TPPC4_HUMAN - dbPTM
TPPC4_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TPPC4_HUMAN
UniProt AC Q9Y296
Protein Name Trafficking protein particle complex subunit 4
Gene Name TRAPPC4
Organism Homo sapiens (Human).
Sequence Length 219
Subcellular Localization Golgi apparatus, cis-Golgi network. Endoplasmic reticulum.
Protein Description May play a role in vesicular transport from endoplasmic reticulum to Golgi..
Protein Sequence MAIFSVYVVNKAGGLIYQLDSYAPRAEAEKTFSYPLDLLLKLHDERVLVAFGQRDGIRVGHAVLAINGMDVNGRYTADGKEVLEYLGNPANYPVSIRFGRPRLTSNEKLMLASMFHSLFAIGSQLSPEQGSSGIEMLETDTFKLHCYQTLTGIKFVVLADPRQAGIDSLLRKIYEIYSDFALKNPFYSLEMPIRCELFDQNLKLALEVAEKAGTFGPGS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
5Phosphorylation---MAIFSVYVVNKA
---CCEEEEEEEECC		13.3624043423
7Phosphorylation-MAIFSVYVVNKAGG
-CCEEEEEEEECCCC		9.4724043423
17PhosphorylationNKAGGLIYQLDSYAP
ECCCCEEEEECCCCC		14.2029496907
21PhosphorylationGLIYQLDSYAPRAEA
CEEEEECCCCCHHHH		31.6129496907
22PhosphorylationLIYQLDSYAPRAEAE
EEEEECCCCCHHHHH		21.9429496907
30UbiquitinationAPRAEAEKTFSYPLD
CCHHHHHHHCCCCHH		63.0221906983
30UbiquitinationAPRAEAEKTFSYPLD
CCHHHHHHHCCCCHH		63.0221906983
41UbiquitinationYPLDLLLKLHDERVL
CCHHHHHHHCCCEEE		43.6921906983
41UbiquitinationYPLDLLLKLHDERVL
CCHHHHHHHCCCEEE		43.6921906983
75PhosphorylationGMDVNGRYTADGKEV
CEECCCCCCCCHHHH		14.0022210691
76PhosphorylationMDVNGRYTADGKEVL
EECCCCCCCCHHHHH		19.5322210691
80UbiquitinationGRYTADGKEVLEYLG
CCCCCCHHHHHHHHC		45.2421906983
92PhosphorylationYLGNPANYPVSIRFG
HHCCCCCCCCEEEEC		13.7122210691
95PhosphorylationNPANYPVSIRFGRPR
CCCCCCCEEEECCCC		11.9822210691
118UbiquitinationLASMFHSLFAIGSQL
HHHHHHHHHHHHHCC		2.23-
139PhosphorylationSGIEMLETDTFKLHC
CCCEEEECCCEEEEE		36.0626074081
141PhosphorylationIEMLETDTFKLHCYQ
CEEEECCCEEEEEEE		30.0426074081
147PhosphorylationDTFKLHCYQTLTGIK
CCEEEEEEECCCCCE		8.1926074081
149PhosphorylationFKLHCYQTLTGIKFV
EEEEEEECCCCCEEE		10.3826074081
149UbiquitinationFKLHCYQTLTGIKFV
EEEEEEECCCCCEEE		10.38-
151PhosphorylationLHCYQTLTGIKFVVL
EEEEECCCCCEEEEE		40.0026074081
157UbiquitinationLTGIKFVVLADPRQA
CCCCEEEEECCHHHC		4.0321906983
168PhosphorylationPRQAGIDSLLRKIYE
HHHCCHHHHHHHHHH		27.6420068231
188PhosphorylationALKNPFYSLEMPIRC
CCCCCCCCCCCEEEE		20.4524247654
203UbiquitinationELFDQNLKLALEVAE
EECCCCHHHHHHHHH		38.98-
211UbiquitinationLALEVAEKAGTFGPG
HHHHHHHHHCCCCCC		42.242190698
219PhosphorylationAGTFGPGS-------
HCCCCCCC-------		39.9324719451
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of TPPC4_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TPPC4_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TPPC4_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
TPPC4_HUMANTRAPPC4physical
21525244
TPPC8_HUMANTRAPPC8physical
21525244
TPPC9_HUMANTRAPPC9physical
21525244
TPC10_HUMANTRAPPC10physical
21525244
TPC11_HUMANTRAPPC11physical
21525244
TPC12_HUMANTRAPPC12physical
21525244
TPC2L_HUMANTRAPPC2Lphysical
21525244
TPC2A_HUMANTRAPPC2physical
21525244
TPC2B_HUMANTRAPPC2physical
21525244
TPC3L_HUMANTRAPPC3Lphysical
21525244
A4_HUMANAPPphysical
21832049
TPPC3_HUMANTRAPPC3physical
26344197
TPC6B_HUMANTRAPPC6Bphysical
26344197
TPC10_HUMANTRAPPC10physical
27173435
RAB3I_HUMANRAB3IPphysical
27173435
TPC2L_HUMANTRAPPC2Lphysical
27173435
TM102_HUMANTMEM102physical
27173435
M21D2_HUMANMB21D2physical
27173435
PDLI7_HUMANPDLIM7physical
27173435
R3GEF_HUMANRAB3IL1physical
27173435
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TPPC4_HUMAN

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Related Literatures of Post-Translational Modification

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