MBL2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MBL2_HUMAN
• UniProt AC: P11226
• Protein Name: Mannose-binding protein C
• Gene Name: MBL2
• Organism: Homo sapiens (Human).
• Sequence Length: 248
• Subcellular Localization: Secreted .
• Protein Description: Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages. May bind DNA..
• Protein Sequence: MSLFPSLPLLLLSMVAASYSETVTCEDAQKTCPAVIACSSPGINGFPGKDGRDGTKGEKGEPGQGLRGLQGPPGKLGPPGNPGPSGSPGPKGQKGDPGKSPDGDSSLAASERKALQTEMARIKKWLTFSLGKQVGNKFFLTNGEIMTFEKVKALCVKFQASVATPRNAAENGAIQNLIKEEAFLGITDEKTEGQFVDLTGNRLTYTNWNEGEPNNAGSDEDCVLLLKNGQWNDVPCSTSHLAVCEFPI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
47	Hydroxylation	SPGINGFPGKDGRDG CCCCCCCCCCCCCCC	50.77	7982896
73	Hydroxylation	LRGLQGPPGKLGPPG CCCCCCCCCCCCCCC	60.42	7982896
79	Hydroxylation	PPGKLGPPGNPGPSG CCCCCCCCCCCCCCC	54.09	7982896
82	Hydroxylation	KLGPPGNPGPSGSPG CCCCCCCCCCCCCCC	63.09	7982896
88	Hydroxylation	NPGPSGSPGPKGQKG CCCCCCCCCCCCCCC	67.63	7982896
100	Phosphorylation	QKGDPGKSPDGDSSL CCCCCCCCCCCCCCC	33.85	-
105	Phosphorylation	GKSPDGDSSLAASER CCCCCCCCCCHHHHH	32.55	21955146
106	Phosphorylation	KSPDGDSSLAASERK CCCCCCCCCHHHHHH	27.11	21955146
110	Phosphorylation	GDSSLAASERKALQT CCCCCHHHHHHHHHH	32.12	21955146

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MBL2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MBL2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MBL2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CALR_HUMAN	CALR	physical	8062452
MASP2_HUMAN	MASP2	physical	10878362
MASP1_HUMAN	MASP1	physical	10878362
TPC2A_HUMAN	TRAPPC2	physical	20498720
TPC2B_HUMAN	TRAPPC2	physical	20498720

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Hydroxylation

"Structure and function of mannan-binding proteins isolated from humanliver and serum.";
Kurata H., Sannoh T., Kozutsumi Y., Yokota Y., Kawasaki T.;
J. Biochem. 115:1148-1154(1994).
Cited for: PROTEIN SEQUENCE OF 21-248, SUBCELLULAR LOCATION, AND HYDROXYLATION ATPRO-47; PRO-73; PRO-79; PRO-82 AND PRO-88.
PubMed: 7982896