RARG_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RARG_HUMAN
• UniProt AC: P13631
• Protein Name: Retinoic acid receptor gamma
• Gene Name: RARG
• Organism: Homo sapiens (Human).
• Sequence Length: 454
• Subcellular Localization: Nucleus.
• Protein Description: Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, acts mainly as an activator of gene expression due to weak binding to corepressors. Required for limb bud development. In concert with RARA or RARB, required for skeletal growth, matrix homeostasis and growth plate function (By similarity)..
• Protein Sequence: MATNKERLFAAGALGPGSGYPGAGFPFAFPGALRGSPPFEMLSPSFRGLGQPDLPKEMASLSVETQSTSSEEMVPSSPSPPPPPRVYKPCFVCNDKSSGYHYGVSSCEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKEAVRNDRNKKKKEVKEEGSPDSYELSPQLEELITKVSKAHQETFPSLCQLGKYTTNSSADHRVQLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLSIADQITLLKAACLDILMLRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFAGQLLPLEMDDTETGLLSAICLICGDRMDLEEPEKVDKLQEPLLEALRLYARRRRPSQPYMFPRMLMKITDLRGISTKGAERAITLKMEIPGPMPPLIREMLENPEMFEDDSSQPGPHPNASSEDEVPGGQGKGGLKSPA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5 (in isoform 3)	Phosphorylation	-	39.60	27135362
7 (in isoform 3)	Phosphorylation	-	36.39	27135362
34	Methylation	FAFPGALRGSPPFEM CCCCCHHCCCCCHHH	42.90	-
36	Phosphorylation	FPGALRGSPPFEMLS CCCHHCCCCCHHHCC	23.98	30266825
43	Phosphorylation	SPPFEMLSPSFRGLG CCCHHHCCHHHCCCC	19.72	25106551
76	Phosphorylation	SSEEMVPSSPSPPPP CCCCCCCCCCCCCCC	43.39	23663014
77	Phosphorylation	SEEMVPSSPSPPPPP CCCCCCCCCCCCCCC	24.27	23663014
79	Phosphorylation	EMVPSSPSPPPPPRV CCCCCCCCCCCCCCC	52.57	23663014
120	Ubiquitination	FFRRSIQKNMVYTCH HHHHHHHHCCEEEEC	45.39	-
172	Sumoylation	NKKKKEVKEEGSPDS HHHHHHHHHCCCCCH	51.65	-
172	Sumoylation	NKKKKEVKEEGSPDS HHHHHHHHHCCCCCH	51.65	28112733
176	Phosphorylation	KEVKEEGSPDSYELS HHHHHCCCCCHHHCC	28.90	30624053
179	Phosphorylation	KEEGSPDSYELSPQL HHCCCCCHHHCCHHH	24.72	30624053
180	Phosphorylation	EEGSPDSYELSPQLE HCCCCCHHHCCHHHH	28.41	27732954
192	Ubiquitination	QLEELITKVSKAHQE HHHHHHHHHHHHHHH	37.20	-
371	Phosphorylation	YARRRRPSQPYMFPR HHHHHCCCCCCCHHH	41.81	25219547
374	Phosphorylation	RRRPSQPYMFPRMLM HHCCCCCCCHHHHHH	12.07	25219547
384	Phosphorylation	PRMLMKITDLRGIST HHHHHHHHHCCCCCC	24.38	23532336
390	Phosphorylation	ITDLRGISTKGAERA HHHCCCCCCCCCHHE	27.22	-
401	Sumoylation	AERAITLKMEIPGPM CHHEEEEEEECCCCC	26.32	28112733
426	Phosphorylation	PEMFEDDSSQPGPHP HHHCCCCCCCCCCCC	43.10	27251275
427	Phosphorylation	EMFEDDSSQPGPHPN HHCCCCCCCCCCCCC	47.60	27251275
436	Phosphorylation	PGPHPNASSEDEVPG CCCCCCCCCCCCCCC	40.68	27251275
437	Phosphorylation	GPHPNASSEDEVPGG CCCCCCCCCCCCCCC	46.81	27251275
452	Phosphorylation	QGKGGLKSPA----- CCCCCCCCCC-----	30.97	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
77	S	Phosphorylation	Kinase	CDK7	P50613	PSP
77	S	Phosphorylation	Kinase	GTF2F1	P35269	PSP
79	S	Phosphorylation	Kinase	CDK7	P50613	PSP
79	S	Phosphorylation	Kinase	MAPK3	P27361	GPS
79	S	Phosphorylation	Kinase	GTF2F1	P35269	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RARG_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RARG_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NCOR1_HUMAN	NCOR1	physical	10336495
NR2F6_HUMAN	NR2F6	physical	10318855
SUZ12_HUMAN	SUZ12	physical	20857416
H2AZ_HUMAN	H2AFZ	physical	20857416
RXRA_HUMAN	RXRA	physical	15604093
PNRC1_HUMAN	PNRC1	physical	15604093
RXRG_HUMAN	RXRG	physical	15604093
PNRC2_HUMAN	PNRC2	physical	15604093
NR0B2_HUMAN	NR0B2	physical	15604093
RXRB_HUMAN	RXRB	physical	15604093
MAP6_HUMAN	MAP6	physical	15604093
ITBP2_HUMAN	ITGB1BP2	physical	15604093
NCOA1_HUMAN	NCOA1	physical	15604093
HACE1_HUMAN	HACE1	physical	19350571
SPHK1_HUMAN	SPHK1	physical	21988832
ZN576_HUMAN	ZNF576	physical	21988832
RHPN2_HUMAN	RHPN2	physical	21988832
PRS8_HUMAN	PSMC5	physical	15604093
RARA_HUMAN	RARA	physical	28514442
PNM8A_HUMAN	PNMAL1	physical	28514442
RXRB_HUMAN	RXRB	physical	28514442
ZPLD1_HUMAN	ZPLD1	physical	28514442
KCNJ6_HUMAN	KCNJ6	physical	28514442
RBL2_HUMAN	RBL2	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB00459: Acitretin
• DB00210: Adapalene
• DB00523: Alitretinoin
• DB00799: Tazarotene
• DB00755: Tretinoin