GDAP1_HUMAN - dbPTM
GDAP1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID GDAP1_HUMAN
UniProt AC Q8TB36
Protein Name Ganglioside-induced differentiation-associated protein 1
Gene Name GDAP1
Organism Homo sapiens (Human).
Sequence Length 358
Subcellular Localization Mitochondrion outer membrane
Multi-pass membrane protein . Cytoplasm .
Protein Description Regulates the mitochondrial network by promoting mitochondrial fission..
Protein Sequence MAERQEEQRGSPPLRAEGKADAEVKLILYHWTHSFSSQKVRLVIAEKALKCEEHDVSLPLSEHNEPWFMRLNSTGEVPVLIHGENIICEATQIIDYLEQTFLDERTPRLMPDKESMYYPRVQHYRELLDSLPMDAYTHGCILHPELTVDSMIPAYATTRIRSQIGNTESELKKLAEENPDLQEAYIAKQKRLKSKLLDHDNVKYLKKILDELEKVLDQVETELQRRNEETPEEGQQPWLCGESFTLADVSLAVTLHRLKFLGFARRNWGNGKRPNLETYYERVLKRKTFNKVLGHVNNILISAVLPTAFRVAKKRAPKVLGTTLVVGLLAGVGYFAFMLFRKRLGSMILAFRPRPNYF
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
11PhosphorylationRQEEQRGSPPLRAEG
HHHHHCCCCCCCHHC		26.0723401153
19UbiquitinationPPLRAEGKADAEVKL
CCCCHHCCCCHHHEE		34.3032142685
45UbiquitinationQKVRLVIAEKALKCE
CCEEEEEEHHHHCCC		12.5424816145
47UbiquitinationVRLVIAEKALKCEEH
EEEEEEHHHHCCCCC		50.4232142685
50UbiquitinationVIAEKALKCEEHDVS
EEEHHHHCCCCCCCC		44.4525621951
63UbiquitinationVSLPLSEHNEPWFMR
CCCCCCCCCCCCEEE		40.3527667366
64UbiquitinationSLPLSEHNEPWFMRL
CCCCCCCCCCCEEEC		53.6322817900
79UbiquitinationNSTGEVPVLIHGENI
CCCCCCCEEECCCCE		10.6822817900
81UbiquitinationTGEVPVLIHGENIIC
CCCCCEEECCCCEEE		3.9022817900
84UbiquitinationVPVLIHGENIICEAT
CCEEECCCCEEEEHH		30.9722817900
86UbiquitinationVLIHGENIICEATQI
EEECCCCEEEEHHHH		3.1232142685
94UbiquitinationICEATQIIDYLEQTF
EEEHHHHHHHHHHHC		1.7333845483
97UbiquitinationATQIIDYLEQTFLDE
HHHHHHHHHHHCCCC		3.3123503661
98UbiquitinationTQIIDYLEQTFLDER
HHHHHHHHHHCCCCC		41.1532142685
104 (in isoform 2)Ubiquitination-61.68-
104UbiquitinationLEQTFLDERTPRLMP
HHHHCCCCCCCCCCC		61.6827667366
105UbiquitinationEQTFLDERTPRLMPD
HHHCCCCCCCCCCCC		50.0922817900
105 (in isoform 2)Ubiquitination-50.09-
113UbiquitinationTPRLMPDKESMYYPR
CCCCCCCHHHCCCCC		45.9024816145
114UbiquitinationPRLMPDKESMYYPRV
CCCCCCHHHCCCCCH		48.3932142685
120 (in isoform 2)Ubiquitination-25.30-
120UbiquitinationKESMYYPRVQHYREL
HHHCCCCCHHHHHHH		25.3022817900
122 (in isoform 2)Ubiquitination-29.22-
122UbiquitinationSMYYPRVQHYRELLD
HCCCCCHHHHHHHHH		29.2222817900
125UbiquitinationYPRVQHYRELLDSLP
CCCHHHHHHHHHCCC		26.4322817900
127UbiquitinationRVQHYRELLDSLPMD
CHHHHHHHHHCCCCC		4.8132142685
130UbiquitinationHYRELLDSLPMDAYT
HHHHHHHCCCCCCCC		34.0532142685
132UbiquitinationRELLDSLPMDAYTHG
HHHHHCCCCCCCCCC		23.6630230243
135UbiquitinationLDSLPMDAYTHGCIL
HHCCCCCCCCCCCCC		12.6033845483
135 (in isoform 2)Ubiquitination-12.60-
135AcetylationLDSLPMDAYTHGCIL
HHCCCCCCCCCCCCC		12.6019608861
137UbiquitinationSLPMDAYTHGCILHP
CCCCCCCCCCCCCCC		17.3232142685
138UbiquitinationLPMDAYTHGCILHPE
CCCCCCCCCCCCCCC		19.2223503661
139UbiquitinationPMDAYTHGCILHPEL
CCCCCCCCCCCCCCC		7.7432142685
139 (in isoform 2)Ubiquitination-7.74-
145UbiquitinationHGCILHPELTVDSMI
CCCCCCCCCCHHHCC		46.4533845483
146UbiquitinationGCILHPELTVDSMIP
CCCCCCCCCHHHCCC		7.1523503661
146 (in isoform 2)Ubiquitination-7.15-
149UbiquitinationLHPELTVDSMIPAYA
CCCCCCHHHCCCHHH		27.5332142685
162PhosphorylationYATTRIRSQIGNTES
HHHHHHHHHCCCCHH		24.6329214152
167PhosphorylationIRSQIGNTESELKKL
HHHHCCCCHHHHHHH		35.3628857561
172UbiquitinationGNTESELKKLAEENP
CCCHHHHHHHHHHCC		41.5121906983
172UbiquitinationGNTESELKKLAEENP
CCCHHHHHHHHHHCC		41.5121906983
173UbiquitinationNTESELKKLAEENPD
CCHHHHHHHHHHCCC		66.6021906983
173UbiquitinationNTESELKKLAEENPD
CCHHHHHHHHHHCCC		66.6021906983
175UbiquitinationESELKKLAEENPDLQ
HHHHHHHHHHCCCHH		30.8227667366
188UbiquitinationLQEAYIAKQKRLKSK
HHHHHHHHHHHHHHH		46.9621906983
188UbiquitinationLQEAYIAKQKRLKSK
HHHHHHHHHHHHHHH		46.9621906983
190UbiquitinationEAYIAKQKRLKSKLL
HHHHHHHHHHHHHCC		60.0225621951
193UbiquitinationIAKQKRLKSKLLDHD
HHHHHHHHHHCCCCH		49.9622817900
195UbiquitinationKQKRLKSKLLDHDNV
HHHHHHHHCCCCHHH		52.0232142685
203AcetylationLLDHDNVKYLKKILD
CCCCHHHHHHHHHHH		51.6319608861
203UbiquitinationLLDHDNVKYLKKILD
CCCCHHHHHHHHHHH		51.6333845483
204PhosphorylationLDHDNVKYLKKILDE
CCCHHHHHHHHHHHH		21.3322817900
206UbiquitinationHDNVKYLKKILDELE
CHHHHHHHHHHHHHH		34.3825621951
207UbiquitinationDNVKYLKKILDELEK
HHHHHHHHHHHHHHH		46.0032142685
214UbiquitinationKILDELEKVLDQVET
HHHHHHHHHHHHHHH		61.8025621951
269UbiquitinationGFARRNWGNGKRPNL
HHHHCCCCCCCCCCH		36.2424816145
270UbiquitinationFARRNWGNGKRPNLE
HHHCCCCCCCCCCHH		44.4122817900
271UbiquitinationARRNWGNGKRPNLET
HHCCCCCCCCCCHHH		24.3422817900
286UbiquitinationYYERVLKRKTFNKVL
HHHHHHCHHHHHHHH		38.8022817900
287AcetylationYERVLKRKTFNKVLG
HHHHHCHHHHHHHHH		56.7526051181
288UbiquitinationERVLKRKTFNKVLGH
HHHHCHHHHHHHHHH		36.1522817900
291UbiquitinationLKRKTFNKVLGHVNN
HCHHHHHHHHHHHHH		34.3522817900
293UbiquitinationRKTFNKVLGHVNNIL
HHHHHHHHHHHHHHH		4.1323503661
301UbiquitinationGHVNNILISAVLPTA
HHHHHHHHHHHHHHH		1.8923503661
304UbiquitinationNNILISAVLPTAFRV
HHHHHHHHHHHHHHH		5.4123503661
305UbiquitinationNILISAVLPTAFRVA
HHHHHHHHHHHHHHH		2.8923503661
312UbiquitinationLPTAFRVAKKRAPKV
HHHHHHHHHHHCCHH		13.8523503661
322PhosphorylationRAPKVLGTTLVVGLL
HCCHHHCHHHHHHHH		16.8822210691
323PhosphorylationAPKVLGTTLVVGLLA
CCHHHCHHHHHHHHH		18.7622210691
328UbiquitinationGTTLVVGLLAGVGYF
CHHHHHHHHHHHHHH		1.6822817900
329UbiquitinationTTLVVGLLAGVGYFA
HHHHHHHHHHHHHHH		2.9922817900
344UbiquitinationFMLFRKRLGSMILAF
HHHHHHHHCCHHHEE		7.1722817900
346UbiquitinationLFRKRLGSMILAFRP
HHHHHHCCHHHEECC		13.7722817900
346PhosphorylationLFRKRLGSMILAFRP
HHHHHHCCHHHEECC		13.7720068231
349UbiquitinationKRLGSMILAFRPRPN
HHHCCHHHEECCCCC		2.4922817900
351UbiquitinationLGSMILAFRPRPNYF
HCCHHHEECCCCCCC		11.2223503661
359UbiquitinationRPRPNYF--------
CCCCCCC--------		23503661
362UbiquitinationPNYF-----------
CCCC-----------		23503661
363UbiquitinationNYF------------
CCC------------		23503661
370Ubiquitination-------------------
-------------------		23503661
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of GDAP1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of GDAP1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of GDAP1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
FIS1_HUMANFIS1physical
21890626
TBB5_HUMANTUBBphysical
21890626
HBB_HUMANHBBphysical
22939629
SAP_HUMANPSAPphysical
22939629
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
214400Charcot-Marie-Tooth disease 4A (CMT4A)
607706Charcot-Marie-Tooth disease, axonal, with vocal cord paresis, autosomal recessive (CMT2RV)
607831Charcot-Marie-Tooth disease 2K (CMT2K)
608340Charcot-Marie-Tooth disease, recessive, intermediate type, A (CMTRIA)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of GDAP1_HUMAN

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Related Literatures of Post-Translational Modification
Acetylation
ReferencePubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-203, AND MASS SPECTROMETRY.

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