dbPTM

RM53_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	RM53_HUMAN
UniProt AC	Q96EL3
Protein Name	39S ribosomal protein L53, mitochondrial
Gene Name	MRPL53
Organism	Homo sapiens (Human).
Sequence Length	112
Subcellular Localization	Mitochondrion .
Protein Description
Protein Sequence	MAAALARLGLRPVKQVRVQFCPFEKNVESTRTFLQTVSSEKVRSTNLNCSVIADVRHDGSEPCVDVLFGDGHRLIMRGAHLTALEMLTAFASHIRARDAAGSGDKPGADTGR

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAAALARLG ------CHHHHHHCC	11.05	-
14	Malonylation	RLGLRPVKQVRVQFC HCCCCCCCEEEEEEC	45.84	32601280
21	S-nitrosocysteine	KQVRVQFCPFEKNVE CEEEEEECCCCCCHH	1.79	-
21	S-nitrosylation	KQVRVQFCPFEKNVE CEEEEEECCCCCCHH	1.79	19483679
25	Acetylation	VQFCPFEKNVESTRT EEECCCCCCHHHHHH	67.67	26051181
25	2-Hydroxyisobutyrylation	VQFCPFEKNVESTRT EEECCCCCCHHHHHH	67.67	-
29	Phosphorylation	PFEKNVESTRTFLQT CCCCCHHHHHHHHHH	20.93	26074081
30	Phosphorylation	FEKNVESTRTFLQTV CCCCHHHHHHHHHHH	21.88	26074081
32	Phosphorylation	KNVESTRTFLQTVSS CCHHHHHHHHHHHCC	28.87	26074081
36	Phosphorylation	STRTFLQTVSSEKVR HHHHHHHHHCCHHHH	25.22	26074081
38	Phosphorylation	RTFLQTVSSEKVRST HHHHHHHCCHHHHHC	35.85	26074081
39	Phosphorylation	TFLQTVSSEKVRSTN HHHHHHCCHHHHHCC	36.78	26074081
41	Ubiquitination	LQTVSSEKVRSTNLN HHHHCCHHHHHCCCC	44.91	33845483
41	2-Hydroxyisobutyrylation	LQTVSSEKVRSTNLN HHHHCCHHHHHCCCC	44.91	-
44	Phosphorylation	VSSEKVRSTNLNCSV HCCHHHHHCCCCCEE	25.32	26074081
45	Phosphorylation	SSEKVRSTNLNCSVI CCHHHHHCCCCCEEE	32.91	26074081
49	Glutathionylation	VRSTNLNCSVIADVR HHHCCCCCEEEEEEC	3.76	22555962
50	Phosphorylation	RSTNLNCSVIADVRH HHCCCCCEEEEEECC	18.58	26074081
63	Glutathionylation	RHDGSEPCVDVLFGD CCCCCCCEEEEEECC	3.42	22555962
82	Phosphorylation	IMRGAHLTALEMLTA HHHHHHHHHHHHHHH	21.23	20068231
88	Phosphorylation	LTALEMLTAFASHIR HHHHHHHHHHHHHHH	20.58	20068231
92	Phosphorylation	EMLTAFASHIRARDA HHHHHHHHHHHHHHC	17.00	20068231
102	Phosphorylation	RARDAAGSGDKPGAD HHHHCCCCCCCCCCC	38.81	20068231
105	Ubiquitination	DAAGSGDKPGADTGR HCCCCCCCCCCCCCC	49.21	24816145
105	Acetylation	DAAGSGDKPGADTGR HCCCCCCCCCCCCCC	49.21	25953088
110	Phosphorylation	GDKPGADTGR----- CCCCCCCCCC-----	34.03	20068231

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of RM53_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of RM53_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of RM53_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
RT28_HUMAN	MRPS28	physical	22939629
RRFM_HUMAN	MRRF	physical	22939629
SPRE_HUMAN	SPR	physical	22939629
UBL4A_HUMAN	UBL4A	physical	22939629
ZC11A_HUMAN	ZC3H11A	physical	22939629
SUGP1_HUMAN	SUGP1	physical	22939629
SOSB1_HUMAN	NABP2	physical	22939629
RS19_HUMAN	RPS19	physical	22939629
SNX3_HUMAN	SNX3	physical	22939629
MPLKI_HUMAN	MPLKIP	physical	22939629
RRBP1_HUMAN	RRBP1	physical	22939629
RS28_HUMAN	RPS28	physical	22939629
RU1C_HUMAN	SNRPC	physical	22939629
STX7_HUMAN	STX7	physical	22939629
TAGL_HUMAN	TAGLN	physical	22939629
TIM44_HUMAN	TIMM44	physical	22939629
UBC9_HUMAN	UBE2I	physical	22939629
THIK_HUMAN	ACAA1	physical	22939629
RIDA_HUMAN	HRSP12	physical	22939629
TPX2_HUMAN	TPX2	physical	22939629
UBE4B_HUMAN	UBE4B	physical	22939629
SCO2_HUMAN	SCO2	physical	22939629
UB2L3_HUMAN	UBE2L3	physical	22939629
VDAC3_HUMAN	VDAC3	physical	22939629
SBDS_HUMAN	SBDS	physical	22939629
TBL2_HUMAN	TBL2	physical	22939629
TIAR_HUMAN	TIAL1	physical	22939629
THY1_HUMAN	THY1	physical	22939629
ADIP_HUMAN	SSX2IP	physical	25416956

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of RM53_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, AND MASS SPECTROMETRY.	19413330 [Abstract]