EFHC2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EFHC2_HUMAN
• UniProt AC: Q5JST6
• Protein Name: EF-hand domain-containing family member C2
• Gene Name: EFHC2
• Organism: Homo sapiens (Human).
• Sequence Length: 749
• Protein Sequence: MALPLLPGNSFNRNVGKEKFHKSQHWGFCNNVMMLVSDEKPGIGGEPLLGQKIKPKCSIYPKGDGSDVPSWVAFDKQVLSFDAYLEEEVLDKSQTNYRIRYYKIYFYPEDDTIQVNEPEVKNSGLLQGTSIRRHRITLPPPDEDQFYTVYHFNVGTEVVFYGRTFKIYDCDAFTRNFLRKIGVKVNPPVQCPEDPYMKIRREVVEHVEPLRPYESLDTLKQFLQYHGKILCFFCLWDDSVSMFGDRRELILHYFLCDDTIEIKELLPHSSGRDALKMFLRRSKLPKNCPPRVYQPGQITDRAVLNSYGDFIKNQADGYLFDRYKLGKVDQEFYKDSDLSLGVTINVWGRKVLLYDCDEFTKSYYKSKYGIENFTSVSCKPPSPPPKIERKFPPYNGFGSEEDSLRNCIDLKPTPHRRNFKKFMEKDSYGSKSNILRFFAKLVTDKCVDLDRMFVISYYLGDDTISVFEPIERNSGIAGGMFLKRSRVKKPGQEVFKSELSEYIKAEELYIGVTVNVNGYLFRLLNADEYTLNYMEQNTDKYPFSNLKLALQKLKQEEGKSRELKQVFKAADSKHTNMVDYNTFRDILMSLTVGNLAEQEFVTIARHYRVPEGTCSDMDFLIALAHEKFKKNMFENFDTFIYSCVYEDREKKNVLPTKDIKRLCKSSRLPLSDDLLESLLSRFEDSEKQIDYKSFFSALNWRKNPVPELQPASYLKERCEDVWLGMPSPIPAKYIDYWTFLKDAFGLEEE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	LPLLPGNSFNRNVGK CCCCCCCCCCCCCCC	29.79	25693802
168	Phosphorylation	YGRTFKIYDCDAFTR ECEEEEEEECCHHHH	15.88	-
220	Acetylation	YESLDTLKQFLQYHG CCCHHHHHHHHHHCC	40.89	25038526
324	Acetylation	GYLFDRYKLGKVDQE CCCCCCCCCCCCCHH	52.21	25038526
367	Acetylation	TKSYYKSKYGIENFT HHHHHHHHHCCCCCE	43.26	25038526
374	Phosphorylation	KYGIENFTSVSCKPP HHCCCCCEECCCCCC	39.54	28060719
375	Phosphorylation	YGIENFTSVSCKPPS HCCCCCEECCCCCCC	14.11	28060719
377	Phosphorylation	IENFTSVSCKPPSPP CCCCEECCCCCCCCC	19.05	28060719
382	Phosphorylation	SVSCKPPSPPPKIER ECCCCCCCCCCCCCC	59.57	28060719
431	Acetylation	EKDSYGSKSNILRFF HHCCCCCHHHHHHHH	43.06	18528539
483	Ubiquitination	IAGGMFLKRSRVKKP CCCCCEECHHCCCCC	36.74	30230243
485	Phosphorylation	GGMFLKRSRVKKPGQ CCCEECHHCCCCCCH	39.58	26074081
497	Phosphorylation	PGQEVFKSELSEYIK CCHHHHHHHHHHHHC	32.10	26074081
500	Phosphorylation	EVFKSELSEYIKAEE HHHHHHHHHHHCHHE	25.05	26074081
502	Phosphorylation	FKSELSEYIKAEELY HHHHHHHHHCHHEEE	12.35	26074081
509	Phosphorylation	YIKAEELYIGVTVNV HHCHHEEEEEEEEEE	10.02	25884760
519	Phosphorylation	VTVNVNGYLFRLLNA EEEEECCEEEEECCC	9.47	25884760
665	Phosphorylation	DIKRLCKSSRLPLSD HHHHHHHHCCCCCCH	21.50	30576142
671	Phosphorylation	KSSRLPLSDDLLESL HHCCCCCCHHHHHHH	27.43	22210691
677	Phosphorylation	LSDDLLESLLSRFED CCHHHHHHHHHHCCC	34.28	24719451
680	Phosphorylation	DLLESLLSRFEDSEK HHHHHHHHHCCCCCC	39.97	24719451
687	Acetylation	SRFEDSEKQIDYKSF HHCCCCCCCCCHHHH	57.41	25038526
715	Acetylation	LQPASYLKERCEDVW CCCHHHHHHHHCCEE	34.57	25038526

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of EFHC2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of EFHC2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EFHC2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TSSK3_HUMAN	TSSK3	physical	25416956
CC120_HUMAN	CCDC120	physical	25416956
LONF1_HUMAN	LONRF1	physical	25416956
EGLN3_HUMAN	EGLN3	physical	25416956
TRI42_HUMAN	TRIM42	physical	25416956
YPEL5_HUMAN	YPEL5	physical	27173435
ARMC8_HUMAN	ARMC8	physical	27173435
RBP10_HUMAN	RANBP10	physical	27173435
WDR26_HUMAN	WDR26	physical	27173435
RANB9_HUMAN	RANBP9	physical	27173435
MAEA_HUMAN	MAEA	physical	27173435

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.