SCMC3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SCMC3_HUMAN
• UniProt AC: Q9BV35
• Protein Name: Calcium-binding mitochondrial carrier protein SCaMC-3
• Gene Name: SLC25A23
• Organism: Homo sapiens (Human).
• Sequence Length: 468
• Subcellular Localization: Mitochondrion inner membrane ; Multi-pass membrane protein .
• Protein Description: Calcium-dependent mitochondrial solute carrier. Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane. [PubMed: 15123600 May act as a ATP-Mg/Pi exchanger that mediates the transport of Mg-ATP in exchange for phosphate, catalyzing the net uptake or efflux of adenine nucleotides into or from the mitochondria]
• Protein Sequence: MRGSPGDAERRQRWGRLFEELDSNKDGRVDVHELRQGLARLGGGNPDPGAQQGISSEGDADPDGGLDLEEFSRYLQEREQRLLLMFHSLDRNQDGHIDVSEIQQSFRALGISISLEQAEKILHSMDRDGTMTIDWQEWRDHFLLHSLENVEDVLYFWKHSTVLDIGECLTVPDEFSKQEKLTGMWWKQLVAGAVAGAVSRTGTAPLDRLKVFMQVHASKTNRLNILGGLRSMVLEGGIRSLWRGNGINVLKIAPESAIKFMAYEQIKRAILGQQETLHVQERFVAGSLAGATAQTIIYPMEVLKTRLTLRRTGQYKGLLDCARRILEREGPRAFYRGYLPNVLGIIPYAGIDLAVYETLKNWWLQQYSHDSADPGILVLLACGTISSTCGQIASYPLALVRTRMQAQASIEGGPQLSMLGLLRHILSQEGMRGLYRGIAPNFMKVIPAVSISYVVYENMKQALGVTSR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	O-linked_Glycosylation	----MRGSPGDAERR ----CCCCCCHHHHH	18.49	30379171
175 (in isoform 3)	Phosphorylation	-	16.81	22617229
181 (in isoform 3)	Phosphorylation	-	5.01	22617229
240	Phosphorylation	VLEGGIRSLWRGNGI HHHCCHHHHHCCCCC	30.29	24719451
251	Ubiquitination	GNGINVLKIAPESAI CCCCCEEEECCHHHH	32.32	27667366
251 (in isoform 4)	Ubiquitination	-	32.32	21906983
251 (in isoform 2)	Ubiquitination	-	32.32	21906983
251 (in isoform 1)	Ubiquitination	-	32.32	21906983
256	Phosphorylation	VLKIAPESAIKFMAY EEEECCHHHHHHHHH	33.95	-
259	Ubiquitination	IAPESAIKFMAYEQI ECCHHHHHHHHHHHH	28.89	-
263	Phosphorylation	SAIKFMAYEQIKRAI HHHHHHHHHHHHHHH	9.14	-
267 (in isoform 4)	Ubiquitination	-	35.16	21906983
267 (in isoform 2)	Ubiquitination	-	35.16	21906983
267 (in isoform 1)	Ubiquitination	-	35.16	21906983
267	Ubiquitination	FMAYEQIKRAILGQQ HHHHHHHHHHHHCCC	35.16	-
292	Phosphorylation	AGSLAGATAQTIIYP HHCCCCHHHHEEEEC	20.55	-
298	Ubiquitination	ATAQTIIYPMEVLKT HHHHEEEECHHHHHH	7.83	27667366
298 (in isoform 3)	Ubiquitination	-	7.83	21906983
308	Phosphorylation	EVLKTRLTLRRTGQY HHHHHHHHHHHHCCC	18.22	22210691
314 (in isoform 3)	Ubiquitination	-	35.83	21906983
367	Phosphorylation	KNWWLQQYSHDSADP HHHHHHHCCCCCCCC	8.60	-
368	Phosphorylation	NWWLQQYSHDSADPG HHHHHHCCCCCCCCC	19.24	-
402 (in isoform 2)	Phosphorylation	-	24.02	30622161
409	Phosphorylation	TRMQAQASIEGGPQL HHHHHHHHCCCCHHH	14.75	23663014
417	Phosphorylation	IEGGPQLSMLGLLRH CCCCHHHHHHHHHHH	13.50	23663014

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SCMC3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SCMC3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SCMC3_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of SCMC3_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.