EPOP_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EPOP_HUMAN
• UniProt AC: A6NHQ4
• Protein Name: Elongin BC and Polycomb repressive complex 2-associated protein {ECO:0000250|UniProtKB:Q7TNS8}
• Gene Name: EPOP {ECO:0000312|HGNC:HGNC:34493}
• Organism: Homo sapiens (Human).
• Sequence Length: 379
• Subcellular Localization: Nucleus . Chromosome . Localizes at both PRC2/EED-EZH2 sites (H3K27me3) and broad H3K4me3 sites on chromatin of embryonic stem cells (ESCs).
• Protein Description: Scaffold protein that serves as a bridging partner between the PRC2/EED-EZH2 complex and the elongin BC complex: required to fine-tune the transcriptional status of Polycomb group (PcG) target genes in embryonic stem cells (ESCs). Plays a key role in genomic regions that display both active and repressive chromatin properties in pluripotent stem cells by sustaining low level expression at PcG target genes: acts by recruiting the elongin BC complex, thereby restricting excessive activity of the PRC2/EED-EZH2 complex. Interaction with USP7 promotes deubiquitination of H2B at promoter sites. Acts as a regulator of neuronal differentiation..
• Protein Sequence: METLCPAPRLAVPASPRGSPCSPTPRKPCRGTQEFSPLCLRALAFCALAKPRASSLGPGPGELAARSPVLRGPQAPLRPGGWAPDGLKHLWAPTGRPGVPNTAAGEDADVAACPRRGEEEEGGGGFPHFGVRSCAPPGRCPAPPHPRESTTSFASAPPRPAPGLEPQRGPAASPPQEPSSRPPSPPAGLSTEPAGPGTAPRPFLPGQPAEVDGNPPPAAPEAPAASPSTASPAPAAPGDLRQEHFDRLIRRSKLWCYAKGFALDTPSLRRGPERPPAKGPARGAAKKRRLPAPPPRTAQPRRPAPTLPTTSTFSLLNCFPCPPALVVGEDGDLKPASSLRLQGDSKPPPAHPLWRWQMGGPAVPEPPGLKFWGINMDES

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
15	Phosphorylation	PRLAVPASPRGSPCS CCCCCCCCCCCCCCC		27134283
19	Phosphorylation	VPASPRGSPCSPTPR CCCCCCCCCCCCCCC		18669648
22	Phosphorylation	SPRGSPCSPTPRKPC CCCCCCCCCCCCCCC		18669648
24	Phosphorylation	RGSPCSPTPRKPCRG CCCCCCCCCCCCCCC		28102081
32	Phosphorylation	PRKPCRGTQEFSPLC CCCCCCCCCCCHHHH		29214152
36	Phosphorylation	CRGTQEFSPLCLRAL CCCCCCCHHHHHHHH		21815630
52	Asymmetric dimethylarginine	FCALAKPRASSLGPG HHHHHCCCHHHCCCC		-
52	Methylation	FCALAKPRASSLGPG HHHHHCCCHHHCCCC		24129315
55	Phosphorylation	LAKPRASSLGPGPGE HHCCCHHHCCCCCCH		25627689
67	Phosphorylation	PGELAARSPVLRGPQ CCHHHHCCCCCCCCC		22210691
149	Phosphorylation	APPHPRESTTSFASA CCCCCCCCCCCCCCC		26546556
152	Phosphorylation	HPRESTTSFASAPPR CCCCCCCCCCCCCCC		26546556
184	Phosphorylation	EPSSRPPSPPAGLST CCCCCCCCCCCCCCC		27050516
265	Phosphorylation	AKGFALDTPSLRRGP HCCEECCCHHHHCCC		23312004
267	Phosphorylation	GFALDTPSLRRGPER CEECCCHHHHCCCCC		24719451
337	Phosphorylation	DGDLKPASSLRLQGD CCCCCCCHHCEECCC		23090842
338	Phosphorylation	GDLKPASSLRLQGDS CCCCCCHHCEECCCC		23090842

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of EPOP_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of EPOP_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EPOP_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of EPOP_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.