| UniProt ID | VSIG4_HUMAN | |
|---|---|---|
| UniProt AC | Q9Y279 | |
| Protein Name | V-set and immunoglobulin domain-containing protein 4 | |
| Gene Name | VSIG4 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 399 | |
| Subcellular Localization |
Membrane Single-pass type I membrane protein . |
|
| Protein Description | Phagocytic receptor, strong negative regulator of T-cell proliferation and IL2 production. Potent inhibitor of the alternative complement pathway convertases.. | |
| Protein Sequence | MGILLGLLLLGHLTVDTYGRPILEVPESVTGPWKGDVNLPCTYDPLQGYTQVLVKWLVQRGSDPVTIFLRDSSGDHIQQAKYQGRLHVSHKVPGDVSLQLSTLEMDDRSHYTCEVTWQTPDGNQVVRDKITELRVQKLSVSKPTVTTGSGYGFTVPQGMRISLQCQARGSPPISYIWYKQQTNNQEPIKVATLSTLLFKPAVIADSGSYFCTAKGQVGSEQHSDIVKFVVKDSSKLLKTKTEAPTTMTYPLKATSTVKQSWDWTTDMDGYLGETSAGPGKSLPVFAIILIISLCCMVVFTMAYIMLCRKTSQQEHVYEAARAHAREANDSGETMRVAIFASGCSSDEPTSQNLGNNYSDEPCIGQEYQIIAQINGNYARLLDTVPLDYEFLATEGKSVC | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 82 | Phosphorylation | DHIQQAKYQGRLHVS CHHHEEEECCEEEEC | 21.15 | - | |
| 89 | Phosphorylation | YQGRLHVSHKVPGDV ECCEEEECCCCCCCE | 13.57 | - | |
| 139 | Phosphorylation | ELRVQKLSVSKPTVT EEEEEEEEECCCEEE | 31.23 | 24719451 | |
| 219 | Phosphorylation | TAKGQVGSEQHSDIV CCCCCCCCCCCCCEE | 34.92 | 28188228 | |
| 235 | Acetylation | FVVKDSSKLLKTKTE EEEECHHHHHCCCCC | 62.89 | 24469771 | |
| 241 | Phosphorylation | SKLLKTKTEAPTTMT HHHHCCCCCCCCCCC | 42.48 | 28634298 | |
| 245 | Phosphorylation | KTKTEAPTTMTYPLK CCCCCCCCCCCEECE | 35.93 | 29759185 | |
| 246 | Phosphorylation | TKTEAPTTMTYPLKA CCCCCCCCCCEECEE | 13.37 | 29759185 | |
| 248 | Phosphorylation | TEAPTTMTYPLKATS CCCCCCCCEECEEEC | 21.64 | 28634298 | |
| 249 | Phosphorylation | EAPTTMTYPLKATST CCCCCCCEECEEECC | 8.85 | 29759185 | |
| 252 | Acetylation | TTMTYPLKATSTVKQ CCCCEECEEECCEEE | 45.15 | 24469777 | |
| 254 | Phosphorylation | MTYPLKATSTVKQSW CCEECEEECCEEECC | 24.28 | 28634298 | |
| 255 | Phosphorylation | TYPLKATSTVKQSWD CEECEEECCEEECCC | 35.74 | 28634298 | |
| 256 | Phosphorylation | YPLKATSTVKQSWDW EECEEECCEEECCCC | 27.63 | 29759185 | |
| 264 | O-linked_Glycosylation | VKQSWDWTTDMDGYL EEECCCCCCCCCCCC | 15.50 | OGP | |
| 310 | Phosphorylation | YIMLCRKTSQQEHVY HHHHHHHHHCHHHHH | 16.65 | 27251275 | |
| 311 | Phosphorylation | IMLCRKTSQQEHVYE HHHHHHHHCHHHHHH | 32.66 | 27251275 | |
| 317 | Phosphorylation | TSQQEHVYEAARAHA HHCHHHHHHHHHHHH | 11.19 | - | |
| 333 | Phosphorylation | EANDSGETMRVAIFA HHCCCCCCEEEEEEE | 17.50 | - | |
| 388 | Phosphorylation | LDTVPLDYEFLATEG HCCCCCCCCHHCCCC | 19.10 | 22817900 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of VSIG4_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of VSIG4_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of VSIG4_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
