NEUM_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NEUM_HUMAN
• UniProt AC: P17677
• Protein Name: Neuromodulin
• Gene Name: GAP43
• Organism: Homo sapiens (Human).
• Sequence Length: 238
• Subcellular Localization: Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Cell projection, growth cone membrane ; Peripheral membrane protein ; Cytoplasmic side . Cell junction, synapse . Cell projection, filopodium membrane ; Peripheral membrane protein . Cy
• Protein Description: This protein is associated with nerve growth. It is a major component of the motile "growth cones" that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction..
• Protein Sequence: MLCCMRRTKQVEKNDDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPEADQEHA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	S-palmitoylation	-----MLCCMRRTKQ -----CCCCCCCCCC	1.33	12105219
4	S-palmitoylation	----MLCCMRRTKQV ----CCCCCCCCCCC	1.78	12105219
19	Ubiquitination	EKNDDDQKIEQDGIK CCCCCCHHHHHCCCC	56.03	-
26	Ubiquitination	KIEQDGIKPEDKAHK HHHHCCCCHHHHHHH	48.13	-
30	Ubiquitination	DGIKPEDKAHKAATK CCCCHHHHHHHHHHH	51.21	-
36	Phosphorylation	DKAHKAATKIQASFR HHHHHHHHHHHHHHH	33.27	26670566
37	Ubiquitination	KAHKAATKIQASFRG HHHHHHHHHHHHHHC	28.26	-
41	Phosphorylation	AATKIQASFRGHITR HHHHHHHHHHCCCCH	10.09	21712546
77	Phosphorylation	DEAPVADGVEKKGEG CCCCCCCCCEECCCC	21.53	24719451
94	Phosphorylation	TAEAAPATGSKPDEP CCCCCCCCCCCCCCC	40.71	21082442
96	Phosphorylation	EAAPATGSKPDEPGK CCCCCCCCCCCCCCC	36.34	26670566
107	Phosphorylation	EPGKAGETPSEEKKG CCCCCCCCCCHHHCC	31.06	18510355
109	Phosphorylation	GKAGETPSEEKKGEG CCCCCCCCHHHCCCC	66.85	18510355
113	Ubiquitination	ETPSEEKKGEGDAAT CCCCHHHCCCCCHHH	66.53	-
120	Phosphorylation	KGEGDAATEQAAPQA CCCCCHHHHHHCCCC	30.28	24114839
130	Phosphorylation	AAPQAPASSEEKAGS HCCCCCCCCHHHCCC	36.90	25307156
131	Phosphorylation	APQAPASSEEKAGSA CCCCCCCCHHHCCCC	52.46	18510355
134	Ubiquitination	APASSEEKAGSAETE CCCCCHHHCCCCCCH	54.73	-
137	Phosphorylation	SSEEKAGSAETESAT CCHHHCCCCCCHHHH	28.00	23312004
140	Phosphorylation	EKAGSAETESATKAS HHCCCCCCHHHHCCC	34.65	23312004
142	Phosphorylation	AGSAETESATKASTD CCCCCCHHHHCCCCC	48.97	18510355
144	Phosphorylation	SAETESATKASTDNS CCCCHHHHCCCCCCC	36.10	18510355
147	Phosphorylation	TESATKASTDNSPSS CHHHHCCCCCCCCCC	37.54	18510355
148	Phosphorylation	ESATKASTDNSPSSK HHHHCCCCCCCCCCC	44.02	18510355
151	Phosphorylation	TKASTDNSPSSKAED HCCCCCCCCCCCCCC	29.03	18510355
153	Phosphorylation	ASTDNSPSSKAEDAP CCCCCCCCCCCCCCC	44.27	29632367
154	Phosphorylation	STDNSPSSKAEDAPA CCCCCCCCCCCCCCC	38.99	18510355
175	Phosphorylation	ADVPAAVTAAAATTP CCCCHHHHHHHHCCH	13.07	29900121
175	O-linked_Glycosylation	ADVPAAVTAAAATTP CCCCHHHHHHHHCCH	13.07	28657654
180	Phosphorylation	AVTAAAATTPAAEDA HHHHHHHCCHHHHHH	28.69	25072903
181	Phosphorylation	VTAAAATTPAAEDAA HHHHHHCCHHHHHHH	13.25	26657352
192	Phosphorylation	EDAAAKATAQPPTET HHHHHHHHCCCCCCC	25.72	21406692
197	Phosphorylation	KATAQPPTETGESSQ HHHCCCCCCCCCCHH	53.51	21406692
199	Phosphorylation	TAQPPTETGESSQAE HCCCCCCCCCCHHHH	49.04	26657352
202	Phosphorylation	PPTETGESSQAEENI CCCCCCCCHHHHHHH	29.15	21406692
203	Phosphorylation	PTETGESSQAEENIE CCCCCCCHHHHHHHH	29.16	21406692
215	Phosphorylation	NIEAVDETKPKESAR HHHHHCCCCCHHHHC	48.46	21406692
216	Methylation	IEAVDETKPKESARQ HHHHCCCCCHHHHCC	52.63	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
41	S	Phosphorylation	Kinase	PHK	-	Uniprot
41	S	Phosphorylation	Kinase	PKC	-	Uniprot
202	S	Phosphorylation	Kinase	CK2	-	Uniprot
203	S	Phosphorylation	Kinase	CK2	-	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NEUM_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NEUM_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PLCD1_HUMAN	PLCD1	physical	12805215
RABE1_HUMAN	RABEP1	physical	9742146

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.