CLIC2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CLIC2_HUMAN
• UniProt AC: O15247
• Protein Name: Chloride intracellular channel protein 2
• Gene Name: CLIC2
• Organism: Homo sapiens (Human).
• Sequence Length: 247
• Subcellular Localization: Cytoplasm . Membrane ; Single-pass membrane protein . Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain.
• Protein Description: Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Modulates the activity of RYR2 and inhibits calcium influx..
• Protein Sequence: MSGLRPGTQVDPEIELFVKAGSDGESIGNCPFCQRLFMILWLKGVKFNVTTVDMTRKPEELKDLAPGTNPPFLVYNKELKTDFIKIEEFLEQTLAPPRYPHLSPKYKESFDVGCNLFAKFSAYIKNTQKEANKNFEKSLLKEFKRLDDYLNTPLLDEIDPDSAEEPPVSRRLFLDGDQLTLADCSLLPKLNIIKVAAKKYRDFDIPAEFSGVWRYLHNAYAREEFTHTCPEDKEIENTYANVAKQKS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSGLRPGTQ ------CCCCCCCCC	46.68	23186163
8	Phosphorylation	MSGLRPGTQVDPEIE CCCCCCCCCCCCCEE	28.27	23186163
57	Ubiquitination	TTVDMTRKPEELKDL EEECCCCCHHHHHHH	47.84	-
62	Ubiquitination	TRKPEELKDLAPGTN CCCHHHHHHHCCCCC	54.71	-
77	Ubiquitination	PPFLVYNKELKTDFI CCEEEEECHHCCCEE	46.89	-
80	Ubiquitination	LVYNKELKTDFIKIE EEEECHHCCCEEEHH	47.33	-
81	Phosphorylation	VYNKELKTDFIKIEE EEECHHCCCEEEHHH	49.09	24719451
93	Phosphorylation	IEEFLEQTLAPPRYP HHHHHHHHCCCCCCC	18.60	24719451
99	Phosphorylation	QTLAPPRYPHLSPKY HHCCCCCCCCCCHHH	10.77	26434776
103	Phosphorylation	PPRYPHLSPKYKESF CCCCCCCCHHHHHHC	19.13	22617229
106	Phosphorylation	YPHLSPKYKESFDVG CCCCCHHHHHHCCCC	24.30	29978859
109	Phosphorylation	LSPKYKESFDVGCNL CCHHHHHHCCCCCHH	23.69	29978859
121	Phosphorylation	CNLFAKFSAYIKNTQ CHHHHHHHHHHHHHH	21.32	29978859
123	Phosphorylation	LFAKFSAYIKNTQKE HHHHHHHHHHHHHHH	15.95	29978859
137	Ubiquitination	EANKNFEKSLLKEFK HHHHHHHHHHHHHHH	42.12	-
138	Phosphorylation	ANKNFEKSLLKEFKR HHHHHHHHHHHHHHH	31.56	24719451
141	Ubiquitination	NFEKSLLKEFKRLDD HHHHHHHHHHHHHHH	67.41	-
149	Phosphorylation	EFKRLDDYLNTPLLD HHHHHHHHHCCCCHH	11.08	30377224
152	Phosphorylation	RLDDYLNTPLLDEID HHHHHHCCCCHHCCC	16.84	30377224
162	Phosphorylation	LDEIDPDSAEEPPVS HHCCCCCCCCCCCCC	42.86	30377224
169	Phosphorylation	SAEEPPVSRRLFLDG CCCCCCCCCEEEECC	19.91	30377224
185	Phosphorylation	QLTLADCSLLPKLNI CEEHHHHCHHHHCCH	33.22	24905233
189	Ubiquitination	ADCSLLPKLNIIKVA HHHCHHHHCCHHHHH	54.88	23000965
194	Ubiquitination	LPKLNIIKVAAKKYR HHHCCHHHHHHHHHC	23.25	23000965
198	Ubiquitination	NIIKVAAKKYRDFDI CHHHHHHHHHCCCCC	40.37	23000965
199	Ubiquitination	IIKVAAKKYRDFDIP HHHHHHHHHCCCCCC	40.57	23000965
233	Acetylation	THTCPEDKEIENTYA CCCCCCCHHHHHHHH	59.95	30587701
238	Phosphorylation	EDKEIENTYANVAKQ CCHHHHHHHHHHHHH	15.95	-
239	Phosphorylation	DKEIENTYANVAKQK CHHHHHHHHHHHHHC	14.04	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CLIC2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CLIC2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CLIC2_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of CLIC2_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 300886: Mental retardation, X-linked, syndromic, 32 (MRXS32)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.