UniProt ID | ARMX3_HUMAN | |
---|---|---|
UniProt AC | Q9UH62 | |
Protein Name | Armadillo repeat-containing X-linked protein 3 | |
Gene Name | ARMCX3 | |
Organism | Homo sapiens (Human). | |
Sequence Length | 379 | |
Subcellular Localization |
Mitochondrion outer membrane Single-pass membrane protein . Cytoplasm . Nucleus . |
|
Protein Description | Regulates mitochondrial aggregation and transport in axons in living neurons. May link mitochondria to the TRAK2-kinesin motor complex via its interaction with Miro and TRAK2. Mitochondrial distribution and dynamics is regulated through ARMCX3 protein degradation, which is promoted by PCK and negatively regulated by WNT1. Enhances the SOX10-mediated transactivation of the neuronal acetylcholine receptor subunit alpha-3 and beta-4 subunit gene promoters.. | |
Protein Sequence | MGYARKVGWVTAGLVIGAGACYCIYRLTRGRKQNKEKMAEGGSGDVDDAGDCSGARYNDWSDDDDDSNESKSIVWYPPWARIGTEAGTRARARARARATRARRAVQKRASPNSDDTVLSPQELQKVLCLVEMSEKPYILEAALIALGNNAAYAFNRDIIRDLGGLPIVAKILNTRDPIVKEKALIVLNNLSVNAENQRRLKVYMNQVCDDTITSRLNSSVQLAGLRLLTNMTVTNEYQHMLANSISDFFRLFSAGNEETKLQVLKLLLNLAENPAMTRELLRAQVPSSLGSLFNKKENKEVILKLLVIFENINDNFKWEENEPTQNQFGEGSLFFFLKEFQVCADKVLGIESHHDFLVKVKVGKFMAKLAEHMFPKSQE | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
38 | Sulfoxidation | RKQNKEKMAEGGSGD CHHCHHHHCCCCCCC | 4.27 | 21406390 | |
43 | Phosphorylation | EKMAEGGSGDVDDAG HHHCCCCCCCCCCCC | 42.55 | 23663014 | |
53 | Phosphorylation | VDDAGDCSGARYNDW CCCCCCCCCCCCCCC | 39.98 | 25849741 | |
57 | Phosphorylation | GDCSGARYNDWSDDD CCCCCCCCCCCCCCC | 19.55 | 22167270 | |
61 | Phosphorylation | GARYNDWSDDDDDSN CCCCCCCCCCCCCCC | 33.74 | 22167270 | |
67 | Phosphorylation | WSDDDDDSNESKSIV CCCCCCCCCCCCCEE | 49.87 | 22167270 | |
70 | Phosphorylation | DDDDSNESKSIVWYP CCCCCCCCCCEEEEC | 35.63 | 22167270 | |
72 | Phosphorylation | DDSNESKSIVWYPPW CCCCCCCCEEEECCC | 31.49 | 22617229 | |
76 | Phosphorylation | ESKSIVWYPPWARIG CCCCEEEECCCCCCC | 6.63 | 23403867 | |
84 | Phosphorylation | PPWARIGTEAGTRAR CCCCCCCHHHHHHHH | 21.94 | 28857561 | |
107 | Ubiquitination | RARRAVQKRASPNSD HHHHHHHHHCCCCCC | 43.25 | - | |
110 | Phosphorylation | RAVQKRASPNSDDTV HHHHHHCCCCCCCCC | 28.75 | 29255136 | |
113 | Phosphorylation | QKRASPNSDDTVLSP HHHCCCCCCCCCCCH | 40.00 | 30266825 | |
116 | Phosphorylation | ASPNSDDTVLSPQEL CCCCCCCCCCCHHHH | 28.47 | 30266825 | |
119 | Phosphorylation | NSDDTVLSPQELQKV CCCCCCCCHHHHHHH | 21.87 | 30266825 | |
170 | Ubiquitination | GGLPIVAKILNTRDP CCHHHHHHHHCCCCH | 36.51 | 21890473 | |
182 | Ubiquitination | RDPIVKEKALIVLNN CCHHHCHHHEEEEEC | 42.65 | 21890473 | |
218 | Phosphorylation | TITSRLNSSVQLAGL HHHHHHCCHHHHHHH | 36.16 | 27499020 | |
237 | Phosphorylation | NMTVTNEYQHMLANS CCCCCHHHHHHHHHH | 13.04 | - | |
260 | Ubiquitination | SAGNEETKLQVLKLL HCCCHHHHHHHHHHH | 39.95 | - | |
265 | Ubiquitination | ETKLQVLKLLLNLAE HHHHHHHHHHHHHCC | 37.93 | - | |
317 | Sumoylation | ENINDNFKWEENEPT HCCCCCCCCCCCCCC | 61.01 | - |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of ARMX3_HUMAN !! |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ARMX3_HUMAN !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ARMX3_HUMAN !! |
Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
---|---|---|---|---|
CLH1_HUMAN | CLTC | physical | 16169070 | |
MIC60_HUMAN | IMMT | physical | 16169070 | |
A4_HUMAN | APP | physical | 21832049 | |
MAF1_HUMAN | MAF1 | physical | 19060904 | |
NPM_HUMAN | NPM1 | physical | 22863883 | |
PRDX3_HUMAN | PRDX3 | physical | 22863883 |
Kegg Disease | ||||||
---|---|---|---|---|---|---|
There are no disease associations of PTM sites. | ||||||
OMIM Disease | ||||||
There are no disease associations of PTM sites. | ||||||
Kegg Drug | ||||||
There are no disease associations of PTM sites. | ||||||
DrugBank | ||||||
There are no disease associations of PTM sites. |
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Phosphorylation | |
Reference | PubMed |
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-61, AND MASSSPECTROMETRY. | |
"Large-scale phosphoproteome analysis of human liver tissue byenrichment and fractionation of phosphopeptides with strong anionexchange chromatography."; Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D.,Zou H., Gu J.; Proteomics 8:1346-1361(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-61, AND MASSSPECTROMETRY. | |
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-61 AND SER-67, AND MASSSPECTROMETRY. |