dbPTM

KR131_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	KR131_HUMAN
UniProt AC	Q8IUC0
Protein Name	Keratin-associated protein 13-1
Gene Name	KRTAP13-1
Organism	Homo sapiens (Human).
Sequence Length	172
Subcellular Localization
Protein Description	In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins..
Protein Sequence	MSYNCCSGNFSSRSCGGYLHYPASSCGFSYPSNQVYSTDLCSPSTCQLGSSLYRGCQQTCWEPTSCQTSYVESSPCQTSCYRPRTSLLCSPCQTTYSGSLGFGSSSCRSLGYGSRSCYSVGCGSSGFRSLGYGGCGFPSLGYGVGFCRPTYLASRSCQSSCYRPTCGSGFYY

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSYNCCSGN ------CCCCCCCCC	25.67	-
3	Phosphorylation	-----MSYNCCSGNF -----CCCCCCCCCC	15.77	-
11	Phosphorylation	NCCSGNFSSRSCGGY CCCCCCCCCCCCCCE	28.92	-
114	Phosphorylation	CRSLGYGSRSCYSVG CHHCCCCCCCEEECC	16.73	-
124	Phosphorylation	CYSVGCGSSGFRSLG EEECCCCCCCCCCCC	31.22	-
168	Phosphorylation	CYRPTCGSGFYY--- CCCCCCCCCCCC---	28.07	-
172	Phosphorylation	TCGSGFYY------- CCCCCCCC-------	15.15	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of KR131_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of KR131_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of KR131_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CF206_HUMAN	C6orf165	physical	25416956
TB10C_HUMAN	TBC1D10C	physical	25416956
KR103_HUMAN	KRTAP10-3	physical	25416956

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of KR131_HUMAN

Related Literatures of Post-Translational Modification