EFR3B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EFR3B_HUMAN
• UniProt AC: Q9Y2G0
• Protein Name: Protein EFR3 homolog B {ECO:0000305}
• Gene Name: EFR3B {ECO:0000312|HGNC:HGNC:29155}
• Organism: Homo sapiens (Human).
• Sequence Length: 817
• Subcellular Localization: Cell membrane ; Lipid-anchor . Cytoplasm, cytosol . Palmitoylation anchors the protein to the plasma membrane (PubMed:23229899, PubMed:25380825). A small amount is observed in the cytosol (PubMed:25380825).
• Protein Description: Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. [PubMed: 23229899]
• Protein Sequence: MYGVCGCCGALRPRYKRLVDNIFPEDPEDGLVKTNMEKLTFYALSAPEKLDRIGAYLSERLIRDVGRHRYGYVCIAMEALDQLLMACHCQSINLFVESFLKMVAKLLESEKPNLQILGTNSFVKFANIEEDTPSYHRSYDFFVSRFSEMCHSSHDDLEIKTKIRMSGIKGLQGVVRKTVNDELQANIWDPQHMDKIVPSLLFNLQHVEEAESRSPSPLQAPEKEKESPAELAERCLRELLGRAAFGNIKNAIKPVLIHLDNHSLWEPKVFAIRCFKIIMYSIQPQHSHLVIQQLLGHLDANSRSAATVRAGIVEVLSEAAVIAATGSVGPTVLEMFNTLLRQLRLSIDYALTGSYDGAVSLGTKIIKEHEERMFQEAVIKTVGSFASTLPTYQRSEVILFIMSKVPRPSLHQAVDTGRTGENRNRLTQIMLLKSLLQVSTGFQCNNMMSALPSNFLDRLLSTALMEDAEIRLFVLEILISFIDRHGNRHKFSTISTLSDISVLKLKVDKCSRQDTVFMKKHSQQLYRHIYLSCKEETNVQKHYEALYGLLALISIELANEEVVVDLIRLVLAVQDVAQVNEENLPVYNRCALYALGAAYLNLISQLTTVPAFCQHIHEVIETRKKEAPYMLPEDVFVERPRLSQNLDGVVIELLFRQSKISEVLGGSGYNSDRLCLPYIPQLTDEDRLSKRRSIGETISLQVEVESRNSPEKEERVPAEEITYETLKKAIVDSVAVEEQERERRRQVVEKFQKAPFEEIAAHCGARASLLQSKLNQIFEITIRPPPSPSGTITAAYGQPQNHSIPVYEMKFPDLCVY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
15	Phosphorylation	CGALRPRYKRLVDNI CHHHCHHHHHHHHHC	11.80	18083107
38 (in isoform 3)	Ubiquitination	-	41.90	21890473
38 (in isoform 1)	Ubiquitination	-	41.90	21890473
38	Ubiquitination	LVKTNMEKLTFYALS CEECCHHHEEEEECC	41.90	21890473
42	Phosphorylation	NMEKLTFYALSAPEK CHHHEEEEECCCHHH	11.03	27050516
56	Phosphorylation	KLDRIGAYLSERLIR HHHHHHHHHHHHHHH	12.92	-
70	Phosphorylation	RDVGRHRYGYVCIAM HHHCCCCCHHHHHCH	13.49	24043423
72	Phosphorylation	VGRHRYGYVCIAMEA HCCCCCHHHHHCHHH	5.34	24043423
91	Phosphorylation	LMACHCQSINLFVES HHHHCCCHHHHHHHH	20.88	24043423
98	Phosphorylation	SINLFVESFLKMVAK HHHHHHHHHHHHHHH	30.49	24719451
105	Acetylation	SFLKMVAKLLESEKP HHHHHHHHHHHCCCC	42.04	20167786
111	Acetylation	AKLLESEKPNLQILG HHHHHCCCCCEEEEE	48.78	20167786
199	Phosphorylation	HMDKIVPSLLFNLQH HHHHHHHHHHHHHHC	27.15	29514088
212	Phosphorylation	QHVEEAESRSPSPLQ HCHHHHHHCCCCCCC	45.14	25849741
214	Phosphorylation	VEEAESRSPSPLQAP HHHHHHCCCCCCCCC	38.72	30266825
216	Phosphorylation	EAESRSPSPLQAPEK HHHHCCCCCCCCCHH	39.22	30266825
223	Ubiquitination	SPLQAPEKEKESPAE CCCCCCHHHCCCHHH	73.38	-
338	Phosphorylation	TVLEMFNTLLRQLRL HHHHHHHHHHHHHHH	18.86	-
352	Phosphorylation	LSIDYALTGSYDGAV HHCCHHHHCCCCCCH	18.86	19690332
360	Phosphorylation	GSYDGAVSLGTKIIK CCCCCCHHHCCHHHH	22.13	19690332
363	Phosphorylation	DGAVSLGTKIIKEHE CCCHHHCCHHHHHHH	25.10	19690332
416	Phosphorylation	SLHQAVDTGRTGENR CHHHHHHCCCCCCCH	23.20	24719451
522	Phosphorylation	TVFMKKHSQQLYRHI CEEEHHHHHHHHHHH	28.62	24719451
643	Phosphorylation	FVERPRLSQNLDGVV CCCCCCCCCCCCHHH	20.50	27732954
678	Phosphorylation	SDRLCLPYIPQLTDE CCCCCCCCCCCCCCH	16.57	28122231
683	Phosphorylation	LPYIPQLTDEDRLSK CCCCCCCCCHHHHHH	31.90	26657352
689	Phosphorylation	LTDEDRLSKRRSIGE CCCHHHHHHCCCCCC	25.63	25849741
693	Phosphorylation	DRLSKRRSIGETISL HHHHHCCCCCCEEEE	38.69	26471730
697	Phosphorylation	KRRSIGETISLQVEV HCCCCCCEEEEEEEE	15.62	26471730
699	Phosphorylation	RSIGETISLQVEVES CCCCCEEEEEEEEEC	21.84	26471730
722	Phosphorylation	RVPAEEITYETLKKA CCCHHHCCHHHHHHH	20.70	25884760
723	Phosphorylation	VPAEEITYETLKKAI CCHHHCCHHHHHHHH	16.75	25884760
725	Phosphorylation	AEEITYETLKKAIVD HHHCCHHHHHHHHHH	33.20	26074081
727	Ubiquitination	EITYETLKKAIVDSV HCCHHHHHHHHHHHH	47.80	-
733	Phosphorylation	LKKAIVDSVAVEEQE HHHHHHHHHHHHHHH	10.90	26074081
768	Phosphorylation	AHCGARASLLQSKLN HHHCHHHHHHHHHHH	24.86	27251275
787	Phosphorylation	ITIRPPPSPSGTITA EEECCCCCCCCCEEE	37.16	22468782

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of EFR3B_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of EFR3B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EFR3B_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of EFR3B_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.