NDUAC_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NDUAC_HUMAN
• UniProt AC: Q9UI09
• Protein Name: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12
• Gene Name: NDUFA12
• Organism: Homo sapiens (Human).
• Sequence Length: 145
• Subcellular Localization: Mitochondrion inner membrane ; Peripheral membrane protein ; Matrix side .
• Protein Description: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone..
• Protein Sequence: MELVQVLKRGLQQITGHGGLRGYLRVFFRTNDAKVGTLVGEDKYGNKYYEDNKQFFGRHRWVVYTTEMNGKNTFWDVDGSMVPPEWHRWLHSMTDDPPTTKPLTARKFIWTNHKFNVTGTPEQYVPYSTTRKKIQEWIPPSTPYK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MELVQVLK -------CHHHHHHH	8.96	22814378
8	Ubiquitination	MELVQVLKRGLQQIT CHHHHHHHHHHHHHH	45.63	23000965
8	2-Hydroxyisobutyrylation	MELVQVLKRGLQQIT CHHHHHHHHHHHHHH	45.63	-
34	Acetylation	FFRTNDAKVGTLVGE EEECCCCCEEEEEEE	44.02	27452117
43	Acetylation	GTLVGEDKYGNKYYE EEEEEECCCCCEEEE	51.24	25825284
43	Ubiquitination	GTLVGEDKYGNKYYE EEEEEECCCCCEEEE	51.24	33845483
43	Malonylation	GTLVGEDKYGNKYYE EEEEEECCCCCEEEE	51.24	26320211
47	Acetylation	GEDKYGNKYYEDNKQ EECCCCCEEEECCCE	44.86	25038526
48	Nitrated tyrosine	EDKYGNKYYEDNKQF ECCCCCEEEECCCEE	18.98	-
48	Nitration	EDKYGNKYYEDNKQF ECCCCCEEEECCCEE	18.98	12857734
49	Nitrated tyrosine	DKYGNKYYEDNKQFF CCCCCEEEECCCEEE	20.58	-
49	Nitration	DKYGNKYYEDNKQFF CCCCCEEEECCCEEE	20.58	12857734
53	Acetylation	NKYYEDNKQFFGRHR CEEEECCCEEECCCC	61.88	25038526
101	Acetylation	TDDPPTTKPLTARKF CCCCCCCCCCEEEEE	40.27	25825284
101	Ubiquitination	TDDPPTTKPLTARKF CCCCCCCCCCEEEEE	40.27	21890473
101	Malonylation	TDDPPTTKPLTARKF CCCCCCCCCCEEEEE	40.27	26320211
102	Ubiquitination	DDPPTTKPLTARKFI CCCCCCCCCEEEEEE	32.62	21890473
120	Phosphorylation	HKFNVTGTPEQYVPY CCCCCCCCHHHCCCC	17.81	28152594
124	Phosphorylation	VTGTPEQYVPYSTTR CCCCHHHCCCCCCCC	11.17	28152594
127	Phosphorylation	TPEQYVPYSTTRKKI CHHHCCCCCCCCHHH	14.49	28152594
128	Phosphorylation	PEQYVPYSTTRKKIQ HHHCCCCCCCCHHHH	19.75	28152594
129	Phosphorylation	EQYVPYSTTRKKIQE HHCCCCCCCCHHHHH	25.44	28152594
130	Phosphorylation	QYVPYSTTRKKIQEW HCCCCCCCCHHHHHH	34.25	28152594
141	Phosphorylation	IQEWIPPSTPYK--- HHHHCCCCCCCC---	36.34	20860994
142	Phosphorylation	QEWIPPSTPYK---- HHHCCCCCCCC----	36.09	30624053

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
120	T	Phosphorylation	Kinase	CDK1	P06493	PSP
142	T	Phosphorylation	Kinase	CDK1	P06493	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NDUAC_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NDUAC_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ZN768_HUMAN	ZNF768	physical	21900206
NDUS4_HUMAN	NDUFS4	physical	22939629
NDUS1_HUMAN	NDUFS1	physical	22939629
NDUB9_HUMAN	NDUFB9	physical	22939629
SURF1_HUMAN	SURF1	physical	22939629
RM15_HUMAN	MRPL15	physical	22939629
TOM22_HUMAN	TOMM22	physical	22939629
NDUA6_HUMAN	NDUFA6	physical	26344197
QCR6_HUMAN	UQCRH	physical	24344204
NDUB9_HUMAN	NDUFB9	physical	24344204
COX6C_HUMAN	COX6C	physical	24344204
NDUB7_HUMAN	NDUFB7	physical	24344204
NDUB5_HUMAN	NDUFB5	physical	24344204
NDUA6_HUMAN	NDUFA6	physical	24344204
BAD_HUMAN	BAD	physical	24344204
MIC60_HUMAN	IMMT	physical	24344204
NDUAD_HUMAN	NDUFA13	physical	24344204
NDUB3_HUMAN	NDUFB3	physical	24344204
NDUS6_HUMAN	NDUFS6	physical	24344204
NDUS4_HUMAN	NDUFS4	physical	24344204
NDUS1_HUMAN	NDUFS1	physical	24344204
NDUB8_HUMAN	NDUFB8	physical	24344204
NDUV1_HUMAN	NDUFV1	physical	24344204
NDUB6_HUMAN	NDUFB6	physical	24344204
NDUV2_HUMAN	NDUFV2	physical	24344204
NDUA9_HUMAN	NDUFA9	physical	24344204
QCR1_HUMAN	UQCRC1	physical	24344204
NDUV3_HUMAN	NDUFV3	physical	24344204
NDUS2_HUMAN	NDUFS2	physical	24344204
NU5M_HUMAN	ND5	physical	24344204
NDUAB_HUMAN	NDUFA11	physical	24344204
MIC27_HUMAN	APOOL	physical	24344204
NDUBA_HUMAN	NDUFB10	physical	24344204
NDUA7_HUMAN	NDUFA7	physical	24344204
UCRI_HUMAN	UQCRFS1	physical	24344204
NDUB4_HUMAN	NDUFB4	physical	24344204
NDUS3_HUMAN	NDUFS3	physical	24344204
NU1M_HUMAN	ND1	physical	24344204
NDUBB_HUMAN	NDUFB11	physical	24344204
NDUS8_HUMAN	NDUFS8	physical	24344204
NDUA5_HUMAN	NDUFA5	physical	24344204
NDUS7_HUMAN	NDUFS7	physical	24344204
NDUA4_HUMAN	NDUFA4	physical	24344204
NDUA2_HUMAN	NDUFA2	physical	24344204

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 256000: Leigh syndrome (LS)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.