TIGD5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TIGD5_HUMAN
• UniProt AC: Q53EQ6
• Protein Name: Tigger transposable element-derived protein 5
• Gene Name: TIGD5
• Organism: Homo sapiens (Human).
• Sequence Length: 642
• Subcellular Localization: Nucleus .
• Protein Sequence: MYPAGPPAGPVPRRGRRPLPGPPAPAPAPVPAARPPPPAPGPRPRVAVKMAFRKAYSIKDKLQAIERVKGGERQASVCRDFGVPGGTLRGWLKDEPKLRWFLEQLGGEVGTQRKKMRLANEEEIDRAVYAWFLALRQHGVPLSGPLIQAQAEAFARQIYGPECTFKASHGWFWRWQKRHGISSQRFYGEAGPPAPSPAPGPPVKEEPALPSGAGPLPDRAPAPPPPAEGGYGDEQIYSASVTGLYWKLLPEQAAPPGAGDPGAGGCGRRWRGDRVTVLLAANLTGSHKLKPLVIGRLPDPPSLRHHNQDKFPASYRYSPDAWLSRPLLRGWFFEEFVPGVKRYLRRSCLQQKAVLLVAHPPCPSPAASMPALDSEDAPVRCRPEPLGPPEELQTPDGAVRVLFLSKGSSRAHIPAPLEQGVVAAFKQLYKRELLRLAVSCASGSPLDFMRSFMLKDMLYLAGLSWDLVQAGSIERCWLLGLRAAFEPRPGEDSAGQPAQAEEAAEHSRVLSDLTHLAALAYKCLAPEEVAEWLHLDDDGGPPEGCREEVGPALPPAAPPAPASLPSAMGGGEDEEEATDYGGTSVPTAGEAVRGLETALRWLENQDPREVGPLRLVQLRSLISMARRLGGIGHTPAGPYDGV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
49	Acetylation	PRPRVAVKMAFRKAY CCCCHHHHHHHHHHH	18.12	25953088
54	Acetylation	AVKMAFRKAYSIKDK HHHHHHHHHHCHHHH	45.26	7696059
57	Phosphorylation	MAFRKAYSIKDKLQA HHHHHHHCHHHHHHH	28.20	24719451
59	Acetylation	FRKAYSIKDKLQAIE HHHHHCHHHHHHHHH	42.76	7683113
61	Ubiquitination	KAYSIKDKLQAIERV HHHCHHHHHHHHHHH	37.18	29967540
93	Methylation	GTLRGWLKDEPKLRW CCCCHHHCCCHHHHH	54.24	-
115	Acetylation	EVGTQRKKMRLANEE CCCHHHHHHCCCCHH	31.29	30592971
143	Phosphorylation	RQHGVPLSGPLIQAQ HHHCCCCCCHHHHHH	32.09	-
164	Phosphorylation	QIYGPECTFKASHGW HHHCCCCEEECCCCC	26.89	-
196	Phosphorylation	EAGPPAPSPAPGPPV CCCCCCCCCCCCCCC	35.48	23312004
204	Sumoylation	PAPGPPVKEEPALPS CCCCCCCCCCCCCCC	63.23	-
204	Ubiquitination	PAPGPPVKEEPALPS CCCCCCCCCCCCCCC	63.23	-
276	Phosphorylation	RWRGDRVTVLLAANL CCCCCCEEEEEEEEC	13.31	-
286	Phosphorylation	LAANLTGSHKLKPLV EEEECCCCCCCCCEE	16.53	30576142
290	Ubiquitination	LTGSHKLKPLVIGRL CCCCCCCCCEEEECC	40.90	29967540
292	Ubiquitination	GSHKLKPLVIGRLPD CCCCCCCEEEECCCC	4.13	21906983
310	Ubiquitination	LRHHNQDKFPASYRY HCCCCCCCCCCCCCC	43.41	-
341	Ubiquitination	EEFVPGVKRYLRRSC HHHHHHHHHHHHHHH	41.04	21963094
406	Ubiquitination	VRVLFLSKGSSRAHI EEEEEECCCCCCCCC	66.03	27667366
406	Acetylation	VRVLFLSKGSSRAHI EEEEEECCCCCCCCC	66.03	26051181
426	Ubiquitination	QGVVAAFKQLYKREL HHHHHHHHHHHHHHH	34.37	-
430	Ubiquitination	AAFKQLYKRELLRLA HHHHHHHHHHHHHHH	48.25	-
444	Phosphorylation	AVSCASGSPLDFMRS HHHHHCCCHHHHHHH	21.57	29759185

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TIGD5_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TIGD5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TIGD5_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
P4HA2_HUMAN	P4HA2	physical	28514442
ZMY19_HUMAN	ZMYND19	physical	28514442
GID4_HUMAN	GID4	physical	28514442
ARMC8_HUMAN	ARMC8	physical	28514442
EFR3A_HUMAN	EFR3A	physical	28514442
RBP10_HUMAN	RANBP10	physical	28514442
OCC1_HUMAN	C12orf75	physical	28514442
RASH_HUMAN	HRAS	physical	28514442
MKLN1_HUMAN	MKLN1	physical	28514442
STEA3_HUMAN	STEAP3	physical	28514442
ERIC5_HUMAN	ERICH5	physical	28514442
EEPD1_HUMAN	EEPD1	physical	28514442
RMD5A_HUMAN	RMND5A	physical	28514442
GNAQ_HUMAN	GNAQ	physical	28514442
GID8_HUMAN	GID8	physical	28514442
NEUM_HUMAN	GAP43	physical	28514442
EFR3B_HUMAN	EFR3B	physical	28514442
RIC8B_HUMAN	RIC8B	physical	28514442
WDR26_HUMAN	WDR26	physical	28514442
MAEA_HUMAN	MAEA	physical	28514442
ZN703_HUMAN	ZNF703	physical	28514442
PHAG1_HUMAN	PAG1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.