| UniProt ID | MIC60_HUMAN | |
|---|---|---|
| UniProt AC | Q16891 | |
| Protein Name | MICOS complex subunit MIC60 | |
| Gene Name | IMMT | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 758 | |
| Subcellular Localization |
Mitochondrion inner membrane Single-pass membrane protein . Mitochondrion . |
|
| Protein Description | Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology. [PubMed: 22114354] | |
| Protein Sequence | MLRACQLSGVTAAAQSCLCGKFVLRPLRPCRRYSTSGSSGLTTGKIAGAGLLFVGGGIGGTILYAKWDSHFRESVEKTIPYSDKLFEMVLGPAAYNVPLPKKSIQSGPLKISSVSEVMKESKQPASQLQKQKGDTPASATAPTEAAQIISAAGDTLSVPAPAVQPEESLKTDHPEIGEGKPTPALSEEASSSSIRERPPEEVAARLAQQEKQEQVKIESLAKSLEDALRQTASVTLQAIAAQNAAVQAVNAHSNILKAAMDNSEIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKEELEKMKSVIENAKKKEVAGAKPHITAAEGKLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKLSTDDLNSLIAHAHRRIDQLNRELAEQKATEKQHITLALEKQKLEEKRAFDSAVAKALEHHRSEIQAEQDRKIEEVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQELKSEFEQNLSEKLSEQELQFRRLSQEQVDNFTLDINTAYARLRGIEQAVQSHAVAEEEARKAHQLWLSVEALKYSMKTSSAETPTIPLGSAVEAIKANCSDNEFTQALTAAIPPESLTRGVYSEETLRARFYAVQKLARRVAMIDETRNSLYQYFLSYLQSLLLFPPQQLKPPPELCPEDINTFKLLSYASYCIEHGDLELAAKFVNQLKGESRRVAQDWLKEARMTLETKQIVEILTAYASAVGIGTTQVQPE | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 33 | Nitration | PLRPCRRYSTSGSSG ECCCCCCCCCCCCCC | - | ||
| 33 | Phosphorylation | PLRPCRRYSTSGSSG ECCCCCCCCCCCCCC | 26462736 | ||
| 34 | Phosphorylation | LRPCRRYSTSGSSGL CCCCCCCCCCCCCCC | 23927012 | ||
| 35 | Phosphorylation | RPCRRYSTSGSSGLT CCCCCCCCCCCCCCC | 28152594 | ||
| 36 | Phosphorylation | PCRRYSTSGSSGLTT CCCCCCCCCCCCCCC | 28152594 | ||
| 38 | Phosphorylation | RRYSTSGSSGLTTGK CCCCCCCCCCCCCCC | 30108239 | ||
| 39 | Phosphorylation | RYSTSGSSGLTTGKI CCCCCCCCCCCCCCC | 25850435 | ||
| 42 | Phosphorylation | TSGSSGLTTGKIAGA CCCCCCCCCCCCCCC | 23927012 | ||
| 43 | Phosphorylation | SGSSGLTTGKIAGAG CCCCCCCCCCCCCCE | 23927012 | ||
| 69 | Phosphorylation | ILYAKWDSHFRESVE HEEEECHHHHHHHHH | 26437602 | ||
| 74 | Phosphorylation | WDSHFRESVEKTIPY CHHHHHHHHHHHCCC | - | ||
| 77 | 2-Hydroxyisobutyrylation | HFRESVEKTIPYSDK HHHHHHHHHCCCCHH | - | ||
| 77 | Ubiquitination | HFRESVEKTIPYSDK HHHHHHHHHCCCCHH | 29967540 | ||
| 78 | Phosphorylation | FRESVEKTIPYSDKL HHHHHHHHCCCCHHH | - | ||
| 82 | Phosphorylation | VEKTIPYSDKLFEMV HHHHCCCCHHHHHHH | - | ||
| 84 | Ubiquitination | KTIPYSDKLFEMVLG HHCCCCHHHHHHHHC | 23503661 | ||
| 84 (in isoform 2) | Ubiquitination | - | - | ||
| 88 | Sulfoxidation | YSDKLFEMVLGPAAY CCHHHHHHHHCCHHH | 28465586 | ||
| 95 | Phosphorylation | MVLGPAAYNVPLPKK HHHCCHHHCCCCCCC | 26074081 | ||
| 101 | Ubiquitination | AYNVPLPKKSIQSGP HHCCCCCCCCCCCCC | 21890473 | ||
| 101 | 2-Hydroxyisobutyrylation | AYNVPLPKKSIQSGP HHCCCCCCCCCCCCC | - | ||
| 101 | Ubiquitination | AYNVPLPKKSIQSGP HHCCCCCCCCCCCCC | 21890473 | ||
| 101 (in isoform 1) | Ubiquitination | - | 21890473 | ||
| 101 (in isoform 2) | Ubiquitination | - | 21890473 | ||
| 101 (in isoform 3) | Ubiquitination | - | 21890473 | ||
| 102 | Malonylation | YNVPLPKKSIQSGPL HCCCCCCCCCCCCCC | 26320211 | ||
| 102 | Ubiquitination | YNVPLPKKSIQSGPL HCCCCCCCCCCCCCC | 21890473 | ||
| 103 | Phosphorylation | NVPLPKKSIQSGPLK CCCCCCCCCCCCCCE | 23401153 | ||
| 106 | Phosphorylation | LPKKSIQSGPLKISS CCCCCCCCCCCEEHH | 25159151 | ||
| 110 | Ubiquitination | SIQSGPLKISSVSEV CCCCCCCEEHHHHHH | 21890473 | ||
| 110 | 2-Hydroxyisobutyrylation | SIQSGPLKISSVSEV CCCCCCCEEHHHHHH | - | ||
| 110 | Malonylation | SIQSGPLKISSVSEV CCCCCCCEEHHHHHH | 26320211 | ||
| 110 | Ubiquitination | SIQSGPLKISSVSEV CCCCCCCEEHHHHHH | 21890473 | ||
| 110 (in isoform 1) | Ubiquitination | - | 21890473 | ||
| 110 (in isoform 2) | Ubiquitination | - | 21890473 | ||
| 110 (in isoform 3) | Ubiquitination | - | 21890473 | ||
| 112 | Phosphorylation | QSGPLKISSVSEVMK CCCCCEEHHHHHHHH | 30266825 | ||
| 113 | Phosphorylation | SGPLKISSVSEVMKE CCCCEEHHHHHHHHH | 30266825 | ||
| 115 | Phosphorylation | PLKISSVSEVMKESK CCEEHHHHHHHHHCC | 30266825 | ||
| 118 | Sulfoxidation | ISSVSEVMKESKQPA EHHHHHHHHHCCCCH | 21406390 | ||
| 119 | Malonylation | SSVSEVMKESKQPAS HHHHHHHHHCCCCHH | 26320211 | ||
| 119 | Ubiquitination | SSVSEVMKESKQPAS HHHHHHHHHCCCCHH | - | ||
| 121 | Phosphorylation | VSEVMKESKQPASQL HHHHHHHCCCCHHHH | 28348404 | ||
| 122 | 2-Hydroxyisobutyrylation | SEVMKESKQPASQLQ HHHHHHCCCCHHHHH | - | ||
| 122 | Ubiquitination | SEVMKESKQPASQLQ HHHHHHCCCCHHHHH | 29967540 | ||
| 126 | Phosphorylation | KESKQPASQLQKQKG HHCCCCHHHHHHHCC | 25159151 | ||
| 129 | Ubiquitination | KQPASQLQKQKGDTP CCCHHHHHHHCCCCC | 23503661 | ||
| 130 | Ubiquitination | QPASQLQKQKGDTPA CCHHHHHHHCCCCCC | 29967540 | ||
| 133 | Ubiquitination | SQLQKQKGDTPASAT HHHHHHCCCCCCCCC | 23503661 | ||
| 135 (in isoform 2) | Phosphorylation | - | 20068231 | ||
| 138 (in isoform 2) | Phosphorylation | - | 20068231 | ||
| 140 (in isoform 2) | Phosphorylation | - | 20068231 | ||
| 144 (in isoform 2) | Phosphorylation | - | 20068231 | ||
| 146 (in isoform 2) | Phosphorylation | - | 20068231 | ||
| 157 | Ubiquitination | SAAGDTLSVPAPAVQ HHCCCCEECCCCCCC | 21890473 | ||
| 157 (in isoform 2) | Phosphorylation | - | 20068231 | ||
| 168 | Phosphorylation | PAVQPEESLKTDHPE CCCCCHHHCCCCCCC | 20068231 | ||
| 169 | Ubiquitination | AVQPEESLKTDHPEI CCCCHHHCCCCCCCC | 29967540 | ||
| 171 (in isoform 3) | Phosphorylation | - | 26437602 | ||
| 180 | Malonylation | HPEIGEGKPTPALSE CCCCCCCCCCCCCCC | 26320211 | ||
| 180 | Ubiquitination | HPEIGEGKPTPALSE CCCCCCCCCCCCCCC | 29967540 | ||
| 182 | Phosphorylation | EIGEGKPTPALSEEA CCCCCCCCCCCCCCC | 29978859 | ||
| 182 (in isoform 3) | Phosphorylation | - | 26437602 | ||
| 186 | Phosphorylation | GKPTPALSEEASSSS CCCCCCCCCCCCCCC | 23401153 | ||
| 190 | Phosphorylation | PALSEEASSSSIRER CCCCCCCCCCCHHHC | 29978859 | ||
| 191 | Phosphorylation | ALSEEASSSSIRERP CCCCCCCCCCHHHCC | 29978859 | ||
| 192 | Phosphorylation | LSEEASSSSIRERPP CCCCCCCCCHHHCCH | 29978859 | ||
| 193 | Phosphorylation | SEEASSSSIRERPPE CCCCCCCCHHHCCHH | 29970186 | ||
| 200 | Acetylation | SIRERPPEEVAARLA CHHHCCHHHHHHHHH | 19608861 | ||
| 200 | Ubiquitination | SIRERPPEEVAARLA CHHHCCHHHHHHHHH | 29967540 | ||
| 210 | Acetylation | AARLAQQEKQEQVKI HHHHHHHHHHHHHHH | 19608861 | ||
| 210 | Ubiquitination | AARLAQQEKQEQVKI HHHHHHHHHHHHHHH | 29967540 | ||
| 211 | 2-Hydroxyisobutyrylation | ARLAQQEKQEQVKIE HHHHHHHHHHHHHHH | - | ||
| 211 | Acetylation | ARLAQQEKQEQVKIE HHHHHHHHHHHHHHH | 19608861 | ||
| 211 | Ubiquitination | ARLAQQEKQEQVKIE HHHHHHHHHHHHHHH | 19608861 | ||
| 212 | Ubiquitination | RLAQQEKQEQVKIES HHHHHHHHHHHHHHH | 23503661 | ||
| 216 | 2-Hydroxyisobutyrylation | QEKQEQVKIESLAKS HHHHHHHHHHHHHHH | - | ||
| 216 | Acetylation | QEKQEQVKIESLAKS HHHHHHHHHHHHHHH | 26051181 | ||
| 219 | Phosphorylation | QEQVKIESLAKSLED HHHHHHHHHHHHHHH | 20886841 | ||
| 221 | Acetylation | QVKIESLAKSLEDAL HHHHHHHHHHHHHHH | 19608861 | ||
| 222 | 2-Hydroxyisobutyrylation | VKIESLAKSLEDALR HHHHHHHHHHHHHHH | - | ||
| 222 | Acetylation | VKIESLAKSLEDALR HHHHHHHHHHHHHHH | 19608861 | ||
| 222 | Ubiquitination | VKIESLAKSLEDALR HHHHHHHHHHHHHHH | 23503661 | ||
| 223 | Phosphorylation | KIESLAKSLEDALRQ HHHHHHHHHHHHHHH | 22673903 | ||
| 226 | Ubiquitination | SLAKSLEDALRQTAS HHHHHHHHHHHHHHH | 23503661 | ||
| 227 | Ubiquitination | LAKSLEDALRQTASV HHHHHHHHHHHHHHH | 23503661 | ||
| 233 | Phosphorylation | DALRQTASVTLQAIA HHHHHHHHHHHHHHH | 26437602 | ||
| 237 | Ubiquitination | QTASVTLQAIAAQNA HHHHHHHHHHHHCHH | 23503661 | ||
| 238 | Ubiquitination | TASVTLQAIAAQNAA HHHHHHHHHHHCHHH | 23503661 | ||
| 257 | Ubiquitination | NAHSNILKAAMDNSE HHCHHHHHHHHCCCH | 23503661 | ||
| 258 | Ubiquitination | AHSNILKAAMDNSEI HCHHHHHHHHCCCHH | 23503661 | ||
| 258 (in isoform 2) | Ubiquitination | - | - | ||
| 259 | Ubiquitination | HSNILKAAMDNSEIA CHHHHHHHHCCCHHC | 23503661 | ||
| 260 | Sulfoxidation | SNILKAAMDNSEIAG HHHHHHHHCCCHHCC | 28183972 | ||
| 263 | Phosphorylation | LKAAMDNSEIAGEKK HHHHHCCCHHCCCCC | 25159151 | ||
| 268 | Ubiquitination | DNSEIAGEKKSAQWR CCCHHCCCCCHHHHH | 23503661 | ||
| 269 | Acetylation | NSEIAGEKKSAQWRT CCHHCCCCCHHHHHH | 25953088 | ||
| 269 | Ubiquitination | NSEIAGEKKSAQWRT CCHHCCCCCHHHHHH | 23503661 | ||
| 270 | Ubiquitination | SEIAGEKKSAQWRTV CHHCCCCCHHHHHHH | 23503661 | ||
| 271 | Ubiquitination | EIAGEKKSAQWRTVE HHCCCCCHHHHHHHH | 23503661 | ||
| 276 | Phosphorylation | KKSAQWRTVEGALKE CCHHHHHHHHHHHHH | 29514088 | ||
| 282 | 2-Hydroxyisobutyrylation | RTVEGALKERRKAVD HHHHHHHHHHHHHHH | - | ||
| 282 | Acetylation | RTVEGALKERRKAVD HHHHHHHHHHHHHHH | 23749302 | ||
| 282 | Malonylation | RTVEGALKERRKAVD HHHHHHHHHHHHHHH | 26320211 | ||
| 282 | Succinylation | RTVEGALKERRKAVD HHHHHHHHHHHHHHH | 23954790 | ||
| 282 | Ubiquitination | RTVEGALKERRKAVD HHHHHHHHHHHHHHH | - | ||
| 283 | Ubiquitination | TVEGALKERRKAVDE HHHHHHHHHHHHHHH | 23503661 | ||
| 286 | 2-Hydroxyisobutyrylation | GALKERRKAVDEAAD HHHHHHHHHHHHHHH | - | ||
| 286 | Acetylation | GALKERRKAVDEAAD HHHHHHHHHHHHHHH | 26051181 | ||
| 287 | Ubiquitination | ALKERRKAVDEAADA HHHHHHHHHHHHHHH | 23503661 | ||
| 304 | 2-Hydroxyisobutyrylation | KAKEELEKMKSVIEN HHHHHHHHHHHHHHH | - | ||
| 306 | 2-Hydroxyisobutyrylation | KEELEKMKSVIENAK HHHHHHHHHHHHHHH | - | ||
| 306 | Acetylation | KEELEKMKSVIENAK HHHHHHHHHHHHHHH | 24431293 | ||
| 306 | Malonylation | KEELEKMKSVIENAK HHHHHHHHHHHHHHH | 30639696 | ||
| 307 | Phosphorylation | EELEKMKSVIENAKK HHHHHHHHHHHHHHH | 28857561 | ||
| 313 | 2-Hydroxyisobutyrylation | KSVIENAKKKEVAGA HHHHHHHHHHHHCCC | - | ||
| 321 | 2-Hydroxyisobutyrylation | KKEVAGAKPHITAAE HHHHCCCCCCEECCC | - | ||
| 342 | Ubiquitination | IVDLDNVVKKVQAAQ EECHHHHHHHHHHHH | 32015554 | ||
| 343 | 2-Hydroxyisobutyrylation | VDLDNVVKKVQAAQS ECHHHHHHHHHHHHH | - | ||
| 344 | 2-Hydroxyisobutyrylation | DLDNVVKKVQAAQSE CHHHHHHHHHHHHHH | - | ||
| 346 | Ubiquitination | DNVVKKVQAAQSEAK HHHHHHHHHHHHHHH | 21890473 | ||
| 350 | Phosphorylation | KKVQAAQSEAKVVSQ HHHHHHHHHHHHHHH | 26437602 | ||
| 352 | Ubiquitination | VQAAQSEAKVVSQYH HHHHHHHHHHHHHHH | 32015554 | ||
| 353 | 2-Hydroxyisobutyrylation | QAAQSEAKVVSQYHE HHHHHHHHHHHHHHH | - | ||
| 353 | Acetylation | QAAQSEAKVVSQYHE HHHHHHHHHHHHHHH | 26051181 | ||
| 353 | Malonylation | QAAQSEAKVVSQYHE HHHHHHHHHHHHHHH | 26320211 | ||
| 353 | Ubiquitination | QAAQSEAKVVSQYHE HHHHHHHHHHHHHHH | 32015554 | ||
| 356 | Phosphorylation | QSEAKVVSQYHELVV HHHHHHHHHHHHHHH | 26437602 | ||
| 358 | Phosphorylation | EAKVVSQYHELVVQA HHHHHHHHHHHHHHC | 23312004 | ||
| 374 | Ubiquitination | DDFKRELDSITPEVL HHHHHHHHHCCCCCC | 32015554 | ||
| 375 | Phosphorylation | DFKRELDSITPEVLP HHHHHHHHCCCCCCC | 25338102 | ||
| 380 | Ubiquitination | LDSITPEVLPGWKGM HHHCCCCCCCCCCCC | 23503661 | ||
| 384 | Ubiquitination | TPEVLPGWKGMSVSD CCCCCCCCCCCCHHH | 32015554 | ||
| 385 | Acetylation | PEVLPGWKGMSVSDL CCCCCCCCCCCHHHH | 24469557 | ||
| 385 | Ubiquitination | PEVLPGWKGMSVSDL CCCCCCCCCCCHHHH | 32015554 | ||
| 387 | Sulfoxidation | VLPGWKGMSVSDLAD CCCCCCCCCHHHHHH | 28183972 | ||
| 388 | Phosphorylation | LPGWKGMSVSDLADK CCCCCCCCHHHHHHH | 29255136 | ||
| 390 | Phosphorylation | GWKGMSVSDLADKLS CCCCCCHHHHHHHCC | 29255136 | ||
| 391 | Ubiquitination | WKGMSVSDLADKLST CCCCCHHHHHHHCCH | 23503661 | ||
| 394 | Ubiquitination | MSVSDLADKLSTDDL CCHHHHHHHCCHHHH | 29967540 | ||
| 395 | Acetylation | SVSDLADKLSTDDLN CHHHHHHHCCHHHHH | 26051181 | ||
| 395 | Ubiquitination | SVSDLADKLSTDDLN CHHHHHHHCCHHHHH | 23503661 | ||
| 397 | Phosphorylation | SDLADKLSTDDLNSL HHHHHHCCHHHHHHH | 26434776 | ||
| 398 | Phosphorylation | DLADKLSTDDLNSLI HHHHHCCHHHHHHHH | 26434776 | ||
| 403 | Phosphorylation | LSTDDLNSLIAHAHR CCHHHHHHHHHHHHH | 27067055 | ||
| 408 | Ubiquitination | LNSLIAHAHRRIDQL HHHHHHHHHHHHHHH | 21890473 | ||
| 411 | Ubiquitination | LIAHAHRRIDQLNRE HHHHHHHHHHHHHHH | 23503661 | ||
| 412 | Ubiquitination | IAHAHRRIDQLNREL HHHHHHHHHHHHHHH | 23503661 | ||
| 412 (in isoform 2) | Ubiquitination | - | - | ||
| 414 | Ubiquitination | HAHRRIDQLNRELAE HHHHHHHHHHHHHHH | 23503661 | ||
| 415 | Ubiquitination | AHRRIDQLNRELAEQ HHHHHHHHHHHHHHH | 23503661 | ||
| 416 | Ubiquitination | HRRIDQLNRELAEQK HHHHHHHHHHHHHHH | 23503661 | ||
| 419 | Ubiquitination | IDQLNRELAEQKATE HHHHHHHHHHHHHHH | 21890473 | ||
| 420 | Ubiquitination | DQLNRELAEQKATEK HHHHHHHHHHHHHHH | 23503661 | ||
| 422 | Ubiquitination | LNRELAEQKATEKQH HHHHHHHHHHHHHHH | 23503661 | ||
| 423 | Ubiquitination | NRELAEQKATEKQHI HHHHHHHHHHHHHHH | 23503661 | ||
| 425 | Ubiquitination | ELAEQKATEKQHITL HHHHHHHHHHHHHHH | 29967540 | ||
| 426 | Ubiquitination | LAEQKATEKQHITLA HHHHHHHHHHHHHHH | 23503661 | ||
| 427 | 2-Hydroxyisobutyrylation | AEQKATEKQHITLAL HHHHHHHHHHHHHHH | - | ||
| 427 | Acetylation | AEQKATEKQHITLAL HHHHHHHHHHHHHHH | 25953088 | ||
| 427 | Malonylation | AEQKATEKQHITLAL HHHHHHHHHHHHHHH | 26320211 | ||
| 427 | Ubiquitination | AEQKATEKQHITLAL HHHHHHHHHHHHHHH | 23503661 | ||
| 431 | Phosphorylation | ATEKQHITLALEKQK HHHHHHHHHHHHHHH | 21406692 | ||
| 432 | Ubiquitination | TEKQHITLALEKQKL HHHHHHHHHHHHHHH | 23503661 | ||
| 435 | Ubiquitination | QHITLALEKQKLEEK HHHHHHHHHHHHHHH | 29967540 | ||
| 436 | 2-Hydroxyisobutyrylation | HITLALEKQKLEEKR HHHHHHHHHHHHHHH | - | ||
| 436 | Acetylation | HITLALEKQKLEEKR HHHHHHHHHHHHHHH | 25953088 | ||
| 436 | Malonylation | HITLALEKQKLEEKR HHHHHHHHHHHHHHH | 26320211 | ||
| 436 | Ubiquitination | HITLALEKQKLEEKR HHHHHHHHHHHHHHH | 29967540 | ||
| 439 | Ubiquitination | LALEKQKLEEKRAFD HHHHHHHHHHHHHHH | 21890473 | ||
| 440 | Acetylation | ALEKQKLEEKRAFDS HHHHHHHHHHHHHHH | 19608861 | ||
| 440 | Ubiquitination | ALEKQKLEEKRAFDS HHHHHHHHHHHHHHH | 23000965 | ||
| 440 (in isoform 2) | Ubiquitination | - | 21890473 | ||
| 442 | 2-Hydroxyisobutyrylation | EKQKLEEKRAFDSAV HHHHHHHHHHHHHHH | - | ||
| 447 | Phosphorylation | EEKRAFDSAVAKALE HHHHHHHHHHHHHHH | 30108239 | ||
| 450 | Acetylation | RAFDSAVAKALEHHR HHHHHHHHHHHHHHH | 19608861 | ||
| 450 | Ubiquitination | RAFDSAVAKALEHHR HHHHHHHHHHHHHHH | 23000965 | ||
| 450 (in isoform 3) | Ubiquitination | - | 21890473 | ||
| 451 | Ubiquitination | AFDSAVAKALEHHRS HHHHHHHHHHHHHHH | 21890473 | ||
| 451 | Acetylation | AFDSAVAKALEHHRS HHHHHHHHHHHHHHH | 19608861 | ||
| 451 | Malonylation | AFDSAVAKALEHHRS HHHHHHHHHHHHHHH | 26320211 | ||
| 451 | Ubiquitination | AFDSAVAKALEHHRS HHHHHHHHHHHHHHH | 23000965 | ||
| 451 (in isoform 1) | Ubiquitination | - | 21890473 | ||
| 458 | Phosphorylation | KALEHHRSEIQAEQD HHHHHHHHHHHHHHH | 23312004 | ||
| 463 | Ubiquitination | HRSEIQAEQDRKIEE HHHHHHHHHHHHHHH | 23503661 | ||
| 473 | Ubiquitination | RKIEEVRDAMENEMR HHHHHHHHHHHHHHH | 23503661 | ||
| 474 | Ubiquitination | KIEEVRDAMENEMRT HHHHHHHHHHHHHHH | 23503661 | ||
| 481 | Phosphorylation | AMENEMRTQLRRQAA HHHHHHHHHHHHHHH | 26437602 | ||
| 484 | Ubiquitination | NEMRTQLRRQAAAHT HHHHHHHHHHHHHCH | 23503661 | ||
| 491 | Phosphorylation | RRQAAAHTDHLRDVL HHHHHHCHHHHHHHH | 26437602 | ||
| 494 | Ubiquitination | AAAHTDHLRDVLRVQ HHHCHHHHHHHHHHH | 23503661 | ||
| 495 | Methylation | AAHTDHLRDVLRVQE HHCHHHHHHHHHHHH | 115480267 | ||
| 495 | Ubiquitination | AAHTDHLRDVLRVQE HHCHHHHHHHHHHHH | 23503661 | ||
| 495 (in isoform 2) | Ubiquitination | - | 21890473 | ||
| 504 | Ubiquitination | VLRVQEQELKSEFEQ HHHHHHHHHHHHHHH | 23503661 | ||
| 505 | Ubiquitination | LRVQEQELKSEFEQN HHHHHHHHHHHHHHH | 32015554 | ||
| 505 (in isoform 2) | Ubiquitination | - | 21890473 | ||
| 505 (in isoform 3) | Ubiquitination | - | 21890473 | ||
| 506 | 2-Hydroxyisobutyrylation | RVQEQELKSEFEQNL HHHHHHHHHHHHHHH | - | ||
| 506 | Acetylation | RVQEQELKSEFEQNL HHHHHHHHHHHHHHH | 26051181 | ||
| 506 | Ubiquitination | RVQEQELKSEFEQNL HHHHHHHHHHHHHHH | 21906983 | ||
| 506 (in isoform 1) | Ubiquitination | - | 21890473 | ||
| 507 | Phosphorylation | VQEQELKSEFEQNLS HHHHHHHHHHHHHHH | 20833797 | ||
| 514 | Phosphorylation | SEFEQNLSEKLSEQE HHHHHHHHHHHCHHH | 25159151 | ||
| 515 | Ubiquitination | EFEQNLSEKLSEQEL HHHHHHHHHHCHHHH | 32015554 | ||
| 515 (in isoform 3) | Ubiquitination | - | 21890473 | ||
| 516 | 2-Hydroxyisobutyrylation | FEQNLSEKLSEQELQ HHHHHHHHHCHHHHH | - | ||
| 516 | Acetylation | FEQNLSEKLSEQELQ HHHHHHHHHCHHHHH | 25038526 | ||
| 516 | Ubiquitination | FEQNLSEKLSEQELQ HHHHHHHHHCHHHHH | 21906983 | ||
| 516 (in isoform 1) | Ubiquitination | - | 21890473 | ||
| 518 | Phosphorylation | QNLSEKLSEQELQFR HHHHHHHCHHHHHHH | 26437602 | ||
| 522 | Ubiquitination | EKLSEQELQFRRLSQ HHHCHHHHHHHHCCH | 23503661 | ||
| 528 | Phosphorylation | ELQFRRLSQEQVDNF HHHHHHCCHHHHHHC | 25849741 | ||
| 533 | Ubiquitination | RLSQEQVDNFTLDIN HCCHHHHHHCEEEHH | 23503661 | ||
| 534 | Ubiquitination | LSQEQVDNFTLDINT CCHHHHHHCEEEHHH | 23503661 | ||
| 536 | Phosphorylation | QEQVDNFTLDINTAY HHHHHHCEEEHHHHH | 28102081 | ||
| 538 | Ubiquitination | QVDNFTLDINTAYAR HHHHCEEEHHHHHHH | 23503661 | ||
| 545 | Ubiquitination | DINTAYARLRGIEQA EHHHHHHHHHCHHHH | 23503661 | ||
| 549 | Ubiquitination | AYARLRGIEQAVQSH HHHHHHCHHHHHHHC | 23503661 | ||
| 553 | Ubiquitination | LRGIEQAVQSHAVAE HHCHHHHHHHCCCCH | 23503661 | ||
| 554 | Ubiquitination | RGIEQAVQSHAVAEE HCHHHHHHHCCCCHH | 23503661 | ||
| 554 (in isoform 2) | Ubiquitination | - | - | ||
| 555 | Phosphorylation | GIEQAVQSHAVAEEE CHHHHHHHCCCCHHH | 20833797 | ||
| 564 | Ubiquitination | AVAEEEARKAHQLWL CCCHHHHHHHHHHHH | 23503661 | ||
| 565 | Acetylation | VAEEEARKAHQLWLS CCHHHHHHHHHHHHH | 26051181 | ||
| 565 | Ubiquitination | VAEEEARKAHQLWLS CCHHHHHHHHHHHHH | 23503661 | ||
| 566 | Ubiquitination | AEEEARKAHQLWLSV CHHHHHHHHHHHHHH | 23503661 | ||
| 569 | Ubiquitination | EARKAHQLWLSVEAL HHHHHHHHHHHHHHH | 23503661 | ||
| 570 | Ubiquitination | ARKAHQLWLSVEALK HHHHHHHHHHHHHHH | 23503661 | ||
| 570 (in isoform 2) | Ubiquitination | - | 21890473 | ||
| 572 | Phosphorylation | KAHQLWLSVEALKYS HHHHHHHHHHHHHHH | 20860994 | ||
| 576 | Ubiquitination | LWLSVEALKYSMKTS HHHHHHHHHHHCCCC | 23503661 | ||
| 577 | Ubiquitination | WLSVEALKYSMKTSS HHHHHHHHHHCCCCC | 23503661 | ||
| 578 | Phosphorylation | LSVEALKYSMKTSSA HHHHHHHHHCCCCCC | 20860994 | ||
| 579 | Phosphorylation | SVEALKYSMKTSSAE HHHHHHHHCCCCCCC | 20860994 | ||
| 580 | Ubiquitination | VEALKYSMKTSSAET HHHHHHHCCCCCCCC | 23503661 | ||
| 580 (in isoform 3) | Ubiquitination | - | 21890473 | ||
| 581 | Ubiquitination | EALKYSMKTSSAETP HHHHHHCCCCCCCCC | 21906983 | ||
| 581 (in isoform 1) | Ubiquitination | - | 21890473 | ||
| 582 | Phosphorylation | ALKYSMKTSSAETPT HHHHHCCCCCCCCCC | 25850435 | ||
| 583 | Phosphorylation | LKYSMKTSSAETPTI HHHHCCCCCCCCCCC | 25850435 | ||
| 584 | Phosphorylation | KYSMKTSSAETPTIP HHHCCCCCCCCCCCC | 25850435 | ||
| 587 | Phosphorylation | MKTSSAETPTIPLGS CCCCCCCCCCCCCCH | 25850435 | ||
| 589 | Phosphorylation | TSSAETPTIPLGSAV CCCCCCCCCCCCHHH | 25850435 | ||
| 589 | Ubiquitination | TSSAETPTIPLGSAV CCCCCCCCCCCCHHH | 29967540 | ||
| 594 | Phosphorylation | TPTIPLGSAVEAIKA CCCCCCCHHHHHHHH | 25850435 | ||
| 597 | Ubiquitination | IPLGSAVEAIKANCS CCCCHHHHHHHHHCC | 21890473 | ||
| 599 | Ubiquitination | LGSAVEAIKANCSDN CCHHHHHHHHHCCCC | 29967540 | ||
| 600 | Ubiquitination | GSAVEAIKANCSDNE CHHHHHHHHHCCCCH | 29967540 | ||
| 608 | Ubiquitination | ANCSDNEFTQALTAA HHCCCCHHHHHHHHC | 21890473 | ||
| 626 | Phosphorylation | ESLTRGVYSEETLRA HHHCCCCCCHHHHHH | 28152594 | ||
| 627 | Phosphorylation | SLTRGVYSEETLRAR HHCCCCCCHHHHHHH | 28152594 | ||
| 628 | Ubiquitination | LTRGVYSEETLRARF HCCCCCCHHHHHHHH | 21890473 | ||
| 629 | Ubiquitination | TRGVYSEETLRARFY CCCCCCHHHHHHHHH | 21890473 | ||
| 629 (in isoform 2) | Ubiquitination | - | 21890473 | ||
| 630 | Phosphorylation | RGVYSEETLRARFYA CCCCCHHHHHHHHHH | 21815630 | ||
| 636 | Phosphorylation | ETLRARFYAVQKLAR HHHHHHHHHHHHHHH | 26437602 | ||
| 639 | Ubiquitination | RARFYAVQKLARRVA HHHHHHHHHHHHHHH | 21890473 | ||
| 640 | Ubiquitination | ARFYAVQKLARRVAM HHHHHHHHHHHHHHC | 21890473 | ||
| 640 | Acetylation | ARFYAVQKLARRVAM HHHHHHHHHHHHHHC | 25953088 | ||
| 640 | Ubiquitination | ARFYAVQKLARRVAM HHHHHHHHHHHHHHC | 21890473 | ||
| 640 (in isoform 1) | Ubiquitination | - | 21890473 | ||
| 651 | Phosphorylation | RVAMIDETRNSLYQY HHHCHHCHHHHHHHH | 21406692 | ||
| 665 | Ubiquitination | YFLSYLQSLLLFPPQ HHHHHHHHHHCCCHH | 23503661 | ||
| 671 | Ubiquitination | QSLLLFPPQQLKPPP HHHHCCCHHHCCCCC | 23503661 | ||
| 676 | Ubiquitination | FPPQQLKPPPELCPE CCHHHCCCCCCCCCC | 23503661 | ||
| 682 | Ubiquitination | KPPPELCPEDINTFK CCCCCCCCCCCCHHH | 23503661 | ||
| 683 | Ubiquitination | PPPELCPEDINTFKL CCCCCCCCCCCHHHH | 23503661 | ||
| 693 | Phosphorylation | NTFKLLSYASYCIEH CHHHHHHHHHHHHHH | - | ||
| 694 | Ubiquitination | TFKLLSYASYCIEHG HHHHHHHHHHHHHHC | 23503661 | ||
| 695 | Phosphorylation | FKLLSYASYCIEHGD HHHHHHHHHHHHHCC | - | ||
| 696 | Phosphorylation | KLLSYASYCIEHGDL HHHHHHHHHHHHCCH | - | ||
| 696 | Ubiquitination | KLLSYASYCIEHGDL HHHHHHHHHHHHCCH | 23503661 | ||
| 697 | Ubiquitination | LLSYASYCIEHGDLE HHHHHHHHHHHCCHH | 23503661 | ||
| 702 | Ubiquitination | SYCIEHGDLELAAKF HHHHHHCCHHHHHHH | 23503661 | ||
| 703 | Ubiquitination | YCIEHGDLELAAKFV HHHHHCCHHHHHHHH | 33845483 | ||
| 703 (in isoform 2) | Ubiquitination | - | - | ||
| 707 | Ubiquitination | HGDLELAAKFVNQLK HCCHHHHHHHHHHHC | 23503661 | ||
| 708 | Ubiquitination | GDLELAAKFVNQLKG CCHHHHHHHHHHHCC | 23503661 | ||
| 713 | Ubiquitination | AAKFVNQLKGESRRV HHHHHHHHCCCHHHH | 33845483 | ||
| 714 | 2-Hydroxyisobutyrylation | AKFVNQLKGESRRVA HHHHHHHCCCHHHHH | - | ||
| 714 | Acetylation | AKFVNQLKGESRRVA HHHHHHHCCCHHHHH | 26051181 | ||
| 714 | Succinylation | AKFVNQLKGESRRVA HHHHHHHCCCHHHHH | 23954790 | ||
| 714 | Ubiquitination | AKFVNQLKGESRRVA HHHHHHHCCCHHHHH | 33845483 | ||
| 715 | Ubiquitination | KFVNQLKGESRRVAQ HHHHHHCCCHHHHHH | 23503661 | ||
| 715 (in isoform 2) | Ubiquitination | - | - | ||
| 725 | Ubiquitination | RRVAQDWLKEARMTL HHHHHHHHHHHHHHH | 23503661 | ||
| 726 | 2-Hydroxyisobutyrylation | RVAQDWLKEARMTLE HHHHHHHHHHHHHHC | - | ||
| 726 | Acetylation | RVAQDWLKEARMTLE HHHHHHHHHHHHHHC | 25953088 | ||
| 726 | Ubiquitination | RVAQDWLKEARMTLE HHHHHHHHHHHHHHC | 23503661 | ||
| 731 | Phosphorylation | WLKEARMTLETKQIV HHHHHHHHHCHHHHH | - | ||
| 734 | Phosphorylation | EARMTLETKQIVEIL HHHHHHCHHHHHHHH | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
| 528 | S | Phosphorylation | Kinase | PRKACA | P17612 | GPS |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of MIC60_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of MIC60_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| PRC2A_HUMAN | PRRC2A | physical | 14667819 | |
| NDEL1_HUMAN | NDEL1 | physical | 20880836 | |
| DISC1_HUMAN | DISC1 | physical | 20880836 | |
| MYOME_HUMAN | PDE4DIP | physical | 21900206 | |
| ALBU_HUMAN | ALB | physical | 21900206 | |
| EF1A1_HUMAN | EEF1A1 | physical | 21900206 | |
| PIAS4_HUMAN | PIAS4 | physical | 15383276 | |
| HAP1_HUMAN | HAP1 | physical | 15383276 | |
| MIC60_HUMAN | IMMT | physical | 15383276 | |
| LRIF1_HUMAN | LRIF1 | physical | 15383276 | |
| NDUA9_HUMAN | NDUFA9 | physical | 22939629 | |
| IMA1_HUMAN | KPNA2 | physical | 21988832 | |
| NDUA9_HUMAN | NDUFA9 | physical | 26344197 | |
| SGPL1_HUMAN | SGPL1 | physical | 26344197 | |
| VDAC1_HUMAN | VDAC1 | physical | 26344197 | |
| VDAC2_HUMAN | VDAC2 | physical | 26344197 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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