| UniProt ID | TPC2A_HUMAN | |
|---|---|---|
| UniProt AC | P0DI81 | |
| Protein Name | Trafficking protein particle complex subunit 2 | |
| Gene Name | TRAPPC2 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 140 | |
| Subcellular Localization | Cytoplasm, perinuclear region . Endoplasmic reticulum-Golgi intermediate compartment . Nucleus . Cytoplasm . Localized in perinuclear granular structures. | |
| Protein Description | Prevents transcriptional repression and induction of cell death by ENO1 (By similarity). May play a role in vesicular transport from endoplasmic reticulum to Golgi.. | |
| Protein Sequence | MSGSFYFVIVGHHDNPVFEMEFLPAGKAESKDDHRHLNQFIAHAALDLVDENMWLSNNMYLKTVDKFNEWFVSAFVTAGHMRFIMLHDIRQEDGIKNFFTDVYDLYIKFSMNPFYEPNSPIRSSAFDRKVQFLGKKHLLS | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Phosphorylation | ------MSGSFYFVI ------CCCEEEEEE | 43.05 | 24043423 | |
| 4 | Phosphorylation | ----MSGSFYFVIVG ----CCCEEEEEEEE | 14.96 | 24043423 | |
| 6 | Phosphorylation | --MSGSFYFVIVGHH --CCCEEEEEEEECC | 9.91 | 24043423 | |
| 100 | Phosphorylation | DGIKNFFTDVYDLYI HCHHHHHHHHHHHHH | 22.03 | 25690035 | |
| 103 | Phosphorylation | KNFFTDVYDLYIKFS HHHHHHHHHHHHEEC | 11.75 | 25690035 | |
| 110 | Phosphorylation | YDLYIKFSMNPFYEP HHHHHEECCCCCCCC | 16.79 | 27080861 | |
| 115 | Phosphorylation | KFSMNPFYEPNSPIR EECCCCCCCCCCCCC | 31.56 | 27732954 | |
| 119 | Phosphorylation | NPFYEPNSPIRSSAF CCCCCCCCCCCCHHH | 32.21 | 25159151 | |
| 129 | Ubiquitination | RSSAFDRKVQFLGKK CCHHHHHHCHHCCHH | 42.08 | - | |
| 135 | Ubiquitination | RKVQFLGKKHLLS-- HHCHHCCHHHCCC-- | 38.88 | - | |
| 135 | Acetylation | RKVQFLGKKHLLS-- HHCHHCCHHHCCC-- | 38.88 | 25953088 | |
| 136 | Ubiquitination | KVQFLGKKHLLS--- HCHHCCHHHCCC--- | 37.37 | - | |
| 153 (in isoform 3) | Phosphorylation | - | 24719451 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of TPC2A_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of TPC2A_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of TPC2A_HUMAN !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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