ZN703_HUMAN - dbPTM
ZN703_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ZN703_HUMAN
UniProt AC Q9H7S9
Protein Name Zinc finger protein 703
Gene Name ZNF703
Organism Homo sapiens (Human).
Sequence Length 590
Subcellular Localization Nucleus . Cytoplasm.
Protein Description Transcriptional corepressor which does not bind directly to DNA and may regulate transcription through recruitment of histone deacetylases to gene promoters. Regulates cell adhesion, migration and proliferation. May be required for segmental gene expression during hindbrain development..
Protein Sequence MSDSPAGSNPRTPESSGSGSGGGGKRPAVPAAVSLLPPADPLRQANRLPIRVLKMLSAHTGHLLHPEYLQPLSSTPVSPIELDAKKSPLALLAQTCSQIGKPDPPPSSKLNSVAAAANGLGAEKDPGRSAPGAASAAAALKQLGDSPAEDKSSFKPYSKGSGGGDSRKDSGSSSVSSTSSSSSSSPGDKAGFRVPSAACPPFPPHGAPVSASSSSSSPGGSRGGSPHHSDCKNGGGVGGGELDKKDQEPKPSPEPAAVSRGGGGEPGAHGGAESGASGRKSEPPSALVGAGHVAPVSPYKPGHSVFPLPPSSIGYHGSIVGAYAGYPSQFVPGLDPSKSGLVGGQLSGGLGLPPGKPPSSSPLTGASPPSFLQGLCRDPYCLGGYHGASHLGGSSCSTCSAHDPAGPSLKAGGYPLVYPGHPLQPAALSSSAAQAALPGHPLYTYGFMLQNEPLPHSCNWVAASGPCDKRFATSEELLSHLRTHTALPGAEKLLAAYPGASGLGSAAAAAAAAASCHLHLPPPAAPGSPGSLSLRNPHTLGLSRYHPYGKSHLSTAGGLAVPSLPTAGPYYSPYALYGQRLASASALGYQ
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Acetylation------MSDSPAGSN
------CCCCCCCCC		46.9619413330
4Phosphorylation----MSDSPAGSNPR
----CCCCCCCCCCC		14.8919413330
8PhosphorylationMSDSPAGSNPRTPES
CCCCCCCCCCCCCCC		45.8522199227
12PhosphorylationPAGSNPRTPESSGSG
CCCCCCCCCCCCCCC		32.4425849741
15PhosphorylationSNPRTPESSGSGSGG
CCCCCCCCCCCCCCC		41.0022199227
16PhosphorylationNPRTPESSGSGSGGG
CCCCCCCCCCCCCCC		35.0025002506
18PhosphorylationRTPESSGSGSGGGGK
CCCCCCCCCCCCCCC		31.5625002506
20PhosphorylationPESSGSGSGGGGKRP
CCCCCCCCCCCCCCC		35.6419413330
73PhosphorylationPEYLQPLSSTPVSPI
HHHHCCCCCCCCCCC		38.5629523821
74PhosphorylationEYLQPLSSTPVSPIE
HHHCCCCCCCCCCCC		44.4029523821
75PhosphorylationYLQPLSSTPVSPIEL
HHCCCCCCCCCCCCC		25.0829523821
78PhosphorylationPLSSTPVSPIELDAK
CCCCCCCCCCCCCCC		22.7426657352
87PhosphorylationIELDAKKSPLALLAQ
CCCCCCCCHHHHHHH		25.1725849741
95PhosphorylationPLALLAQTCSQIGKP
HHHHHHHHHHHHCCC		14.4429978859
97PhosphorylationALLAQTCSQIGKPDP
HHHHHHHHHHCCCCC		28.3729978859
124AcetylationANGLGAEKDPGRSAP
HCCCCCCCCCCCCCC		69.5523236377
129PhosphorylationAEKDPGRSAPGAASA
CCCCCCCCCCCHHHH		44.7430387612
135PhosphorylationRSAPGAASAAAALKQ
CCCCCHHHHHHHHHH		20.2222210691
141AcetylationASAAAALKQLGDSPA
HHHHHHHHHHCCCCC		38.4626051181
146PhosphorylationALKQLGDSPAEDKSS
HHHHHCCCCCCCHHC		24.9821815630
153PhosphorylationSPAEDKSSFKPYSKG
CCCCCHHCCCCCCCC		42.92-
157PhosphorylationDKSSFKPYSKGSGGG
CHHCCCCCCCCCCCC		24.49-
166PhosphorylationKGSGGGDSRKDSGSS
CCCCCCCCCCCCCCC		44.50-
170PhosphorylationGGDSRKDSGSSSVSS
CCCCCCCCCCCCCCC		43.5423312004
172PhosphorylationDSRKDSGSSSVSSTS
CCCCCCCCCCCCCCC		24.3223312004
173PhosphorylationSRKDSGSSSVSSTSS
CCCCCCCCCCCCCCC		37.9823312004
174PhosphorylationRKDSGSSSVSSTSSS
CCCCCCCCCCCCCCC		27.9327794612
176PhosphorylationDSGSSSVSSTSSSSS
CCCCCCCCCCCCCCC		29.8227794612
177PhosphorylationSGSSSVSSTSSSSSS
CCCCCCCCCCCCCCC		30.1023312004
177O-linked_GlycosylationSGSSSVSSTSSSSSS
CCCCCCCCCCCCCCC		30.1030620550
178PhosphorylationGSSSVSSTSSSSSSS
CCCCCCCCCCCCCCC		25.7328450419
179PhosphorylationSSSVSSTSSSSSSSP
CCCCCCCCCCCCCCC		30.1228450419
179O-linked_GlycosylationSSSVSSTSSSSSSSP
CCCCCCCCCCCCCCC		30.1230620550
180PhosphorylationSSVSSTSSSSSSSPG
CCCCCCCCCCCCCCC		34.0428450419
181PhosphorylationSVSSTSSSSSSSPGD
CCCCCCCCCCCCCCC		33.7228450419
182PhosphorylationVSSTSSSSSSSPGDK
CCCCCCCCCCCCCCC		35.8728450419
183PhosphorylationSSTSSSSSSSPGDKA
CCCCCCCCCCCCCCC		36.4625849741
184PhosphorylationSTSSSSSSSPGDKAG
CCCCCCCCCCCCCCC		42.3625849741
185PhosphorylationTSSSSSSSPGDKAGF
CCCCCCCCCCCCCCC		34.5521955146
189AcetylationSSSSPGDKAGFRVPS
CCCCCCCCCCCCCCC		57.2223236377
210PhosphorylationPPHGAPVSASSSSSS
CCCCCCCCCCCCCCC		22.7525849741
212PhosphorylationHGAPVSASSSSSSPG
CCCCCCCCCCCCCCC		24.2126657352
213PhosphorylationGAPVSASSSSSSPGG
CCCCCCCCCCCCCCC		33.6830278072
214PhosphorylationAPVSASSSSSSPGGS
CCCCCCCCCCCCCCC		31.5730278072
215PhosphorylationPVSASSSSSSPGGSR
CCCCCCCCCCCCCCC		36.4630278072
216PhosphorylationVSASSSSSSPGGSRG
CCCCCCCCCCCCCCC		42.3630278072
217PhosphorylationSASSSSSSPGGSRGG
CCCCCCCCCCCCCCC		29.5225849741
221PhosphorylationSSSSPGGSRGGSPHH
CCCCCCCCCCCCCCC		33.4025849741
225PhosphorylationPGGSRGGSPHHSDCK
CCCCCCCCCCCCCCC		24.7225849741
229PhosphorylationRGGSPHHSDCKNGGG
CCCCCCCCCCCCCCC		41.4922496350
252PhosphorylationKDQEPKPSPEPAAVS
CCCCCCCCCCCCCCC		48.2829255136
259PhosphorylationSPEPAAVSRGGGGEP
CCCCCCCCCCCCCCC		22.0830242111
259O-linked_GlycosylationSPEPAAVSRGGGGEP
CCCCCCCCCCCCCCC		22.0830620550
260MethylationPEPAAVSRGGGGEPG
CCCCCCCCCCCCCCC		40.97115920609
297PhosphorylationAGHVAPVSPYKPGHS
CCCCCCCCCCCCCCC		22.8124719451
299PhosphorylationHVAPVSPYKPGHSVF
CCCCCCCCCCCCCCC		23.4724719451
339PhosphorylationPGLDPSKSGLVGGQL
CCCCHHCCCCCCCCC		41.52-
347PhosphorylationGLVGGQLSGGLGLPP
CCCCCCCCCCCCCCC		23.95-
359PhosphorylationLPPGKPPSSSPLTGA
CCCCCCCCCCCCCCC		52.5628348404
360PhosphorylationPPGKPPSSSPLTGAS
CCCCCCCCCCCCCCC		41.5728348404
361PhosphorylationPGKPPSSSPLTGASP
CCCCCCCCCCCCCCC		28.4128348404
364PhosphorylationPPSSSPLTGASPPSF
CCCCCCCCCCCCCHH		33.8028348404
367PhosphorylationSSPLTGASPPSFLQG
CCCCCCCCCCHHHHH		38.3928348404
470MethylationASGPCDKRFATSEEL
CCCCCCHHCCCHHHH		17.12-
528PhosphorylationPPPAAPGSPGSLSLR
CCCCCCCCCCCCCCC		25.6528348404
531PhosphorylationAAPGSPGSLSLRNPH
CCCCCCCCCCCCCCC		20.4017081983
533PhosphorylationPGSPGSLSLRNPHTL
CCCCCCCCCCCCCCC		27.2917081983
539PhosphorylationLSLRNPHTLGLSRYH
CCCCCCCCCCCCCCC		24.6328509920
544MethylationPHTLGLSRYHPYGKS
CCCCCCCCCCCCCCC		38.53115920617
550MethylationSRYHPYGKSHLSTAG
CCCCCCCCCCCCCCC		28.94115920605
554PhosphorylationPYGKSHLSTAGGLAV
CCCCCCCCCCCCCCC		15.7026503514
555PhosphorylationYGKSHLSTAGGLAVP
CCCCCCCCCCCCCCC		35.3626503514
566PhosphorylationLAVPSLPTAGPYYSP
CCCCCCCCCCCCCCH		49.9226503514
571PhosphorylationLPTAGPYYSPYALYG
CCCCCCCCCHHHHHH		13.3026503514
572PhosphorylationPTAGPYYSPYALYGQ
CCCCCCCCHHHHHHH		12.9426503514
580MethylationPYALYGQRLASASAL
HHHHHHHHHHHHHHH		28.0558860405
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ZN703_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ZN703_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ZN703_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of ZN703_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ZN703_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-4; SER-8; THR-12;SER-15; SER-20 AND SER-252, AND MASS SPECTROMETRY.

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