dbPTM

RNBP6_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	RNBP6_HUMAN
UniProt AC	O60518
Protein Name	Ran-binding protein 6
Gene Name	RANBP6
Organism	Homo sapiens (Human).
Sequence Length	1105
Subcellular Localization	Cytoplasm. Nucleus.
Protein Description	May function in nuclear protein import as nuclear transport receptor..
Protein Sequence	MAATASAGVPATVSEKQEFYQLLKNLINPSCMVRRQAEEIYENIPGLCKTTFLLDAVRNRRAGYEVRQMAAALLRRLLSSGFEEVYPNLPADVQRDVKIELILAVKLETHASMRKKLCDIFAVLARNLIDEDGTNHWPEGLKFLIDSIYSKNVVLWEVALHVFWHFPGIFGTQERHDLDIIKRLLDQCIQDQEHPAIRTLSARAAAAFVLANENNIALFKDFADLLPGILQAVNDSCYQDDDSVLESLVEIADTVPKYLGPYLEDTLQLSLKLCGDSRLSNLQRQLALEVIVTLSETATPMLKKHTNIIAQAVPHILAMMVDLQDDEDWVNADEMEEDDFDSNAVAAESALDRLACGLGGKVVLPMTKEHIMQMLQSPDWKYRHAGLMALSAIGEGCHQQMESILDETVNSVLLFLQDPHPRVRAAACTTLGQMATDFAPNFQKKFHETVIAALLRTMENQGNQRVQSHAASALIIFIEDCPKSLLVLYVDSMVKNLHSVLVIKLQELIRNGTKLALEQLVTTIASVADTIEEKFVPYYDIFMPSLKHIVELAVQKELKLLRGKTIECISHIGLAVGKEKFMQDASNVMQLLLKTQSDLNNMEDDDPQTSYMVSAWARMCKILGKDFQQYLPLVIEPLIKTASAKPDVALLDTQDVENMSDDDGWQFVNLGDQQSFGIKTSGLEAKATACQMLVYYAKELREGFVEYTEQVVKLMVPLLKFYFHDNVRVAAAESMPFLLECARIRGPEYLAQMWQFICDPLIKAIGTEPDTDVLSEIMNSFAKSIEVMGDGCLNDEHLEELGGILKAKLEGHFKNQELRQVKRQEENYDQQVEMSLQDEDECDVYILTKVSDILHSLFSTYKEKILPWFEQLLPLIVNLICSSRPWPDRQWGLCIFDDIIEHCSPTSFKYVEYFRWPMLLNMRDNNPEVRQAAAYGLGVMAQFGGDDYRSLCSEAVPLLVKVIKCANSKTKKNVIATENCISAIGKILKFKPNCVNVDEVLPHWLSWLPLHEDKEEAIQTLSFLCDLIESNHPVVIGPNNSNLPKIISIIAEGKINETINYEDPCAKRLANVVRQVQTSEDLWLECVSQLDDEQQEALQELLNFA

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAATASAGV ------CCCCCCCCC	25.48	19413330
4	Phosphorylation	----MAATASAGVPA ----CCCCCCCCCCC	28.36	20071362
6	Phosphorylation	--MAATASAGVPATV --CCCCCCCCCCCCC	22.62	25867546
12	Phosphorylation	ASAGVPATVSEKQEF CCCCCCCCCCCHHHH	20.63	20071362
14	Phosphorylation	AGVPATVSEKQEFYQ CCCCCCCCCHHHHHH	34.42	21712546
16	Ubiquitination	VPATVSEKQEFYQLL CCCCCCCHHHHHHHH	47.85	21890473
112	Phosphorylation	VKLETHASMRKKLCD EHHHHCHHHHHHHHH	16.12	-
247	Phosphorylation	DDDSVLESLVEIADT CCHHHHHHHHHHHHH	33.29	-
280	Phosphorylation	LCGDSRLSNLQRQLA HHCCHHHHHHHHHHH	34.09	-
293	Phosphorylation	LALEVIVTLSETATP HHHHHHHHHHHCCCH	17.28	21406692
295	Phosphorylation	LEVIVTLSETATPML HHHHHHHHHCCCHHH	24.44	21406692
297	Phosphorylation	VIVTLSETATPMLKK HHHHHHHCCCHHHHH	32.24	21406692
299	Phosphorylation	VTLSETATPMLKKHT HHHHHCCCHHHHHHH	19.36	21406692
445	Ubiquitination	FAPNFQKKFHETVIA CCHHHHHHHHHHHHH	40.96	-
614	Phosphorylation	PQTSYMVSAWARMCK HHHHHHHHHHHHHHH	11.10	-
621	Ubiquitination	SAWARMCKILGKDFQ HHHHHHHHHHCCCHH	31.46	-
625	Ubiquitination	RMCKILGKDFQQYLP HHHHHHCCCHHHHHH	52.50	-
630	Phosphorylation	LGKDFQQYLPLVIEP HCCCHHHHHHHHHHH	10.25	-
641	Phosphorylation	VIEPLIKTASAKPDV HHHHHHHHCCCCCCE	20.89	-
653	Phosphorylation	PDVALLDTQDVENMS CCEEEECCCCCCCCC	27.00	29523821
660	Phosphorylation	TQDVENMSDDDGWQF CCCCCCCCCCCCCEE	49.85	29523821
707	Phosphorylation	LREGFVEYTEQVVKL HHCCHHHHHHHHHHH	15.41	-
708	Phosphorylation	REGFVEYTEQVVKLM HCCHHHHHHHHHHHH	13.36	-
720	Ubiquitination	KLMVPLLKFYFHDNV HHHHHHHHHHCCCCC	45.78	-
722	Phosphorylation	MVPLLKFYFHDNVRV HHHHHHHHCCCCCCH	9.83	26074081
734	Phosphorylation	VRVAAAESMPFLLEC CCHHHHHCCCHHHHH	27.33	26074081
808	Ubiquitination	LGGILKAKLEGHFKN HHHHHHHHHHHHCCC	45.55	-
814	Ubiquitination	AKLEGHFKNQELRQV HHHHHHCCCHHHHHH	52.63	-
819	Methylation	HFKNQELRQVKRQEE HCCCHHHHHHHHHHH	38.19	-
835	Phosphorylation	YDQQVEMSLQDEDEC CHHHHHHHHCCCCCC	14.90	30177828
845	Phosphorylation	DEDECDVYILTKVSD CCCCCCEEEEEHHHH	4.13	30177828
848	Phosphorylation	ECDVYILTKVSDILH CCCEEEEEHHHHHHH	21.60	30177828
851	Phosphorylation	VYILTKVSDILHSLF EEEEEHHHHHHHHHH	22.08	29759185
856	Phosphorylation	KVSDILHSLFSTYKE HHHHHHHHHHHHHHH	27.88	29759185
859	Phosphorylation	DILHSLFSTYKEKIL HHHHHHHHHHHHHHH	35.80	29759185
961	Acetylation	EAVPLLVKVIKCANS HHHHHHHHHHHHCCC	37.91	25953088
986	Ubiquitination	NCISAIGKILKFKPN HHHHHHHHHHCCCCC	38.46	-
1048	Phosphorylation	SNLPKIISIIAEGKI CCHHHHHHHHHCCCC	16.06	20068231
1058	Phosphorylation	AEGKINETINYEDPC HCCCCCCCCCCCCHH	15.27	20068231
1061	Phosphorylation	KINETINYEDPCAKR CCCCCCCCCCHHHHH	20.19	29514088
1067	Ubiquitination	NYEDPCAKRLANVVR CCCCHHHHHHHHHHH	55.45	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of RNBP6_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of RNBP6_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of RNBP6_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SYK_HUMAN	KARS	physical	22863883
KCD12_HUMAN	KCTD12	physical	22863883
PEX5_HUMAN	PEX5	physical	22863883
CLH1_HUMAN	CLTC	physical	26344197
COPB_HUMAN	COPB1	physical	26344197
MCM7_HUMAN	MCM7	physical	26344197
ATP9A_HUMAN	ATP9A	physical	28514442
ARMX3_HUMAN	ARMCX3	physical	28514442
STEA3_HUMAN	STEAP3	physical	28514442
AT2B3_HUMAN	ATP2B3	physical	28514442
S27A2_HUMAN	SLC27A2	physical	28514442
CC033_HUMAN	C3orf33	physical	28514442
EXOG_HUMAN	EXOG	physical	28514442
TYW1B_HUMAN	TYW1B	physical	28514442
SMIM8_HUMAN	SMIM8	physical	28514442
MUL1_HUMAN	MUL1	physical	28514442
PMGT1_HUMAN	POMGNT1	physical	28514442
ZFPL1_HUMAN	ZFPL1	physical	28514442
LNP_HUMAN	KIAA1715	physical	28514442
MICU2_HUMAN	MICU2	physical	28514442
PM34_HUMAN	SLC25A17	physical	28514442
TV23C_HUMAN	TVP23C	physical	28514442
PGES2_HUMAN	PTGES2	physical	28514442
MA1B1_HUMAN	MAN1B1	physical	28514442
TIM14_HUMAN	DNAJC19	physical	28514442
DAAM1_HUMAN	DAAM1	physical	28514442
TIM16_HUMAN	PAM16	physical	28514442
TM186_HUMAN	TMEM186	physical	28514442
NOG2_HUMAN	GNL2	physical	28514442
DHR13_HUMAN	DHRS13	physical	28514442
MCL1_HUMAN	MCL1	physical	28514442
MICU1_HUMAN	MICU1	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of RNBP6_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, AND MASS SPECTROMETRY.	19413330 [Abstract]