dbPTM

SUZ12_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SUZ12_HUMAN
UniProt AC	Q15022
Protein Name	Polycomb protein SUZ12
Gene Name	SUZ12
Organism	Homo sapiens (Human).
Sequence Length	739
Subcellular Localization	Nucleus .
Protein Description	Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A..
Protein Sequence	MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Methylation	---MAPQKHGGGGGG ---CCCCCCCCCCCC	43.06	115980289
14	Phosphorylation	GGGGGGGSGPSAGSG CCCCCCCCCCCCCCC	51.29	23186163
17	Phosphorylation	GGGGSGPSAGSGGGG CCCCCCCCCCCCCCC	49.11	25159151
20	Phosphorylation	GSGPSAGSGGGGFGG CCCCCCCCCCCCCCH	33.70	23917254
35	Phosphorylation	SAAVAAATASGGKSG HHHHHHHHCCCCCCC	19.34	25850435
37	Phosphorylation	AVAAATASGGKSGGG HHHHHHCCCCCCCCC	43.66	25159151
72	Sumoylation	GAAVLPVKKPKMEHV CCEEEECCCCCCCCC	62.51	-
72	Sumoylation	GAAVLPVKKPKMEHV CCEEEECCCCCCCCC	62.51	18628979
73	Sumoylation	AAVLPVKKPKMEHVQ CEEEECCCCCCCCCC	50.53	-
73	Sumoylation	AAVLPVKKPKMEHVQ CEEEECCCCCCCCCC	50.53	18628979
75	Sumoylation	VLPVKKPKMEHVQAD EEECCCCCCCCCCCC	66.84	18628979
75	Sumoylation	VLPVKKPKMEHVQAD EEECCCCCCCCCCCC	66.84	-
92	Ubiquitination	LFLQAFEKPTQIYRF HHHHHHCCHHHHHHH	47.08	-
131	Phosphorylation	RTNIKRKTFKVDDML CCCCCCCEEEHHHHH	32.49	16674116
139	Phosphorylation	FKVDDMLSKVEKMKG EEHHHHHHHHHHHCC	28.19	16674116
140	Sumoylation	KVDDMLSKVEKMKGE EHHHHHHHHHHHCCC	50.91	-
140	Sumoylation	KVDDMLSKVEKMKGE EHHHHHHHHHHHCCC	50.91	-
140	Acetylation	KVDDMLSKVEKMKGE EHHHHHHHHHHHCCC	50.91	19812019
143	Acetylation	DMLSKVEKMKGEQES HHHHHHHHHCCCCHH	49.23	19812027
145	Acetylation	LSKVEKMKGEQESHS HHHHHHHCCCCHHCC	71.07	19812035
170	Acetylation	GFFHKNDKPSPNSEN ECCCCCCCCCCCCCC	57.71	25953088
172	Phosphorylation	FHKNDKPSPNSENEQ CCCCCCCCCCCCCCC	42.32	30576142
197	Ubiquitination	KVCHKKRKDVSCPIR HHHHHCCCCCCCCCC	71.95	-
223	Acetylation	NPDLNQTKPGNFPSL CCCCCCCCCCCCCCE	40.96	26051181
223	Sumoylation	NPDLNQTKPGNFPSL CCCCCCCCCCCCCCE	40.96	28112733
223	Ubiquitination	NPDLNQTKPGNFPSL CCCCCCCCCCCCCCE	40.96	-
240	Phosphorylation	SSNEFEPSNSHMVKS ECCCCCCCCCHHCEE	43.71	25627689
246	Acetylation	PSNSHMVKSYSLLFR CCCCHHCEEEEEEEE	35.78	25953088
248	Phosphorylation	NSHMVKSYSLLFRVT CCHHCEEEEEEEEEC	9.53	24719451
255	Phosphorylation	YSLLFRVTRPGRREF EEEEEEECCCCCCCC	27.22	24719451
293	Acetylation	RNREDGEKTFVAQMT HCCCCCCEEEEEEEE	53.44	25953088
328	Phosphorylation	EMEECPISKKRATWE HHHHCCCCCCCCCHH	19.78	30576142
336	Phosphorylation	KKRATWETILDGKRL CCCCCHHHHHCCCCC	20.57	-
341	Ubiquitination	WETILDGKRLPPFET HHHHHCCCCCCCCCC	50.89	21890473
341	Acetylation	WETILDGKRLPPFET HHHHHCCCCCCCCCC	50.89	25953088
358	Phosphorylation	QGPTLQFTLRWTGET CCCEEEEEEEEECCC	11.49	24719451
368	Ubiquitination	WTGETNDKSTAPIAK EECCCCCCCCCCCCC	52.34	21890473
375	Ubiquitination	KSTAPIAKPLATRNS CCCCCCCCCCCCCCC	41.08	21890473
375	Acetylation	KSTAPIAKPLATRNS CCCCCCCCCCCCCCC	41.08	25953088
379	Phosphorylation	PIAKPLATRNSESLH CCCCCCCCCCCHHHC	37.76	25159151
382	Phosphorylation	KPLATRNSESLHQEN CCCCCCCCHHHCCCC	25.85	23663014
384	Phosphorylation	LATRNSESLHQENKP CCCCCCHHHCCCCCC	30.85	23663014
390	Sumoylation	ESLHQENKPGSVKPT HHHCCCCCCCCCCCC	50.43	28112733
390	Ubiquitination	ESLHQENKPGSVKPT HHHCCCCCCCCCCCC	50.43	-
393	Phosphorylation	HQENKPGSVKPTQTI CCCCCCCCCCCCCEE	35.18	23917254
395	Ubiquitination	ENKPGSVKPTQTIAV CCCCCCCCCCCEEEE	44.00	-
397	Phosphorylation	KPGSVKPTQTIAVKE CCCCCCCCCEEEEEE	32.40	23186163
399	Phosphorylation	GSVKPTQTIAVKESL CCCCCCCEEEEEEEH	17.24	23186163
403	Methylation	PTQTIAVKESLTTDL CCCEEEEEEEHHHCH	32.34	24129315
405	Phosphorylation	QTIAVKESLTTDLQT CEEEEEEEHHHCHHH	25.87	22210691
407	Phosphorylation	IAVKESLTTDLQTRK EEEEEEHHHCHHHHH	27.78	22210691
412	Phosphorylation	SLTTDLQTRKEKDTP EHHHCHHHHHHCCCC	51.51	-
414	Methylation	TTDLQTRKEKDTPNE HHCHHHHHHCCCCCH	72.93	116252705
418	Phosphorylation	QTRKEKDTPNENRQK HHHHHCCCCCHHHHH	38.80	30576142
430	Phosphorylation	RQKLRIFYQFLYNNN HHHHHHHHHHHHCCC	8.93	24043423
434	Phosphorylation	RIFYQFLYNNNTRQQ HHHHHHHHCCCCCCC	19.68	24043423
438	Phosphorylation	QFLYNNNTRQQTEAR HHHHCCCCCCCCCCC	31.79	24043423
461	Phosphorylation	TLNCRKLYSLLKHLK HHHHHHHHHHHHHHH	10.58	24719451
462	Phosphorylation	LNCRKLYSLLKHLKL HHHHHHHHHHHHHHH	37.35	24719451
465	Acetylation	RKLYSLLKHLKLCHS HHHHHHHHHHHHHHH	52.78	26051181
478	Phosphorylation	HSRFIFNYVYHPKGA HHHHHEEECCCCCCC	7.52	23663014
480	Phosphorylation	RFIFNYVYHPKGARI HHHEEECCCCCCCEE	11.31	23663014
483	Acetylation	FNYVYHPKGARIDVS EEECCCCCCCEEEEE	52.47	25953088
537	Ubiquitination	VCRPKRTKASMSEFL EECCCCCCCHHHHHH	42.36	21890473
539	Phosphorylation	RPKRTKASMSEFLES CCCCCCCHHHHHHHC	25.13	30266825
541	Phosphorylation	KRTKASMSEFLESED CCCCCHHHHHHHCCC	23.77	30266825
546	Phosphorylation	SMSEFLESEDGEVEQ HHHHHHHCCCCCEEE	43.04	29255136
565	Phosphorylation	SSGHNRLYFHSDTCL CCCCCEEEEECCCEE	8.94	24732914
568	Phosphorylation	HNRLYFHSDTCLPLR CCEEEEECCCEEECC	25.39	23898821
570	Phosphorylation	RLYFHSDTCLPLRPQ EEEEECCCEEECCCC	20.96	23898821
583	Phosphorylation	PQEMEVDSEDEKDPE CCCCCCCCCCCCCHH	52.72	25159151
595	Ubiquitination	DPEWLREKTITQIEE CHHHHHHHHEEEEHH	38.50	-
604	Phosphorylation	ITQIEEFSDVNEGEK EEEEHHHCCCCHHHH	43.88	-
687	Ubiquitination	KLREMQQKLEKGESA HHHHHHHHHHCCCCC	41.54	-
693	Phosphorylation	QKLEKGESASPANEE HHHHCCCCCCCCCHH	42.59	30266825
695	Phosphorylation	LEKGESASPANEEIT HHCCCCCCCCCHHCC	33.55	23401153
702	Phosphorylation	SPANEEITEEQNGTA CCCCHHCCHHHCCCC	36.43	30266825
708	Phosphorylation	ITEEQNGTANGFSEI CCHHHCCCCCCCHHC	25.21	30266825
713	Phosphorylation	NGTANGFSEINSKEK CCCCCCCHHCCCCCH	38.68	29978859
724	Phosphorylation	SKEKALETDSVSGVS CCCHHHHCCCCCCCC	34.13	29255136
726	Phosphorylation	EKALETDSVSGVSKQ CHHHHCCCCCCCCHH	26.13	23401153
728	Phosphorylation	ALETDSVSGVSKQSK HHHCCCCCCCCHHHH	37.11	25262027
731	Phosphorylation	TDSVSGVSKQSKKQK CCCCCCCCHHHHHCC	28.62	30108239
732	Acetylation	DSVSGVSKQSKKQKL CCCCCCCHHHHHCCC	57.07	25953088
734	Phosphorylation	VSGVSKQSKKQKL-- CCCCCHHHHHCCC--	45.62	20873877

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
539	S	Phosphorylation	Kinase	PLK1	P53350	PSP
541	S	Phosphorylation	Kinase	PLK1	P53350	PSP
546	S	Phosphorylation	Kinase	PLK1	P53350	PSP
-	K	Ubiquitination	E3 ubiquitin ligase	PJA1	Q8NG27	PMID:21513699

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SUZ12_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SUZ12_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
AEBP2_HUMAN	AEBP2	physical	15225548
RBBP4_HUMAN	RBBP4	physical	15225548
MEP50_HUMAN	WDR77	physical	16712789
GTF2I_HUMAN	GTF2I	physical	17970752
SNAI1_HUMAN	SNAI1	physical	18519590
EZH1_HUMAN	EZH1	physical	19026781
EZH2_HUMAN	EZH2	physical	19026781
SUZ12_HUMAN	SUZ12	physical	19026781
EED_HUMAN	EED	physical	19026781
KDM5A_HUMAN	KDM5A	physical	18483221
EED_HUMAN	EED	physical	18483221
EZH2_HUMAN	EZH2	physical	18483221
EZH2_HUMAN	EZH2	physical	21378168
WT1_HUMAN	WT1	physical	21378168
DNMT1_HUMAN	DNMT1	physical	21378168
MEP50_HUMAN	WDR77	physical	22169276
CDK8_HUMAN	CDK8	physical	22668559
CDK19_HUMAN	CDK19	physical	22668559
MED6_HUMAN	MED6	physical	22668559
MED17_HUMAN	MED17	physical	22668559
EZH2_HUMAN	EZH2	physical	20075857
JARD2_HUMAN	JARID2	physical	20075857
EZH1_HUMAN	EZH1	physical	20075857
EED_HUMAN	EED	physical	20075857
AEBP2_HUMAN	AEBP2	physical	20075857
RBBP4_HUMAN	RBBP4	physical	20075857
RBBP7_HUMAN	RBBP7	physical	20075857
HDAC2_HUMAN	HDAC2	physical	20075857
PLEC_HUMAN	PLEC	physical	24457600
TR150_HUMAN	THRAP3	physical	24457600
EED_HUMAN	EED	physical	24457600
EZH2_HUMAN	EZH2	physical	24457600
ACTG_HUMAN	ACTG1	physical	24457600
MTOR_HUMAN	MTOR	physical	24457600
AEBP2_HUMAN	AEBP2	physical	24457600
ERH_HUMAN	ERH	physical	24457600
ILF3_HUMAN	ILF3	physical	24457600
IF4A3_HUMAN	EIF4A3	physical	24457600
PCNT_HUMAN	PCNT	physical	24457600
LC7L2_HUMAN	LUC7L2	physical	24457600
ACINU_HUMAN	ACIN1	physical	24457600
NUCL_HUMAN	NCL	physical	24457600
DDX5_HUMAN	DDX5	physical	24457600
H2AY_HUMAN	H2AFY	physical	24457600
PRP8_HUMAN	PRPF8	physical	24457600
BCLF1_HUMAN	BCLAF1	physical	24457600
H12_HUMAN	HIST1H1C	physical	24457600
SRSF1_HUMAN	SRSF1	physical	24457600
RBBP4_HUMAN	RBBP4	physical	24457600
ANM1_HUMAN	PRMT1	physical	24457600
U520_HUMAN	SNRNP200	physical	24457600
EZH1_HUMAN	EZH1	physical	24457600
LIMA1_HUMAN	LIMA1	physical	24457600
CDKAL_HUMAN	CDKAL1	physical	24457600
UBB_HUMAN	UBB	physical	24457600
SON_HUMAN	SON	physical	24457600
AKAP9_HUMAN	AKAP9	physical	24457600
YBOX1_HUMAN	YBX1	physical	24457600
PABP4_HUMAN	PABPC4	physical	24457600
RNPS1_HUMAN	RNPS1	physical	24457600
TRA2A_HUMAN	TRA2A	physical	24457600
RBP56_HUMAN	TAF15	physical	24457600
TIF1B_HUMAN	TRIM28	physical	24457600
ARGI1_HUMAN	ARG1	physical	24457600
DHX9_HUMAN	DHX9	physical	24457600
MYH14_HUMAN	MYH14	physical	24457600
NUMA1_HUMAN	NUMA1	physical	24457600
SF3B1_HUMAN	SF3B1	physical	24457600
PHF1_HUMAN	PHF1	physical	24457600
SRS10_HUMAN	SRSF10	physical	24457600
MTF2_HUMAN	MTF2	physical	24457600
PKP1_HUMAN	PKP1	physical	24457600
ANDR_HUMAN	AR	physical	24457600
ELAV1_HUMAN	ELAVL1	physical	24457600
RBM14_HUMAN	RBM14	physical	24457600
LST8_HUMAN	MLST8	physical	24457600
H10_HUMAN	H1F0	physical	24457600
GCN1_HUMAN	GCN1L1	physical	24457600
U5S1_HUMAN	EFTUD2	physical	24457600
DYHC1_HUMAN	DYNC1H1	physical	24457600
SRSF9_HUMAN	SRSF9	physical	24457600
FMR1_HUMAN	FMR1	physical	24457600
ATPB_HUMAN	ATP5B	physical	24457600
DDX3X_HUMAN	DDX3X	physical	24457600
CHTOP_HUMAN	CHTOP	physical	24457600
HP1B3_HUMAN	HP1BP3	physical	24457600
LARP1_HUMAN	LARP1	physical	24457600
MIC60_HUMAN	IMMT	physical	24457600
NCBP1_HUMAN	NCBP1	physical	24457600
RSMN_HUMAN	SNRPN	physical	24457600
RU17_HUMAN	SNRNP70	physical	24457600
ILF2_HUMAN	ILF2	physical	24457600
EWS_HUMAN	EWSR1	physical	24457600
SAFB2_HUMAN	SAFB2	physical	24457600
RACK1_HUMAN	GNB2L1	physical	24457600
PHF19_HUMAN	PHF19	physical	24457600
MGN_HUMAN	MAGOH	physical	24457600
SRSF5_HUMAN	SRSF5	physical	24457600
SF3B2_HUMAN	SF3B2	physical	24457600
AT2A2_HUMAN	ATP2A2	physical	24457600
SRBS2_HUMAN	SORBS2	physical	24457600
DX39B_HUMAN	DDX39B	physical	24457600
U2AF2_HUMAN	U2AF2	physical	24457600
H2B1B_HUMAN	HIST1H2BB	physical	24457600
NOP58_HUMAN	NOP58	physical	24457600
RENT1_HUMAN	UPF1	physical	24457600
SRSF6_HUMAN	SRSF6	physical	24457600
SF3B3_HUMAN	SF3B3	physical	24457600
LUC7L_HUMAN	LUC7L	physical	24457600
RALY_HUMAN	RALY	physical	24457600
FBRL_HUMAN	FBL	physical	24457600
SRSF3_HUMAN	SRSF3	physical	24457600
XRCC5_HUMAN	XRCC5	physical	24457600
H2B1A_HUMAN	HIST1H2BA	physical	24457600
THOC4_HUMAN	ALYREF	physical	24457600
SNRPA_HUMAN	SNRPA	physical	24457600
NCBP3_HUMAN	C17orf85	physical	24457600
MYO1C_HUMAN	MYO1C	physical	24457600
NEB2_HUMAN	PPP1R9B	physical	24457600
RBBP7_HUMAN	RBBP7	physical	24457600
NAT10_HUMAN	NAT10	physical	24457600
RBM8A_HUMAN	RBM8A	physical	24457600
ZN326_HUMAN	ZNF326	physical	24457600
MIC19_HUMAN	CHCHD3	physical	24457600
DSRAD_HUMAN	ADAR	physical	24457600
DREB_HUMAN	DBN1	physical	24457600
FXR2_HUMAN	FXR2	physical	24457600
SYF1_HUMAN	XAB2	physical	24457600
SLTM_HUMAN	SLTM	physical	24457600
SRSF8_HUMAN	SRSF8	physical	24457600
SMD3_HUMAN	SNRPD3	physical	24457600
ATD3A_HUMAN	ATAD3A	physical	24457600
CHD4_HUMAN	CHD4	physical	24457600
C1QBP_HUMAN	C1QBP	physical	24457600
YBOX3_HUMAN	YBX3	physical	24457600
H2A2A_HUMAN	HIST2H2AA3	physical	24457600
PABP2_HUMAN	PABPN1	physical	24457600
RBM39_HUMAN	RBM39	physical	24457600
U2AF1_HUMAN	U2AF1	physical	24457600
UIF_HUMAN	FYTTD1	physical	24457600
ATPG_HUMAN	ATP5C1	physical	24457600
CRNL1_HUMAN	CRNKL1	physical	24457600
SRSF7_HUMAN	SRSF7	physical	24457600
SFXN1_HUMAN	SFXN1	physical	24457600
TERA_HUMAN	VCP	physical	24457600
CBX8_HUMAN	CBX8	physical	24457600
H2AW_HUMAN	H2AFY2	physical	24457600
EFTU_HUMAN	TUFM	physical	24457600
FUBP2_HUMAN	KHSRP	physical	24457600
RAN_HUMAN	RAN	physical	24457600
VGF_HUMAN	VGF	physical	24457600
PRDX1_HUMAN	PRDX1	physical	24457600
PHF5A_HUMAN	PHF5A	physical	24457600
PTBP1_HUMAN	PTBP1	physical	24457600
KPYM_HUMAN	PKM	physical	24457600
RCC1_HUMAN	RCC1	physical	24457600
TCPG_HUMAN	CCT3	physical	24457600
CALR_HUMAN	CALR	physical	24457600
CNBP_HUMAN	CNBP	physical	24457600
CBX3_HUMAN	CBX3	physical	24457600
CPSF7_HUMAN	CPSF7	physical	24457600
IF2B_HUMAN	EIF2S2	physical	24457600
FXR1_HUMAN	FXR1	physical	24457600
SAP18_HUMAN	SAP18	physical	24457600
LMNB2_HUMAN	LMNB2	physical	24457600
MYL6_HUMAN	MYL6	physical	24457600
FIP1_HUMAN	FIP1L1	physical	24457600
SMD1_HUMAN	SNRPD1	physical	24457600
RU2A_HUMAN	SNRPA1	physical	24457600
CK5P2_HUMAN	CDK5RAP2	physical	24457600
SERA_HUMAN	PHGDH	physical	24457600
TRI25_HUMAN	TRIM25	physical	24457600
E2AK3_HUMAN	EIF2AK3	physical	24457600
LEG7_HUMAN	LGALS7	physical	24457600
LDHB_HUMAN	LDHB	physical	24457600
NH2L1_HUMAN	NHP2L1	physical	24457600
PDLI5_HUMAN	PDLIM5	physical	24457600
NDRG1_HUMAN	NDRG1	physical	24457600
NOP2_HUMAN	NOP2	physical	24457600
RCN1_HUMAN	RCN1	physical	24457600
RL1D1_HUMAN	RSL1D1	physical	24457600
RUVB2_HUMAN	RUVBL2	physical	24457600
SF01_HUMAN	SF1	physical	24457600
SMCA5_HUMAN	SMARCA5	physical	24457600
THOC2_HUMAN	THOC2	physical	24457600
TPIS_HUMAN	TPI1	physical	24457600
ZC3HD_HUMAN	ZC3H13	physical	24457600
S39A7_HUMAN	SLC39A7	physical	24457600
ACACA_HUMAN	ACACA	physical	24457600
AKP8L_HUMAN	AKAP8L	physical	24457600
KAP2_HUMAN	PRKAR2A	physical	24457600
CSK2B_HUMAN	CSNK2B	physical	24457600
CEP57_HUMAN	CEP57	physical	24457600
MCM7_HUMAN	MCM7	physical	24457600
RBP2_HUMAN	RANBP2	physical	24457600
FLNB_HUMAN	FLNB	physical	24457600
H2A1B_HUMAN	HIST1H2AE	physical	24457600
AQR_HUMAN	AQR	physical	24457600
KHDR1_HUMAN	KHDRBS1	physical	24457600
MFAP1_HUMAN	MFAP1	physical	24457600
PTCD3_HUMAN	PTCD3	physical	24457600
PLMN_HUMAN	PLG	physical	24457600
PRP17_HUMAN	CDC40	physical	24457600
PDIA3_HUMAN	PDIA3	physical	24457600
SPR2G_HUMAN	SPRR2G	physical	24457600
SF3A1_HUMAN	SF3A1	physical	24457600
P66B_HUMAN	GATAD2B	physical	24457600
TYY1_HUMAN	YY1	physical	24457600
ABLM1_HUMAN	ABLIM1	physical	24457600
AIFM1_HUMAN	AIFM1	physical	24457600
ATPO_HUMAN	ATP5O	physical	24457600
CPSF6_HUMAN	CPSF6	physical	24457600
COPA_HUMAN	COPA	physical	24457600
DNJA1_HUMAN	DNAJA1	physical	24457600
RING2_HUMAN	RNF2	physical	24457600
FUBP3_HUMAN	FUBP3	physical	24457600
GSDMA_HUMAN	GSDMA	physical	24457600
NHP2_HUMAN	NHP2	physical	24457600
DKC1_HUMAN	DKC1	physical	24457600
HEAT1_HUMAN	HEATR1	physical	24457600
H2A2B_HUMAN	HIST2H2AB	physical	24457600
LC7L3_HUMAN	LUC7L3	physical	24457600
LA_HUMAN	SSB	physical	24457600
SYNE1_HUMAN	SYNE1	physical	24457600
NUP93_HUMAN	NUP93	physical	24457600
NXF1_HUMAN	NXF1	physical	24457600
NOLC1_HUMAN	NOLC1	physical	24457600
PPIB_HUMAN	PPIB	physical	24457600
PLRG1_HUMAN	PLRG1	physical	24457600
SF3B6_HUMAN	SF3B6	physical	24457600
PRP19_HUMAN	PRPF19	physical	24457600
SPF27_HUMAN	BCAS2	physical	24457600
DDX23_HUMAN	DDX23	physical	24457600
PHB_HUMAN	PHB	physical	24457600
PHB2_HUMAN	PHB2	physical	24457600
JARD2_HUMAN	JARID2	physical	24457600
DHX30_HUMAN	DHX30	physical	24457600
GLYR1_HUMAN	GLYR1	physical	24457600
RCL1_HUMAN	RCL1	physical	24457600
RBM4_HUMAN	RBM4	physical	24457600
PGAM5_HUMAN	PGAM5	physical	24457600
SNW1_HUMAN	SNW1	physical	24457600
SAM50_HUMAN	SAMM50	physical	24457600
SF3A3_HUMAN	SF3A3	physical	24457600
STML2_HUMAN	STOML2	physical	24457600
SMC3_HUMAN	SMC3	physical	24457600
TFAM_HUMAN	TFAM	physical	24457600
SNUT1_HUMAN	SART1	physical	24457600
AFG32_HUMAN	AFG3L2	physical	24457600
AMOL1_HUMAN	AMOTL1	physical	24457600
SYEP_HUMAN	EPRS	physical	24457600
CSRP1_HUMAN	CSRP1	physical	24457600
DAZP1_HUMAN	DAZAP1	physical	24457600
RPB2_HUMAN	POLR2B	physical	24457600
EMD_HUMAN	EMD	physical	24457600
ERLN1_HUMAN	ERLIN1	physical	24457600
GDAP1_HUMAN	GDAP1	physical	24457600
GTF2I_HUMAN	GTF2I	physical	24457600
HDAC1_HUMAN	HDAC1	physical	24457600
LCOR_HUMAN	C10orf12	physical	24457600
IGLL5_HUMAN	IGLL5	physical	24457600
KRR1_HUMAN	KRR1	physical	24457600
LPP_HUMAN	LPP	physical	24457600
TIM50_HUMAN	TIMM50	physical	24457600
NGDN_HUMAN	NGDN	physical	24457600
NUP88_HUMAN	NUP88	physical	24457600
NOG1_HUMAN	GTPBP4	physical	24457600
ISY1_HUMAN	ISY1	physical	24457600
RBM22_HUMAN	RBM22	physical	24457600
DDX56_HUMAN	DDX56	physical	24457600
RRP5_HUMAN	PDCD11	physical	24457600
P5CR1_HUMAN	PYCR1	physical	24457600
RBM34_HUMAN	RBM34	physical	24457600
MSI2H_HUMAN	MSI2	physical	24457600
SMD2_HUMAN	SNRPD2	physical	24457600
SF3B4_HUMAN	SF3B4	physical	24457600
TF65_HUMAN	RELA	physical	24457600
SSRD_HUMAN	SSR4	physical	24457600
SNR40_HUMAN	SNRNP40	physical	24457600
DDX18_HUMAN	DDX18	physical	24457600
ERG24_HUMAN	TM7SF2	physical	24457600
OST48_HUMAN	DDOST	physical	24457600
XPO2_HUMAN	CSE1L	physical	24457600
ALDOA_HUMAN	ALDOA	physical	24457600
GCSP_HUMAN	GLDC	physical	24457600
CO052_HUMAN	C15orf52	physical	24457600
KLK2_HUMAN	KLK2	physical	24457600
MTA1_HUMAN	MTA1	physical	24457600
M2OM_HUMAN	SLC25A11	physical	24457600
EBP2_HUMAN	EBNA1BP2	physical	24457600
RB15B_HUMAN	RBM15B	physical	24457600
REPI1_HUMAN	REPIN1	physical	24457600
TASOR_HUMAN	FAM208A	physical	24457600
RBM4B_HUMAN	RBM4B	physical	24457600
RBM5_HUMAN	RBM5	physical	24457600
SKP1_HUMAN	SKP1	physical	24457600
SDF2L_HUMAN	SDF2L1	physical	24457600
THOC6_HUMAN	THOC6	physical	24457600
TRAF4_HUMAN	TRAF4	physical	24457600
UFD1_HUMAN	UFD1L	physical	24457600
E41L5_HUMAN	EPB41L5	physical	24457600
CALX_HUMAN	CANX	physical	24457600
DNJC9_HUMAN	DNAJC9	physical	24457600
ERGI1_HUMAN	ERGIC1	physical	24457600
TBL1Y_HUMAN	TBL1Y	physical	24457600
H1X_HUMAN	H1FX	physical	24457600
NU107_HUMAN	NUP107	physical	24457600
PDIA1_HUMAN	P4HB	physical	24457600
G3BP2_HUMAN	G3BP2	physical	24457600
RN114_HUMAN	RNF114	physical	24457600
FUS_HUMAN	FUS	physical	24457600
U2AF4_HUMAN	U2AF1L4	physical	24457600
TBL2_HUMAN	TBL2	physical	24457600
UTP15_HUMAN	UTP15	physical	24457600
TRI37_HUMAN	TRIM37	physical	25470042
EZH2_HUMAN	EZH2	physical	25470042
EZH2_HUMAN	EZH2	physical	26748827
MDM2_HUMAN	MDM2	physical	26748827
HNF4A_HUMAN	HNF4A	physical	25391650
MTF2_HUMAN	MTF2	physical	28514442
JARD2_HUMAN	JARID2	physical	28514442
EZH1_HUMAN	EZH1	physical	28514442
LCOR_HUMAN	C10orf12	physical	28514442
EED_HUMAN	EED	physical	28514442
PHF1_HUMAN	PHF1	physical	28514442
EZH2_HUMAN	EZH2	physical	28514442
EPOP_HUMAN	C17orf96	physical	28514442
RBBP4_HUMAN	RBBP4	physical	28514442
KHDR2_HUMAN	KHDRBS2	physical	28514442
RBM5_HUMAN	RBM5	physical	28514442
DDX5_HUMAN	DDX5	physical	27338022
EZH2_HUMAN	EZH2	physical	27338022
EED_HUMAN	EED	physical	27338022

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SUZ12_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-546, AND MASSSPECTROMETRY.	19690332 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-546 AND SER-583, ANDMASS SPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-546, AND MASSSPECTROMETRY.	18669648 [Abstract]
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-546 AND SER-583, ANDMASS SPECTROMETRY.	18220336 [Abstract]
"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis."; Wang B., Malik R., Nigg E.A., Korner R.; Anal. Chem. 80:9526-9533(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-726, AND MASSSPECTROMETRY.	19007248 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-546, AND MASSSPECTROMETRY.	17081983 [Abstract]
"Large-scale characterization of HeLa cell nuclear phosphoproteins."; Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-546, AND MASSSPECTROMETRY.	15302935 [Abstract]
"Quantitative phosphoproteome profiling of Wnt3a-mediated signalingnetwork: indicating the involvement of ribonucleoside-diphosphatereductase M2 subunit phosphorylation at residue serine 20 in canonicalWnt signal transduction."; Tang L.-Y., Deng N., Wang L.-S., Dai J., Wang Z.-L., Jiang X.-S.,Li S.-J., Li L., Sheng Q.-H., Wu D.-Q., Li L., Zeng R.; Mol. Cell. Proteomics 6:1952-1967(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-418, AND MASSSPECTROMETRY.	17693683 [Abstract]
Sumoylation
Reference	PubMed
"The polycomb repressive complex 2 is a potential target of SUMOmodifications."; Riising E.M., Boggio R., Chiocca S., Helin K., Pasini D.; PLoS ONE 3:E2704-E2704(2008). Cited for: SUMOYLATION AT LYS-72; LYS-73 AND LYS-75.	18628979 [Abstract]