PDK1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PDK1_HUMAN
• UniProt AC: Q15118
• Protein Name: [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial
• Gene Name: PDK1
• Organism: Homo sapiens (Human).
• Sequence Length: 436
• Subcellular Localization: Mitochondrion matrix .
• Protein Description: Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Plays an important role in cellular responses to hypoxia and is important for cell proliferation under hypoxia. Protects cells against apoptosis in response to hypoxia and oxidative stress..
• Protein Sequence: MRLARLLRGAALAGPGPGLRAAGFSRSFSSDSGSSPASERGVPGQVDFYARFSPSPLSMKQFLDFGSVNACEKTSFMFLRQELPVRLANIMKEISLLPDNLLRTPSVQLVQSWYIQSLQELLDFKDKSAEDAKAIYDFTDTVIRIRNRHNDVIPTMAQGVIEYKESFGVDPVTSQNVQYFLDRFYMSRISIRMLLNQHSLLFGGKGKGSPSHRKHIGSINPNCNVLEVIKDGYENARRLCDLYYINSPELELEELNAKSPGQPIQVVYVPSHLYHMVFELFKNAMRATMEHHANRGVYPPIQVHVTLGNEDLTVKMSDRGGGVPLRKIDRLFNYMYSTAPRPRVETSRAVPLAGFGYGLPISRLYAQYFQGDLKLYSLEGYGTDAVIYIKALSTDSIERLPVYNKAAWKHYNTNHEADDWCVPSREPKDMTTFRSA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
25	Phosphorylation	GLRAAGFSRSFSSDS CCCHHCCEECCCCCC	26.54	12177059
35	Phosphorylation	FSSDSGSSPASERGV CCCCCCCCCHHHCCC	28.19	26437602
49	Phosphorylation	VPGQVDFYARFSPSP CCCCEEEEEECCCCC	7.75	28060719
67	Phosphorylation	KQFLDFGSVNACEKT HHHHCCCCCCCCCCC	16.52	19835603
133	Ubiquitination	DKSAEDAKAIYDFTD CCCHHHHHHHHHHHH	47.87	-
136	Phosphorylation	AEDAKAIYDFTDTVI HHHHHHHHHHHHHHH	15.18	25147952
230	Ubiquitination	CNVLEVIKDGYENAR CCEEHHHHHHHHHHH	50.72	-
243	Phosphorylation	ARRLCDLYYINSPEL HHHHHHEEEECCCCC	6.77	25147952
244	Phosphorylation	RRLCDLYYINSPELE HHHHHEEEECCCCCC	10.83	18083107
268	Phosphorylation	GQPIQVVYVPSHLYH CCCCEEEEECHHHHH	14.05	22817900
319	Methylation	LTVKMSDRGGGVPLR EEEEECCCCCCCCHH	38.05	-
336	Phosphorylation	DRLFNYMYSTAPRPR HHHHHHHHCCCCCCC	7.78	-
338	Phosphorylation	LFNYMYSTAPRPRVE HHHHHHCCCCCCCCC	24.16	-
346	Phosphorylation	APRPRVETSRAVPLA CCCCCCCCCCCCCCC	22.21	19835603
347	Phosphorylation	PRPRVETSRAVPLAG CCCCCCCCCCCCCCC	12.53	19835603
357	Phosphorylation	VPLAGFGYGLPISRL CCCCCCCCCCCHHHH	17.15	19835603
366	Phosphorylation	LPISRLYAQYFQGDL CCHHHHHHHHHCCCE	11.37	27251275
393	Phosphorylation	VIYIKALSTDSIERL EEEEEECCCCCHHHC	34.72	12177059
396	Phosphorylation	IKALSTDSIERLPVY EEECCCCCHHHCCCC	26.83	12177059
403	Phosphorylation	SIERLPVYNKAAWKH CHHHCCCCCHHHHHH	14.70	28060719
405	Ubiquitination	ERLPVYNKAAWKHYN HHCCCCCHHHHHHCC	23.07	-
405	Succinylation	ERLPVYNKAAWKHYN HHCCCCCHHHHHHCC	23.07	-
405	Succinylation	ERLPVYNKAAWKHYN HHCCCCCHHHHHHCC	23.07	-
431	Phosphorylation	SREPKDMTTFRSA-- CCCCCCCCCCCCC--	32.68	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
136	Y	Phosphorylation	Kinase	FGFR1	P11362	Uniprot
243	Y	Phosphorylation	Kinase	ABL	P00519	PSP
243	Y	Phosphorylation	Kinase	FGFR1	P11362	Uniprot
243	Y	Phosphorylation	Kinase	FLT3	P36888	Uniprot
243	Y	Phosphorylation	Kinase	JAK2	O60674	Uniprot
244	Y	Phosphorylation	Kinase	FGFR1	P11362	Uniprot
338	T	Phosphorylation	Kinase	PGK1	P00558	PSP
346	T	Phosphorylation	Kinase	AKT1	P31749	PSP
346	T	Phosphorylation	Kinase	AKT2	P31751	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PDK1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PDK1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PDK2_HUMAN	PDK2	physical	12573248
GNDS_HUMAN	RALGDS	physical	11889038
KS6B1_HUMAN	RPS6KB1	physical	11733037
RPTOR_HUMAN	RPTOR	physical	12150926
PKN2_HUMAN	PKN2	physical	10753910
PKN1_HUMAN	PKN1	physical	10753910
SGK1_HUMAN	SGK1	physical	17314099
XRCC6_HUMAN	XRCC6	physical	21900206
UBP4_HUMAN	USP4	physical	22347420
PDK1_HUMAN	PDK1	physical	18003900
PDK2_HUMAN	PDK2	physical	26186194
PDK3_HUMAN	PDK3	physical	26186194
ODPX_HUMAN	PDHX	physical	26186194
ODPA_HUMAN	PDHA1	physical	26186194
RPTOR_HUMAN	RPTOR	physical	24516643
MTOR_HUMAN	MTOR	physical	24516643
CO4A5_HUMAN	COL4A5	physical	26496610
HMGN1_HUMAN	HMGN1	physical	26496610
MYH1_HUMAN	MYH1	physical	26496610
PDK2_HUMAN	PDK2	physical	26496610
PDK3_HUMAN	PDK3	physical	26496610
SPG7_HUMAN	SPG7	physical	26496610
STXB2_HUMAN	STXBP2	physical	26496610
MKNK1_HUMAN	MKNK1	physical	26496610
CELF2_HUMAN	CELF2	physical	26496610
SRCAP_HUMAN	SRCAP	physical	26496610
RASF8_HUMAN	RASSF8	physical	26496610
RIMS1_HUMAN	RIMS1	physical	26496610
VWA8_HUMAN	VWA8	physical	26496610
COG4_HUMAN	COG4	physical	26496610
NECT3_HUMAN	PVRL3	physical	26496610
P5CR2_HUMAN	PYCR2	physical	26496610
NSF1C_HUMAN	NSFL1C	physical	26496610
ZNFX1_HUMAN	ZNFX1	physical	26496610
VKOR1_HUMAN	VKORC1	physical	26496610
ILKAP_HUMAN	ILKAP	physical	26496610
TRI47_HUMAN	TRIM47	physical	26496610
ATG4A_HUMAN	ATG4A	physical	26496610
NRBP2_HUMAN	NRBP2	physical	26496610
ODPA_HUMAN	PDHA1	physical	24486017
PDK2_HUMAN	PDK2	physical	28514442
CRBN_HUMAN	CRBN	physical	28514442
ODPX_HUMAN	PDHX	physical	28514442
DENR_HUMAN	DENR	physical	28514442
ITB3_HUMAN	ITGB3	physical	10896934

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.