NDUA9_HUMAN - dbPTM
NDUA9_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID NDUA9_HUMAN
UniProt AC Q16795
Protein Name NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial
Gene Name NDUFA9
Organism Homo sapiens (Human).
Sequence Length 377
Subcellular Localization Mitochondrion matrix .
Protein Description Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone..
Protein Sequence MAAAAQSRVVRVLSMSRSAITAIATSVCHGPPCRQLHHALMPHGKGGRSSVSGIVATVFGATGFLGRYVVNHLGRMGSQVIIPYRCDKYDIMHLRPMGDLGQLLFLEWDARDKDSIRRVVQHSNVVINLIGRDWETKNFDFEDVFVKIPQAIAQLSKEAGVEKFIHVSHLNANIKSSSRYLRNKAVGEKVVRDAFPEAIIVKPSDIFGREDRFLNSFASMHRFGPIPLGSLGWKTVKQPVYVVDVSKGIVNAVKDPDANGKSFAFVGPSRYLLFHLVKYIFAVAHRLFLPFPLPLFAYRWVARVFEISPFEPWITRDKVERMHITDMKLPHLPGLEDLGIQATPLELKAIEVLRRHRTYRWLSAEIEDVKPAKTVNI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
7Phosphorylation-MAAAAQSRVVRVLS
-CCHHHHHHHHHHHH		23.4724719451
14PhosphorylationSRVVRVLSMSRSAIT
HHHHHHHHCCHHHHH		16.3224043423
16PhosphorylationVVRVLSMSRSAITAI
HHHHHHCCHHHHHHH		21.5124719451
57PhosphorylationSVSGIVATVFGATGF
CHHHHHHHHHCCCCH		12.8922210691
75MethylationYVVNHLGRMGSQVII
HHHHHHHCCCCEEEE		32.42115485741
78PhosphorylationNHLGRMGSQVIIPYR
HHHHCCCCEEEEEEC		16.3620068231
84PhosphorylationGSQVIIPYRCDKYDI
CCEEEEEECCCCCCE		17.2921406692
123PhosphorylationIRRVVQHSNVVINLI
HHHHHHHCCEEEEEC		17.7720068231
137UbiquitinationIGRDWETKNFDFEDV
CCCCCCCCCCCHHHH		44.0721906983
147UbiquitinationDFEDVFVKIPQAIAQ
CHHHHHHHHHHHHHH		36.8923503661
157UbiquitinationQAIAQLSKEAGVEKF
HHHHHHHHHHCCCEE		61.2423503661
163UbiquitinationSKEAGVEKFIHVSHL
HHHHCCCEEEEHHHH		47.4123503661
175SuccinylationSHLNANIKSSSRYLR
HHHCCCCCCCHHHHH		44.0623954790
175MalonylationSHLNANIKSSSRYLR
HHHCCCCCCCHHHHH		44.0626320211
175SuccinylationSHLNANIKSSSRYLR
HHHCCCCCCCHHHHH		44.06-
189SuccinylationRNKAVGEKVVRDAFP
HHHHHCCHHHHHHCC		39.8527452117
189MalonylationRNKAVGEKVVRDAFP
HHHHHCCHHHHHHCC		39.8526320211
1892-HydroxyisobutyrylationRNKAVGEKVVRDAFP
HHHHHCCHHHHHHCC		39.85-
189UbiquitinationRNKAVGEKVVRDAFP
HHHHHCCHHHHHHCC		39.8524816145
189AcetylationRNKAVGEKVVRDAFP
HHHHHCCHHHHHHCC		39.8525953088
202UbiquitinationFPEAIIVKPSDIFGR
CCCCEEECHHHHCCC		28.5323503661
204PhosphorylationEAIIVKPSDIFGRED
CCEEECHHHHCCCCH		37.31-
234UbiquitinationPLGSLGWKTVKQPVY
CCCCCCCEECCCCEE		41.4622817900
234AcetylationPLGSLGWKTVKQPVY
CCCCCCCEECCCCEE		41.4630590943
237UbiquitinationSLGWKTVKQPVYVVD
CCCCEECCCCEEEEE		54.8622817900
247AcetylationVYVVDVSKGIVNAVK
EEEEECCCCHHHHHC		53.1326051181
254AcetylationKGIVNAVKDPDANGK
CCHHHHHCCCCCCCC		62.2226051181
254UbiquitinationKGIVNAVKDPDANGK
CCHHHHHCCCCCCCC		62.2222817900
254SuccinylationKGIVNAVKDPDANGK
CCHHHHHCCCCCCCC		62.2223954790
328AcetylationRMHITDMKLPHLPGL
CCEECCCCCCCCCCC		62.7723954790
343PhosphorylationEDLGIQATPLELKAI
HHHCCCCCCHHHHHH		16.42-
348AcetylationQATPLELKAIEVLRR
CCCCHHHHHHHHHHH		37.6326051181
348UbiquitinationQATPLELKAIEVLRR
CCCCHHHHHHHHHHH		37.6333845483
370UbiquitinationSAEIEDVKPAKTVNI
HCCCCCCCCCCCCCC		52.1323503661
370AcetylationSAEIEDVKPAKTVNI
HCCCCCCCCCCCCCC		52.1326051181
373UbiquitinationIEDVKPAKTVNI---
CCCCCCCCCCCC---		62.6323503661
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of NDUA9_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of NDUA9_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of NDUA9_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
NDUS1_HUMANNDUFS1physical
22939629
NDUV1_HUMANNDUFV1physical
22939629
NDUAC_HUMANNDUFA12physical
22939629
NDUB8_HUMANNDUFB8physical
22939629
NNTM_HUMANNNTphysical
22939629
OPA1_HUMANOPA1physical
22939629
AFG32_HUMANAFG3L2physical
26344197
VATC1_HUMANATP6V1C1physical
26344197
IQGA1_HUMANIQGAP1physical
26344197
NDUA6_HUMANNDUFA6physical
26344197
NDUBA_HUMANNDUFB10physical
26344197
SSRA_HUMANSSR1physical
26344197
NDUAB_HUMANNDUFA11physical
24344204
EMC8_HUMANEMC8physical
24344204
NDUS6_HUMANNDUFS6physical
24344204
NDUA6_HUMANNDUFA6physical
24344204
NU5M_HUMANND5physical
24344204
NDUV3_HUMANNDUFV3physical
24344204
NDUV2_HUMANNDUFV2physical
24344204
CYB_HUMANCYTBphysical
24344204
NDUBA_HUMANNDUFB10physical
24344204
NDUS4_HUMANNDUFS4physical
24344204
NDUB8_HUMANNDUFB8physical
24344204
NDUB4_HUMANNDUFB4physical
24344204
NDUA2_HUMANNDUFA2physical
24344204
NDUS2_HUMANNDUFS2physical
24344204
NDUB3_HUMANNDUFB3physical
24344204
QCR9_HUMANUQCR10physical
24344204
NDUA5_HUMANNDUFA5physical
24344204
NDUS7_HUMANNDUFS7physical
24344204
NDUB5_HUMANNDUFB5physical
24344204
NDUV1_HUMANNDUFV1physical
24344204
NDUBB_HUMANNDUFB11physical
24344204
NDUS1_HUMANNDUFS1physical
24344204
NDUS3_HUMANNDUFS3physical
24344204
NDUAC_HUMANNDUFA12physical
24344204
NDUA7_HUMANNDUFA7physical
24344204
NDUAA_HUMANNDUFA10physical
24344204
UCRI_HUMANUQCRFS1physical
24344204
MCU_HUMANMCUphysical
24344204
ACPM_HUMANNDUFAB1physical
24344204
NDUB7_HUMANNDUFB7physical
24344204
NDUS8_HUMANNDUFS8physical
24344204
NDUB1_HUMANNDUFB1physical
24344204
TIDC1_HUMANTIMMDC1physical
24344204
SOAT1_HUMANSOAT1physical
27173435
NDUS1_HUMANNDUFS1physical
27173435
ACAP2_HUMANACAP2physical
27173435
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of NDUA9_HUMAN

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Related Literatures of Post-Translational Modification

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