MASP2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MASP2_HUMAN
• UniProt AC: O00187
• Protein Name: Mannan-binding lectin serine protease 2
• Gene Name: MASP2
• Organism: Homo sapiens (Human).
• Sequence Length: 686
• Subcellular Localization: Secreted.
• Protein Description: Serum protease that plays an important role in the activation of the complement system via mannose-binding lectin. After activation by auto-catalytic cleavage it cleaves C2 and C4, leading to their activation and to the formation of C3 convertase..
• Protein Sequence: MRLLTLLGLLCGSVATPLGPKWPEPVFGRLASPGFPGEYANDQERRWTLTAPPGYRLRLYFTHFDLELSHLCEYDFVKLSSGAKVLATLCGQESTDTERAPGKDTFYSLGSSLDITFRSDYSNEKPFTGFEAFYAAEDIDECQVAPGEAPTCDHHCHNHLGGFYCSCRAGYVLHRNKRTCSALCSGQVFTQRSGELSSPEYPRPYPKLSSCTYSISLEEGFSVILDFVESFDVETHPETLCPYDFLKIQTDREEHGPFCGKTLPHRIETKSNTVTITFVTDESGDHTGWKIHYTSTAQPCPYPMAPPNGHVSPVQAKYILKDSFSIFCETGYELLQGHLPLKSFTAVCQKDGSWDRPMPACSIVDCGPPDDLPSGRVEYITGPGVTTYKAVIQYSCEETFYTMKVNDGKYVCEADGFWTSSKGEKSLPVCEPVCGLSARTTGGRIYGGQKAKPGDFPWQVLILGGTTAAGALLYDNWVLTAAHAVYEQKHDASALDIRMGTLKRLSPHYTQAWSEAVFIHEGYTHDAGFDNDIALIKLNNKVVINSNITPICLPRKEAESFMRTDDIGTASGWGLTQRGFLARNLMYVDIPIVDHQKCTAAYEKPPYPRGSVTANMLCAGLESGGKDSCRGDSGGALVFLDSETERWFVGGIVSWGSMNCGEAGQYGVYTKVINYIPWIENIISDF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
158	Hydroxylation	TCDHHCHNHLGGFYC CCCCCCCCCCCCCEE	37.16	-
250	Phosphorylation	YDFLKIQTDREEHGP CCEEEECCCHHHHCC	40.26	-
262	Phosphorylation	HGPFCGKTLPHRIET HCCCCCCCCCCEEEE	30.70	-
388	Phosphorylation	TGPGVTTYKAVIQYS CCCCCCCEEEEEEEE	6.38	-
394	Phosphorylation	TYKAVIQYSCEETFY CEEEEEEEECCEEEE	12.26	-
401	Phosphorylation	YSCEETFYTMKVNDG EECCEEEEEEEEECC	17.22	-
549	Phosphorylation	VVINSNITPICLPRK EEECCCCCCCCCCHH	15.73	-
587	Phosphorylation	FLARNLMYVDIPIVD EECCCEEEEECEEEC	9.72	21214269
599	Phosphorylation	IVDHQKCTAAYEKPP EECCCCCCCCCCCCC	22.74	-
602	Phosphorylation	HQKCTAAYEKPPYPR CCCCCCCCCCCCCCC	23.25	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MASP2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MASP2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MASP2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
FCN2_HUMAN	FCN2	physical	12421953

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.