EI2BA_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EI2BA_HUMAN
• UniProt AC: Q14232
• Protein Name: Translation initiation factor eIF-2B subunit alpha
• Gene Name: EIF2B1
• Organism: Homo sapiens (Human).
• Sequence Length: 305
• Protein Description: Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP..
• Protein Sequence: MDDKELIEYFKSQMKEDPDMASAVAAIRTLLEFLKRDKGETIQGLRANLTSAIETLCGVDSSVAVSSGGELFLRFISLASLEYSDYSKCKKIMIERGELFLRRISLSRNKIADLCHTFIKDGATILTHAYSRVVLRVLEAAVAAKKRFSVYVTESQPDLSGKKMAKALCHLNVPVTVVLDAAVGYIMEKADLVIVGAEGVVENGGIINKIGTNQMAVCAKAQNKPFYVVAESFKFVRLFPLNQQDVPDKFKYKADTLKVAQTGQDLKEEHPWVDYTAPSLITLLFTDLGVLTPSAVSDELIKLYL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11	Ubiquitination	KELIEYFKSQMKEDP HHHHHHHHHHHCCCC	38.59	22817900
15	Ubiquitination	EYFKSQMKEDPDMAS HHHHHHHCCCCCHHH	51.86	21890473
15	Acetylation	EYFKSQMKEDPDMAS HHHHHHHCCCCCHHH	51.86	25953088
15	Ubiquitination	EYFKSQMKEDPDMAS HHHHHHHCCCCCHHH	51.86	21906983
20	Sulfoxidation	QMKEDPDMASAVAAI HHCCCCCHHHHHHHH	3.74	21406390
29	Phosphorylation	SAVAAIRTLLEFLKR HHHHHHHHHHHHHHH	29.58	21406692
35	2-Hydroxyisobutyrylation	RTLLEFLKRDKGETI HHHHHHHHHCCCCCH	64.96	-
35	Ubiquitination	RTLLEFLKRDKGETI HHHHHHHHHCCCCCH	64.96	22817900
35	Acetylation	RTLLEFLKRDKGETI HHHHHHHHHCCCCCH	64.96	19608861
35	Ubiquitination	RTLLEFLKRDKGETI HHHHHHHHHCCCCCH	64.96	21890473
38	Ubiquitination	LEFLKRDKGETIQGL HHHHHHCCCCCHHHH	63.78	33845483
38	2-Hydroxyisobutyrylation	LEFLKRDKGETIQGL HHHHHHCCCCCHHHH	63.78	-
38	Ubiquitination	LEFLKRDKGETIQGL HHHHHHCCCCCHHHH	63.78	-
50	Phosphorylation	QGLRANLTSAIETLC HHHHHHHHHHHHHHH	18.87	22210691
51	Phosphorylation	GLRANLTSAIETLCG HHHHHHHHHHHHHHC	30.34	22210691
77	Phosphorylation	ELFLRFISLASLEYS HHHHHHHHHHHCCCC	18.38	29083192
80	Phosphorylation	LRFISLASLEYSDYS HHHHHHHHCCCCCHH	27.33	29083192
83	Phosphorylation	ISLASLEYSDYSKCK HHHHHCCCCCHHHHC	16.49	29083192
84	Phosphorylation	SLASLEYSDYSKCKK HHHHCCCCCHHHHCE	22.24	29083192
86	Phosphorylation	ASLEYSDYSKCKKIM HHCCCCCHHHHCEEE	12.23	21712546
87	Phosphorylation	SLEYSDYSKCKKIMI HCCCCCHHHHCEEEE	36.25	21712546
105	O-linked_Glycosylation	ELFLRRISLSRNKIA HHHHHHHHCCCCHHH	20.62	30379171
105	Phosphorylation	ELFLRRISLSRNKIA HHHHHHHHCCCCHHH	20.62	20068231
107	Phosphorylation	FLRRISLSRNKIADL HHHHHHCCCCHHHHH	27.32	24702127
120	Acetylation	DLCHTFIKDGATILT HHHHHHHHCCHHHHH	46.01	26051181
130	Phosphorylation	ATILTHAYSRVVLRV HHHHHHHHHHHHHHH	6.87	20393185
145	Acetylation	LEAAVAAKKRFSVYV HHHHHHHHHCEEEEE	34.44	25953088
145	Ubiquitination	LEAAVAAKKRFSVYV HHHHHHHHHCEEEEE	34.44	33845483
145	Methylation	LEAAVAAKKRFSVYV HHHHHHHHHCEEEEE	34.44	-
149	Phosphorylation	VAAKKRFSVYVTESQ HHHHHCEEEEEECCC	19.30	27251275
160	Phosphorylation	TESQPDLSGKKMAKA ECCCCCCCCHHHHHH	56.82	25332170
162	Ubiquitination	SQPDLSGKKMAKALC CCCCCCCHHHHHHHH	35.68	-
163	Acetylation	QPDLSGKKMAKALCH CCCCCCHHHHHHHHC	47.84	24848925
215	Sulfoxidation	NKIGTNQMAVCAKAQ CEECCCCHHHHHHCC	3.07	21406390
253	Ubiquitination	VPDKFKYKADTLKVA CCCHHHHHHHHHHCC	40.14	29967540
258	Ubiquitination	KYKADTLKVAQTGQD HHHHHHHHCCCCCCC	37.30	32015554
258	2-Hydroxyisobutyrylation	KYKADTLKVAQTGQD HHHHHHHHCCCCCCC	37.30	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of EI2BA_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of EI2BA_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EI2BA_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
EI2BG_HUMAN	EIF2B3	physical	17353931
PDIA4_HUMAN	PDIA4	physical	17353931
EI2BE_HUMAN	EIF2B5	physical	17353931
DCD_HUMAN	DCD	physical	17353931
HNRPL_HUMAN	HNRNPL	physical	17353931
EI2BE_HUMAN	EIF2B5	physical	10858531
EI2BD_YEAST	GCD2	physical	21795329
EI2BB_HUMAN	EIF2B2	physical	21795329
EI2BE_YEAST	GCD6	physical	21795329
EI2BA_HUMAN	EIF2B1	physical	25416956
GORS2_HUMAN	GORASP2	physical	25416956
NTAQ1_HUMAN	WDYHV1	physical	25416956
RD3_HUMAN	RD3	physical	25416956
EI2BE_HUMAN	EIF2B5	physical	26344197
THTM_HUMAN	MPST	physical	26344197
SPB13_HUMAN	SERPINB13	physical	26344197
EI2BD_HUMAN	EIF2B4	physical	28514442
EI2BG_HUMAN	EIF2B3	physical	28514442
EI2BE_HUMAN	EIF2B5	physical	28514442
BZW2_HUMAN	BZW2	physical	27173435
MCU_HUMAN	MCU	physical	27173435

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 603896: Leukodystrophy with vanishing white matter (VWM)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-35, AND MASS SPECTROMETRY.
PubMed: 19608861