TM102_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TM102_HUMAN
• UniProt AC: Q8N9M5
• Protein Name: Transmembrane protein 102
• Gene Name: TMEM102
• Organism: Homo sapiens (Human).
• Sequence Length: 508
• Subcellular Localization: Cell membrane ; Single-pass membrane protein . Although it is found at the cell surface, the majority of the molecules seems to be located in intracellular compartments.
• Protein Description: Selectively involved in CSF2 deprivation-induced apoptosis via a mitochondria-dependent pathway..
• Protein Sequence: MASAVWGSAPWWGPPPPAPARPLTDIDFCSGAQLQELTQLIQELGVQESWSDGPKPGADLLRAKDFVFSLLGLVHRRDPRFPPQAELLLLRGGIREGSLDLGHAPLGPYARGPHYDAGFTLLVPMFSLDGTELQLDLESCYAQVCLPEMVCGTPIREMWQDCLGPPVPGARDSIHRTESEESSKDWQSSVDQPHSYVTEHEAPVSLEKSPSDVSASESPQHDVVDLGSTAPLKTMSSDVTKAAVESPVPKPSEAREAWPTLCSAQVAAWFFATLAAVAESLIPVPGAPRLVHAARHAGFTTVLLATPEPPRRLLLFDLIPVVSVAGWPEGARSHSWAGPLASESASFYLVPGGGTERPCASAWQLCFARQELALKARIPAPLLQAHAAAQALLRPLVAGTRAAAPYLLRTLLYWACERLPALYLARPENAGACCLGLLDELGRVLEAGTLPHYFLNGRQLRTGDDSAALLGELARLRGDPARALRAAVEEAKVARKGGGLAGVGGGAH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
64	Ubiquitination	GADLLRAKDFVFSLL CHHHHHHHHHHHHHH	45.31	-
173	Phosphorylation	PVPGARDSIHRTESE CCCCCHHCCCCCCCC	18.10	29449344
177	Phosphorylation	ARDSIHRTESEESSK CHHCCCCCCCCCCCC	29.69	28857561
179	Phosphorylation	DSIHRTESEESSKDW HCCCCCCCCCCCCHH	46.15	26657352
182	Phosphorylation	HRTESEESSKDWQSS CCCCCCCCCCHHHHH	38.34	28857561
183	Phosphorylation	RTESEESSKDWQSSV CCCCCCCCCHHHHHC	37.60	25693802
188	Phosphorylation	ESSKDWQSSVDQPHS CCCCHHHHHCCCCCC	28.24	25693802
189	Phosphorylation	SSKDWQSSVDQPHSY CCCHHHHHCCCCCCC	18.02	25693802
195	Phosphorylation	SSVDQPHSYVTEHEA HHCCCCCCCCCCCCC	28.16	28348404
205	Phosphorylation	TEHEAPVSLEKSPSD CCCCCCCCCCCCHHH	29.74	28348404
209	Phosphorylation	APVSLEKSPSDVSAS CCCCCCCCHHHCCCC	21.91	22199227
211	Phosphorylation	VSLEKSPSDVSASES CCCCCCHHHCCCCCC	58.70	22199227
214	Phosphorylation	EKSPSDVSASESPQH CCCHHHCCCCCCCCC	30.94	25159151
216	Phosphorylation	SPSDVSASESPQHDV CHHHCCCCCCCCCCC	30.97	30576142
218	Phosphorylation	SDVSASESPQHDVVD HHCCCCCCCCCCCCC	27.62	30278072
228	Phosphorylation	HDVVDLGSTAPLKTM CCCCCCCCCCCCEEC	28.79	28634298
229	Phosphorylation	DVVDLGSTAPLKTMS CCCCCCCCCCCEECC	30.42	28634298
233	Ubiquitination	LGSTAPLKTMSSDVT CCCCCCCEECCCHHH	40.91	22817900
246	Phosphorylation	VTKAAVESPVPKPSE HHHHHHCCCCCCCHH	25.30	26657352
252	Phosphorylation	ESPVPKPSEAREAWP CCCCCCCHHHHHHHH	50.44	27251275
449	Phosphorylation	GRVLEAGTLPHYFLN HHHHHHCCCCEEECC	44.13	29209046
453	Phosphorylation	EAGTLPHYFLNGRQL HHCCCCEEECCCCCC	14.07	29209046
462	Phosphorylation	LNGRQLRTGDDSAAL CCCCCCCCCCHHHHH	54.26	23403867
466	Phosphorylation	QLRTGDDSAALLGEL CCCCCCHHHHHHHHH	21.85	23403867
496	Ubiquitination	EEAKVARKGGGLAGV HHHHHHHCCCCCCCC	52.77	29967540
496	Acetylation	EEAKVARKGGGLAGV HHHHHHHCCCCCCCC	52.77	30592993

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TM102_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TM102_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TM102_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TPC10_HUMAN	TRAPPC10	physical	27173435
TPC2L_HUMAN	TRAPPC2L	physical	27173435
PDLI7_HUMAN	PDLIM7	physical	27173435
M21D2_HUMAN	MB21D2	physical	27173435

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.