXW11	physical	26186194
DHTK1_HUMAN	DHTKD1	physical	26186194
RT36_HUMAN	MRPS36	physical	26186194
SIAH2_HUMAN	SIAH2	physical	26186194
FMC1_HUMAN	C7orf55	physical	26186194
PCBP3_HUMAN	PCBP3	physical	26186194
ODPX_HUMAN	PDHX	physical	26186194
SLX4I_HUMAN	SLX4IP	physical	26186194
ODB2_HUMAN	DBT	physical	26186194
AIFM1_HUMAN	AIFM1	physical	26344197
ALDOC_HUMAN	ALDOC	physical	26344197
AT1B1_HUMAN	ATP1B1	physical	26344197
CAPZB_HUMAN	CAPZB	physical	26344197
CGL_HUMAN	CTH	physical	26344197
DHTK1_HUMAN	DHTKD1	physical	26344197
ODO2_HUMAN	DLST	physical	26344197
FUMH_HUMAN	FH	physical	26344197
HNRH2_HUMAN	HNRNPH2	physical	26344197
HSDL2_HUMAN	HSDL2	physical	26344197
INO1_HUMAN	ISYNA1	physical	26344197
RM09_HUMAN	MRPL9	physical	26344197
CPSF5_HUMAN	NUDT21	physical	26344197
ODO1_HUMAN	OGDH	physical	26344197
ODPA_HUMAN	PDHA1	physical	26344197
SDHB_HUMAN	SDHB	physical	26344197
SNX12_HUMAN	SNX12	physical	26344197
STIP1_HUMAN	STIP1	physical	26344197
SUCB2_HUMAN	SUCLG2	physical	26344197
TOM40_HUMAN	TOMM40	physical	26344197
UCHL3_HUMAN	UCHL3	physical	26344197
OGDHL_HUMAN	OGDHL	physical	28514442
ODPX_HUMAN	PDHX	physical	28514442
ODB2_HUMAN	DBT	physical	28514442
RT36_HUMAN	MRPS36	physical	28514442
SLX4I_HUMAN	SLX4IP	physical	28514442
FBW1A_HUMAN	BTRC	physical	28514442
ODO2_HUMAN	DLST	physical	28514442
FBW1B_HUMAN	FBXW11	physical	28514442
FMC1_HUMAN	C7orf55	physical	28514442
ODO1_HUMAN	OGDH	physical	28514442
SYPM_HUMAN	PARS2	physical	28514442
NFS1_HUMAN	NFS1	physical	28514442
PDK3_HUMAN	PDK3	physical	28514442
ODPA_HUMAN	PDHA1	physical	28514442
PCBP3_HUMAN	PCBP3	physical	28514442
ODP2_HUMAN	DLAT	physical	28514442
SORL_HUMAN	SORL1	physical	28514442
PRDX2_HUMAN	PRDX2	physical	29128334
EF1B_HUMAN	EEF1B2	physical	29128334
PTBP1_HUMAN	PTBP1	physical	29128334
PSME3_HUMAN	PSME3	physical	29128334
RFA3_HUMAN	RPA3	physical	29128334
SYYC_HUMAN	YARS	physical	29128334
PDIA6_HUMAN	PDIA6	physical	29128334
ENPL_HUMAN	HSP90B1	physical	29128334
EIF3I_HUMAN	EIF3I	physical	29128334
PAIRB_HUMAN	SERBP1	physical	29128334
HPRT_HUMAN	HPRT1	physical	29128334
1433E_HUMAN	YWHAE	physical	29128334
UBE2N_HUMAN	UBE2N	physical	29128334
ARF1_HUMAN	ARF1	physical	29128334
CYBP_HUMAN	CACYBP	physical	29128334
PIMT_HUMAN	PCMT1	physical	29128334
APT_HUMAN	APRT	physical	29128334
UBC12_HUMAN	UBE2M	physical	29128334
PSD11_HUMAN	PSMD11	physical	29128334
DCD_HUMAN	DCD	physical	29128334
NAA50_HUMAN	NAA50	physical	29128334
RUVB1_HUMAN	RUVBL1	physical	29128334
KCD12_HUMAN	KCTD12	physical	29128334
BAF_HUMAN	BANF1	physical	29128334
CDK1_HUMAN	CDK1	physical	29128334
ETFA_HUMAN	ETFA	physical	29128334
TCP4_HUMAN	SUB1	physical	29128334
PRDX3_HUMAN	PRDX3	physical	29128334
TCPQ_HUMAN	CCT8	physical	29128334
PSMD2_HUMAN	PSMD2	physical	29128334
EF1G_HUMAN	EEF1G	physical	29128334
PRS6B_HUMAN	PSMC4	physical	29128334
EIF3G_HUMAN	EIF3G	physical	29128334
IDH3A_HUMAN	IDH3A	physical	29128334
PRDX6_HUMAN	PRDX6	physical	29128334
CLCB_HUMAN	CLTB	physical	29128334
TCPB_HUMAN	CCT2	physical	29128334
OAT_HUMAN	OAT	physical	29128334
CN166_HUMAN	C14orf166	physical	29128334
1433T_HUMAN	YWHAQ	physical	29128334
1433Z_HUMAN	YWHAZ	physical	29128334
1433B_HUMAN	YWHAB	physical	29128334
SERPH_HUMAN	SERPINH1	physical	29128334
KTHY_HUMAN	DTYMK	physical	29128334
EF2_HUMAN	EEF2	physical	29128334
MGME1_HUMAN	MGME1	physical	29128334
PRS4_HUMAN	PSMC1	physical	29128334
COPZ1_HUMAN	COPZ1	physical	29128334
TERA_HUMAN	VCP	physical	29128334
ARF4_HUMAN	ARF4	physical	29128334
OTUB1_HUMAN	OTUB1	physical	29128334
PABP1_HUMAN	PABPC1	physical	29128334
DHB4_HUMAN	HSD17B4	physical	29128334
PSMD7_HUMAN	PSMD7	physical	29128334
XRCC6_HUMAN	XRCC6	physical	29128334
PP1A_HUMAN	PPP1CA	physical	29128334
LDHB_HUMAN	LDHB	physical	29128334
KAD2_HUMAN	AK2	physical	29128334
AP1B1_HUMAN	AP1B1	physical	29128334
UBE2K_HUMAN	UBE2K	physical	29128334
MTDC_HUMAN	MTHFD2	physical	29128334
EIF3B_HUMAN	EIF3B	physical	29128334
EIF3F_HUMAN	EIF3F	physical	29128334
COPE_HUMAN	COPE	physical	29128334
RUVB2_HUMAN	RUVBL2	physical	29128334
SOSSC_HUMAN	INIP	physical	29128334
HCD2_HUMAN	HSD17B10	physical	29128334
AP1S2_HUMAN	AP1S2	physical	29128334
PPAC_HUMAN	ACP1	physical	29128334
TRAP1_HUMAN	TRAP1	physical	29128334
SC23A_HUMAN	SEC23A	physical	29128334
NUDC_HUMAN	NUDC	physical	29128334
PRS10_HUMAN	PSMC6	physical	29128334
EF1D_HUMAN	EEF1D	physical	29128334
PSD10_HUMAN	PSMD10	physical	29128334
CPSF5_HUMAN	NUDT21	physical	29128334
RL30_HUMAN	RPL30	physical	29128334
KAP2_HUMAN	PRKAR2A	physical	29128334
PA1B3_HUMAN	PAFAH1B3	physical	29128334
IPYR_HUMAN	PPA1	physical	29128334
MCA3_HUMAN	EEF1E1	physical	29128334
PBDC1_HUMAN	PBDC1	physical	29128334
UBA1_HUMAN	UBA1	physical	29128334
DNJA2_HUMAN	DNAJA2	physical	29128334
CAP1_HUMAN	CAP1	physical	29128334
HSDL2_HUMAN	HSDL2	physical	29128334
DBLOH_HUMAN	DIABLO	physical	29128334
PUR6_HUMAN	PAICS	physical	29128334
SF3B6_HUMAN	SF3B6	physical	29128334
IMB1_HUMAN	KPNB1	physical	29128334
SYDC_HUMAN	DARS	physical	29128334
PSD13_HUMAN	PSMD13	physical	29128334
PRS6A_HUMAN	PSMC3	physical	29128334
ATG3_HUMAN	ATG3	physical	29128334
LAP2A_HUMAN	TMPO	physical	29128334
LAP2B_HUMAN	TMPO	physical	29128334
PGAM1_HUMAN	PGAM1	physical	29128334
CDC42_HUMAN	CDC42	physical	29128334
RT18B_HUMAN	MRPS18B	physical	29128334
RAGP1_HUMAN	RANGAP1	physical	29128334
BUB3_HUMAN	BUB3	physical	29128334
SAR1A_HUMAN	SAR1A	physical	29128334
LDHA_HUMAN	LDHA	physical	29128334
G3BP1_HUMAN	G3BP1	physical	29128334
RFA2_HUMAN	RPA2	physical	29128334
RAB1A_HUMAN	RAB1A	physical	29128334
GSTP1_HUMAN	GSTP1	physical	29128334
PLST_HUMAN	PLS3	physical	29128334
BAG2_HUMAN	BAG2	physical	29128334
H1X_HUMAN	H1FX	physical	29128334
ODPB_HUMAN	PDHB	physical	29128334
GLYM_HUMAN	SHMT2	physical	29128334
RTCB_HUMAN	RTCB	physical	29128334
PDC6I_HUMAN	PDCD6IP	physical	29128334
SET_HUMAN	SET	physical	29128334
DC1L1_HUMAN	DYNC1LI1	physical	29128334
EIF3M_HUMAN	EIF3M	physical	29128334
RPAB3_HUMAN	POLR2H	physical	29128334
ACTZ_HUMAN	ACTR1A	physical	29128334
GCP60_HUMAN	ACBD3	physical	29128334
ABHDA_HUMAN	ABHD10	physical	29128334
TTC4_HUMAN	TTC4	physical	29128334
TCPH_HUMAN	CCT7	physical	29128334
PSMD6_HUMAN	PSMD6	physical	29128334
ODPA_HUMAN	PDHA1	physical	29128334
ILF2_HUMAN	ILF2	physical	29128334
NAA10_HUMAN	NAA10	physical	29128334
VAT1_HUMAN	VAT1	physical	29128334
IF2A_HUMAN	EIF2S1	physical	29128334
OLA1_HUMAN	OLA1	physical	29128334
SYEP_HUMAN	EPRS	physical	29128334
PDCL3_HUMAN	PDCL3	physical	29128334
TEBP_HUMAN	PTGES3	physical	29128334
CSN4_HUMAN	COPS4	physical	29128334
EFTS_HUMAN	TSFM	physical	29128334
SKP1_HUMAN	SKP1	physical	29128334
1433G_HUMAN	YWHAG	physical	29128334
RL12_HUMAN	RPL12	physical	29128334
FA98B_HUMAN	FAM98B	physical	29128334
AN32A_HUMAN	ANP32A	physical	29128334
CHRD1_HUMAN	CHORDC1	physical	29128334
HYOU1_HUMAN	HYOU1	physical	29128334
SRP72_HUMAN	SRP72	physical	29128334
2AAA_HUMAN	PPP2R1A	physical	29128334
AP1M1_HUMAN	AP1M1	physical	29128334
DCTP1_HUMAN	DCTPP1	physical	29128334
UFM1_HUMAN	UFM1	physical	29128334
RBBP7_HUMAN	RBBP7	physical	29128334
RBBP4_HUMAN	RBBP4	physical	29128334
RPAC1_HUMAN	POLR1C	physical	29128334
UCK2_HUMAN	UCK2	physical	29128334
PSPC1_HUMAN	PSPC1	physical	29128334
CSN7B_HUMAN	COPS7B	physical	29128334
RFA1_HUMAN	RPA1	physical	29128334
DYL1_HUMAN	DYNLL1	physical	29128334
RT22_HUMAN	MRPS22	physical	29128334
PIPNB_HUMAN	PITPNB	physical	29128334
IST1_HUMAN	IST1	physical	29128334
RPB3_HUMAN	POLR2C	physical	29128334
S10A8_HUMAN	S100A8	physical	29128334
SYRC_HUMAN	RARS	physical	29128334
CDC37_HUMAN	CDC37	physical	29128334
TIM13_HUMAN	TIMM13	physical	29128334
KCRB_HUMAN	CKB	physical	29128334
AP3S1_HUMAN	AP3S1	physical	29128334
ECHM_HUMAN	ECHS1	physical	29128334
ANXA7_HUMAN	ANXA7	physical	29128334
RT31_HUMAN	MRPS31	physical	29128334
RT29_HUMAN	DAP3	physical	29128334
MRRP1_HUMAN	TRMT10C	physical	29128334
EI2BA_HUMAN	EIF2B1	physical	29128334
C1TC_HUMAN	MTHFD1	physical	29128334
ERH_HUMAN	ERH	physical	29128334
STK26_HUMAN	STK26	physical	29128334
TIF1B_HUMAN	TRIM28	physical	29128334
SNX1_HUMAN	SNX1	physical	29128334
CSN8_HUMAN	COPS8	physical	29128334
API5_HUMAN	API5	physical	29128334
THIO_HUMAN	TXN	physical	29128334
PRPS1_HUMAN	PRPS1	physical	29128334
AIMP2_HUMAN	AIMP2	physical	29128334
CSK2B_HUMAN	CSNK2B	physical	29128334
NACAM_HUMAN	NACA	physical	29128334
NACA_HUMAN	NACA	physical	29128334
RB11A_HUMAN	RAB11A	physical	29128334
MACD1_HUMAN	MACROD1	physical	29128334
EIF3K_HUMAN	EIF3K	physical	29128334
CXL14_HUMAN	CXCL14	physical	29128334
PTMA_HUMAN	PTMA	physical	29128334
UBE2S_HUMAN	UBE2S	physical	29128334
IKBE_HUMAN	NFKBIE	physical	29128334
CC124_HUMAN	CCDC124	physical	29128334
MIF_HUMAN	MIF	physical	29128334
SEPT2_HUMAN	SEPT2	physical	29128334
1433F_HUMAN	YWHAH	physical	29128334
SYIC_HUMAN	IARS	physical	29128334
FEN1_HUMAN	FEN1	physical	29128334
ACTN1_HUMAN	ACTN1	physical	29128334
COPD_HUMAN	ARCN1	physical	29128334
NH2L1_HUMAN	NHP2L1	physical	29128334
H2AV_HUMAN	H2AFV	physical	29128334
SNX2_HUMAN	SNX2	physical	29128334
NP1L1_HUMAN	NAP1L1	physical	29128334
NDUS3_HUMAN	NDUFS3	physical	29128334
ADRM1_HUMAN	ADRM1	physical	29128334
RL27_HUMAN	RPL27	physical	29128334
IF4A3_HUMAN	EIF4A3	physical	29128334
PROF1_HUMAN	PFN1	physical	29128334
PROF2_HUMAN	PFN2	physical	29128334
ACTN4_HUMAN	ACTN4	physical	29128334
FAS_HUMAN	FASN	physical	29128334
FBRL_HUMAN	FBL	physical	29128334
ELAV1_HUMAN	ELAVL1	physical	29128334
LDH6A_HUMAN	LDHAL6A	physical	29128334
RPA34_HUMAN	CD3EAP	physical	29128334
MCM4_HUMAN	MCM4	physical	29128334
NOLC1_HUMAN	NOLC1	physical	29128334
STML2_HUMAN	STOML2	physical	29128334
CPSF6_HUMAN	CPSF6	physical	29128334
DDX1_HUMAN	DDX1	physical	29128334
PLAK_HUMAN	JUP	physical	29128334
RMXL2_HUMAN	RBMXL2	physical	29128334
PRS8_HUMAN	PSMC5	physical	29128334
FMR1_HUMAN	FMR1	physical	29128334
RAB5C_HUMAN	RAB5C	physical	29128334
RL10A_HUMAN	RPL10A	physical	29128334
ENOB_HUMAN	ENO3	physical	29128334
ERF1_HUMAN	ETF1	physical	29128334
EIF3C_HUMAN	EIF3C	physical	29128334
ATX10_HUMAN	ATXN10	physical	29128334
XRCC5_HUMAN	XRCC5	physical	29128334
PRP19_HUMAN	PRPF19	physical	29128334
SYFA_HUMAN	FARSA	physical	29128334
DKC1_HUMAN	DKC1	physical	29128334
DESP_HUMAN	DSP	physical	29128334
PPM1G_HUMAN	PPM1G	physical	29128334
DDX23_HUMAN	DDX23	physical	29128334
EIF3D_HUMAN	EIF3D	physical	29128334
TPM1_HUMAN	TPM1	physical	29128334
SRRT_HUMAN	SRRT	physical	29128334
CTNA1_HUMAN	CTNNA1	physical	29128334
SND1_HUMAN	SND1	physical	29128334
ADPPT_HUMAN	AASDHPPT	physical	29128334
AIMP1_HUMAN	AIMP1	physical	29128334
P5CR2_HUMAN	PYCR2	physical	29128334
RT35_HUMAN	MRPS35	physical	29128334
PUR2_HUMAN	GART	physical	29128334
STRAP_HUMAN	STRAP	physical	29128334
TWF1_HUMAN	TWF1	physical	29128334
EI2BB_HUMAN	EIF2B2	physical	29128334
PININ_HUMAN	PNN	physical	29128334
CSTF3_HUMAN	CSTF3	physical	29128334
CDK9_HUMAN	CDK9	physical	29128334
H2AY_HUMAN	H2AFY	physical	29128334
PSMD4_HUMAN	PSMD4	physical	29128334
GALK1_HUMAN	GALK1	physical	29128334
METK2_HUMAN	MAT2A	physical	29128334
DNJA1_HUMAN	DNAJA1	physical	29128334
MP2K2_HUMAN	MAP2K2	physical	29128334
MCM3_HUMAN	MCM3	physical	29128334
MCM6_HUMAN	MCM6	physical	29128334
SMCE1_HUMAN	SMARCE1	physical	29128334
IRS4_HUMAN	IRS4	physical	29128334
HSP74_HUMAN	HSPA4	physical	29128334
DX39B_HUMAN	DDX39B	physical	29128334
HS105_HUMAN	HSPH1	physical	29128334
SEPT7_HUMAN	SEPT7	physical	29128334
RL1D1_HUMAN	RSL1D1	physical	29128334
SP16H_HUMAN	SUPT16H	physical	29128334
PSMD3_HUMAN	PSMD3	physical	29128334
EHD1_HUMAN	EHD1	physical	29128334
UBP2L_HUMAN	UBAP2L	physical	29128334
LARP1_HUMAN	LARP1	physical	29128334
E2AK2_HUMAN	EIF2AK2	physical	29128334
SYLC_HUMAN	LARS	physical	29128334
AIFM1_HUMAN	AIFM1	physical	29128334
P66A_HUMAN	GATAD2A	physical	29128334
EIF3A_HUMAN	EIF3A	physical	29128334
SYQ_HUMAN	QARS	physical	29128334
IF4G1_HUMAN	EIF4G1	physical	29128334
ELP2_HUMAN	ELP2	physical	29128334
DSC1_HUMAN	DSC1	physical	29128334
ZCCHV_HUMAN	ZC3HAV1	physical	29128334
BCLF1_HUMAN	BCLAF1	physical	29128334
TR150_HUMAN	THRAP3	physical	29128334
SMC3_HUMAN	SMC3	physical	29128334
COPA_HUMAN	COPA	physical	29128334
VIGLN_HUMAN	HDLBP	physical	29128334
ACINU_HUMAN	ACIN1	physical	29128334
H2A1B_HUMAN	HIST1H2AE	physical	29128334
KAD4_HUMAN	AK4	physical	29128334
ES1_HUMAN	C21orf33	physical	29128334
H2B1D_HUMAN	HIST1H2BD	physical	29128334
H2B1C_HUMAN	HIST1H2BD	physical	29128334
SMN_HUMAN	SMN1	physical	29128334
BOLA2_HUMAN	BOLA2	physical	29128334

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
246900	Dihydrolipoamide dehydrogenase deficiency (DLDD)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of DLDH_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-143; LYS-267; LYS-320;LYS-410; LYS-417 AND LYS-420, AND MASS SPECTROMETRY.	19608861 [Abstract]