TPPC5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TPPC5_HUMAN
• UniProt AC: Q8IUR0
• Protein Name: Trafficking protein particle complex subunit 5
• Gene Name: TRAPPC5
• Organism: Homo sapiens (Human).
• Sequence Length: 188
• Subcellular Localization: Golgi apparatus, cis-Golgi network. Endoplasmic reticulum.
• Protein Description: May play a role in vesicular transport from endoplasmic reticulum to Golgi..
• Protein Sequence: MEARFTRGKSALLERALARPRTEVSLSAFALLFSELVQHCQSRVFSVAELQSRLAALGRQVGARVLDALVAREKGARRETKVLGALLFVKGAVWKALFGKEADKLEQANDDARTFYIIEREPLINTYISVPKENSTLNCASFTAGIVEAVLTHSGFPAKVTAHWHKGTTLMIKFEEAVIARDRALEGR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Malonylation	EARFTRGKSALLERA CCCCCCHHHHHHHHH	29.30	26320211
9	Methylation	EARFTRGKSALLERA CCCCCCHHHHHHHHH	29.30	115979561
9	Ubiquitination	EARFTRGKSALLERA CCCCCCHHHHHHHHH	29.30	27667366
10	Phosphorylation	ARFTRGKSALLERAL CCCCCHHHHHHHHHH	27.29	23401153
100	Ubiquitination	VWKALFGKEADKLEQ HHHHHHCCHHHHHHH	42.25	22817900
104	Ubiquitination	LFGKEADKLEQANDD HHCCHHHHHHHCCCC	62.06	22817900
116	Phosphorylation	NDDARTFYIIEREPL CCCCCEEEEEECCCC	10.61	27642862
126	Phosphorylation	EREPLINTYISVPKE ECCCCCCEEEECCCC	18.42	-
127	Phosphorylation	REPLINTYISVPKEN CCCCCCEEEECCCCC	6.16	-
129	Phosphorylation	PLINTYISVPKENST CCCCEEEECCCCCCC	23.19	24719451
166	Ubiquitination	KVTAHWHKGTTLMIK EEEEEECCCCEEEEE	53.41	29967540

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TPPC5_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TPPC5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TPPC5_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TPC10_HUMAN	TRAPPC10	physical	21525244
TPC2A_HUMAN	TRAPPC2	physical	21525244
TPC2B_HUMAN	TRAPPC2	physical	21525244
TPC3L_HUMAN	TRAPPC3L	physical	21525244
TPPC3_HUMAN	TRAPPC3	physical	26344197
TPPC1_HUMAN	TRAPPC1	physical	28514442
TPC12_HUMAN	TRAPPC12	physical	28514442
TPC2L_HUMAN	TRAPPC2L	physical	28514442
TPC11_HUMAN	TRAPPC11	physical	28514442
TPC13_HUMAN	TRAPPC13	physical	28514442
TPC6A_HUMAN	TRAPPC6A	physical	28514442
TPC6B_HUMAN	TRAPPC6B	physical	28514442
CG043_HUMAN	C7orf43	physical	28514442
TPPC4_HUMAN	TRAPPC4	physical	28514442
TPC10_HUMAN	TRAPPC10	physical	28514442
TPPC3_HUMAN	TRAPPC3	physical	28514442
TPPC8_HUMAN	TRAPPC8	physical	28514442
TPPC9_HUMAN	TRAPPC9	physical	28514442
F174A_HUMAN	FAM174A	physical	28514442
BGAL_HUMAN	GLB1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.