GID8_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GID8_HUMAN
• UniProt AC: Q9NWU2
• Protein Name: Glucose-induced degradation protein 8 homolog
• Gene Name: GID8
• Organism: Homo sapiens (Human).
• Sequence Length: 228
• Subcellular Localization: Nucleus .
• Protein Sequence: MSYAEKPDEITKDEWMEKLNNLHVQRADMNRLIMNYLVTEGFKEAAEKFRMESGIEPSVDLETLDERIKIREMILKGQIQEAIALINSLHPELLDTNRYLYFHLQQQHLIELIRQRETEAALEFAQTQLAEQGEESRECLTEMERTLALLAFDSPEESPFGDLLHTMQRQKVWSEVNQAVLDYENRESTPKLAKLLKLLLWAQNELDQKKVKYPKMTDLSKGVIEEPK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSYAEKPDE ------CCCCCCCCC		28355574
3	Phosphorylation	-----MSYAEKPDEI -----CCCCCCCCCC		30108239
6	Ubiquitination	--MSYAEKPDEITKD --CCCCCCCCCCCHH		33845483
11	Phosphorylation	AEKPDEITKDEWMEK CCCCCCCCHHHHHHH		28464451
39	Phosphorylation	LIMNYLVTEGFKEAA HHHHHHHHHCHHHHH		28464451
53	Phosphorylation	AEKFRMESGIEPSVD HHHHHHHCCCCCCCC		-
58	Phosphorylation	MESGIEPSVDLETLD HHCCCCCCCCHHHHH		-
63	Phosphorylation	EPSVDLETLDERIKI CCCCCHHHHHHHHHH		-
171	Ubiquitination	LHTMQRQKVWSEVNQ HHHHHHHHHHHHHHH		21890473
183	Phosphorylation	VNQAVLDYENRESTP HHHHHHCCCCCCCCH		28450419
188	Phosphorylation	LDYENRESTPKLAKL HCCCCCCCCHHHHHH		30624053
189	Phosphorylation	DYENRESTPKLAKLL CCCCCCCCHHHHHHH		30624053
191	Ubiquitination	ENRESTPKLAKLLKL CCCCCCHHHHHHHHH		-
194	Ubiquitination	ESTPKLAKLLKLLLW CCCHHHHHHHHHHHH		22817900
197	Ubiquitination	PKLAKLLKLLLWAQN HHHHHHHHHHHHHHH		21906983
209	Ubiquitination	AQNELDQKKVKYPKM HHHHHHHHCCCCCCC		32015554
221	Ubiquitination	PKMTDLSKGVIEEPK CCCCCHHCCCCCCCC		21906983

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GID8_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
48	K	ubiquitylation	Polyubiquitinated through 'Lys-48'-polyubiquitin chains, leading to proteasomal degradation in the absence of Wnt stimulation.	28829046

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GID8_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MKLN1_HUMAN	MKLN1	physical	17467196
MAEA_HUMAN	MAEA	physical	17467196
GID8_HUMAN	GID8	physical	17467196
RMD5A_HUMAN	RMND5A	physical	17467196
RANB9_HUMAN	RANBP9	physical	17467196
TBL1X_HUMAN	TBL1X	physical	22939629
RANB9_HUMAN	RANBP9	physical	22863883
RBP10_HUMAN	RANBP10	physical	26344197
RANB9_HUMAN	RANBP9	physical	26344197
RMD5A_HUMAN	RMND5A	physical	27173435
MAEA_HUMAN	MAEA	physical	27173435
WDR26_HUMAN	WDR26	physical	27173435
RANB9_HUMAN	RANBP9	physical	27173435
NGAL_HUMAN	LCN2	physical	27173435
PGRC2_HUMAN	PGRMC2	physical	27173435
ARMC8_HUMAN	ARMC8	physical	27173435
INVO_HUMAN	IVL	physical	27173435
SAP3_HUMAN	GM2A	physical	27173435
SPR2D_HUMAN	SPRR2D	physical	27173435
RMD5B_HUMAN	RMND5B	physical	27173435
MKLN1_HUMAN	MKLN1	physical	27173435
LIS1_HUMAN	PAFAH1B1	physical	27173435
RBP10_HUMAN	RANBP10	physical	27173435
EFHC2_HUMAN	EFHC2	physical	27173435
YPEL5_HUMAN	YPEL5	physical	27173435
RAB8A_HUMAN	RAB8A	physical	27173435

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.