| UniProt ID | IF2M_HUMAN | |
|---|---|---|
| UniProt AC | P46199 | |
| Protein Name | Translation initiation factor IF-2, mitochondrial | |
| Gene Name | MTIF2 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 727 | |
| Subcellular Localization | Mitochondrion. | |
| Protein Description | One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.. | |
| Protein Sequence | MNQKLLKLENLLRFHTIYRQLHSLCQRRALRQWRHGFSSAYPVWTAQLCAWPWPTDVLTGAALSQYRLLVTKKEEGPWKSQLSSTKSKKVVEVWIGMTIEELARAMEKNTDYVYEALLNTDIDIDSLEADSHLDEVWIKEVITKAGMKLKWSKLKQDKVRKNKDAVRRPQADPALLTPRSPVVTIMGHVDHGKTTLLDKFRKTQVAAVETGGITQHIGAFLVSLPSGEKITFLDTPGHAAFSAMRARGAQVTDIVVLVVAADDGVMKQTVESIQHAKDAQVPIILAVNKCDKAEADPEKVKKELLAYDVVCEDYGGDVQAVPVSALTGDNLMALAEATVALAEMLELKADPNGPVEGTVIESFTDKGRGLVTTAIIQRGTLRKGSVLVAGKCWAKVRLMFDENGKTIDEAYPSMPVGITGWRDLPSAGEEILEVESEPRAREVVDWRKYEQEQEKGQEDLKIIEEKRKEHKEAHQKAREKYGHLLWKKRSILRFLERKEQIPLKPKEKRERDSNVLSVIIKGDVDGSVEAILNIIDTYDASHECELELVHFGVGDVSANDVNLAETFDGVIYGFNVNAGNVIQQSAAKKGVKIKLHKIIYRLVEDLQEELSSRLPCAVEEHPVGEASILATFSVTEGKKKVPVAGCRVQKGQLEKQKKFKLTRNGHVIWKGSLTSLKHHKDDISIVKTGMDCGLSLDEDNMEFQVGDRIVCYEEKQIQAKTSWDPGF | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 177 | Phosphorylation | QADPALLTPRSPVVT CCCHHHCCCCCCEEE | 19.94 | - | |
| 235 | Phosphorylation | EKITFLDTPGHAAFS CCEEEECCCCHHHHH | 33.06 | - | |
| 366 | Ubiquitination | VIESFTDKGRGLVTT EEEEECCCCCCEEEE | 47.66 | - | |
| 406 | Phosphorylation | MFDENGKTIDEAYPS EECCCCCCCCCCCCC | 34.75 | 29507054 | |
| 411 | Phosphorylation | GKTIDEAYPSMPVGI CCCCCCCCCCCCCCC | 8.19 | 20068231 | |
| 413 | Phosphorylation | TIDEAYPSMPVGITG CCCCCCCCCCCCCCC | 24.04 | 20068231 | |
| 419 | Phosphorylation | PSMPVGITGWRDLPS CCCCCCCCCEECCCC | 25.43 | 20068231 | |
| 426 | Phosphorylation | TGWRDLPSAGEEILE CCEECCCCCCCCEEE | 57.09 | - | |
| 449 | Phosphorylation | EVVDWRKYEQEQEKG HHCCHHHHHHHHHHC | 17.80 | 18452278 | |
| 513 | Phosphorylation | KEKRERDSNVLSVII HHHCCCCCCEEEEEE | 34.75 | 23186163 | |
| 684 | Phosphorylation | KHHKDDISIVKTGMD CCCCCCCEEEECCCC | 28.46 | 24719451 | |
| 688 | Phosphorylation | DDISIVKTGMDCGLS CCCEEEECCCCCCCC | 27.18 | - | |
| 715 | Acetylation | RIVCYEEKQIQAKTS EEEEEECHHHHCCCC | 40.54 | 26051181 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of IF2M_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of IF2M_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of IF2M_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of IF2M_HUMAN !! | ||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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