dbPTM

NDUA7_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	NDUA7_HUMAN
UniProt AC	O95182
Protein Name	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7
Gene Name	NDUFA7
Organism	Homo sapiens (Human).
Sequence Length	113
Subcellular Localization	Mitochondrion inner membrane Peripheral membrane protein Matrix side .
Protein Description	Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone..
Protein Sequence	MASATRLIQRLRNWASGHDLQGKLQLRYQEISKRTQPPPKLPVGPSHKLSNNYYCTRDGRRESVPPSIIMSSQKALVSGKPAESSAVAATEKKAVTPAPPIKRWELSSDQPYL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MASATRLIQ ------CCHHHHHHH	14.10	-
3	Phosphorylation	-----MASATRLIQR -----CCHHHHHHHH	28.95	28270605
5	Phosphorylation	---MASATRLIQRLR ---CCHHHHHHHHHH	24.42	28270605
12	Methylation	TRLIQRLRNWASGHD HHHHHHHHHHHCCCC	38.54	115484701
23	Ubiquitination	SGHDLQGKLQLRYQE CCCCCHHHHHHHHHH	21.79	22817900
32	Phosphorylation	QLRYQEISKRTQPPP HHHHHHHHHHCCCCC	18.48	23312004
33	2-Hydroxyisobutyrylation	LRYQEISKRTQPPPK HHHHHHHHHCCCCCC	66.19	-
40	Succinylation	KRTQPPPKLPVGPSH HHCCCCCCCCCCCCC	71.80	27452117
40	Malonylation	KRTQPPPKLPVGPSH HHCCCCCCCCCCCCC	71.80	26320211
40	Acetylation	KRTQPPPKLPVGPSH HHCCCCCCCCCCCCC	71.80	-
53	Phosphorylation	SHKLSNNYYCTRDGR CCCCCCCEEECCCCC	12.27	21945579
54	Phosphorylation	HKLSNNYYCTRDGRR CCCCCCEEECCCCCC	6.89	21945579
56	Phosphorylation	LSNNYYCTRDGRRES CCCCEEECCCCCCCC	18.70	21945579
63	Phosphorylation	TRDGRRESVPPSIIM CCCCCCCCCCHHHEE	37.81	23312004
67	Phosphorylation	RRESVPPSIIMSSQK CCCCCCHHHEEECCE	20.76	18691976
78	Phosphorylation	SSQKALVSGKPAESS ECCEEHHCCCCCCCC	41.78	17081983
80	Malonylation	QKALVSGKPAESSAV CEEHHCCCCCCCCCC	33.28	26320211
80	Acetylation	QKALVSGKPAESSAV CEEHHCCCCCCCCCC	33.28	26051181
84	Phosphorylation	VSGKPAESSAVAATE HCCCCCCCCCCCCCC	26.21	26437602
85	Phosphorylation	SGKPAESSAVAATEK CCCCCCCCCCCCCCC	20.47	-
90	Phosphorylation	ESSAVAATEKKAVTP CCCCCCCCCCCCCCC	38.30	-
92	2-Hydroxyisobutyrylation	SAVAATEKKAVTPAP CCCCCCCCCCCCCCC	41.50	-
92	Acetylation	SAVAATEKKAVTPAP CCCCCCCCCCCCCCC	41.50	26051181
96	Phosphorylation	ATEKKAVTPAPPIKR CCCCCCCCCCCCCCC	20.70	23312004
102	2-Hydroxyisobutyrylation	VTPAPPIKRWELSSD CCCCCCCCCEECCCC	58.18	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of NDUA7_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of NDUA7_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of NDUA7_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
AAKB1_HUMAN	PRKAB1	physical	16169070
RL38_HUMAN	RPL38	physical	22939629
TIM44_HUMAN	TIMM44	physical	22939629
RRBP1_HUMAN	RRBP1	physical	22939629
PIN1_HUMAN	PIN1	physical	22939629
SBDS_HUMAN	SBDS	physical	22939629
RAB8A_HUMAN	RAB8A	physical	22939629
PDLI5_HUMAN	PDLIM5	physical	22939629
RBM27_HUMAN	RBM27	physical	22939629
RRFM_HUMAN	MRRF	physical	22939629
TAGL_HUMAN	TAGLN	physical	22939629
PIN4_HUMAN	PIN4	physical	22939629
RAGP1_HUMAN	RANGAP1	physical	22939629
UBL4A_HUMAN	UBL4A	physical	22939629
PDLI7_HUMAN	PDLIM7	physical	22939629
TPX2_HUMAN	TPX2	physical	22939629
UB2L3_HUMAN	UBE2L3	physical	22939629
SNX3_HUMAN	SNX3	physical	22939629
ECI2_HUMAN	ECI2	physical	22939629
RIDA_HUMAN	HRSP12	physical	22939629
RBMS1_HUMAN	RBMS1	physical	22939629
SUGP1_HUMAN	SUGP1	physical	22939629
QKI_HUMAN	QKI	physical	22939629
PQBP1_HUMAN	PQBP1	physical	22939629
PAF15_HUMAN	KIAA0101	physical	22939629
TBL2_HUMAN	TBL2	physical	22939629
RFX5_HUMAN	RFX5	physical	22939629
STX7_HUMAN	STX7	physical	22939629
MPLKI_HUMAN	MPLKIP	physical	22939629
RU1C_HUMAN	SNRPC	physical	22939629
SCO2_HUMAN	SCO2	physical	22939629
SOSB1_HUMAN	NABP2	physical	22939629
RT28_HUMAN	MRPS28	physical	22939629
ZC11A_HUMAN	ZC3H11A	physical	22939629
RM14_HUMAN	MRPL14	physical	22939629
OLA1_HUMAN	OLA1	physical	22939629
SRRM2_HUMAN	SRRM2	physical	22939629
TOM40_HUMAN	TOMM40	physical	22939629
RS28_HUMAN	RPS28	physical	22939629
UBC9_HUMAN	UBE2I	physical	22939629
P66B_HUMAN	GATAD2B	physical	22939629
UBE4B_HUMAN	UBE4B	physical	22939629
VDAC3_HUMAN	VDAC3	physical	22939629
NLTP_HUMAN	SCP2	physical	22939629
THIK_HUMAN	ACAA1	physical	22939629
NU214_HUMAN	NUP214	physical	22939629
MDFI_HUMAN	MDFI	physical	19060904

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of NDUA7_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-63, AND MASSSPECTROMETRY.	18220336 [Abstract]