IL24_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IL24_HUMAN
• UniProt AC: Q13007
• Protein Name: Interleukin-24
• Gene Name: IL24
• Organism: Homo sapiens (Human).
• Sequence Length: 206
• Subcellular Localization: Secreted .
• Protein Description: Has antiproliferative properties on melanoma cells and may contribute to terminal cell differentiation..
• Protein Sequence: MNFQQRLQSLWTLARPFCPPLLATASQMQMVVLPCLGFTLLLWSQVSGAQGQEFHFGPCQVKGVVPQKLWEAFWAVKDTMQAQDNITSARLLQQEVLQNVSDAESCYLVHTLLEFYLKTVFKNYHNRTVEVRTLKSFSTLANNFVLIVSQLQPSQENEMFSIRDSAHRRFLLFRRAFKQLDVEAALTKALGEVDILLTWMQKFYKL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
63 (in isoform 4)	Phosphorylation	-	27.14	-
85	N-linked_Glycosylation	DTMQAQDNITSARLL HHHHHHHCHHHHHHH	27.62	UniProtKB CARBOHYD
88	Phosphorylation	QAQDNITSARLLQQE HHHHCHHHHHHHHHH	13.95	-
99	N-linked_Glycosylation	LQQEVLQNVSDAESC HHHHHHHCCCHHHHH	30.97	UniProtKB CARBOHYD
101	Phosphorylation	QEVLQNVSDAESCYL HHHHHCCCHHHHHHH	38.36	-
111	Phosphorylation	ESCYLVHTLLEFYLK HHHHHHHHHHHHHHH	26.09	-
122	Ubiquitination	FYLKTVFKNYHNRTV HHHHHHHHHCCCCEE	52.87	23078624
126	N-linked_Glycosylation	TVFKNYHNRTVEVRT HHHHHCCCCEEEEEE	30.84	UniProtKB CARBOHYD
133	Phosphorylation	NRTVEVRTLKSFSTL CCEEEEEEHHHHHHH	43.65	-
161	Phosphorylation	SQENEMFSIRDSAHR CCCCCCCCCCCHHHH	18.53	-
198	Phosphorylation	GEVDILLTWMQKFYK HHHHHHHHHHHHHHC	18.55	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of IL24_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
122	K	ubiquitylation	Ubiquitination at Lys-122 promotes proteasomal degradation.	23078624

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IL24_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CLUS_HUMAN	CLU	physical	21732348
RARG_HUMAN	RARG	physical	21988832
CHK2_HUMAN	CHEK2	physical	25640309

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.