PDK2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PDK2_HUMAN
• UniProt AC: Q15119
• Protein Name: [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial
• Gene Name: PDK2
• Organism: Homo sapiens (Human).
• Sequence Length: 407
• Subcellular Localization: Mitochondrion matrix.
• Protein Description: Kinase that plays a key role in the regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Inhibition of pyruvate dehydrogenase decreases glucose utilization and increases fat metabolism. Mediates cellular responses to insulin. Plays an important role in maintaining normal blood glucose levels and in metabolic adaptation to nutrient availability. Via its regulation of pyruvate dehydrogenase activity, plays an important role in maintaining normal blood pH and in preventing the accumulation of ketone bodies under starvation. Plays a role in the regulation of cell proliferation and in resistance to apoptosis under oxidative stress. Plays a role in p53/TP53-mediated apoptosis..
• Protein Sequence: MRWVWALLKNASLAGAPKYIEHFSKFSPSPLSMKQFLDFGSSNACEKTSFTFLRQELPVRLANIMKEINLLPDRVLSTPSVQLVQSWYVQSLLDIMEFLDKDPEDHRTLSQFTDALVTIRNRHNDVVPTMAQGVLEYKDTYGDDPVSNQNIQYFLDRFYLSRISIRMLINQHTLIFDGSTNPAHPKHIGSIDPNCNVSEVVKDAYDMAKLLCDKYYMASPDLEIQEINAANSKQPIHMVYVPSHLYHMLFELFKNAMRATVESHESSLILPPIKVMVALGEEDLSIKMSDRGGGVPLRKIERLFSYMYSTAPTPQPGTGGTPLAGFGYGLPISRLYAKYFQGDLQLFSMEGFGTDAVIYLKALSTDSVERLPVYNKSAWRHYQTIQEAGDWCVPSTEPKNTSTYRVS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
110	Phosphorylation	PEDHRTLSQFTDALV HHHHHHHHHHHHHHH	23.72	20071362
113	Phosphorylation	HRTLSQFTDALVTIR HHHHHHHHHHHHHHH	16.84	20071362
118	Phosphorylation	QFTDALVTIRNRHND HHHHHHHHHHHCCCC	18.31	20071362
129	Phosphorylation	RHNDVVPTMAQGVLE CCCCCCCCCCCCCHH	17.33	28857561
215	Phosphorylation	AKLLCDKYYMASPDL HHHHHHHHHCCCCCC	5.80	-
216	Phosphorylation	KLLCDKYYMASPDLE HHHHHHHHCCCCCCC	7.61	-
285	Phosphorylation	ALGEEDLSIKMSDRG EECCCCEEEEECCCC	32.27	-
289	Phosphorylation	EDLSIKMSDRGGGVP CCEEEEECCCCCCCC	21.10	28555341
291	Methylation	LSIKMSDRGGGVPLR EEEEECCCCCCCCHH	38.05	-
305	Phosphorylation	RKIERLFSYMYSTAP HHHHHHHHHHHHCCC	17.37	25002506
306	Phosphorylation	KIERLFSYMYSTAPT HHHHHHHHHHHCCCC	7.85	25002506
308	Phosphorylation	ERLFSYMYSTAPTPQ HHHHHHHHHCCCCCC	8.47	25002506
309	Phosphorylation	RLFSYMYSTAPTPQP HHHHHHHHCCCCCCC	11.10	25002506
310	Phosphorylation	LFSYMYSTAPTPQPG HHHHHHHCCCCCCCC	21.11	25002506
312	Ubiquitination	SYMYSTAPTPQPGTG HHHHHCCCCCCCCCC	44.70	27667366
313	Phosphorylation	YMYSTAPTPQPGTGG HHHHCCCCCCCCCCC	31.90	25002506
318	Phosphorylation	APTPQPGTGGTPLAG CCCCCCCCCCCCCCC	38.84	25002506
321	Phosphorylation	PQPGTGGTPLAGFGY CCCCCCCCCCCCCCC	19.24	25002506
328	Phosphorylation	TPLAGFGYGLPISRL CCCCCCCCCCCHHHH	17.15	25002506
333	Phosphorylation	FGYGLPISRLYAKYF CCCCCCHHHHHHHHH	17.81	25002506
359	Phosphorylation	FGTDAVIYLKALSTD CCCCEEEEEEECCCC	8.78	25332170
374	Phosphorylation	SVERLPVYNKSAWRH CCCCCCCCCHHHHHH	18.22	28060719
376	Ubiquitination	ERLPVYNKSAWRHYQ CCCCCCCHHHHHHHH	24.70	27667366
376	Succinylation	ERLPVYNKSAWRHYQ CCCCCCCHHHHHHHH	24.70	-
376	Succinylation	ERLPVYNKSAWRHYQ CCCCCCCHHHHHHHH	24.70	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PDK2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PDK2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PDK2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ODP2_HUMAN	DLAT	physical	12816949
ODPX_HUMAN	PDHX	physical	12816949
VSIG4_HUMAN	VSIG4	physical	21988832

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.