TR150_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TR150_HUMAN
• UniProt AC: Q9Y2W1
• Protein Name: Thyroid hormone receptor-associated protein 3
• Gene Name: THRAP3 {ECO:0000312|HGNC:HGNC:22964}
• Organism: Homo sapiens (Human).
• Sequence Length: 955
• Subcellular Localization: Nucleus . Nucleus, nucleoplasm . Nucleus speckle .
• Protein Description: Involved in pre-mRNA splicing. Remains associated with spliced mRNA after splicing which probably involves interactions with the exon junction complex (EJC). Can trigger mRNA decay which seems to be independent of nonsense-mediated decay involving premature stop codons (PTC) recognition. May be involved in nuclear mRNA decay. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45 is proposed to sequester phosphorylated SFPQ from PTPRC/CD45 pre-mRNA in resting T-cells. Involved in cyclin-D1/CCND1 mRNA stability probably by acting as component of the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in response to DNA damage. Is excluced from DNA damage sites in a manner that parallels transcription inhibition; the function may involve the SNARP complex. Initially thought to play a role in transcriptional coactivation through its association with the TRAP complex; however, it is not regarded as a stable Mediator complex subunit. Cooperatively with HELZ2, enhances the transcriptional activation mediated by PPARG, maybe through the stabilization of the PPARG binding to DNA in presence of ligand. May play a role in the terminal stage of adipocyte differentiation. Plays a role in the positive regulation of the circadian clock. Acts as a coactivator of the CLOCK-ARNTL/BMAL1 heterodimer and promotes its transcriptional activator activity and binding to circadian target genes. [PubMed: 24043798]
• Protein Sequence: MSKTNKSKSGSRSSRSRSASRSRSRSFSKSRSRSRSLSRSRKRRLSSRSRSRSYSPAHNRERNHPRVYQNRDFRGHNRGYRRPYYFRGRNRGFYPWGQYNRGGYGNYRSNWQNYRQAYSPRRGRSRSRSPKRRSPSPRSRSHSRNSDKSSSDRSRRSSSSRSSSNHSRVESSKRKSAKEKKSSSKDSRPSQAAGDNQGDEAKEQTFSGGTSQDTKASESSKPWPDATYGTGSASRASAVSELSPRERSPALKSPLQSVVVRRRSPRPSPVPKPSPPLSSTSQMGSTLPSGAGYQSGTHQGQFDHGSGSLSPSKKSPVGKSPPSTGSTYGSSQKEESAASGGAAYTKRYLEEQKTENGKDKEQKQTNTDKEKIKEKGSFSDTGLGDGKMKSDSFAPKTDSEKPFRGSQSPKRYKLRDDFEKKMADFHKEEMDDQDKDKAKGRKESEFDDEPKFMSKVIGANKNQEEEKSGKWEGLVYAPPGKEKQRKTEELEEESFPERSKKEDRGKRSEGGHRGFVPEKNFRVTAYKAVQEKSSSPPPRKTSESRDKLGAKGDFPTGKSSFSITREAQVNVRMDSFDEDLARPSGLLAQERKLCRDLVHSNKKEQEFRSIFQHIQSAQSQRSPSELFAQHIVTIVHHVKEHHFGSSGMTLHERFTKYLKRGTEQEAAKNKKSPEIHRRIDISPSTFRKHGLAHDEMKSPREPGYKAEGKYKDDPVDLRLDIERRKKHKERDLKRGKSRESVDSRDSSHSRERSAEKTEKTHKGSKKQKKHRRARDRSRSSSSSSQSSHSYKAEEYTEETEEREESTTGFDKSRLGTKDFVGPSERGGGRARGTFQFRARGRGWGRGNYSGNNNNNSNNDFQKRNREEEWDPEYTPKSKKYYLHDDREGEGSDKWVSRGRGRGAFPRGRGRFMFRKSSTSPKWAHDKFSGEEGEIEDDESGTENREEKDNIQPTTE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSKTNKSKS ------CCCCCCCCC	48.46	22814378
2	Phosphorylation	------MSKTNKSKS ------CCCCCCCCC	48.46	17287340
7	Phosphorylation	-MSKTNKSKSGSRSS -CCCCCCCCCCCCCH	33.84	21601212
16	Phosphorylation	SGSRSSRSRSASRSR CCCCCHHCHHHHHHH	32.32	21601212
17	Methylation	GSRSSRSRSASRSRS CCCCHHCHHHHHHHH	34.82	-
20	Phosphorylation	SSRSRSASRSRSRSF CHHCHHHHHHHHHHH	31.84	22210691
22	Phosphorylation	RSRSASRSRSRSFSK HCHHHHHHHHHHHHH	31.92	21601212
24	Phosphorylation	RSASRSRSRSFSKSR HHHHHHHHHHHHHHH	33.26	23663014
26	Phosphorylation	ASRSRSRSFSKSRSR HHHHHHHHHHHHHHH	34.81	23663014
28	Phosphorylation	RSRSRSFSKSRSRSR HHHHHHHHHHHHHHH	30.85	23663014
30	Phosphorylation	RSRSFSKSRSRSRSL HHHHHHHHHHHHHHH	34.00	23663014
32	Phosphorylation	RSFSKSRSRSRSLSR HHHHHHHHHHHHHCH	41.52	24300666
34	Phosphorylation	FSKSRSRSRSLSRSR HHHHHHHHHHHCHHH	27.71	22817900
36	Phosphorylation	KSRSRSRSLSRSRKR HHHHHHHHHCHHHHH	31.76	22817900
38	Phosphorylation	RSRSRSLSRSRKRRL HHHHHHHCHHHHHHH	29.47	24300666
40	Phosphorylation	RSRSLSRSRKRRLSS HHHHHCHHHHHHHHH	38.48	24144214
46	Phosphorylation	RSRKRRLSSRSRSRS HHHHHHHHHHHHCCC	23.15	29116813
47	Phosphorylation	SRKRRLSSRSRSRSY HHHHHHHHHHHCCCC	38.58	29116813
49	Phosphorylation	KRRLSSRSRSRSYSP HHHHHHHHHCCCCCC	36.23	23663014
51	Phosphorylation	RLSSRSRSRSYSPAH HHHHHHHCCCCCCCC	27.16	22167270
53	Phosphorylation	SSRSRSRSYSPAHNR HHHHHCCCCCCCCCC	31.07	22167270
54	Phosphorylation	SRSRSRSYSPAHNRE HHHHCCCCCCCCCCC	19.98	30266825
55	Phosphorylation	RSRSRSYSPAHNRER HHHCCCCCCCCCCCC	19.50	22167270
62	Methylation	SPAHNRERNHPRVYQ CCCCCCCCCCCCCCC	43.45	115918901
64	Ubiquitination	AHNRERNHPRVYQNR CCCCCCCCCCCCCCC	20.12	21890473
66	Asymmetric dimethylarginine	NRERNHPRVYQNRDF CCCCCCCCCCCCCCC	32.02	-
66	Methylation	NRERNHPRVYQNRDF CCCCCCCCCCCCCCC	32.02	24129315
68	Phosphorylation	ERNHPRVYQNRDFRG CCCCCCCCCCCCCCC	11.01	22817900
68	Ubiquitination	ERNHPRVYQNRDFRG CCCCCCCCCCCCCCC	11.01	22817900
71	Dimethylation	HPRVYQNRDFRGHNR CCCCCCCCCCCCCCC	28.99	-
71	Methylation	HPRVYQNRDFRGHNR CCCCCCCCCCCCCCC	28.99	54560303
74	Dimethylation	VYQNRDFRGHNRGYR CCCCCCCCCCCCCCC	50.15	-
74	Methylation	VYQNRDFRGHNRGYR CCCCCCCCCCCCCCC	50.15	54560311
78	Methylation	RDFRGHNRGYRRPYY CCCCCCCCCCCCCCE	37.53	115918905
80	Ubiquitination	FRGHNRGYRRPYYFR CCCCCCCCCCCCEEC	10.54	22817900
81	Methylation	RGHNRGYRRPYYFRG CCCCCCCCCCCEECC	35.60	115918913
83	Ubiquitination	HNRGYRRPYYFRGRN CCCCCCCCCEECCCC	21.12	21890473
87	Methylation	YRRPYYFRGRNRGFY CCCCCEECCCCCCCC	27.34	24395845
91	Dimethylation	YYFRGRNRGFYPWGQ CEECCCCCCCCCCCC	34.93	-
91	Methylation	YYFRGRNRGFYPWGQ CEECCCCCCCCCCCC	34.93	54560287
94	Phosphorylation	RGRNRGFYPWGQYNR CCCCCCCCCCCCCCC	10.82	28152594
101	Asymmetric dimethylarginine	YPWGQYNRGGYGNYR CCCCCCCCCCCCCCC	34.67	-
101	Methylation	YPWGQYNRGGYGNYR CCCCCCCCCCCCCCC	34.67	24129315
107	Phosphorylation	NRGGYGNYRSNWQNY CCCCCCCCCCCHHHH	15.85	22817900
108	Asymmetric dimethylarginine	RGGYGNYRSNWQNYR CCCCCCCCCCHHHHH	27.75	-
108	Methylation	RGGYGNYRSNWQNYR CCCCCCCCCCHHHHH	27.75	24129315
114	Phosphorylation	YRSNWQNYRQAYSPR CCCCHHHHHHHCCCC	6.76	-
115	Methylation	RSNWQNYRQAYSPRR CCCHHHHHHHCCCCC	23.39	83364511
118	Phosphorylation	WQNYRQAYSPRRGRS HHHHHHHCCCCCCCC	15.74	26846344
119	Phosphorylation	QNYRQAYSPRRGRSR HHHHHHCCCCCCCCC	18.23	28355574
132	Ubiquitination	SRSRSPKRRSPSPRS CCCCCCCCCCCCCCC	47.93	21890473
134	Phosphorylation	SRSPKRRSPSPRSRS CCCCCCCCCCCCCCC	33.49	27273156
136	Phosphorylation	SPKRRSPSPRSRSHS CCCCCCCCCCCCCCC	33.90	27273156
139	Phosphorylation	RRSPSPRSRSHSRNS CCCCCCCCCCCCCCC	41.33	23403867
143	Phosphorylation	SPRSRSHSRNSDKSS CCCCCCCCCCCCCCC	34.11	-
149	Phosphorylation	HSRNSDKSSSDRSRR CCCCCCCCCCHHHHH	39.81	-
150	Phosphorylation	SRNSDKSSSDRSRRS CCCCCCCCCHHHHHH	41.83	-
151	Phosphorylation	RNSDKSSSDRSRRSS CCCCCCCCHHHHHHH	44.10	-
154	Phosphorylation	DKSSSDRSRRSSSSR CCCCCHHHHHHHCCC	36.72	-
157	Phosphorylation	SSDRSRRSSSSRSSS CCHHHHHHHCCCCHH	33.20	23322592
158	Phosphorylation	SDRSRRSSSSRSSSN CHHHHHHHCCCCHHH	30.44	25884760
159	Phosphorylation	DRSRRSSSSRSSSNH HHHHHHHCCCCHHHH	30.90	25599653
160	Phosphorylation	RSRRSSSSRSSSNHS HHHHHHCCCCHHHHH	37.82	25599653
162	Phosphorylation	RRSSSSRSSSNHSRV HHHHCCCCHHHHHHH	39.81	25599653
163	Phosphorylation	RSSSSRSSSNHSRVE HHHCCCCHHHHHHHH	33.77	25884760
164	Phosphorylation	SSSSRSSSNHSRVES HHCCCCHHHHHHHHH	39.55	25849741
167	Phosphorylation	SRSSSNHSRVESSKR CCCHHHHHHHHHHHH	42.12	25849741
171	Phosphorylation	SNHSRVESSKRKSAK HHHHHHHHHHHHHHH	38.00	26846344
171	Ubiquitination	SNHSRVESSKRKSAK HHHHHHHHHHHHHHH	38.00	21890473
172	Phosphorylation	NHSRVESSKRKSAKE HHHHHHHHHHHHHHH	23.99	23322592
178	Acetylation	SSKRKSAKEKKSSSK HHHHHHHHHHHCCCC	76.72	18530807
178	Ubiquitination	SSKRKSAKEKKSSSK HHHHHHHHHHHCCCC	76.72	24816145
182	Phosphorylation	KSAKEKKSSSKDSRP HHHHHHHCCCCCCCH	51.41	28176443
183	Phosphorylation	SAKEKKSSSKDSRPS HHHHHHCCCCCCCHH	50.73	28176443
184	Phosphorylation	AKEKKSSSKDSRPSQ HHHHHCCCCCCCHHH	47.80	25159151
185	Acetylation	KEKKSSSKDSRPSQA HHHHCCCCCCCHHHH	62.77	26051181
187	Phosphorylation	KKSSSKDSRPSQAAG HHCCCCCCCHHHHCC	50.23	25159151
190	Phosphorylation	SSKDSRPSQAAGDNQ CCCCCCHHHHCCCCC	31.20	25159151
202	"N6,N6-dimethyllysine"	DNQGDEAKEQTFSGG CCCCHHHHHHCCCCC	48.59	-
202	Acetylation	DNQGDEAKEQTFSGG CCCCHHHHHHCCCCC	48.59	26051181
202	Methylation	DNQGDEAKEQTFSGG CCCCHHHHHHCCCCC	48.59	-
202	Sumoylation	DNQGDEAKEQTFSGG CCCCHHHHHHCCCCC	48.59	25114211
202	Ubiquitination	DNQGDEAKEQTFSGG CCCCHHHHHHCCCCC	48.59	29967540
205	Phosphorylation	GDEAKEQTFSGGTSQ CHHHHHHCCCCCCCC	22.36	29255136
207	Phosphorylation	EAKEQTFSGGTSQDT HHHHHCCCCCCCCCC	39.43	29255136
210	Phosphorylation	EQTFSGGTSQDTKAS HHCCCCCCCCCCCCC	27.09	23401153
211	Phosphorylation	QTFSGGTSQDTKASE HCCCCCCCCCCCCCC	29.36	17525332
214	Phosphorylation	SGGTSQDTKASESSK CCCCCCCCCCCCCCC	22.37	28176443
215	Sumoylation	GGTSQDTKASESSKP CCCCCCCCCCCCCCC	59.20	28112733
215	Ubiquitination	GGTSQDTKASESSKP CCCCCCCCCCCCCCC	59.20	23000965
217	Phosphorylation	TSQDTKASESSKPWP CCCCCCCCCCCCCCC	39.30	23403867
219	Phosphorylation	QDTKASESSKPWPDA CCCCCCCCCCCCCCC	40.96	25159151
220	Phosphorylation	DTKASESSKPWPDAT CCCCCCCCCCCCCCC	38.39	23927012
221	Acetylation	TKASESSKPWPDATY CCCCCCCCCCCCCCC	61.45	19608861
221	Sumoylation	TKASESSKPWPDATY CCCCCCCCCCCCCCC	61.45	28112733
221	Ubiquitination	TKASESSKPWPDATY CCCCCCCCCCCCCCC	61.45	23000965
227	Phosphorylation	SKPWPDATYGTGSAS CCCCCCCCCCCCCHH	29.84	23927012
228	Phosphorylation	KPWPDATYGTGSASR CCCCCCCCCCCCHHH	17.89	27273156
230	Phosphorylation	WPDATYGTGSASRAS CCCCCCCCCCHHHHH	19.97	22167270
232	Phosphorylation	DATYGTGSASRASAV CCCCCCCCHHHHHHH	23.94	22167270
234	Phosphorylation	TYGTGSASRASAVSE CCCCCCHHHHHHHHH	30.03	23401153
237	Phosphorylation	TGSASRASAVSELSP CCCHHHHHHHHHCCH	28.26	29255136
240	Phosphorylation	ASRASAVSELSPRER HHHHHHHHHCCHHHC	32.32	29255136
243	Phosphorylation	ASAVSELSPRERSPA HHHHHHCCHHHCCHH	20.19	19664994
248	Phosphorylation	ELSPRERSPALKSPL HCCHHHCCHHHCCCC	15.12	19664994
252	Acetylation	RERSPALKSPLQSVV HHCCHHHCCCCEEEE	52.73	25953088
252	Methylation	RERSPALKSPLQSVV HHCCHHHCCCCEEEE	52.73	24129315
252	Sumoylation	RERSPALKSPLQSVV HHCCHHHCCCCEEEE	52.73	28112733
252	Ubiquitination	RERSPALKSPLQSVV HHCCHHHCCCCEEEE	52.73	33845483
253	Phosphorylation	ERSPALKSPLQSVVV HCCHHHCCCCEEEEE	31.52	19664994
257	Phosphorylation	ALKSPLQSVVVRRRS HHCCCCEEEEEECCC	25.27	26846344
264	Phosphorylation	SVVVRRRSPRPSPVP EEEEECCCCCCCCCC	24.37	23401153
268	Phosphorylation	RRRSPRPSPVPKPSP ECCCCCCCCCCCCCC	39.55	23401153
274	Phosphorylation	PSPVPKPSPPLSSTS CCCCCCCCCCCCCCC	45.32	23663014
278	Phosphorylation	PKPSPPLSSTSQMGS CCCCCCCCCCCCCCC	37.03	23663014
279	Phosphorylation	KPSPPLSSTSQMGST CCCCCCCCCCCCCCC	39.50	23663014
280	Phosphorylation	PSPPLSSTSQMGSTL CCCCCCCCCCCCCCC	21.43	23663014
281	Phosphorylation	SPPLSSTSQMGSTLP CCCCCCCCCCCCCCC	21.81	23663014
285	Phosphorylation	SSTSQMGSTLPSGAG CCCCCCCCCCCCCCC	22.79	22167270
286	Phosphorylation	STSQMGSTLPSGAGY CCCCCCCCCCCCCCC	36.64	23663014
289	Phosphorylation	QMGSTLPSGAGYQSG CCCCCCCCCCCCCCC	44.37	23401153
293	Phosphorylation	TLPSGAGYQSGTHQG CCCCCCCCCCCCCCC	10.04	22167270
295	Phosphorylation	PSGAGYQSGTHQGQF CCCCCCCCCCCCCCC	36.86	23401153
297	Phosphorylation	GAGYQSGTHQGQFDH CCCCCCCCCCCCCCC	19.10	22167270
306	Phosphorylation	QGQFDHGSGSLSPSK CCCCCCCCCCCCCCC	23.07	23401153
308	Phosphorylation	QFDHGSGSLSPSKKS CCCCCCCCCCCCCCC	27.63	23401153
310	Phosphorylation	DHGSGSLSPSKKSPV CCCCCCCCCCCCCCC	28.91	23401153
312	Phosphorylation	GSGSLSPSKKSPVGK CCCCCCCCCCCCCCC	49.71	22167270
315	Phosphorylation	SLSPSKKSPVGKSPP CCCCCCCCCCCCCCC	28.67	23927012
320	Phosphorylation	KKSPVGKSPPSTGST CCCCCCCCCCCCCCC	35.79	29255136
323	Phosphorylation	PVGKSPPSTGSTYGS CCCCCCCCCCCCCCC	49.11	29255136
324	Phosphorylation	VGKSPPSTGSTYGSS CCCCCCCCCCCCCCC	40.71	29255136
324	Ubiquitination	VGKSPPSTGSTYGSS CCCCCCCCCCCCCCC	40.71	24816145
326	Phosphorylation	KSPPSTGSTYGSSQK CCCCCCCCCCCCCHH	20.67	20201521
327	Phosphorylation	SPPSTGSTYGSSQKE CCCCCCCCCCCCHHH	32.99	20201521
328	Phosphorylation	PPSTGSTYGSSQKEE CCCCCCCCCCCHHHH	19.39	20201521
330	Phosphorylation	STGSTYGSSQKEESA CCCCCCCCCHHHHHH	21.12	30278072
331	Phosphorylation	TGSTYGSSQKEESAA CCCCCCCCHHHHHHH	40.69	30278072
333	Acetylation	STYGSSQKEESAASG CCCCCCHHHHHHHCC	66.45	26051181
333	Sumoylation	STYGSSQKEESAASG CCCCCCHHHHHHHCC	66.45	28112733
336	Phosphorylation	GSSQKEESAASGGAA CCCHHHHHHHCCCHH	30.17	29255136
339	Phosphorylation	QKEESAASGGAAYTK HHHHHHHCCCHHHHH	37.16	29255136
344	Phosphorylation	AASGGAAYTKRYLEE HHCCCHHHHHHHHHH	16.56	23927012
345	Phosphorylation	ASGGAAYTKRYLEEQ HCCCHHHHHHHHHHH	12.34	23403867
346	2-Hydroxyisobutyrylation	SGGAAYTKRYLEEQK CCCHHHHHHHHHHHC	26.77	-
346	Acetylation	SGGAAYTKRYLEEQK CCCHHHHHHHHHHHC	26.77	25953088
346	Neddylation	SGGAAYTKRYLEEQK CCCHHHHHHHHHHHC	26.77	32015554
346	Sumoylation	SGGAAYTKRYLEEQK CCCHHHHHHHHHHHC	26.77	28112733
346	Ubiquitination	SGGAAYTKRYLEEQK CCCHHHHHHHHHHHC	26.77	32015554
348	Phosphorylation	GAAYTKRYLEEQKTE CHHHHHHHHHHHCCC	21.74	18452278
353	Sumoylation	KRYLEEQKTENGKDK HHHHHHHCCCCCCCH	62.17	28112733
354	Phosphorylation	RYLEEQKTENGKDKE HHHHHHCCCCCCCHH	34.08	28555341
365	Phosphorylation	KDKEQKQTNTDKEKI CCHHHHCCCCCHHHH	47.31	-
367	Phosphorylation	KEQKQTNTDKEKIKE HHHHCCCCCHHHHHH	52.41	-
371	2-Hydroxyisobutyrylation	QTNTDKEKIKEKGSF CCCCCHHHHHHHCCC	65.89	-
373	Acetylation	NTDKEKIKEKGSFSD CCCHHHHHHHCCCCC	65.52	25953088
375	2-Hydroxyisobutyrylation	DKEKIKEKGSFSDTG CHHHHHHHCCCCCCC	55.65	-
375	Acetylation	DKEKIKEKGSFSDTG CHHHHHHHCCCCCCC	55.65	25953088
375	Sumoylation	DKEKIKEKGSFSDTG CHHHHHHHCCCCCCC	55.65	28112733
375	Ubiquitination	DKEKIKEKGSFSDTG CHHHHHHHCCCCCCC	55.65	32015554
377	Phosphorylation	EKIKEKGSFSDTGLG HHHHHHCCCCCCCCC	32.42	29255136
379	Phosphorylation	IKEKGSFSDTGLGDG HHHHCCCCCCCCCCC	35.64	19664994
381	Phosphorylation	EKGSFSDTGLGDGKM HHCCCCCCCCCCCCC	32.86	22167270
387	Sumoylation	DTGLGDGKMKSDSFA CCCCCCCCCCCCCCC	48.14	-
387	Acetylation	DTGLGDGKMKSDSFA CCCCCCCCCCCCCCC	48.14	23954790
387	Sumoylation	DTGLGDGKMKSDSFA CCCCCCCCCCCCCCC	48.14	25114211
387	Ubiquitination	DTGLGDGKMKSDSFA CCCCCCCCCCCCCCC	48.14	33845483
389	Sumoylation	GLGDGKMKSDSFAPK CCCCCCCCCCCCCCC	55.38	28112733
389	Ubiquitination	GLGDGKMKSDSFAPK CCCCCCCCCCCCCCC	55.38	32015554
390	O-linked_Glycosylation	LGDGKMKSDSFAPKT CCCCCCCCCCCCCCC	34.68	30379171
390	Phosphorylation	LGDGKMKSDSFAPKT CCCCCCCCCCCCCCC	34.68	30108239
392	Phosphorylation	DGKMKSDSFAPKTDS CCCCCCCCCCCCCCC	30.33	30108239
396	Sumoylation	KSDSFAPKTDSEKPF CCCCCCCCCCCCCCC	62.63	28112733
397	Phosphorylation	SDSFAPKTDSEKPFR CCCCCCCCCCCCCCC	43.64	25159151
399	Phosphorylation	SFAPKTDSEKPFRGS CCCCCCCCCCCCCCC	53.39	23927012
401	Acetylation	APKTDSEKPFRGSQS CCCCCCCCCCCCCCC	54.10	23749302
401	Sumoylation	APKTDSEKPFRGSQS CCCCCCCCCCCCCCC	54.10	28112733
406	Phosphorylation	SEKPFRGSQSPKRYK CCCCCCCCCCCCCCC	24.19	23927012
408	Phosphorylation	KPFRGSQSPKRYKLR CCCCCCCCCCCCCCH	33.80	23927012
412	Phosphorylation	GSQSPKRYKLRDDFE CCCCCCCCCCHHHHH	22.09	26074081
420	2-Hydroxyisobutyrylation	KLRDDFEKKMADFHK CCHHHHHHHHHHHHH	48.09	-
420	Acetylation	KLRDDFEKKMADFHK CCHHHHHHHHHHHHH	48.09	23749302
421	Sumoylation	LRDDFEKKMADFHKE CHHHHHHHHHHHHHH	31.93	28112733
427	Sumoylation	KKMADFHKEEMDDQD HHHHHHHHHHCCHHH	56.19	-
427	Acetylation	KKMADFHKEEMDDQD HHHHHHHHHHCCHHH	56.19	26051181
427	Sumoylation	KKMADFHKEEMDDQD HHHHHHHHHHCCHHH	56.19	28112733
435	Acetylation	EEMDDQDKDKAKGRK HHCCHHHHHHHCCCC	56.34	26051181
442	Trimethylation	KDKAKGRKESEFDDE HHHHCCCCHHHCCCC	74.41	-
442	Methylation	KDKAKGRKESEFDDE HHHHCCCCHHHCCCC	74.41	-
444	Phosphorylation	KAKGRKESEFDDEPK HHCCCCHHHCCCCHH	46.74	23401153
451	Sumoylation	SEFDDEPKFMSKVIG HHCCCCHHHHHHHHC	52.21	-
451	2-Hydroxyisobutyrylation	SEFDDEPKFMSKVIG HHCCCCHHHHHHHHC	52.21	-
451	Sumoylation	SEFDDEPKFMSKVIG HHCCCCHHHHHHHHC	52.21	25114211
451	Ubiquitination	SEFDDEPKFMSKVIG HHCCCCHHHHHHHHC	52.21	21906983
455	Acetylation	DEPKFMSKVIGANKN CCHHHHHHHHCCCCC	26.53	19608861
455	Sumoylation	DEPKFMSKVIGANKN CCHHHHHHHHCCCCC	26.53	28112733
455	Ubiquitination	DEPKFMSKVIGANKN CCHHHHHHHHCCCCC	26.53	22817900
461	Sumoylation	SKVIGANKNQEEEKS HHHHCCCCCHHHHHC	60.52	-
461	2-Hydroxyisobutyrylation	SKVIGANKNQEEEKS HHHHCCCCCHHHHHC	60.52	-
461	Acetylation	SKVIGANKNQEEEKS HHHHCCCCCHHHHHC	60.52	26051181
461	Sumoylation	SKVIGANKNQEEEKS HHHHCCCCCHHHHHC	60.52	28112733
461	Ubiquitination	SKVIGANKNQEEEKS HHHHCCCCCHHHHHC	60.52	-
467	Sumoylation	NKNQEEEKSGKWEGL CCCHHHHHCCCEECE	68.72	-
467	Sumoylation	NKNQEEEKSGKWEGL CCCHHHHHCCCEECE	68.72	28112733
467	Ubiquitination	NKNQEEEKSGKWEGL CCCHHHHHCCCEECE	68.72	22817900
468	Phosphorylation	KNQEEEKSGKWEGLV CCHHHHHCCCEECEE	49.21	21945579
470	Sumoylation	QEEEKSGKWEGLVYA HHHHHCCCEECEEEC	49.52	-
470	Acetylation	QEEEKSGKWEGLVYA HHHHHCCCEECEEEC	49.52	23954790
470	Sumoylation	QEEEKSGKWEGLVYA HHHHHCCCEECEEEC	49.52	28112733
470	Ubiquitination	QEEEKSGKWEGLVYA HHHHHCCCEECEEEC	49.52	21906983
476	Phosphorylation	GKWEGLVYAPPGKEK CCEECEEECCCCCHH	20.59	21945579
481	2-Hydroxyisobutyrylation	LVYAPPGKEKQRKTE EEECCCCCHHHHCHH	68.46	-
481	Acetylation	LVYAPPGKEKQRKTE EEECCCCCHHHHCHH	68.46	25953088
481	Malonylation	LVYAPPGKEKQRKTE EEECCCCCHHHHCHH	68.46	30639696
481	Sumoylation	LVYAPPGKEKQRKTE EEECCCCCHHHHCHH	68.46	28112733
483	Acetylation	YAPPGKEKQRKTEEL ECCCCCHHHHCHHHH	59.91	7363963
486	Sumoylation	PGKEKQRKTEELEEE CCCHHHHCHHHHHHH	58.77	-
486	Acetylation	PGKEKQRKTEELEEE CCCHHHHCHHHHHHH	58.77	26051181
486	Sumoylation	PGKEKQRKTEELEEE CCCHHHHCHHHHHHH	58.77	28112733
486	Ubiquitination	PGKEKQRKTEELEEE CCCHHHHCHHHHHHH	58.77	33845483
487	Phosphorylation	GKEKQRKTEELEEES CCHHHHCHHHHHHHH	36.56	23401153
494	Phosphorylation	TEELEEESFPERSKK HHHHHHHHCCHHHCC	49.75	25159151
499	Phosphorylation	EESFPERSKKEDRGK HHHCCHHHCCHHCCC	46.55	25159151
500	Methylation	ESFPERSKKEDRGKR HHCCHHHCCHHCCCC	67.42	116254045
508	Phosphorylation	KEDRGKRSEGGHRGF CHHCCCCCCCCCCCC	44.04	25159151
513	Methylation	KRSEGGHRGFVPEKN CCCCCCCCCCCCCCC	43.45	12020415
519	2-Hydroxyisobutyrylation	HRGFVPEKNFRVTAY CCCCCCCCCEEEEEH	56.14	-
519	Acetylation	HRGFVPEKNFRVTAY CCCCCCCCCEEEEEH	56.14	19608861
519	Malonylation	HRGFVPEKNFRVTAY CCCCCCCCCEEEEEH	56.14	26320211
519	Ubiquitination	HRGFVPEKNFRVTAY CCCCCCCCCEEEEEH	56.14	27667366
524	Phosphorylation	PEKNFRVTAYKAVQE CCCCEEEEEHHHHHH	21.73	26074081
526	Phosphorylation	KNFRVTAYKAVQEKS CCEEEEEHHHHHHHC	7.07	26074081
527	Acetylation	NFRVTAYKAVQEKSS CEEEEEHHHHHHHCC	39.35	23749302
527	Sumoylation	NFRVTAYKAVQEKSS CEEEEEHHHHHHHCC	39.35	28112733
533	Phosphorylation	YKAVQEKSSSPPPRK HHHHHHHCCCCCCCC	34.98	30266825
534	Phosphorylation	KAVQEKSSSPPPRKT HHHHHHCCCCCCCCC	58.91	30266825
535	Phosphorylation	AVQEKSSSPPPRKTS HHHHHCCCCCCCCCC	48.82	30266825
541	Phosphorylation	SSPPPRKTSESRDKL CCCCCCCCCHHHHHH	38.72	26074081
542	Phosphorylation	SPPPRKTSESRDKLG CCCCCCCCHHHHHHC	36.29	26074081
544	Phosphorylation	PPRKTSESRDKLGAK CCCCCCHHHHHHCCC	45.61	26074081
551	Acetylation	SRDKLGAKGDFPTGK HHHHHCCCCCCCCCC	58.16	26051181
551	Neddylation	SRDKLGAKGDFPTGK HHHHHCCCCCCCCCC	58.16	32015554
551	Sumoylation	SRDKLGAKGDFPTGK HHHHHCCCCCCCCCC	58.16	28112733
551	Ubiquitination	SRDKLGAKGDFPTGK HHHHHCCCCCCCCCC	58.16	32015554
556	Phosphorylation	GAKGDFPTGKSSFSI CCCCCCCCCCCCEEE	58.18	26074081
558	Acetylation	KGDFPTGKSSFSITR CCCCCCCCCCEEEEE	45.46	25953088
558	Neddylation	KGDFPTGKSSFSITR CCCCCCCCCCEEEEE	45.46	32015554
558	Sumoylation	KGDFPTGKSSFSITR CCCCCCCCCCEEEEE	45.46	28112733
558	Ubiquitination	KGDFPTGKSSFSITR CCCCCCCCCCEEEEE	45.46	21906983
559	Phosphorylation	GDFPTGKSSFSITRE CCCCCCCCCEEEEEE	37.65	30266825
560	Phosphorylation	DFPTGKSSFSITREA CCCCCCCCEEEEEEE	26.88	30266825
562	Phosphorylation	PTGKSSFSITREAQV CCCCCCEEEEEEEEE	25.62	23401153
564	Phosphorylation	GKSSFSITREAQVNV CCCCEEEEEEEEEEE	22.66	19691289
573	Sulfoxidation	EAQVNVRMDSFDEDL EEEEEEECCCCCHHH	4.39	21406390
575	Phosphorylation	QVNVRMDSFDEDLAR EEEEECCCCCHHHHC	25.84	29255136
584	Phosphorylation	DEDLARPSGLLAQER CHHHHCCCCHHHHHH	36.20	23927012
600	Phosphorylation	LCRDLVHSNKKEQEF HHHHHHHCCHHHHHH	42.75	25159151
602	2-Hydroxyisobutyrylation	RDLVHSNKKEQEFRS HHHHHCCHHHHHHHH	61.78	-
602	Sumoylation	RDLVHSNKKEQEFRS HHHHHCCHHHHHHHH	61.78	28112733
602	Ubiquitination	RDLVHSNKKEQEFRS HHHHHCCHHHHHHHH	61.78	24816145
609	Phosphorylation	KKEQEFRSIFQHIQS HHHHHHHHHHHHHHH	32.83	24732914
616	Phosphorylation	SIFQHIQSAQSQRSP HHHHHHHHHHHCCCH	27.89	24732914
619	Phosphorylation	QHIQSAQSQRSPSEL HHHHHHHHCCCHHHH	27.55	25849741
622	Phosphorylation	QSAQSQRSPSELFAQ HHHHHCCCHHHHHHH	25.74	30266825
624	Phosphorylation	AQSQRSPSELFAQHI HHHCCCHHHHHHHHH	48.45	30266825
633	Phosphorylation	LFAQHIVTIVHHVKE HHHHHHHHHHHHHHH	19.37	24732914
639	Acetylation	VTIVHHVKEHHFGSS HHHHHHHHHHCCCCC	47.15	11921623
645	Phosphorylation	VKEHHFGSSGMTLHE HHHHCCCCCCCCHHH	23.83	22210691
646	Phosphorylation	KEHHFGSSGMTLHER HHHCCCCCCCCHHHH	32.72	22210691
657	Phosphorylation	LHERFTKYLKRGTEQ HHHHHHHHHHHCHHH	17.88	27251275
662	Phosphorylation	TKYLKRGTEQEAAKN HHHHHHCHHHHHHHH	38.23	20068231
672	Phosphorylation	EAAKNKKSPEIHRRI HHHHHCCCHHHHHCC	29.40	22167270
682	Phosphorylation	IHRRIDISPSTFRKH HHHCCCCCHHHHHHH	14.73	19664994
684	Phosphorylation	RRIDISPSTFRKHGL HCCCCCHHHHHHHCC	33.13	22167270
685	Phosphorylation	RIDISPSTFRKHGLA CCCCCHHHHHHHCCC	30.73	22167270
697	2-Hydroxyisobutyrylation	GLAHDEMKSPREPGY CCCCCCCCCCCCCCC	56.09	-
697	Acetylation	GLAHDEMKSPREPGY CCCCCCCCCCCCCCC	56.09	26822725
697	Sumoylation	GLAHDEMKSPREPGY CCCCCCCCCCCCCCC	56.09	28112733
697	Ubiquitination	GLAHDEMKSPREPGY CCCCCCCCCCCCCCC	56.09	32015554
698	Phosphorylation	LAHDEMKSPREPGYK CCCCCCCCCCCCCCC	28.07	29255136
704	Phosphorylation	KSPREPGYKAEGKYK CCCCCCCCCCCCCCC	20.10	23927012
705	Sumoylation	SPREPGYKAEGKYKD CCCCCCCCCCCCCCC	45.97	-
705	Acetylation	SPREPGYKAEGKYKD CCCCCCCCCCCCCCC	45.97	25953088
705	Sumoylation	SPREPGYKAEGKYKD CCCCCCCCCCCCCCC	45.97	28112733
709	Acetylation	PGYKAEGKYKDDPVD CCCCCCCCCCCCCCH	40.40	19608861
709	Sumoylation	PGYKAEGKYKDDPVD CCCCCCCCCCCCCCH	40.40	28112733
710	Nitration	GYKAEGKYKDDPVDL CCCCCCCCCCCCCHH	30.42	-
710	Phosphorylation	GYKAEGKYKDDPVDL CCCCCCCCCCCCCHH	30.42	-
711	Sumoylation	YKAEGKYKDDPVDLR CCCCCCCCCCCCHHH	60.17	-
711	2-Hydroxyisobutyrylation	YKAEGKYKDDPVDLR CCCCCCCCCCCCHHH	60.17	-
711	Acetylation	YKAEGKYKDDPVDLR CCCCCCCCCCCCHHH	60.17	25953088
711	Methylation	YKAEGKYKDDPVDLR CCCCCCCCCCCCHHH	60.17	110879537
711	Sumoylation	YKAEGKYKDDPVDLR CCCCCCCCCCCCHHH	60.17	28112733
711	Ubiquitination	YKAEGKYKDDPVDLR CCCCCCCCCCCCHHH	60.17	33845483
737	Phosphorylation	RDLKRGKSRESVDSR HHHHCCCCCHHHHCC	44.07	25849741
740	Phosphorylation	KRGKSRESVDSRDSS HCCCCCHHHHCCCCH	30.07	27362937
743	Phosphorylation	KSRESVDSRDSSHSR CCCHHHHCCCCHHHH	35.51	27362937
746	Phosphorylation	ESVDSRDSSHSRERS HHHHCCCCHHHHHHH	28.92	26055452
747	Phosphorylation	SVDSRDSSHSRERSA HHHCCCCHHHHHHHH	29.76	20044836
749	Phosphorylation	DSRDSSHSRERSAEK HCCCCHHHHHHHHHH	37.47	20044836
753	Phosphorylation	SSHSRERSAEKTEKT CHHHHHHHHHHHHHH	35.71	26657352
756	Sumoylation	SRERSAEKTEKTHKG HHHHHHHHHHHHCCC	62.80	-
756	Methylation	SRERSAEKTEKTHKG HHHHHHHHHHHHCCC	62.80	23748837
756	Sumoylation	SRERSAEKTEKTHKG HHHHHHHHHHHHCCC	62.80	25218447
757	Phosphorylation	RERSAEKTEKTHKGS HHHHHHHHHHHCCCC	33.93	28176443
759	Sumoylation	RSAEKTEKTHKGSKK HHHHHHHHHCCCCHH	62.25	-
759	Sumoylation	RSAEKTEKTHKGSKK HHHHHHHHHCCCCHH	62.25	25218447
777	Phosphorylation	HRRARDRSRSSSSSS HHHHHHHCCCCCCCC	40.58	25137130
779	Phosphorylation	RARDRSRSSSSSSQS HHHHHCCCCCCCCCC	35.50	25849741
780	Phosphorylation	ARDRSRSSSSSSQSS HHHHCCCCCCCCCCC	32.88	25137130
781	Phosphorylation	RDRSRSSSSSSQSSH HHHCCCCCCCCCCCC	35.17	25849741
782	Phosphorylation	DRSRSSSSSSQSSHS HHCCCCCCCCCCCCC	35.64	25137130
783	Phosphorylation	RSRSSSSSSQSSHSY HCCCCCCCCCCCCCE	34.05	25137130
784	Phosphorylation	SRSSSSSSQSSHSYK CCCCCCCCCCCCCEE	35.71	25137130
786	Phosphorylation	SSSSSSQSSHSYKAE CCCCCCCCCCCEECH	31.78	25849741
787	Phosphorylation	SSSSSQSSHSYKAEE CCCCCCCCCCEECHH	14.60	29449344
789	Phosphorylation	SSSQSSHSYKAEEYT CCCCCCCCEECHHHC	30.21	29449344
790	Phosphorylation	SSQSSHSYKAEEYTE CCCCCCCEECHHHCH	14.59	25137130
795	Phosphorylation	HSYKAEEYTEETEER CCEECHHHCHHHHHH	15.79	29255136
796	Phosphorylation	SYKAEEYTEETEERE CEECHHHCHHHHHHH	30.53	29255136
799	Phosphorylation	AEEYTEETEEREEST CHHHCHHHHHHHHHC	36.59	25849741
802	Methylation	YTEETEEREESTTGF HCHHHHHHHHHCCCC	46.91	115918909
805	Phosphorylation	ETEEREESTTGFDKS HHHHHHHHCCCCCHH	26.90	29255136
806	Phosphorylation	TEEREESTTGFDKSR HHHHHHHCCCCCHHH	33.93	29255136
807	Phosphorylation	EEREESTTGFDKSRL HHHHHHCCCCCHHHC	45.17	29255136
811	2-Hydroxyisobutyrylation	ESTTGFDKSRLGTKD HHCCCCCHHHCCCCC	34.90	-
811	Acetylation	ESTTGFDKSRLGTKD HHCCCCCHHHCCCCC	34.90	19608861
811	Ubiquitination	ESTTGFDKSRLGTKD HHCCCCCHHHCCCCC	34.90	19608861
823	Phosphorylation	TKDFVGPSERGGGRA CCCCCCCCCCCCCCC	33.72	22817900
825	Methylation	DFVGPSERGGGRARG CCCCCCCCCCCCCCC	54.09	24395855
829	Methylation	PSERGGGRARGTFQF CCCCCCCCCCCEEEE	25.12	82954751
831	Methylation	ERGGGRARGTFQFRA CCCCCCCCCEEEEEE	43.24	24395865
833	Phosphorylation	GGGRARGTFQFRARG CCCCCCCEEEEEECC	14.54	22817900
837	Dimethylation	ARGTFQFRARGRGWG CCCEEEEEECCCCCC	16.76	-
837	Methylation	ARGTFQFRARGRGWG CCCEEEEEECCCCCC	16.76	30763353
839	Dimethylation	GTFQFRARGRGWGRG CEEEEEECCCCCCCC	30.96	-
839	Methylation	GTFQFRARGRGWGRG CEEEEEECCCCCCCC	30.96	30763359
841	Dimethylation	FQFRARGRGWGRGNY EEEEECCCCCCCCCC	31.94	-
841	Methylation	FQFRARGRGWGRGNY EEEEECCCCCCCCCC	31.94	24383761
845	Asymmetric dimethylarginine	ARGRGWGRGNYSGNN ECCCCCCCCCCCCCC	24.55	-
845	Methylation	ARGRGWGRGNYSGNN ECCCCCCCCCCCCCC	24.55	24383771
848	Phosphorylation	RGWGRGNYSGNNNNN CCCCCCCCCCCCCCC	22.30	25367160
849	Phosphorylation	GWGRGNYSGNNNNNS CCCCCCCCCCCCCCC	38.76	25367160
873	Phosphorylation	EEEWDPEYTPKSKKY HHCCCCCCCCCCCCE	33.46	30266825
874	Phosphorylation	EEWDPEYTPKSKKYY HCCCCCCCCCCCCEE	23.68	19664994
875	Ubiquitination	EWDPEYTPKSKKYYL CCCCCCCCCCCCEEE	37.71	32015554
876	Acetylation	WDPEYTPKSKKYYLH CCCCCCCCCCCEEEC	68.08	26051181
876	Sumoylation	WDPEYTPKSKKYYLH CCCCCCCCCCCEEEC	68.08	28112733
876	Ubiquitination	WDPEYTPKSKKYYLH CCCCCCCCCCCEEEC	68.08	32015554
877	Phosphorylation	DPEYTPKSKKYYLHD CCCCCCCCCCEEECC	35.27	24732914
879	2-Hydroxyisobutyrylation	EYTPKSKKYYLHDDR CCCCCCCCEEECCCC	46.34	-
879	Acetylation	EYTPKSKKYYLHDDR CCCCCCCCEEECCCC	46.34	27452117
879	Sumoylation	EYTPKSKKYYLHDDR CCCCCCCCEEECCCC	46.34	28112733
880	Phosphorylation	YTPKSKKYYLHDDRE CCCCCCCEEECCCCC	18.26	20068231
881	Phosphorylation	TPKSKKYYLHDDREG CCCCCCEEECCCCCC	13.36	20068231
886	Methylation	KYYLHDDREGEGSDK CEEECCCCCCCCCCC	60.93	115918921
891	Phosphorylation	DDREGEGSDKWVSRG CCCCCCCCCCCCCCC	31.54	20068231
897	Methylation	GSDKWVSRGRGRGAF CCCCCCCCCCCCCCC	29.25	24395875
899	Methylation	DKWVSRGRGRGAFPR CCCCCCCCCCCCCCC	30.44	24395885
906	Methylation	RGRGAFPRGRGRFMF CCCCCCCCCCCCEEE	40.77	24396719
908	Dimethylation	RGAFPRGRGRFMFRK CCCCCCCCCCEEEEC	34.10	-
908	Methylation	RGAFPRGRGRFMFRK CCCCCCCCCCEEEEC	34.10	54549131
910	Dimethylation	AFPRGRGRFMFRKSS CCCCCCCCEEEECCC	20.63	-
910	Methylation	AFPRGRGRFMFRKSS CCCCCCCCEEEECCC	20.63	54549135
916	O-linked_Glycosylation	GRFMFRKSSTSPKWA CCEEEECCCCCCCCC	34.29	30379171
916	Phosphorylation	GRFMFRKSSTSPKWA CCEEEECCCCCCCCC	34.29	23403867
917	Phosphorylation	RFMFRKSSTSPKWAH CEEEECCCCCCCCCC	35.62	23403867
918	Phosphorylation	FMFRKSSTSPKWAHD EEEECCCCCCCCCCC	57.02	23403867
919	Phosphorylation	MFRKSSTSPKWAHDK EEECCCCCCCCCCCC	26.82	23403867
926	Acetylation	SPKWAHDKFSGEEGE CCCCCCCCCCCCCCC	31.40	23236377
927	Phosphorylation	PKWAHDKFSGEEGEI CCCCCCCCCCCCCCC	16.46	32142685
928	Phosphorylation	KWAHDKFSGEEGEIE CCCCCCCCCCCCCCC	51.54	29255136
938	Phosphorylation	EGEIEDDESGTENRE CCCCCCCCCCCCCHH	64.49	32142685
939	Phosphorylation	GEIEDDESGTENREE CCCCCCCCCCCCHHH	58.99	19664994
941	Phosphorylation	IEDDESGTENREEKD CCCCCCCCCCHHHHC	39.09	29255136
953	Phosphorylation	EKDNIQPTTE----- HHCCCCCCCC-----	27.47	23401153
954	Phosphorylation	KDNIQPTTE------ HCCCCCCCC------	46.51	30278072

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
68	Y	Phosphorylation	Kinase	SRC	P12931	PSP
107	Y	Phosphorylation	Kinase	SRC	P12931	PSP
118	Y	Phosphorylation	Kinase	SRC	P12931	PSP
344	Y	Phosphorylation	Kinase	SRC	P12931	PSP
874	T	Phosphorylation	Kinase	CDK2	P24941	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TR150_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TR150_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
POL_HV1H2	gag-pol	physical	20016921
PUF60_HUMAN	PUF60	physical	26344197
RNPS1_HUMAN	RNPS1	physical	26344197
RS19_HUMAN	RPS19	physical	26344197
SSRP1_HUMAN	SSRP1	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-221; LYS-401; LYS-455;LYS-519; LYS-709 AND LYS-811, AND MASS SPECTROMETRY.
PubMed: 19608861

Phosphorylation

"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-243; SER-253; SER-315;SER-320; SER-377; SER-379; SER-575; SER-682; THR-874; SER-928 ANDSER-939, AND MASS SPECTROMETRY.
PubMed: 19690332

"Large-scale proteomics analysis of the human kinome.";
Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.;
Mol. Cell. Proteomics 8:1751-1764(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-243, AND MASSSPECTROMETRY.
PubMed: 19369195

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-207; SER-211; SER-243;SER-310; SER-315; SER-320; SER-323; TYR-328; SER-379; SER-408;SER-682; SER-928; SER-939 AND THR-941, AND MASS SPECTROMETRY.
PubMed: 19413330

"Large-scale phosphoproteome analysis of human liver tissue byenrichment and fractionation of phosphopeptides with strong anionexchange chromatography.";
Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D.,Zou H., Gu J.;
Proteomics 8:1346-1361(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-928 AND SER-939, ANDMASS SPECTROMETRY.
PubMed: 18318008

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-232; SER-237; SER-240;SER-243; SER-248; SER-253; SER-379; SER-406; SER-408; SER-575;SER-682; THR-874; SER-928 AND SER-939, AND MASS SPECTROMETRY.
PubMed: 18669648

"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle.";
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.;
Mol. Cell 31:438-448(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-243, AND MASSSPECTROMETRY.
PubMed: 18691976

"Phosphorylation analysis of primary human T lymphocytes usingsequential IMAC and titanium oxide enrichment.";
Carrascal M., Ovelleiro D., Casas V., Gay M., Abian J.;
J. Proteome Res. 7:5167-5176(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-243, AND MASSSPECTROMETRY.
PubMed: 19367720

"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis.";
Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III;
J. Proteome Res. 7:1346-1351(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-243; SER-248; SER-253AND SER-682, AND MASS SPECTROMETRY.
PubMed: 18220336

"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column.";
Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.;
Anal. Sci. 24:161-166(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-243; SER-248; SER-253AND SER-682, AND MASS SPECTROMETRY.
PubMed: 18187866

"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis.";
Wang B., Malik R., Nigg E.A., Korner R.;
Anal. Chem. 80:9526-9533(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-240; SER-243; SER-253;SER-320; SER-562; SER-575; SER-682; SER-684 AND THR-685, AND MASSSPECTROMETRY.
PubMed: 19007248

"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage.";
Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.;
Science 316:1160-1166(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-211; SER-406 ANDSER-408, AND MASS SPECTROMETRY.
PubMed: 17525332

"Global proteomic profiling of phosphopeptides using electron transferdissociation tandem mass spectrometry.";
Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A.;
Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2; SER-315; SER-320;SER-444; SER-508; SER-672; SER-682; SER-698; SER-939 AND THR-941, ANDMASS SPECTROMETRY.
PubMed: 17287340

"Improved titanium dioxide enrichment of phosphopeptides from HeLacells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.";
Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.;
J. Proteome Res. 6:4150-4162(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-243; SER-248; SER-253;SER-682 AND SER-698, AND MASS SPECTROMETRY.
PubMed: 17924679

"Phosphoproteome analysis of the human mitotic spindle.";
Nousiainen M., Sillje H.H.W., Sauer G., Nigg E.A., Koerner R.;
Proc. Natl. Acad. Sci. U.S.A. 103:5391-5396(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-682 AND THR-874, ANDMASS SPECTROMETRY.
PubMed: 16565220

"A probability-based approach for high-throughput proteinphosphorylation analysis and site localization.";
Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.;
Nat. Biotechnol. 24:1285-1292(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-243 AND SER-682, ANDMASS SPECTROMETRY.
PubMed: 16964243

"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-240; SER-243; SER-248;SER-253; SER-264; SER-268; SER-315; SER-320; SER-379; SER-406;SER-408; SER-535; SER-575; THR-662; SER-672; SER-682; SER-698;SER-823; THR-833; SER-928 AND SER-939, AND MASS SPECTROMETRY.
PubMed: 17081983

"Global phosphoproteome of HT-29 human colon adenocarcinoma cells.";
Kim J.-E., Tannenbaum S.R., White F.M.;
J. Proteome Res. 4:1339-1346(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-243, AND MASSSPECTROMETRY.
PubMed: 16083285

"Large-scale characterization of HeLa cell nuclear phosphoproteins.";
Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-211; SER-237; SER-243;SER-320; SER-379; SER-534; SER-535; SER-682 AND SER-939, AND MASSSPECTROMETRY.
PubMed: 15302935