PLCD1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PLCD1_HUMAN
• UniProt AC: P51178
• Protein Name: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1
• Gene Name: PLCD1
• Organism: Homo sapiens (Human).
• Sequence Length: 756
• Protein Description: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. Essential for trophoblast and placental development..
• Protein Sequence: MDSGRDFLTLHGLQDDEDLQALLKGSQLLKVKSSSWRRERFYKLQEDCKTIWQESRKVMRTPESQLFSIEDIQEVRMGHRTEGLEKFARDVPEDRCFSIVFKDQRNTLDLIAPSPADAQHWVLGLHKIIHHSGSMDQRQKLQHWIHSCLRKADKNKDNKMSFKELQNFLKELNIQVDDSYARKIFRECDHSQTDSLEDEEIEAFYKMLTQRVEIDRTFAEAAGSGETLSVDQLVTFLQHQQREEAAGPALALSLIERYEPSETAKAQRQMTKDGFLMYLLSADGSAFSLAHRRVYQDMGQPLSHYLVSSSHNTYLLEDQLAGPSSTEAYIRALCKGCRCLELDCWDGPNQEPIIYHGYTFTSKILFCDVLRAIRDYAFKASPYPVILSLENHCTLEQQRVMARHLHAILGPMLLNRPLDGVTNSLPSPEQLKGKILLKGKKLGGLLPPGGEGGPEATVVSDEDEAAEMEDEAVRSRVQHKPKEDKLRLAQELSDMVIYCKSVHFGGFSSPGTPGQAFYEMASFSENRALRLLQESGNGFVRHNVGHLSRIYPAGWRTDSSNYSPVEMWNGGCQIVALNFQTPGPEMDVYQGRFQDNGACGYVLKPAFLRDPNGTFNPRALAQGPWWARKRLNIRVISGQQLPKVNKNKNSIVDPKVTVEIHGVSRDVASRQTAVITNNGFNPWWDTEFAFEVVVPDLALIRFLVEDYDASSKNDFIGQSTIPLNSLKQGYRHVHLMSKNGDQHPSATLFVKISLQD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10 (in isoform 2)	Phosphorylation	-	3.07	27282143
12 (in isoform 2)	Phosphorylation	-	28.31	25849741
12	Phosphorylation	RDFLTLHGLQDDEDL CCCEEECCCCCHHHH	28.31	24719451
16 (in isoform 2)	Phosphorylation	-	38.05	28102081
21 (in isoform 2)	Phosphorylation	-	23.35	28102081
26	Phosphorylation	LQALLKGSQLLKVKS HHHHHHCCCEEEECC	18.96	20058876
42	Phosphorylation	SWRRERFYKLQEDCK CHHHHHHHHHHHHHH	19.60	21060948
49	Ubiquitination	YKLQEDCKTIWQESR HHHHHHHHHHHHHHH	56.20	-
50	Phosphorylation	KLQEDCKTIWQESRK HHHHHHHHHHHHHHH	33.50	21060948
57	Ubiquitination	TIWQESRKVMRTPES HHHHHHHHHHCCCHH	50.06	-
61	Phosphorylation	ESRKVMRTPESQLFS HHHHHHCCCHHHCCC	17.20	24719451
86	Ubiquitination	HRTEGLEKFARDVPE CCCCHHHHHHHCCCC	49.74	-
102	Ubiquitination	RCFSIVFKDQRNTLD CEEEEEEECCCCCEE	41.90	-
132	Phosphorylation	LHKIIHHSGSMDQRQ HHHHHHCCCCHHHHH	20.57	23401153
134	Phosphorylation	KIIHHSGSMDQRQKL HHHHCCCCHHHHHHH	23.38	27732954
147	Phosphorylation	KLQHWIHSCLRKADK HHHHHHHHHHHHHHC	13.00	24275569
155	Phosphorylation	CLRKADKNKDNKMSF HHHHHHCCCCCCCCH	58.42	27251275
161	Phosphorylation	KNKDNKMSFKELQNF CCCCCCCCHHHHHHH	34.47	28857561
163	Ubiquitination	KDNKMSFKELQNFLK CCCCCCHHHHHHHHH	50.65	21906983
168	Phosphorylation	SFKELQNFLKELNIQ CHHHHHHHHHHHCCC	7.13	27251275
179	Phosphorylation	LNIQVDDSYARKIFR HCCCCCHHHHHHHHH	19.07	24076635
180	Phosphorylation	NIQVDDSYARKIFRE CCCCCHHHHHHHHHH	19.88	25690035
182	Phosphorylation	QVDDSYARKIFRECD CCCHHHHHHHHHHCC	25.11	27251275
191	Phosphorylation	IFRECDHSQTDSLED HHHHCCCCCCCCCCH	22.86	26657352
191	O-linked_Glycosylation	IFRECDHSQTDSLED HHHHCCCCCCCCCCH	22.86	UniProtKB CARBOHYD
193	O-linked_Glycosylation	RECDHSQTDSLEDEE HHCCCCCCCCCCHHH	30.48	UniProtKB CARBOHYD
193	Phosphorylation	RECDHSQTDSLEDEE HHCCCCCCCCCCHHH	30.48	26657352
195	Phosphorylation	CDHSQTDSLEDEEIE CCCCCCCCCCHHHHH	36.73	25849741
200	Phosphorylation	TDSLEDEEIEAFYKM CCCCCHHHHHHHHHH	59.45	27251275
216	Phosphorylation	TQRVEIDRTFAEAAG HHHHHCCHHHHHHHC	37.09	27251275
258	Phosphorylation	ALSLIERYEPSETAK HHHHHHHCCCCHHHH	21.28	-
295	Phosphorylation	SLAHRRVYQDMGQPL HHHHHHHHHHCCCCC	9.29	24043423
303	Phosphorylation	QDMGQPLSHYLVSSS HHCCCCCCCEEECCC	19.44	24043423
305	Phosphorylation	MGQPLSHYLVSSSHN CCCCCCCEEECCCCC	12.86	24043423
308	Phosphorylation	PLSHYLVSSSHNTYL CCCCEEECCCCCEEE	24.43	24043423
309	Phosphorylation	LSHYLVSSSHNTYLL CCCEEECCCCCEEEE	28.30	24043423
310	Phosphorylation	SHYLVSSSHNTYLLE CCEEECCCCCEEEEC	17.16	24043423
313	Phosphorylation	LVSSSHNTYLLEDQL EECCCCCEEEECCHH	15.32	24043423
314	Phosphorylation	VSSSHNTYLLEDQLA ECCCCCEEEECCHHC	18.01	24043423
324	Phosphorylation	EDQLAGPSSTEAYIR CCHHCCCCCHHHHHH	49.31	24043423
325	Phosphorylation	DQLAGPSSTEAYIRA CHHCCCCCHHHHHHH	33.14	24043423
326	Phosphorylation	QLAGPSSTEAYIRAL HHCCCCCHHHHHHHH	29.04	24043423
329	Phosphorylation	GPSSTEAYIRALCKG CCCCHHHHHHHHHCC	5.68	24043423
457	Phosphorylation	GEGGPEATVVSDEDE CCCCCCCEEECCHHH	21.56	26657352
460	Phosphorylation	GPEATVVSDEDEAAE CCCCEEECCHHHHHH	30.83	30266825
475	Phosphorylation	MEDEAVRSRVQHKPK HHHHHHHHHHCCCCH	30.15	23090842
481	Phosphorylation	RSRVQHKPKEDKLRL HHHHCCCCHHHHHHH	43.05	27251275
501	Phosphorylation	DMVIYCKSVHFGGFS HCCEEEECCEECCCC	19.77	-
508	Phosphorylation	SVHFGGFSSPGTPGQ CCEECCCCCCCCCCH	38.61	28348404
509	Phosphorylation	VHFGGFSSPGTPGQA CEECCCCCCCCCCHH	25.70	28348404
512	Phosphorylation	GGFSSPGTPGQAFYE CCCCCCCCCCHHHHH	27.85	28348404
535	Phosphorylation	ALRLLQESGNGFVRH HHHHHHHCCCCCEEC	25.29	22468782
557	Phosphorylation	IYPAGWRTDSSNYSP EECCCCCCCCCCCCC	33.45	24043423
559	Phosphorylation	PAGWRTDSSNYSPVE CCCCCCCCCCCCCCE	21.63	24043423
560	Phosphorylation	AGWRTDSSNYSPVEM CCCCCCCCCCCCCEE	42.47	24043423
562	Phosphorylation	WRTDSSNYSPVEMWN CCCCCCCCCCCEEEC	19.12	24043423
563	Phosphorylation	RTDSSNYSPVEMWNG CCCCCCCCCCEEECC	27.07	24043423
581	Phosphorylation	IVALNFQTPGPEMDV EEEEECCCCCCCCEE	26.52	24043423
589	Phosphorylation	PGPEMDVYQGRFQDN CCCCCEEEEECCCCC	10.86	24043423
637	Phosphorylation	RLNIRVISGQQLPKV CCCEEEECCCCCCCC	27.91	21406692
650	Phosphorylation	KVNKNKNSIVDPKVT CCCCCCCCCCCCCEE	26.12	23532336
657	Phosphorylation	SIVDPKVTVEIHGVS CCCCCCEEEEEECCC	20.67	29083192
664	Phosphorylation	TVEIHGVSRDVASRQ EEEEECCCCCCHHCC	27.62	29083192
671	Phosphorylation	SRDVASRQTAVITNN CCCCHHCCEEEEECC	31.17	27251275
710	Phosphorylation	LVEDYDASSKNDFIG HHHCCCCCCCCCCCC	38.66	27251275
711	Phosphorylation	VEDYDASSKNDFIGQ HHCCCCCCCCCCCCC	36.88	27251275
712	Ubiquitination	EDYDASSKNDFIGQS HCCCCCCCCCCCCCC	59.03	21906983
719	Phosphorylation	KNDFIGQSTIPLNSL CCCCCCCCCCCHHHH	24.08	27174698
720	Phosphorylation	NDFIGQSTIPLNSLK CCCCCCCCCCHHHHC	20.80	27174698
725	Phosphorylation	QSTIPLNSLKQGYRH CCCCCHHHHCCCCCE	44.63	27174698
730	Phosphorylation	LNSLKQGYRHVHLMS HHHHCCCCCEEEEEC	8.61	27174698
731	Phosphorylation	NSLKQGYRHVHLMSK HHHCCCCCEEEEECC	31.98	27251275

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PLCD1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PLCD1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PLCD1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RALA_HUMAN	RALA	physical	15817490
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 151600: Nail disorder, non-syndromic congenital, 3 (NDNC3)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.