dbPTM

RL38_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	RL38_HUMAN
UniProt AC	P63173
Protein Name	60S ribosomal protein L38
Gene Name	RPL38
Organism	Homo sapiens (Human).
Sequence Length	70
Subcellular Localization
Protein Description
Protein Sequence	MPRKIEEIKDFLLTARRKDAKSVKIKKNKDNVKFKVRCSRYLYTLVITDKEKAEKLKQSLPPGLAVKELK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Ubiquitination	----MPRKIEEIKDF ----CCCCHHHHHHH	48.91	21906983
4	Sumoylation	----MPRKIEEIKDF ----CCCCHHHHHHH	48.91	28112733
4	2-Hydroxyisobutyrylation	----MPRKIEEIKDF ----CCCCHHHHHHH	48.91	-
9	Acetylation	PRKIEEIKDFLLTAR CCCHHHHHHHHHHHH	45.79	19608861
9	Ubiquitination	PRKIEEIKDFLLTAR CCCHHHHHHHHHHHH	45.79	21890473
9	2-Hydroxyisobutyrylation	PRKIEEIKDFLLTAR CCCHHHHHHHHHHHH	45.79	-
9	Sumoylation	PRKIEEIKDFLLTAR CCCHHHHHHHHHHHH	45.79	28112733
9	Sumoylation	PRKIEEIKDFLLTAR CCCHHHHHHHHHHHH	45.79	-
9	Ubiquitination	PRKIEEIKDFLLTAR CCCHHHHHHHHHHHH	45.79	21906983
14	Phosphorylation	EIKDFLLTARRKDAK HHHHHHHHHHCCCCC	21.92	-
16	Methylation	KDFLLTARRKDAKSV HHHHHHHHCCCCCCC	40.73	115492169
33	Ubiquitination	KKNKDNVKFKVRCSR ECCCCCCEEEEEEEE	45.80	21906983
39	Phosphorylation	VKFKVRCSRYLYTLV CEEEEEEEEEEEEEE	17.25	27422710
41	Phosphorylation	FKVRCSRYLYTLVIT EEEEEEEEEEEEEEC	6.43	28152594
43	Phosphorylation	VRCSRYLYTLVITDK EEEEEEEEEEEECCH	6.79	28152594
44	Phosphorylation	RCSRYLYTLVITDKE EEEEEEEEEEECCHH	16.38	28152594
48	Phosphorylation	YLYTLVITDKEKAEK EEEEEEECCHHHHHH	33.27	29978859
50	2-Hydroxyisobutyrylation	YTLVITDKEKAEKLK EEEEECCHHHHHHHH	53.09	-
50	Ubiquitination	YTLVITDKEKAEKLK EEEEECCHHHHHHHH	53.09	21890473
50	Acetylation	YTLVITDKEKAEKLK EEEEECCHHHHHHHH	53.09	25953088
50	Ubiquitination	YTLVITDKEKAEKLK EEEEECCHHHHHHHH	53.09	21906983
52	Acetylation	LVITDKEKAEKLKQS EEECCHHHHHHHHHH	68.53	23749302
52	Ubiquitination	LVITDKEKAEKLKQS EEECCHHHHHHHHHH	68.53	-
55	Ubiquitination	TDKEKAEKLKQSLPP CCHHHHHHHHHHCCC	66.88	21890473
55	Ubiquitination	TDKEKAEKLKQSLPP CCHHHHHHHHHHCCC	66.88	21906983
57	Ubiquitination	KEKAEKLKQSLPPGL HHHHHHHHHHCCCCC	49.24	21906983
57	Ubiquitination	KEKAEKLKQSLPPGL HHHHHHHHHHCCCCC	49.24	21890473
59	Phosphorylation	KAEKLKQSLPPGLAV HHHHHHHHCCCCCCC	41.05	21712546
67	Sumoylation	LPPGLAVKELK---- CCCCCCCCCCC----	52.28	19608861
67	Ubiquitination	LPPGLAVKELK---- CCCCCCCCCCC----	52.28	21906983
67	Acetylation	LPPGLAVKELK---- CCCCCCCCCCC----	52.28	19608861
67	Ubiquitination	LPPGLAVKELK---- CCCCCCCCCCC----	52.28	21890473

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of RL38_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of RL38_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of RL38_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RS6_HUMAN	RPS6	physical	22939629
RS12_HUMAN	RPS12	physical	22939629
RS28_HUMAN	RPS28	physical	22939629
RS15A_HUMAN	RPS15A	physical	22939629
RS19_HUMAN	RPS19	physical	22939629
RS25_HUMAN	RPS25	physical	22939629
RL5_HUMAN	RPL5	physical	22939629
RL8_HUMAN	RPL8	physical	22939629
RL3_HUMAN	RPL3	physical	22939629
RL7_HUMAN	RPL7	physical	22939629
RS13_HUMAN	RPS13	physical	22939629
RS2_HUMAN	RPS2	physical	22939629
RL7A_HUMAN	RPL7A	physical	22939629
SRPRB_HUMAN	SRPRB	physical	22939629
SLIRP_HUMAN	SLIRP	physical	22939629
RM53_HUMAN	MRPL53	physical	22939629
RRBP1_HUMAN	RRBP1	physical	22939629
EHD4_HUMAN	EHD4	physical	22863883
ROA1_HUMAN	HNRNPA1	physical	22863883
SYIC_HUMAN	IARS	physical	22863883
IF2B3_HUMAN	IGF2BP3	physical	22863883
NMT1_HUMAN	NMT1	physical	22863883
PLCG1_HUMAN	PLCG1	physical	22863883
RIC8A_HUMAN	RIC8A	physical	22863883
NIPA_HUMAN	ZC3HC1	physical	22863883
EF1G_HUMAN	EEF1G	physical	26344197
PESC_HUMAN	PES1	physical	26344197
RL10_HUMAN	RPL10	physical	26344197
RL10A_HUMAN	RPL10A	physical	26344197
RL13_HUMAN	RPL13	physical	26344197
RL13A_HUMAN	RPL13A	physical	26344197
RL15_HUMAN	RPL15	physical	26344197
RL19_HUMAN	RPL19	physical	26344197
RL22_HUMAN	RPL22	physical	26344197
RL23A_HUMAN	RPL23A	physical	26344197
RL26_HUMAN	RPL26	physical	26344197
RL27_HUMAN	RPL27	physical	26344197
RL27A_HUMAN	RPL27A	physical	26344197
RL34_HUMAN	RPL34	physical	26344197
RL37A_HUMAN	RPL37A	physical	26344197
RL4_HUMAN	RPL4	physical	26344197
RL7_HUMAN	RPL7	physical	26344197
RL7A_HUMAN	RPL7A	physical	26344197
RLA0_HUMAN	RPLP0	physical	26344197
RLA1_HUMAN	RPLP1	physical	26344197
RLA2_HUMAN	RPLP2	physical	26344197
RS14_HUMAN	RPS14	physical	26344197
RS18_HUMAN	RPS18	physical	26344197
RS23_HUMAN	RPS23	physical	26344197
RS26_HUMAN	RPS26	physical	26344197
RS27_HUMAN	RPS27	physical	26344197
RS4X_HUMAN	RPS4X	physical	26344197
RS6_HUMAN	RPS6	physical	26344197
RS7_HUMAN	RPS7	physical	26344197

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of RL38_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-9 AND LYS-67, AND MASSSPECTROMETRY.	19608861 [Abstract]