POL_HV1H2 - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: POL_HV1H2
• UniProt AC: P04585
• Protein Name: Gag-Pol polyprotein
• Gene Name: gag-pol
• Organism: Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1).
• Sequence Length: 1435
• Subcellular Localization: Gag-Pol polyprotein: Host cell membrane; Lipid-anchor . Host endosome, host multivesicular body . These locations are linked to virus assembly sites. The main location is the cell membrane, but under some circumstances, late endosomal compartments ca
• Protein Description: Gag-Pol polyprotein: Mediates, with Gag polyprotein, the essential events in virion assembly, including binding the plasma membrane, making the protein-protein interactions necessary to create spherical particles, recruiting the viral Env proteins, and packaging the genomic RNA via direct interactions with the RNA packaging sequence (Psi). Gag-Pol polyprotein may regulate its own translation, by the binding genomic RNA in the 5'-UTR. At low concentration, the polyprotein would promote translation, whereas at high concentration, the polyprotein would encapsidate genomic RNA and then shut off translation.; Matrix protein p17: Targets the polyprotein to the plasma membrane via a multipartite membrane-binding signal, that includes its myristoylated N-terminus (By similarity). Matrix protein is part of the pre-integration complex. Implicated in the release from host cell mediated by Vpu. Binds to RNA (By similarity).; Capsid protein p24: Forms the conical core that encapsulates the genomic RNA-nucleocapsid complex in the virion. [PubMed: 8648689 Most core are conical, with only 7% tubular. The core is constituted by capsid protein hexamer subunits. The core is disassembled soon after virion entry]
• Protein Sequence: MGARASVLSGGELDRWEKIRLRPGGKKKYKLKHIVWASRELERFAVNPGLLETSEGCRQILGQLQPSLQTGSEELRSLYNTVATLYCVHQRIEIKDTKEALDKIEEEQNKSKKKAQQAAADTGHSNQVSQNYPIVQNIQGQMVHQAISPRTLNAWVKVVEEKAFSPEVIPMFSALSEGATPQDLNTMLNTVGGHQAAMQMLKETINEEAAEWDRVHPVHAGPIAPGQMREPRGSDIAGTTSTLQEQIGWMTNNPPIPVGEIYKRWIILGLNKIVRMYSPTSILDIRQGPKEPFRDYVDRFYKTLRAEQASQEVKNWMTETLLVQNANPDCKTILKALGPAATLEEMMTACQGVGGPGHKARVLAEAMSQVTNSATIMMQRGNFRNQRKIVKCFNCGKEGHTARNCRAPRKKGCWKCGKEGHQMKDCTERQANFLREDLAFLQGKAREFSSEQTRANSPTRRELQVWGRDNNSPSEAGADRQGTVSFNFPQVTLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFIKVRQYDQILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNFPISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVIPLTEEAELELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGAHTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTPPLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNRGRQKVVTLTDTTNQKTELQAIYLALQDSGLEVNIVTDSQYALGIIQAQPDQSESELVNQIIEQLIKKEKVYLAWVPAHKGIGGNEQVDKLVSAGIRKVLFLDGIDKAQDEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGIWQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTIHTDNGSNFTGATVRAACWWAGIKQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAVFIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRNPLWKGPAKLLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCVASRQDED

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Myristoylation	------MGARASVLS ------CCCCEECCC	34.77	-
132	Phosphorylation	SNQVSQNYPIVQNIQ CCHHHCCCCEEECCC	6.16	-
1405	Acetylation	IQDNSDIKVVPRRKA ECCCCCCEEEECHHH	42.02	20226045
1411	Acetylation	IKVVPRRKAKIIRDY CEEEECHHHHHHHHH	56.14	20226045
1413	Acetylation	VVPRRKAKIIRDYGK EEECHHHHHHHHHHH	41.52	20226045
1420	Acetylation	KIIRDYGKQMAGDDC HHHHHHHHHHCCCCC	30.58	20226045

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of POL_HV1H2 !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of POL_HV1H2 !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of POL_HV1H2 !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
POL_HV1H2	gag-pol	physical	7542140
PSIP1_HUMAN	PSIP1	physical	12407101
PSIP1_HUMAN	PSIP1	physical	15895093
SNF5_HUMAN	SMARCB1	physical	14963118
XRCC6_HUMAN	XRCC6	physical	21454661
POL_HV1H2	gag-pol	physical	21454548
NFKB1_HUMAN	NFKB1	physical	2017258
BCL2_HUMAN	BCL2	physical	8790371
RAD18_HUMAN	RAD18	physical	12016221
NEF_HV1H2	nef	physical	15137387
PFD3_HUMAN	VBP1	physical	17698809
VHL_HUMAN	VHL	physical	17698809
CUL2_HUMAN	CUL2	physical	17698809
EED_HUMAN	EED	physical	14610174
EP300_HUMAN	EP300	physical	16096645
PSIP1_HUMAN	PSIP1	physical	20016921
BTF3_HUMAN	BTF3	physical	20016921
TR150_HUMAN	THRAP3	physical	20016921
HMGN2_HUMAN	HMGN2	physical	20016921
RANB9_HUMAN	RANBP9	physical	20016921
EIF3H_HUMAN	EIF3H	physical	20016921
EF1A1_HUMAN	EEF1A1	physical	20016921
ROA2_HUMAN	HNRNPA2B1	physical	20016921
STMN1_HUMAN	STMN1	physical	20016921
RL23_HUMAN	RPL23	physical	20016921
CCD32_HUMAN	C15orf57	physical	20016921
EIF3D_HUMAN	EIF3D	physical	22190034
VIME_HUMAN	VIM	physical	22944692
DAXX_HUMAN	DAXX	physical	21556766
EIF3F_HUMAN	EIF3F	physical	22190034
EIF3C_HUMAN	EIF3C	physical	22190034
EIF3A_HUMAN	EIF3A	physical	22190034
EIF3L_HUMAN	EIF3L	physical	22190034
EIF3K_HUMAN	EIF3K	physical	22190034
UBR4_HUMAN	UBR4	physical	22190034
OSBL3_HUMAN	OSBPL3	physical	22190034
EIF3H_HUMAN	EIF3H	physical	22190034
EIF3E_HUMAN	EIF3E	physical	22190034
EIF3B_HUMAN	EIF3B	physical	22190034
RUVB1_HUMAN	RUVBL1	physical	22190034
PDIA4_HUMAN	PDIA4	physical	22190034
NFU1_HUMAN	NFU1	physical	22190034
SUCB1_HUMAN	SUCLA2	physical	22190034
PDIA6_HUMAN	PDIA6	physical	22190034
MCM7_HUMAN	MCM7	physical	22190034
PELO_HUMAN	PELO	physical	22190034
RCN1_HUMAN	RCN1	physical	22190034
CCAR2_HUMAN	CCAR2	physical	22190034
TYSD1_HUMAN	TYSND1	physical	22190034
EIF3I_HUMAN	EIF3I	physical	22190034
HEMH_HUMAN	FECH	physical	22190034
RECQ1_HUMAN	RECQL	physical	22190034
LG3BP_HUMAN	LGALS3BP	physical	22190034
LIMD1_HUMAN	LIMD1	physical	22190034
EIF3G_HUMAN	EIF3G	physical	22190034
CATB_HUMAN	CTSB	physical	22190034
RIR2_HUMAN	RRM2	physical	22190034
PSIP1_HUMAN	PSIP1	physical	22190034
MCM4_HUMAN	MCM4	physical	22190034
GRB2_HUMAN	GRB2	physical	22190034
PP2AB_HUMAN	PPP2CB	physical	22190034
MCM6_HUMAN	MCM6	physical	22190034
ANC2_HUMAN	ANAPC2	physical	22190034
NUDC_HUMAN	NUDC	physical	22190034
IDH3A_HUMAN	IDH3A	physical	22190034
ARRB2_HUMAN	ARRB2	physical	22190034
POL_HV1H2	gag-pol	physical	22190034
SSA27_HUMAN	SSSCA1	physical	22190034
GOGA1_HUMAN	GOLGA1	physical	22190034
DPOE3_HUMAN	POLE3	physical	22190034
DPOE1_HUMAN	POLE	physical	22190034
HGH1_HUMAN	HGH1	physical	22190034
SF3A3_HUMAN	SF3A3	physical	22190034
HERC2_HUMAN	HERC2	physical	22190034
FNIP1_HUMAN	FNIP1	physical	22190034
DIAP1_HUMAN	DIAPH1	physical	22190034
FLCN_HUMAN	FLCN	physical	22190034
DPOE4_HUMAN	POLE4	physical	22190034
EIF3M_HUMAN	EIF3M	physical	22190034
IF122_HUMAN	IFT122	physical	22190034
ARHGC_HUMAN	ARHGEF12	physical	22190034
DOHH_HUMAN	DOHH	physical	22190034
EPIPL_HUMAN	EPPK1	physical	22190034
TRPS1_HUMAN	TRPS1	physical	22190034
PFD3_HUMAN	VBP1	physical	22190034
FOXC1_HUMAN	FOXC1	physical	22190034
ALMS1_HUMAN	ALMS1	physical	22190034
OSBL6_HUMAN	OSBPL6	physical	22190034
SYSC_HUMAN	SARS	physical	22190034
CARM1_HUMAN	CARM1	physical	22190034
EST1A_HUMAN	SMG6	physical	22190034
PUM2_HUMAN	PUM2	physical	22190034
APC1_HUMAN	ANAPC1	physical	22190034
MSH2_HUMAN	MSH2	physical	22190034
PARP4_HUMAN	PARP4	physical	22190034
AKAP9_HUMAN	AKAP9	physical	22190034
DOK1_HUMAN	DOK1	physical	22190034
MCL1_HUMAN	MCL1	physical	22190034
FAD1_HUMAN	FLAD1	physical	22190034
SAHH_HUMAN	AHCY	physical	22190034
BICD2_HUMAN	BICD2	physical	22190034
FKBP4_HUMAN	FKBP4	physical	22190034
GAK_HUMAN	GAK	physical	22190034
NFAT5_HUMAN	NFAT5	physical	22190034
EMAL3_HUMAN	EML3	physical	22190034
NHRF1_HUMAN	SLC9A3R1	physical	22190034
VIR_HUMAN	KIAA1429	physical	22190034
KCRU_HUMAN	CKMT1B	physical	22190034
UN45A_HUMAN	UNC45A	physical	22190034
PLOD1_HUMAN	PLOD1	physical	22190034
MIP18_HUMAN	FAM96B	physical	22190034
CAND2_HUMAN	CAND2	physical	22190034
UBA1_HUMAN	UBA1	physical	22190034
HDDC2_HUMAN	HDDC2	physical	22190034
WDR61_HUMAN	WDR61	physical	22190034
PLAP_HUMAN	PLAA	physical	22190034
HEAT1_HUMAN	HEATR1	physical	22190034
RNBP6_HUMAN	RANBP6	physical	22190034
1433E_HUMAN	YWHAE	physical	22190034
CIAO1_HUMAN	CIAO1	physical	22190034
1433B_HUMAN	YWHAB	physical	22190034
ZNT7_HUMAN	SLC30A7	physical	22190034
IPO4_HUMAN	IPO4	physical	22190034
PLOD2_HUMAN	PLOD2	physical	22190034
1433Z_HUMAN	YWHAZ	physical	22190034
1433G_HUMAN	YWHAG	physical	22190034
DESP_HUMAN	DSP	physical	22190034
KAT2A_HUMAN	KAT2A	physical	20226045

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.