TPC2B_HUMAN - dbPTM
TPC2B_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TPC2B_HUMAN
UniProt AC P0DI82
Protein Name Trafficking protein particle complex subunit 2B
Gene Name TRAPPC2B
Organism Homo sapiens (Human).
Sequence Length 140
Subcellular Localization Nucleus . Cytoplasm, perinuclear region . Endoplasmic reticulum-Golgi intermediate compartment . Cytoplasm . Localized in perinuclear granular structures.
Protein Description Prevents transcriptional repression and induction of cell death by ENO1. May play a role in vesicular transport from endoplasmic reticulum to Golgi..
Protein Sequence MSGSFYFVIVGHHDNPVFEMEFLPAGKAESKDDHRHLNQFIAHAALDLVDENMWLSNNMYLKTVDKFNEWFVSAFVTAGHMRFIMLHDIRQEDGIKNFFTDVYDLYIKFSMNPFYEPNSPIRSSAFDRKVQFLGKKHLLS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSGSFYFVI
------CCCEEEEEE		43.0524043423
4Phosphorylation----MSGSFYFVIVG
----CCCEEEEEEEE		14.9624043423
6Phosphorylation--MSGSFYFVIVGHH
--CCCEEEEEEEECC		9.9124043423
100PhosphorylationDGIKNFFTDVYDLYI
HCHHHHHHHHHHHHH		22.0325690035
103PhosphorylationKNFFTDVYDLYIKFS
HHHHHHHHHHHHEEC		11.7525690035
110PhosphorylationYDLYIKFSMNPFYEP
HHHHHEECCCCCCCC		16.7927080861
115PhosphorylationKFSMNPFYEPNSPIR
EECCCCCCCCCCCCC		31.5627732954
119PhosphorylationNPFYEPNSPIRSSAF
CCCCCCCCCCCCHHH		32.2125159151
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of TPC2B_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TPC2B_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TPC2B_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CLIC1_HUMANCLIC1physical
12681486
CLIC2_HUMANCLIC2physical
12681486
TPPC8_HUMANTRAPPC8physical
21525244
TPC10_HUMANTRAPPC10physical
21525244
TPPC9_HUMANTRAPPC9physical
21525244
TPC12_HUMANTRAPPC12physical
21525244
TPC11_HUMANTRAPPC11physical
21525244
TPPC3_HUMANTRAPPC3physical
21525244
TPC3L_HUMANTRAPPC3Lphysical
21525244
TPPC4_HUMANTRAPPC4physical
21525244
TPPC5_HUMANTRAPPC5physical
21525244
TPC6A_HUMANTRAPPC6Aphysical
21525244
TPC6B_HUMANTRAPPC6Bphysical
21525244
PITX1_HUMANPITX1physical
20498720
STF1_HUMANNR5A1physical
20498720
TPC2A_HUMANTRAPPC2physical
20498720
TPC2B_HUMANTRAPPC2physical
20498720
MBL2_HUMANMBL2physical
20498720
TPPC5_HUMANTRAPPC5physical
28514442
TPPC1_HUMANTRAPPC1physical
28514442
TPC12_HUMANTRAPPC12physical
28514442
ANM2_HUMANPRMT2physical
28514442
TPC2L_HUMANTRAPPC2Lphysical
28514442
TPC11_HUMANTRAPPC11physical
28514442
TPC6A_HUMANTRAPPC6Aphysical
28514442
TPC13_HUMANTRAPPC13physical
28514442
TPPC8_HUMANTRAPPC8physical
28514442
TPPC9_HUMANTRAPPC9physical
28514442
TPPC4_HUMANTRAPPC4physical
28514442
TPC10_HUMANTRAPPC10physical
28514442
CG043_HUMANC7orf43physical
28514442
TPC6B_HUMANTRAPPC6Bphysical
28514442
TPPC3_HUMANTRAPPC3physical
28514442
TR61B_HUMANTRMT61Bphysical
28514442
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TPC2B_HUMAN

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Related Literatures of Post-Translational Modification

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