ARMX3_HUMAN - dbPTM
ARMX3_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ARMX3_HUMAN
UniProt AC Q9UH62
Protein Name Armadillo repeat-containing X-linked protein 3
Gene Name ARMCX3
Organism Homo sapiens (Human).
Sequence Length 379
Subcellular Localization Mitochondrion outer membrane
Single-pass membrane protein . Cytoplasm . Nucleus .
Protein Description Regulates mitochondrial aggregation and transport in axons in living neurons. May link mitochondria to the TRAK2-kinesin motor complex via its interaction with Miro and TRAK2. Mitochondrial distribution and dynamics is regulated through ARMCX3 protein degradation, which is promoted by PCK and negatively regulated by WNT1. Enhances the SOX10-mediated transactivation of the neuronal acetylcholine receptor subunit alpha-3 and beta-4 subunit gene promoters..
Protein Sequence MGYARKVGWVTAGLVIGAGACYCIYRLTRGRKQNKEKMAEGGSGDVDDAGDCSGARYNDWSDDDDDSNESKSIVWYPPWARIGTEAGTRARARARARATRARRAVQKRASPNSDDTVLSPQELQKVLCLVEMSEKPYILEAALIALGNNAAYAFNRDIIRDLGGLPIVAKILNTRDPIVKEKALIVLNNLSVNAENQRRLKVYMNQVCDDTITSRLNSSVQLAGLRLLTNMTVTNEYQHMLANSISDFFRLFSAGNEETKLQVLKLLLNLAENPAMTRELLRAQVPSSLGSLFNKKENKEVILKLLVIFENINDNFKWEENEPTQNQFGEGSLFFFLKEFQVCADKVLGIESHHDFLVKVKVGKFMAKLAEHMFPKSQE
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
38SulfoxidationRKQNKEKMAEGGSGD
CHHCHHHHCCCCCCC
4.2721406390
43PhosphorylationEKMAEGGSGDVDDAG
HHHCCCCCCCCCCCC
42.5523663014
53PhosphorylationVDDAGDCSGARYNDW
CCCCCCCCCCCCCCC
39.9825849741
57PhosphorylationGDCSGARYNDWSDDD
CCCCCCCCCCCCCCC
19.5522167270
61PhosphorylationGARYNDWSDDDDDSN
CCCCCCCCCCCCCCC
33.7422167270
67PhosphorylationWSDDDDDSNESKSIV
CCCCCCCCCCCCCEE
49.8722167270
70PhosphorylationDDDDSNESKSIVWYP
CCCCCCCCCCEEEEC
35.6322167270
72PhosphorylationDDSNESKSIVWYPPW
CCCCCCCCEEEECCC
31.4922617229
76PhosphorylationESKSIVWYPPWARIG
CCCCEEEECCCCCCC
6.6323403867
84PhosphorylationPPWARIGTEAGTRAR
CCCCCCCHHHHHHHH
21.9428857561
107UbiquitinationRARRAVQKRASPNSD
HHHHHHHHHCCCCCC
43.25-
110PhosphorylationRAVQKRASPNSDDTV
HHHHHHCCCCCCCCC
28.7529255136
113PhosphorylationQKRASPNSDDTVLSP
HHHCCCCCCCCCCCH
40.0030266825
116PhosphorylationASPNSDDTVLSPQEL
CCCCCCCCCCCHHHH
28.4730266825
119PhosphorylationNSDDTVLSPQELQKV
CCCCCCCCHHHHHHH
21.8730266825
170UbiquitinationGGLPIVAKILNTRDP
CCHHHHHHHHCCCCH
36.5121890473
182UbiquitinationRDPIVKEKALIVLNN
CCHHHCHHHEEEEEC
42.6521890473
218PhosphorylationTITSRLNSSVQLAGL
HHHHHHCCHHHHHHH
36.1627499020
237PhosphorylationNMTVTNEYQHMLANS
CCCCCHHHHHHHHHH
13.04-
260UbiquitinationSAGNEETKLQVLKLL
HCCCHHHHHHHHHHH
39.95-
265UbiquitinationETKLQVLKLLLNLAE
HHHHHHHHHHHHHCC
37.93-
317SumoylationENINDNFKWEENEPT
HCCCCCCCCCCCCCC
61.01-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ARMX3_HUMAN !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ARMX3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ARMX3_HUMAN !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CLH1_HUMANCLTCphysical
16169070
MIC60_HUMANIMMTphysical
16169070
A4_HUMANAPPphysical
21832049
MAF1_HUMANMAF1physical
19060904
NPM_HUMANNPM1physical
22863883
PRDX3_HUMANPRDX3physical
22863883

Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ARMX3_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-61, AND MASSSPECTROMETRY.
"Large-scale phosphoproteome analysis of human liver tissue byenrichment and fractionation of phosphopeptides with strong anionexchange chromatography.";
Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D.,Zou H., Gu J.;
Proteomics 8:1346-1361(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-61, AND MASSSPECTROMETRY.
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-61 AND SER-67, AND MASSSPECTROMETRY.

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