THIK_HUMAN - dbPTM
THIK_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID THIK_HUMAN
UniProt AC P09110
Protein Name 3-ketoacyl-CoA thiolase, peroxisomal
Gene Name ACAA1
Organism Homo sapiens (Human).
Sequence Length 424
Subcellular Localization Peroxisome.
Protein Description
Protein Sequence MQRLQVVLGHLRGPADSGWMPQAAPCLSGAPQASAADVVVVHGRRTAICRAGRGGFKDTTPDELLSAVMTAVLKDVNLRPEQLGDICVGNVLQPGAGAIMARIAQFLSDIPETVPLSTVNRQCSSGLQAVASIAGGIRNGSYDIGMACGVESMSLADRGNPGNITSRLMEKEKARDCLIPMGITSENVAERFGISREKQDTFALASQQKAARAQSKGCFQAEIVPVTTTVHDDKGTKRSITVTQDEGIRPSTTMEGLAKLKPAFKKDGSTTAGNSSQVSDGAAAILLARRSKAEELGLPILGVLRSYAVVGVPPDIMGIGPAYAIPVALQKAGLTVSDVDIFEINEAFASQAAYCVEKLRLPPEKVNPLGGAVALGHPLGCTGARQVITLLNELKRRGKRAYGVVSMCIGTGMGAAAVFEYPGN
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
59PhosphorylationGRGGFKDTTPDELLS
CCCCCCCCCHHHHHH		40.6022817900
60PhosphorylationRGGFKDTTPDELLSA
CCCCCCCCHHHHHHH		38.5922817900
70PhosphorylationELLSAVMTAVLKDVN
HHHHHHHHHHHHHCC		13.66110740119
108PhosphorylationARIAQFLSDIPETVP
HHHHHHHHCCCCCCC		34.4826503514
124PhosphorylationSTVNRQCSSGLQAVA
HHHCHHHHHHHHHHH		21.0767053219
125PhosphorylationTVNRQCSSGLQAVAS
HHCHHHHHHHHHHHH		51.6622496350
132PhosphorylationSGLQAVASIAGGIRN
HHHHHHHHHHCCCCC		13.3322496350
141PhosphorylationAGGIRNGSYDIGMAC
HCCCCCCCCCCCCCC		24.1528622833
141 (in isoform 2)Phosphorylation-24.1519690332
142 (in isoform 2)Phosphorylation-16.9919690332
152 (in isoform 2)Phosphorylation-15.9719690332
165PhosphorylationRGNPGNITSRLMEKE
CCCCCCHHHHHHHHH		16.2822210691
166PhosphorylationGNPGNITSRLMEKEK
CCCCCHHHHHHHHHH		21.4469003189
181SulfoxidationARDCLIPMGITSENV
HHHCEECCCCCCHHH		4.8721406390
185PhosphorylationLIPMGITSENVAERF
EECCCCCCHHHHHHH		25.8323322592
198UbiquitinationRFGISREKQDTFALA
HHCCCHHHHCHHHHH		52.98-
198AcetylationRFGISREKQDTFALA
HHCCCHHHHCHHHHH		52.9823749302
209UbiquitinationFALASQQKAARAQSK
HHHHHHHHHHHHHCC		36.05-
215PhosphorylationQKAARAQSKGCFQAE
HHHHHHHCCCCEEEE		29.9928857561
234AcetylationTTTVHDDKGTKRSIT
EEEEECCCCCEEEEE		74.6423954790
237MalonylationVHDDKGTKRSITVTQ
EECCCCCEEEEEEEC		53.4626320211
237AcetylationVHDDKGTKRSITVTQ
EECCCCCEEEEEEEC		53.4623749302
239PhosphorylationDDKGTKRSITVTQDE
CCCCCEEEEEEECCC		24.9428857561
251PhosphorylationQDEGIRPSTTMEGLA
CCCCCCCCCCHHHHH		27.0228857561
252PhosphorylationDEGIRPSTTMEGLAK
CCCCCCCCCHHHHHH		32.6128857561
253PhosphorylationEGIRPSTTMEGLAKL
CCCCCCCCHHHHHHC		19.9828857561
254SulfoxidationGIRPSTTMEGLAKLK
CCCCCCCHHHHHHCC		3.7821406390
259AcetylationTTMEGLAKLKPAFKK
CCHHHHHHCCCCCCC		63.1823236377
266MalonylationKLKPAFKKDGSTTAG
HCCCCCCCCCCCCCC		61.9526320211
269PhosphorylationPAFKKDGSTTAGNSS
CCCCCCCCCCCCCCC		32.4963711941
271PhosphorylationFKKDGSTTAGNSSQV
CCCCCCCCCCCCCCC		33.9728102081
275PhosphorylationGSTTAGNSSQVSDGA
CCCCCCCCCCCCHHH		22.6428102081
276PhosphorylationSTTAGNSSQVSDGAA
CCCCCCCCCCCHHHH		38.3028102081
279PhosphorylationAGNSSQVSDGAAAIL
CCCCCCCCHHHHHHH		23.7728102081
291PhosphorylationAILLARRSKAEELGL
HHHHHHHHHHHHHCC		30.5728857561
292UbiquitinationILLARRSKAEELGLP
HHHHHHHHHHHHCCC		58.9921890473
323PhosphorylationIMGIGPAYAIPVALQ
CCCCCHHHHHHHHHH		14.277105033
337PhosphorylationQKAGLTVSDVDIFEI
HHCCCCCCCCCHHHC		27.0469010297
3652-HydroxyisobutyrylationKLRLPPEKVNPLGGA
HHCCCHHHCCCCCCC		53.75-
389PhosphorylationTGARQVITLLNELKR
CCHHHHHHHHHHHHH		26.7435103433
395AcetylationITLLNELKRRGKRAY
HHHHHHHHHCCCCHH		33.5925953088
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of THIK_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of THIK_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of THIK_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ZDHC5_HUMANZDHHC5physical
22939629
TPPC5_HUMANTRAPPC5physical
22939629
VDAC3_HUMANVDAC3physical
22939629
TXD11_HUMANTXNDC11physical
21988832
PEX7_HUMANPEX7physical
26186194
MTDC_HUMANMTHFD2physical
26186194
IF1AX_HUMANEIF1AXphysical
26186194
TPPC9_HUMANTRAPPC9physical
26186194
CF226_HUMANC6orf226physical
26186194
PEX5_HUMANPEX5physical
26186194
CATA_HUMANCATphysical
26344197
CDK12_HUMANCDK12physical
26344197
PEX7_HUMANPEX7physical
28514442
TPPC9_HUMANTRAPPC9physical
28514442
MTDC_HUMANMTHFD2physical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of THIK_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-59 AND THR-60, AND MASSSPECTROMETRY.

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