dbPTM

RRP5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	RRP5_HUMAN
UniProt AC	Q14690
Protein Name	Protein RRP5 homolog
Gene Name	PDCD11
Organism	Homo sapiens (Human).
Sequence Length	1871
Subcellular Localization	Nucleus, nucleolus .
Protein Description	Essential for the generation of mature 18S rRNA, specifically necessary for cleavages at sites A0, 1 and 2 of the 47S precursor. Directly interacts with U3 snoRNA.; Involved in the biogenesis of rRNA..
Protein Sequence	MANLEESFPRGGTRKIHKPEKAFQQSVEQDNLFDISTEEGSTKRKKSQKGPAKTKKLKIEKRESSKSAREKFEILSVESLCEGMRILGCVKEVNELELVISLPNGLQGFVQVTEICDAYTKKLNEQVTQEQPLKDLLHLPELFSPGMLVRCVVSSLGITDRGKKSVKLSLNPKNVNRVLSAEALKPGMLLTGTVSSLEDHGYLVDIGVDGTRAFLPLLKAQEYIRQKNKGAKLKVGQYLNCIVEKVKGNGGVVSLSVGHSEVSTAIATEQQSWNLNNLLPGLVVKAQVQKVTPFGLTLNFLTFFTGVVDFMHLDPKKAGTYFSNQAVRACILCVHPRTRVVHLSLRPIFLQPGRPLTRLSCQNLGAVLDDVPVQGFFKKAGATFRLKDGVLAYARLSHLSDSKNVFNPEAFKPGNTHKCRIIDYSQMDELALLSLRTSIIEAQYLRYHDIEPGAVVKGTVLTIKSYGMLVKVGEQMRGLVPPMHLADILMKNPEKKYHIGDEVKCRVLLCDPEAKKLMMTLKKTLIESKLPVITCYADAKPGLQTHGFIIRVKDYGCIVKFYNNVQGLVPKHELSTEYIPDPERVFYTGQVVKVVVLNCEPSKERMLLSFKLSSDPEPKKEPAGHSQKKGKAINIGQLVDVKVLEKTKDGLEVAVLPHNIRAFLPTSHLSDHVANGPLLHHWLQAGDILHRVLCLSQSEGRVLLCRKPALVSTVEGGQDPKNFSEIHPGMLLIGFVKSIKDYGVFIQFPSGLSGLAPKAIMSDKFVTSTSDHFVEGQTVAAKVTNVDEEKQRMLLSLRLSDCGLGDLAITSLLLLNQCLEELQGVRSLMSNRDSVLIQTLAEMTPGMFLDLVVQEVLEDGSVVFSGGPVPDLVLKASRYHRAGQEVESGQKKKVVILNVDLLKLEVHVSLHQDLVNRKARKLRKGSEHQAIVQHLEKSFAIASLVETGHLAAFSLTSHLNDTFRFDSEKLQVGQGVSLTLKTTEPGVTGLLLAVEGPAAKRTMRPTQKDSETVDEDEEVDPALTVGTIKKHTLSIGDMVTGTVKSIKPTHVVVTLEDGIIGCIHASHILDDVPEGTSPTTKLKVGKTVTARVIGGRDMKTFKYLPISHPRFVRTIPELSVRPSELEDGHTALNTHSVSPMEKIKQYQAGQTVTCFLKKYNVVKKWLEVEIAPDIRGRIPLLLTSLSFKVLKHPDKKFRVGQALRATVVGPDSSKTLLCLSLTGPHKLEEGEVAMGRVVKVTPNEGLTVSFPFGKIGTVSIFHMSDSYSETPLEDFVPQKVVRCYILSTADNVLTLSLRSSRTNPETKSKVEDPEINSIQDIKEGQLLRGYVGSIQPHGVFFRLGPSVVGLARYSHVSQHSPSKKALYNKHLPEGKLLTARVLRLNHQKNLVELSFLPGDTGKPDVLSASLEGQLTKQEERKTEAEERDQKGEKKNQKRNEKKNQKGQEEVEMPSKEKQQPQKPQAQKRGGRECRESGSEQERVSKKPKKAGLSEEDDSLVDVYYREGKEEAEETNVLPKEKQTKPAEAPRLQLSSGFAWNVGLDSLTPALPPLAESSDSEEDEKPHQATIKKSKKERELEKQKAEKELSRIEEALMDPGRQPESADDFDRLVLSSPNSSILWLQYMAFHLQATEIEKARAVAERALKTISFREEQEKLNVWVALLNLENMYGSQESLTKVFERAVQYNEPLKVFLHLADIYAKSEKFQEAGELYNRMLKRFRQEKAVWIKYGAFLLRRSQAAASHRVLQRALECLPSKEHVDVIAKFAQLEFQLGDAERAKAIFENTLSTYPKRTDVWSVYIDMTIKHGSQKDVRDIFERVIHLSLAPKRMKFFFKRYLDYEKQHGTEKDVQAVKAKALEYVEAKSSVLED

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MANLEESFP ------CCCHHHHCC	40.39	22223895
7	Phosphorylation	-MANLEESFPRGGTR -CCCHHHHCCCCCCC	31.04	25159151
10	Methylation	NLEESFPRGGTRKIH CHHHHCCCCCCCCCC	54.91	115486713
13	Phosphorylation	ESFPRGGTRKIHKPE HHCCCCCCCCCCCCH	31.45	21406692
36	Phosphorylation	QDNLFDISTEEGSTK HCCCCCCCCCCCCCC	31.45	30266825
37	Phosphorylation	DNLFDISTEEGSTKR CCCCCCCCCCCCCCC	38.09	24732914
41	Phosphorylation	DISTEEGSTKRKKSQ CCCCCCCCCCCCCCC	33.75	30266825
42	Phosphorylation	ISTEEGSTKRKKSQK CCCCCCCCCCCCCCC	45.80	24732914
43	Acetylation	STEEGSTKRKKSQKG CCCCCCCCCCCCCCC	65.01	26051181
58	Ubiquitination	PAKTKKLKIEKRESS CCCCCCCCCCCCCCC	58.67	-
76	Phosphorylation	REKFEILSVESLCEG HHHHEECHHHHHHHH	29.51	20873877
79	Phosphorylation	FEILSVESLCEGMRI HEECHHHHHHHHHHH	35.84	20873877
89	S-nitrosocysteine	EGMRILGCVKEVNEL HHHHHHCCEEECCEE	3.37	-
89	S-nitrosylation	EGMRILGCVKEVNEL HHHHHHCCEEECCEE	3.37	19483679
144	Phosphorylation	LHLPELFSPGMLVRC HCCHHHCCCCHHHHH	32.92	28450419
167	Acetylation	DRGKKSVKLSLNPKN CCCCCEEEEECCHHC	39.18	25953088
167	Ubiquitination	DRGKKSVKLSLNPKN CCCCCEEEEECCHHC	39.18	-
169	Phosphorylation	GKKSVKLSLNPKNVN CCCEEEEECCHHCHH	22.00	-
173	Ubiquitination	VKLSLNPKNVNRVLS EEEECCHHCHHHHCC	72.89	-
180	Phosphorylation	KNVNRVLSAEALKPG HCHHHHCCHHHCCCC	22.62	25159151
195	Phosphorylation	MLLTGTVSSLEDHGY EEEEECEECHHHCCE	29.10	27251275
196	Phosphorylation	LLTGTVSSLEDHGYL EEEECEECHHHCCEE	31.29	27251275
202	Phosphorylation	SSLEDHGYLVDIGVD ECHHHCCEEEEEEEC	10.51	27251275
211	Phosphorylation	VDIGVDGTRAFLPLL EEEEECCHHHHHHHH	17.85	27251275
219	Methylation	RAFLPLLKAQEYIRQ HHHHHHHHHHHHHHH	56.56	44498311
219	Ubiquitination	RAFLPLLKAQEYIRQ HHHHHHHHHHHHHHH	56.56	21890473
245	Acetylation	YLNCIVEKVKGNGGV HHHHHEEEECCCCCE	38.05	26051181
245	Ubiquitination	YLNCIVEKVKGNGGV HHHHHEEEECCCCCE	38.05	-
320	Phosphorylation	LDPKKAGTYFSNQAV CCHHHCCCCCCCHHH	26.67	28152594
321	Phosphorylation	DPKKAGTYFSNQAVR CHHHCCCCCCCHHHH	12.23	28152594
323	Phosphorylation	KKAGTYFSNQAVRAC HHCCCCCCCHHHHHH	20.02	28152594
344	Phosphorylation	RTRVVHLSLRPIFLQ CCEEEEEECEEEECC	13.88	24719451
357	Phosphorylation	LQPGRPLTRLSCQNL CCCCCCCCCEECCCC	32.04	-
361	Glutathionylation	RPLTRLSCQNLGAVL CCCCCEECCCCCCCC	3.53	22555962
378	Acetylation	VPVQGFFKKAGATFR CCCCCHHHHCCCEEE	39.18	26051181
378	Methylation	VPVQGFFKKAGATFR CCCCCHHHHCCCEEE	39.18	115974699
379	Methylation	PVQGFFKKAGATFRL CCCCHHHHCCCEEEE	47.07	115974707
393	Phosphorylation	LKDGVLAYARLSHLS ECCCHHHHHHHHCCC	6.52	30576142
397	Phosphorylation	VLAYARLSHLSDSKN HHHHHHHHCCCCCCC	19.48	30576142
400	Phosphorylation	YARLSHLSDSKNVFN HHHHHCCCCCCCCCC	34.12	22617229
402	Phosphorylation	RLSHLSDSKNVFNPE HHHCCCCCCCCCCHH	23.82	27794612
412	Acetylation	VFNPEAFKPGNTHKC CCCHHHCCCCCCCEE	60.09	26051181
434	Phosphorylation	MDELALLSLRTSIIE CCHHHHHHHHHHHHH	19.36	24719451
437	Phosphorylation	LALLSLRTSIIEAQY HHHHHHHHHHHHHHH	29.57	30266825
438	Phosphorylation	ALLSLRTSIIEAQYL HHHHHHHHHHHHHHH	18.35	30266825
444	Phosphorylation	TSIIEAQYLRYHDIE HHHHHHHHHHHCCCC	10.53	23186163
459	Phosphorylation	PGAVVKGTVLTIKSY CCCEEECEEEEEEEE	13.46	20068231
462	Phosphorylation	VVKGTVLTIKSYGML EEECEEEEEEEECEE	23.25	20068231
465	Phosphorylation	GTVLTIKSYGMLVKV CEEEEEEEECEEEEH	24.06	20068231
466	Phosphorylation	TVLTIKSYGMLVKVG EEEEEEEECEEEEHH	11.10	20068231
496	Acetylation	LMKNPEKKYHIGDEV HHHCCCCCCCCCCCC	40.16	26051181
496	Ubiquitination	LMKNPEKKYHIGDEV HHHCCCCCCCCCCCC	40.16	-
504	2-Hydroxyisobutyrylation	YHIGDEVKCRVLLCD CCCCCCCEEEEEEEC	17.80	-
504	Acetylation	YHIGDEVKCRVLLCD CCCCCCCEEEEEEEC	17.80	25953088
504	Ubiquitination	YHIGDEVKCRVLLCD CCCCCCCEEEEEEEC	17.80	-
515	2-Hydroxyisobutyrylation	LLCDPEAKKLMMTLK EEECHHHHHHHHHHH	44.79	-
515	Acetylation	LLCDPEAKKLMMTLK EEECHHHHHHHHHHH	44.79	25953088
520	Phosphorylation	EAKKLMMTLKKTLIE HHHHHHHHHHHHHHH	22.81	23532336
529	Acetylation	KKTLIESKLPVITCY HHHHHHHCCCEEEEE	43.98	26051181
540	Acetylation	ITCYADAKPGLQTHG EEEECCCCCCCCCCC	39.92	26051181
553	Acetylation	HGFIIRVKDYGCIVK CCEEEEEECCCEEEE	35.07	26051181
560	Acetylation	KDYGCIVKFYNNVQG ECCCEEEEEECCCCC	23.40	26051181
571	Acetylation	NVQGLVPKHELSTEY CCCCCCCCCCCCCCC	42.08	26051181
571	Ubiquitination	NVQGLVPKHELSTEY CCCCCCCCCCCCCCC	42.08	-
587	Phosphorylation	PDPERVFYTGQVVKV CCHHHEEECCCEEEE	13.70	28152594
588	Phosphorylation	DPERVFYTGQVVKVV CHHHEEECCCEEEEE	15.07	28152594
602	Phosphorylation	VVLNCEPSKERMLLS EEEECCCCCCEEEEE	25.51	-
603	Acetylation	VLNCEPSKERMLLSF EEECCCCCCEEEEEE	61.12	25953088
603	Ubiquitination	VLNCEPSKERMLLSF EEECCCCCCEEEEEE	61.12	-
609	Phosphorylation	SKERMLLSFKLSSDP CCCEEEEEEEECCCC	19.17	24719451
613	Phosphorylation	MLLSFKLSSDPEPKK EEEEEEECCCCCCCC	33.03	23663014
614	Phosphorylation	LLSFKLSSDPEPKKE EEEEEECCCCCCCCC	68.56	23663014
619	Ubiquitination	LSSDPEPKKEPAGHS ECCCCCCCCCCCCCC	69.02	-
626	Phosphorylation	KKEPAGHSQKKGKAI CCCCCCCCCCCCCCC	42.66	-
631	Acetylation	GHSQKKGKAINIGQL CCCCCCCCCCCHHHC	55.78	26051181
631	Ubiquitination	GHSQKKGKAINIGQL CCCCCCCCCCCHHHC	55.78	-
642	Acetylation	IGQLVDVKVLEKTKD HHHCCEEEEEEECCC	36.32	26051181
642	Sumoylation	IGQLVDVKVLEKTKD HHHCCEEEEEEECCC	36.32	-
642	Ubiquitination	IGQLVDVKVLEKTKD HHHCCEEEEEEECCC	36.32	-
713	Phosphorylation	RKPALVSTVEGGQDP CCCEEEEEECCCCCC	18.33	28787133
724	Phosphorylation	GQDPKNFSEIHPGML CCCCCCHHHCCCCCE	45.06	28787133
738	Phosphorylation	LLIGFVKSIKDYGVF EEHHHHHCHHHHEEE	29.57	-
740	Acetylation	IGFVKSIKDYGVFIQ HHHHHCHHHHEEEEE	52.57	26051181
742	Phosphorylation	FVKSIKDYGVFIQFP HHHCHHHHEEEEECC	15.36	-
762	Phosphorylation	LAPKAIMSDKFVTST CCCHHHHCCCCCCCC	31.38	21406692
764	2-Hydroxyisobutyrylation	PKAIMSDKFVTSTSD CHHHHCCCCCCCCCC	34.13	-
764	Acetylation	PKAIMSDKFVTSTSD CHHHHCCCCCCCCCC	34.13	26051181
764	Ubiquitination	PKAIMSDKFVTSTSD CHHHHCCCCCCCCCC	34.13	-
767	Phosphorylation	IMSDKFVTSTSDHFV HHCCCCCCCCCCCCC	29.44	21406692
768	Phosphorylation	MSDKFVTSTSDHFVE HCCCCCCCCCCCCCC	22.17	21406692
769	Phosphorylation	SDKFVTSTSDHFVEG CCCCCCCCCCCCCCC	28.89	21406692
770	Phosphorylation	DKFVTSTSDHFVEGQ CCCCCCCCCCCCCCC	28.93	21406692
778	Phosphorylation	DHFVEGQTVAAKVTN CCCCCCCEEEEEEEC	23.99	21406692
784	Phosphorylation	QTVAAKVTNVDEEKQ CEEEEEEECCCHHHH	28.90	21406692
790	2-Hydroxyisobutyrylation	VTNVDEEKQRMLLSL EECCCHHHHHHHHHH	40.95	-
790	Acetylation	VTNVDEEKQRMLLSL EECCCHHHHHHHHHH	40.95	23749302
790	Ubiquitination	VTNVDEEKQRMLLSL EECCCHHHHHHHHHH	40.95	-
844	Phosphorylation	IQTLAEMTPGMFLDL HHHHHHCCCCCHHHH	14.27	29759185
917	Dimethylation	LHQDLVNRKARKLRK HCHHHHHHHHHHHHC	26.91	-
917	Methylation	LHQDLVNRKARKLRK HCHHHHHHHHHHHHC	26.91	24410669
924	Acetylation	RKARKLRKGSEHQAI HHHHHHHCCCHHHHH	76.77	26051181
926	Phosphorylation	ARKLRKGSEHQAIVQ HHHHHCCCHHHHHHH	34.63	25849741
977	Phosphorylation	LQVGQGVSLTLKTTE CCCCCCEEEEEEECC	23.59	24719451
1000	Acetylation	AVEGPAAKRTMRPTQ EEECHHHHCCCCCCC	50.97	26051181
1000	Ubiquitination	AVEGPAAKRTMRPTQ EEECHHHHCCCCCCC	50.97	-
1002	Phosphorylation	EGPAAKRTMRPTQKD ECHHHHCCCCCCCCC	19.47	30576142
1006	Phosphorylation	AKRTMRPTQKDSETV HHCCCCCCCCCCCCC	37.57	28555341
1010	Phosphorylation	MRPTQKDSETVDEDE CCCCCCCCCCCCCCC	42.05	30266825
1012	Phosphorylation	PTQKDSETVDEDEEV CCCCCCCCCCCCCCC	36.89	30266825
1027	Phosphorylation	DPALTVGTIKKHTLS CCCCCHHHEEECEEE	25.86	28060719
1029	Acetylation	ALTVGTIKKHTLSIG CCCHHHEEECEEEHH	38.04	26051181
1029	Ubiquitination	ALTVGTIKKHTLSIG CCCHHHEEECEEEHH	38.04	-
1030	Sumoylation	LTVGTIKKHTLSIGD CCHHHEEECEEEHHH	37.66	25114211
1030	Ubiquitination	LTVGTIKKHTLSIGD CCHHHEEECEEEHHH	37.66	-
1076	Phosphorylation	LDDVPEGTSPTTKLK HCCCCCCCCCCCCEE	29.85	22210691
1079	Phosphorylation	VPEGTSPTTKLKVGK CCCCCCCCCCEECCC	36.01	22210691
1080	Phosphorylation	PEGTSPTTKLKVGKT CCCCCCCCCEECCCE	37.45	22210691
1102	Acetylation	GRDMKTFKYLPISHP CCCCCCEEEEECCCH	51.62	26051181
1103	Phosphorylation	RDMKTFKYLPISHPR CCCCCEEEEECCCHH	17.33	-
1186	Phosphorylation	PLLLTSLSFKVLKHP HHHHHHHHHEECCCC	23.84	24719451
1206	Phosphorylation	VGQALRATVVGPDSS CCCEEEEEEECCCCC	14.86	26074081
1212	Phosphorylation	ATVVGPDSSKTLLCL EEEECCCCCCEEEEE	36.55	26074081
1213	Phosphorylation	TVVGPDSSKTLLCLS EEECCCCCCEEEEEE	36.72	26074081
1215	Phosphorylation	VGPDSSKTLLCLSLT ECCCCCCEEEEEECC	27.23	26074081
1220	Phosphorylation	SKTLLCLSLTGPHKL CCEEEEEECCCCCCC	23.92	26074081
1222	Phosphorylation	TLLCLSLTGPHKLEE EEEEEECCCCCCCCC	45.34	26074081
1239	Acetylation	VAMGRVVKVTPNEGL CCCEEEEEECCCCCE	37.22	26051181
1266	Phosphorylation	SIFHMSDSYSETPLE EEEEECCCCCCCCHH	24.21	-
1279	Acetylation	LEDFVPQKVVRCYIL HHHCCCCCCEEEEEE	36.31	26051181
1287	Phosphorylation	VVRCYILSTADNVLT CEEEEEEECCCCEEE	16.40	30576142
1288	Phosphorylation	VRCYILSTADNVLTL EEEEEEECCCCEEEE	34.29	30576142
1294	Phosphorylation	STADNVLTLSLRSSR ECCCCEEEEEECCCC	15.26	30576142
1296	Phosphorylation	ADNVLTLSLRSSRTN CCCEEEEEECCCCCC	19.26	24719451
1309	Acetylation	TNPETKSKVEDPEIN CCCCCCCCCCCCCCC	51.72	26051181
1309	Ubiquitination	TNPETKSKVEDPEIN CCCCCCCCCCCCCCC	51.72	-
1317	Phosphorylation	VEDPEINSIQDIKEG CCCCCCCCCHHHHCC	27.56	28450419
1322	Acetylation	INSIQDIKEGQLLRG CCCCHHHHCCCCCCE	65.17	26051181
1330	Phosphorylation	EGQLLRGYVGSIQPH CCCCCCEECCEECCC	8.66	28152594
1346	Phosphorylation	VFFRLGPSVVGLARY EEEECCHHHHHHHCC	27.86	20068231
1353	Phosphorylation	SVVGLARYSHVSQHS HHHHHHCCCCCCCCC	9.49	29396449
1354	Phosphorylation	VVGLARYSHVSQHSP HHHHHCCCCCCCCCC	16.32	29396449
1357	Phosphorylation	LARYSHVSQHSPSKK HHCCCCCCCCCCCHH	19.42	21955146
1360	Phosphorylation	YSHVSQHSPSKKALY CCCCCCCCCCHHHHH	24.19	21955146
1362	Phosphorylation	HVSQHSPSKKALYNK CCCCCCCCHHHHHCC	50.21	21955146
1363	2-Hydroxyisobutyrylation	VSQHSPSKKALYNKH CCCCCCCHHHHHCCC	45.51	-
1363	Acetylation	VSQHSPSKKALYNKH CCCCCCCHHHHHCCC	45.51	23749302
1364	Acetylation	SQHSPSKKALYNKHL CCCCCCHHHHHCCCC	48.22	22361519
1369	Acetylation	SKKALYNKHLPEGKL CHHHHHCCCCCCCHH	32.72	26051181
1369	Ubiquitination	SKKALYNKHLPEGKL CHHHHHCCCCCCCHH	32.72	-
1378	Phosphorylation	LPEGKLLTARVLRLN CCCCHHHHHHHHHHH	23.89	-
1407	Phosphorylation	TGKPDVLSASLEGQL CCCCCHHHHHHHCCC	18.70	27732954
1409	Phosphorylation	KPDVLSASLEGQLTK CCCHHHHHHHCCCCH	24.47	27732954
1416	Sumoylation	SLEGQLTKQEERKTE HHHCCCCHHHHHHHH	65.39	28112733
1454	Phosphorylation	QEEVEMPSKEKQQPQ HHHCCCCCHHCCCCC	52.73	19691289
1455	Acetylation	EEVEMPSKEKQQPQK HHCCCCCHHCCCCCC	64.16	26051181
1476	Phosphorylation	GGRECRESGSEQERV CCHHHHHCCCHHHHH	28.41	25159151
1493	Phosphorylation	KPKKAGLSEEDDSLV CCCCCCCCCCCCCHH	37.71	23927012
1498	Phosphorylation	GLSEEDDSLVDVYYR CCCCCCCCHHHHHHH	42.48	23927012
1503	Phosphorylation	DDSLVDVYYREGKEE CCCHHHHHHHCCHHH	7.73	24732914
1508	Acetylation	DVYYREGKEEAEETN HHHHHCCHHHHHHCC	47.86	26051181
1519	Acetylation	EETNVLPKEKQTKPA HHCCCCCHHHCCCCC	73.68	26051181
1534	Phosphorylation	EAPRLQLSSGFAWNV CCCCEEECCCCCEEC	18.56	24144214
1535	Phosphorylation	APRLQLSSGFAWNVG CCCEEECCCCCEECC	46.66	24144214
1545	Phosphorylation	AWNVGLDSLTPALPP CEECCHHHCCCCCCC	38.90	24144214
1547	Phosphorylation	NVGLDSLTPALPPLA ECCHHHCCCCCCCCC	15.52	24144214
1556	Phosphorylation	ALPPLAESSDSEEDE CCCCCCCCCCCCCCC	33.56	25137130
1557	Phosphorylation	LPPLAESSDSEEDEK CCCCCCCCCCCCCCC	36.34	24144214
1559	Phosphorylation	PLAESSDSEEDEKPH CCCCCCCCCCCCCCC	44.85	24144214
1569	Phosphorylation	DEKPHQATIKKSKKE CCCCCHHHHHHHHHH	27.10	24144214
1589	Phosphorylation	QKAEKELSRIEEALM HHHHHHHHHHHHHHC	32.10	27422710
1647	Ubiquitination	AVAERALKTISFREE HHHHHHHHHCCCHHH	42.71	-
1648	Phosphorylation	VAERALKTISFREEQ HHHHHHHHCCCHHHH	23.78	23927012
1650	Phosphorylation	ERALKTISFREEQEK HHHHHHCCCHHHHHH	24.39	29496963
1703	Acetylation	HLADIYAKSEKFQEA HHHHHHHHCHHHHHH	42.02	26051181
1706	2-Hydroxyisobutyrylation	DIYAKSEKFQEAGEL HHHHHCHHHHHHHHH	60.48	-
1706	Acetylation	DIYAKSEKFQEAGEL HHHHHCHHHHHHHHH	60.48	26051181
1706	Ubiquitination	DIYAKSEKFQEAGEL HHHHHCHHHHHHHHH	60.48	-
1725	Acetylation	LKRFRQEKAVWIKYG HHHHHHHHCHHHHHH	39.64	26051181
1757	Phosphorylation	RALECLPSKEHVDVI HHHHCCCCHHHHHHH	37.41	24719451
1781	Ubiquitination	LGDAERAKAIFENTL CCCHHHHHHHHHCCC	48.51	21890473
1787	Phosphorylation	AKAIFENTLSTYPKR HHHHHHCCCCCCCCC	18.19	28152594
1789	Phosphorylation	AIFENTLSTYPKRTD HHHHCCCCCCCCCCC	24.69	28152594
1790	Phosphorylation	IFENTLSTYPKRTDV HHHCCCCCCCCCCCE	47.13	28152594
1791	Phosphorylation	FENTLSTYPKRTDVW HHCCCCCCCCCCCEE	11.90	28152594
1799	Phosphorylation	PKRTDVWSVYIDMTI CCCCCEEEEEEEEEE	12.61	29759185
1801	Phosphorylation	RTDVWSVYIDMTIKH CCCEEEEEEEEEECC	5.91	29759185
1805	Phosphorylation	WSVYIDMTIKHGSQK EEEEEEEEECCCCHH	24.11	29759185
1825	Phosphorylation	FERVIHLSLAPKRMK HHHHHHHHHCHHHHH	14.34	22210691
1829	2-Hydroxyisobutyrylation	IHLSLAPKRMKFFFK HHHHHCHHHHHHHHH	60.56	-
1849	Ubiquitination	EKQHGTEKDVQAVKA HHHHCCHHHHHHHHH	64.14	-
1855	2-Hydroxyisobutyrylation	EKDVQAVKAKALEYV HHHHHHHHHHHHHHH	47.38	-
1855	Acetylation	EKDVQAVKAKALEYV HHHHHHHHHHHHHHH	47.38	25953088
1857	Ubiquitination	DVQAVKAKALEYVEA HHHHHHHHHHHHHHH	48.03	-
1861	Phosphorylation	VKAKALEYVEAKSSV HHHHHHHHHHHHHHH	12.39	-
1865	Sumoylation	ALEYVEAKSSVLED- HHHHHHHHHHHCCC-	29.74	-
1866	Phosphorylation	LEYVEAKSSVLED-- HHHHHHHHHHCCC--	32.50	20860994
1867	Phosphorylation	EYVEAKSSVLED--- HHHHHHHHHCCC---	29.98	30576142

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of RRP5_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of RRP5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of RRP5_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
SPT6H_HUMAN	SUPT6H	physical	26344197

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of RRP5_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, AND MASS SPECTROMETRY.	19413330 [Abstract]
"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis."; Wang B., Malik R., Nigg E.A., Korner R.; Anal. Chem. 80:9526-9533(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-7; THR-437; SER-438 ANDSER-1454, ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, AND MASSSPECTROMETRY.	19007248 [Abstract]
Phosphorylation
Reference	PubMed
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1493 AND SER-1498, ANDMASS SPECTROMETRY.	18669648 [Abstract]
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1498, AND MASSSPECTROMETRY.	18691976 [Abstract]
"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis."; Wang B., Malik R., Nigg E.A., Korner R.; Anal. Chem. 80:9526-9533(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-7; THR-437; SER-438 ANDSER-1454, ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, AND MASSSPECTROMETRY.	19007248 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1360, AND MASSSPECTROMETRY.	17081983 [Abstract]