dbPTM

SRSF8_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SRSF8_HUMAN
UniProt AC	Q9BRL6
Protein Name	Serine/arginine-rich splicing factor 8
Gene Name	SRSF8
Organism	Homo sapiens (Human).
Sequence Length	282
Subcellular Localization	Nucleus .
Protein Description	Involved in pre-mRNA alternative splicing..
Protein Sequence	MSCGRPPPDVDGMITLKVDNLTYRTSPDSLRRVFEKYGRVGDVYIPREPHTKAPRGFAFVRFHDRRDAQDAEAAMDGAELDGRELRVQVARYGRRDLPRSRQGEPRGRSRGGGYGRRSRSYGRRSRSPRRRHRSRSRGPSCSRSRSRSRYRGSRYSRSPYSRSPYSRSRYSRSPYSRSRYRESRYGGSHYSSSGYSNSRYSRYHSSRSHSKSGSSTSSRSASTSKSSSARRSKSSSVSRSRSRSRSSSMTRSPPRVSKRKSKSRSRSKRPPKSPEEEGQMSS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSCGRPPPD ------CCCCCCCCC	25.86	19413330
2	Phosphorylation	------MSCGRPPPD ------CCCCCCCCC	25.86	25159151
15	Phosphorylation	PDVDGMITLKVDNLT CCCCCCEEEEECCEE	16.19	23186163
22	Phosphorylation	TLKVDNLTYRTSPDS EEEECCEEEECCHHH	19.74	22617229
23	Phosphorylation	LKVDNLTYRTSPDSL EEECCEEEECCHHHH	18.30	22617229
25	Phosphorylation	VDNLTYRTSPDSLRR ECCEEEECCHHHHHH	33.91	23401153
26	Phosphorylation	DNLTYRTSPDSLRRV CCEEEECCHHHHHHH	20.08	25159151
29	Phosphorylation	TYRTSPDSLRRVFEK EEECCHHHHHHHHHH	27.45	27794612
31	Methylation	RTSPDSLRRVFEKYG ECCHHHHHHHHHHHC	36.35	115917785
36	Acetylation	SLRRVFEKYGRVGDV HHHHHHHHHCCCCCE	41.35	22634819
36 (in isoform 2)	Ubiquitination	-	41.35	21890473
36 (in isoform 1)	Ubiquitination	-	41.35	21890473
36	Ubiquitination	SLRRVFEKYGRVGDV HHHHHHHHHCCCCCE	41.35	21906983
39	Methylation	RVFEKYGRVGDVYIP HHHHHHCCCCCEEEC	26.59	-
44	Phosphorylation	YGRVGDVYIPREPHT HCCCCCEEECCCCCC	15.22	28152594
100	Phosphorylation	GRRDLPRSRQGEPRG CCCCCCHHCCCCCCC	27.32	17081983
106	Methylation	RSRQGEPRGRSRGGG HHCCCCCCCCCCCCC	49.18	54559683
110	Methylation	GEPRGRSRGGGYGRR CCCCCCCCCCCCCCC	46.55	54559679
114	Phosphorylation	GRSRGGGYGRRSRSY CCCCCCCCCCCCCCC	15.67	20860994
118	Phosphorylation	GGGYGRRSRSYGRRS CCCCCCCCCCCCCCC	24.98	30576142
120	Phosphorylation	GYGRRSRSYGRRSRS CCCCCCCCCCCCCCC	32.93	30576142
125	Phosphorylation	SRSYGRRSRSPRRRH CCCCCCCCCCCCHHH	35.43	20068231
127	Phosphorylation	SYGRRSRSPRRRHRS CCCCCCCCCCHHHHH	24.81	20068231
134	Phosphorylation	SPRRRHRSRSRGPSC CCCHHHHHHCCCCCC	28.60	26074081
136	Phosphorylation	RRRHRSRSRGPSCSR CHHHHHHCCCCCCCC	42.72	26074081
140	Phosphorylation	RSRSRGPSCSRSRSR HHHCCCCCCCCCCCC	27.78	26074081
142	Phosphorylation	RSRGPSCSRSRSRSR HCCCCCCCCCCCCCC	37.31	26074081
144	Phosphorylation	RGPSCSRSRSRSRYR CCCCCCCCCCCCCCC	20.50	29449344
146	Phosphorylation	PSCSRSRSRSRYRGS CCCCCCCCCCCCCCC	35.54	29449344
153	Phosphorylation	SRSRYRGSRYSRSPY CCCCCCCCCCCCCCC	21.03	21955146
155	Phosphorylation	SRYRGSRYSRSPYSR CCCCCCCCCCCCCCC	15.33	21955146
156	Phosphorylation	RYRGSRYSRSPYSRS CCCCCCCCCCCCCCC	25.77	23401153
158	Phosphorylation	RGSRYSRSPYSRSPY CCCCCCCCCCCCCCC	23.42	23401153
160	Phosphorylation	SRYSRSPYSRSPYSR CCCCCCCCCCCCCCC	20.26	23401153
161	Phosphorylation	RYSRSPYSRSPYSRS CCCCCCCCCCCCCCC	29.66	21955146
163	Phosphorylation	SRSPYSRSPYSRSRY CCCCCCCCCCCCCCC	23.42	26055452
165	Phosphorylation	SPYSRSPYSRSRYSR CCCCCCCCCCCCCCC	20.26	23663014
166	Phosphorylation	PYSRSPYSRSRYSRS CCCCCCCCCCCCCCC	27.45	22617229
168	Phosphorylation	SRSPYSRSRYSRSPY CCCCCCCCCCCCCCC	29.63	21955146
170	Phosphorylation	SPYSRSRYSRSPYSR CCCCCCCCCCCCCCC	15.07	21955146
171	Phosphorylation	PYSRSRYSRSPYSRS CCCCCCCCCCCCCCH	25.77	23401153
173	Phosphorylation	SRSRYSRSPYSRSRY CCCCCCCCCCCCHHH	23.42	23401153
175	Phosphorylation	SRYSRSPYSRSRYRE CCCCCCCCCCHHHHC	20.26	23401153
176	Phosphorylation	RYSRSPYSRSRYRES CCCCCCCCCHHHHCC	27.45	21955146
178	Phosphorylation	SRSPYSRSRYRESRY CCCCCCCHHHHCCCC	27.94	-
180	Phosphorylation	SPYSRSRYRESRYGG CCCCCHHHHCCCCCC	21.70	25907765
183	Phosphorylation	SRSRYRESRYGGSHY CCHHHHCCCCCCCCC	23.08	25907765
185	Phosphorylation	SRYRESRYGGSHYSS HHHHCCCCCCCCCCC	34.81	29396449
188	Phosphorylation	RESRYGGSHYSSSGY HCCCCCCCCCCCCCC	18.19	28450419
190	Phosphorylation	SRYGGSHYSSSGYSN CCCCCCCCCCCCCCC	16.37	28450419
191	Phosphorylation	RYGGSHYSSSGYSNS CCCCCCCCCCCCCCC	16.77	22617229
192	Phosphorylation	YGGSHYSSSGYSNSR CCCCCCCCCCCCCCC	22.18	28152594
193	Phosphorylation	GGSHYSSSGYSNSRY CCCCCCCCCCCCCCC	35.49	29496963
195	Phosphorylation	SHYSSSGYSNSRYSR CCCCCCCCCCCCCCC	13.46	28450419
196	Phosphorylation	HYSSSGYSNSRYSRY CCCCCCCCCCCCCCC	31.67	26055452
198	Phosphorylation	SSSGYSNSRYSRYHS CCCCCCCCCCCCCCC	27.01	22617229
200	Phosphorylation	SGYSNSRYSRYHSSR CCCCCCCCCCCCCCC	9.42	25907765
201	Phosphorylation	GYSNSRYSRYHSSRS CCCCCCCCCCCCCCC	25.83	28152594
203	Phosphorylation	SNSRYSRYHSSRSHS CCCCCCCCCCCCCCC	10.50	29759185
205	Phosphorylation	SRYSRYHSSRSHSKS CCCCCCCCCCCCCCC	20.65	20068231
215	Phosphorylation	SHSKSGSSTSSRSAS CCCCCCCCCCCCCCC	35.51	30576142
216	Phosphorylation	HSKSGSSTSSRSAST CCCCCCCCCCCCCCC	32.21	30576142
218	Phosphorylation	KSGSSTSSRSASTSK CCCCCCCCCCCCCCC	30.28	23312004
220	Phosphorylation	GSSTSSRSASTSKSS CCCCCCCCCCCCCCC	28.63	23312004
222	Phosphorylation	STSSRSASTSKSSSA CCCCCCCCCCCCCCC	34.16	17929957
223	Phosphorylation	TSSRSASTSKSSSAR CCCCCCCCCCCCCCH	39.63	23312004
224	Phosphorylation	SSRSASTSKSSSARR CCCCCCCCCCCCCHH	28.22	17929957
227	Phosphorylation	SASTSKSSSARRSKS CCCCCCCCCCHHHCC	31.58	21955146
233	Methylation	SSSARRSKSSSVSRS CCCCHHHCCCCCCHH	53.17	-
235	Phosphorylation	SARRSKSSSVSRSRS CCHHHCCCCCCHHHH	38.20	26546556
236	Phosphorylation	ARRSKSSSVSRSRSR CHHHCCCCCCHHHHH	31.07	19651622
238	Phosphorylation	RSKSSSVSRSRSRSR HHCCCCCCHHHHHCC	26.87	19651622
240	Phosphorylation	KSSSVSRSRSRSRSS CCCCCCHHHHHCCCC	27.40	19651622
241	Methylation	SSSVSRSRSRSRSSS CCCCCHHHHHCCCCC	34.67	24377429
241	Dimethylation	SSSVSRSRSRSRSSS CCCCCHHHHHCCCCC	34.67	-
247	Phosphorylation	SRSRSRSSSMTRSPP HHHHCCCCCCCCCCC	24.02	30576142
248	Phosphorylation	RSRSRSSSMTRSPPR HHHCCCCCCCCCCCC	25.97	30576142
250	Phosphorylation	RSRSSSMTRSPPRVS HCCCCCCCCCCCCCC	29.91	17001009
252	Phosphorylation	RSSSMTRSPPRVSKR CCCCCCCCCCCCCCC	30.04	30576142
267	Phosphorylation	KSKSRSRSKRPPKSP CCCCCCCCCCCCCCH	33.97	23403867
273	Phosphorylation	RSKRPPKSPEEEGQM CCCCCCCCHHHCCCC	43.23	29255136
281	Phosphorylation	PEEEGQMSS------ HHHCCCCCC------	25.63	25159151
282	Phosphorylation	EEEGQMSS------- HHCCCCCC-------	38.61	25159151

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of SRSF8_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SRSF8_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SRSF8_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SRSF8_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-273 AND SER-281, ANDMASS SPECTROMETRY.	18669648 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-100, AND MASSSPECTROMETRY.	17081983 [Abstract]