LONF1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LONF1_HUMAN
• UniProt AC: Q17RB8
• Protein Name: LON peptidase N-terminal domain and RING finger protein 1
• Gene Name: LONRF1
• Organism: Homo sapiens (Human).
• Sequence Length: 773
• Protein Sequence: MSSPAVARTSPGGSREMAPAPQGRGRFWEVGGGSGHRLERAAAESERWELLLRRGELLALGGHLKGALEAFAAALRRGAPARPECLGALVDCLVFNYRLRHGLGWSAAPVAGADGGAGGLLRCLGCRGFLSEPVTVPCGHSYCRRCLRRELRARCRLCRDRLPPATASATDAEGTAPRPPPLAAAIAASDFRTSVVLNHLAEKWFPGQRERARAAGRLGELLHQGRYREALAAACEALRAEPSDLIVKIYRAESYAGLQEFKAAIEDLNAVLFQLPDWPEVYFRKGKVLCDAGFLGDALQLFLQCLALDEDFAPAKLQVQKILCDLLLPENLKEGLKESSWSSLPCTKNRPFDFHSVMEESQSLNEPSPKQSEEIPEVTSEPVKGSLNRAQSAQSINSTEMPAREDCLKRVSSEPVLSVQEKGVLLKRKLSLLEQDVIVNEDGRNKLKKQGETPNEVCMFSLAYGDIPEELIDVSDFECSLCMRLFFEPVTTPCGHSFCKNCLERCLDHAPYCPLCKESLKEYLADRRYCVTQLLEELIVKYLPDELSERKKIYDEETAELSHLTKNVPIFVCTMAYPTVPCPLHVFEPRYRLMIRRSIQTGTKQFGMCVSDTQNSFADYGCMLQIRNVHFLPDGRSVVDTVGGKRFRVLKRGMKDGYCTADIEYLEDVKVENEDEIKNLRELHDLVYSQACSWFQNLRDRFRSQILQHFGSMPEREENLQAAPNGPAWCWWLLAVLPVDPRYQLSVLSMKSLKERLTKIQHILTYFSRDQSK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSSPAVART ------CCCCCCCCC	45.06	27794612
2	O-linked_Glycosylation	------MSSPAVART ------CCCCCCCCC	45.06	30379171
3	Phosphorylation	-----MSSPAVARTS -----CCCCCCCCCC	18.64	27794612
9	Phosphorylation	SSPAVARTSPGGSRE CCCCCCCCCCCCCCC	29.54	-
77	Dimethylation	AFAAALRRGAPARPE HHHHHHHHCCCCCHH	46.61	-
77	Methylation	AFAAALRRGAPARPE HHHHHHHHCCCCCHH	46.61	30762545
82	Methylation	LRRGAPARPECLGAL HHHCCCCCHHHHHHH	26.87	30762551
82	Dimethylation	LRRGAPARPECLGAL HHHCCCCCHHHHHHH	26.87	-
203	Methylation	VLNHLAEKWFPGQRE HHHHHHHHHCCCHHH	48.83	23644510
203	Ubiquitination	VLNHLAEKWFPGQRE HHHHHHHHHCCCHHH	48.83	-
227	Phosphorylation	ELLHQGRYREALAAA HHHHHCHHHHHHHHH	21.45	30576142
243	Phosphorylation	EALRAEPSDLIVKIY HHHHCCCCCEEEEEH	36.23	30576142
333	Ubiquitination	LLLPENLKEGLKESS HHCCCHHHHHHHHCC	62.41	32015554
372	Phosphorylation	NEPSPKQSEEIPEVT CCCCHHCCCCCCCCC	43.24	-
379	Phosphorylation	SEEIPEVTSEPVKGS CCCCCCCCCCCCCCC	26.22	27732954
380	Phosphorylation	EEIPEVTSEPVKGSL CCCCCCCCCCCCCCC	45.11	27732954
384	Ubiquitination	EVTSEPVKGSLNRAQ CCCCCCCCCCCCHHH	54.20	29967540
392	Phosphorylation	GSLNRAQSAQSINST CCCCHHHHCCCCCCC	27.56	27251275
395	Phosphorylation	NRAQSAQSINSTEMP CHHHHCCCCCCCCCC	24.37	24702127
398	Phosphorylation	QSAQSINSTEMPARE HHCCCCCCCCCCCHH	24.87	24702127
399	Phosphorylation	SAQSINSTEMPARED HCCCCCCCCCCCHHH	31.64	24702127
409	Ubiquitination	PAREDCLKRVSSEPV CCHHHHHHHHCCCCC	58.02	-
412	Phosphorylation	EDCLKRVSSEPVLSV HHHHHHHCCCCCCCH	32.77	25159151
413	Phosphorylation	DCLKRVSSEPVLSVQ HHHHHHCCCCCCCHH	42.96	27050516
429	Ubiquitination	KGVLLKRKLSLLEQD HCHHHHHHHHHHHCC	40.62	-
431	Phosphorylation	VLLKRKLSLLEQDVI HHHHHHHHHHHCCEE	33.66	24719451
500	Ubiquitination	PCGHSFCKNCLERCL CCCCHHHHHHHHHHH	49.00	-
603	Phosphorylation	RRSIQTGTKQFGMCV HHHHHCCCCEECEEE	25.67	-
626	Phosphorylation	DYGCMLQIRNVHFLP CCCEEEEEEEEEECC	2.81	32142685
630	Phosphorylation	MLQIRNVHFLPDGRS EEEEEEEEECCCCCE	23.29	32142685
637	Phosphorylation	HFLPDGRSVVDTVGG EECCCCCEEEECCCC	31.83	32142685
641	Phosphorylation	DGRSVVDTVGGKRFR CCCEEEECCCCEEEE	14.94	32142685
645	Ubiquitination	VVDTVGGKRFRVLKR EEECCCCEEEEECCC	42.29	-
766	Phosphorylation	KIQHILTYFSRDQSK HHHHHHHHHHCCCCC	8.98	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LONF1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LONF1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LONF1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TRIM9_HUMAN	TRIM9	physical	22493164
LONF1_HUMAN	LONRF1	physical	25416956
KR131_HUMAN	KRTAP13-1	physical	25416956
TRI42_HUMAN	TRIM42	physical	25416956
IHO1_HUMAN	CCDC36	physical	25416956
IQCF2_HUMAN	IQCF2	physical	25416956
LONF2_HUMAN	LONRF2	physical	28514442
GOGA2_HUMAN	GOLGA2	physical	28514442
KCNJ5_HUMAN	KCNJ5	physical	28514442
ISCU_HUMAN	ISCU	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.