TR61B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TR61B_HUMAN
• UniProt AC: Q9BVS5
• Protein Name: tRNA (adenine(58)-N(1))-methyltransferase, mitochondrial
• Gene Name: TRMT61B
• Organism: Homo sapiens (Human).
• Sequence Length: 477
• Subcellular Localization: Mitochondrion .
• Protein Description: Methyltransferase that catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in various tRNAs in mitochondrion, including tRNA(Leu) (deciphering codons UUA or UUG), tRNA(Lys) and tRNA(Ser) (deciphering codons UCA, UCU, UCG or UCC). [PubMed: 23097428 Catalyzes the formation of 1-methyladenosine at position 947 of mitochondrial 16S ribosomal RNA and this modification is most likely important for mitoribosomal structure and function]
• Protein Sequence: MLMAWCRGPVLLCLRQGLGTNSFLHGLGQEPFEGARSLCCRSSPRDLRDGEREHEAAQRKAPGAESCPSLPLSISDIGTGCLSSLENLRLPTLREESSPRELEDSSGDQGRCGPTHQGSEDPSMLSQAQSATEVEERHVSPSCSTSRERPFQAGELILAETGEGETKFKKLFRLNNFGLLNSNWGAVPFGKIVGKFPGQILRSSFGKQYMLRRPALEDYVVLMKRGTAITFPKDINMILSMMDINPGDTVLEAGSGSGGMSLFLSKAVGSQGRVISFEVRKDHHDLAKKNYKHWRDSWKLSHVEEWPDNVDFIHKDISGATEDIKSLTFDAVALDMLNPHVTLPVFYPHLKHGGVCAVYVVNITQVIELLDGIRTCELALSCEKISEVIVRDWLVCLAKQKNGILAQKVESKINTDVQLDSQEKIGVKGELFQEDDHEESHSDFPYGSFPYVARPVHWQPGHTAFLVKLRKVKPQLN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
42	Phosphorylation	ARSLCCRSSPRDLRD HHHHHCCCCCCCCCC	30.68	17081983
43	Phosphorylation	RSLCCRSSPRDLRDG HHHHCCCCCCCCCCC	12.47	17081983
257	Phosphorylation	VLEAGSGSGGMSLFL EEECCCCCCHHHHEE	33.59	23286773
261	Phosphorylation	GSGSGGMSLFLSKAV CCCCCHHHHEEEEHH	21.17	23286773
315	Ubiquitination	DNVDFIHKDISGATE CCCEEEECCCCCCCH	52.52	29967540
318	Phosphorylation	DFIHKDISGATEDIK EEEECCCCCCCHHHH	32.29	29514088
321	Phosphorylation	HKDISGATEDIKSLT ECCCCCCCHHHHHCC	37.40	29514088
424	Ubiquitination	VQLDSQEKIGVKGEL CCCCHHCCCCCCCEE	36.80	29967540

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TR61B_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TR61B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TR61B_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
FAM9B_HUMAN	FAM9B	physical	25416956
SYCM_HUMAN	CARS2	physical	28514442
ATPF2_HUMAN	ATPAF2	physical	28514442
HEM1_HUMAN	ALAS1	physical	28514442
NDUF5_HUMAN	NDUFAF5	physical	28514442
ACAD9_HUMAN	ACAD9	physical	28514442
HNRPK_HUMAN	HNRNPK	physical	28514442
MMAB_HUMAN	MMAB	physical	28514442
PDK1_HUMAN	PDK1	physical	28514442
GLSK_HUMAN	GLS	physical	28514442
ACSF3_HUMAN	ACSF3	physical	28514442
LYRM7_HUMAN	LYRM7	physical	28514442
IF2M_HUMAN	MTIF2	physical	28514442
ODB2_HUMAN	DBT	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.