DCD_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DCD_HUMAN
• UniProt AC: P81605
• Protein Name: Dermcidin
• Gene Name: DCD
• Organism: Homo sapiens (Human).
• Sequence Length: 110
• Subcellular Localization: Secreted.
• Protein Description: DCD-1 displays antimicrobial activity thereby limiting skin infection by potential pathogens in the first few hours after bacterial colonization. Highly effective against E.coli, E.faecalis, S.aureus and C.albicans. Optimal pH and salt concentration resemble the conditions in sweat. Also exhibits proteolytic activity, cleaving on the C-terminal side of Arg and, to a lesser extent, Lys residues. [PubMed: 17448443; Survival-promoting peptide promotes survival of neurons and displays phosphatase activity. It may bind IgG.]
• Protein Sequence: MRFMTLLFLTALAGALVCAYDPEAASAPGSGNPCHEASAAQKENAGEDPGLARQAPKPRKQRSSLLEKGLDGAKKAVGGLGKLGKDAVEDLESVGKGAVHDVKDVLDSVL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
20	Phosphorylation	AGALVCAYDPEAASA HHHHHHHCCHHHHCC	27.23	21397687
26	O-linked_Glycosylation	AYDPEAASAPGSGNP HCCHHHHCCCCCCCC	41.88	OGP
63	Phosphorylation	PKPRKQRSSLLEKGL CCCHHHHHHHHHHCH	23.89	21406692
64	Phosphorylation	KPRKQRSSLLEKGLD CCHHHHHHHHHHCHH	38.88	24719451
68	Acetylation	QRSSLLEKGLDGAKK HHHHHHHHCHHHHHH	65.82	19608861
85	Acetylation	GGLGKLGKDAVEDLE CCCHHHCHHHHHHHH	53.61	26051181
103	Acetylation	KGAVHDVKDVLDSVL CCHHHCHHHHHHHHC	48.45	26822725

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DCD_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DCD_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DCD_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
IL24_HUMAN	IL24	physical	21988832

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-68, AND MASS SPECTROMETRY.
PubMed: 19608861